摘要:
Disclosed is means capable of solving trouble in managing data formats and procedures and capable of carrying out advanced preprocessing more intuitively. A data aggregate to be inputted to a mining engine is converted into hierarchical unit trees, and node conditions of the hierarchical unit trees are changed, whereby the data aggregate and a data structure are subjected to dynamic conversion/edition processing. Thus, a system is constructed, in which preprocessing for data mining is unitarily managed/semi-automated.
摘要:
New information is extracted efficiently and exhaustively to predict the function of genes or proteins. First, known-sequence data with high relevance to a search object sequence or structure information is obtained using a sequence database. Then, documents relevant to the resultant known-sequence data are retrieved, using a document database. Feature words common to a plurality of documents extracted are extracted and outputted.
摘要:
(A) Luminance data is prepared. (B) A group of first order differential values is obtained from luminance values of said luminance data along a first direction, a group of second order differential values is obtained from the group of first order differential values, and first data is output in accordance with the group of second order differential values. There is provided a stain inspection method having high inspection correctness.
摘要:
In a speaker device 10 having: a magnetic circuit 13 including a magnet 14 and a yoke 11; a voice coil 16 which is placed in a magnetic gap 12 of the magnetic circuit 13; and a diaphragm 17 which is vibrating available in a state where the diaphragm is coupled with the voice coil 16, a peripheral edge of the diaphragm 17 being fixed to a housing 20, a damper holder 30 is disposed in a portion where a damper 27 is attached to the housing 20. The damper holder 30 is in point contact with the housing 20 via three or more projections 31 which are disposed on one of the damper holder 30 and the housing 20. Preferably, the damper holder 30 is made of a hybrid material of a resin (polypropylene) and tungsten, and has a specific gravity of 10.0 or larger.
摘要:
Selection of clones having the kinase and/or phosphatase-like structure from clones which had been isolated and the structures thereof had been determined in the Helix Research Institute (helix clones; Japanese Patent Application No. 2000-183767) was conducted. Two novel genes were provided by carrying out homology search for all the helix clones by using the amino acid sequences of known kinases and phosphatases as queries. The genes are expected to be involved in intracellular signal transduction. The physiological functions of the inventive genes can be tested by using reporter gene assay systems capable of detecting signal transduction. The proteins of the present invention are useful as target molecules in drug discovery and in the development of new pharmaceuticals.
摘要:
A multicolor fluorescence detection type electrophoresis apparatus comprises an electrophoretic device having migration lanes in which fragment groups specifically labeled by fluorophores of different light emission peak wavelengths are mixed, added, and migrated. It identifies and detects the fragment groups. It uses laser beams of different wavelengths for exciting the fluorophores in the migration lanes. The laser beams are irradiated to separate positions on the migration lanes for detection of a few kinds of fluorophores at irradiation positions. For the purpose, multicolor optical filters are arranged near the irradiation positions to identify and detect lights emitted from the fluorophores excited by wavelength at every irradiation position.
摘要:
A charge coupled device (CCD) has a charge storage region and a potential barrier region. The CCD includes a first layer made of a first conductivity type semiconductor, a second layer made of a second conductivity type semiconductor and provided on the first layer, where the first and second conductivity types are mutually opposite types selected from n-type and p-type semiconductors, a third layer made of a first conductivity type semiconductor, impurity diffusion regions provided in at least a surface part of the third layer and having an impurity density higher than that of the third layer, a first gate electrode provided on the third layer between two mutually adjacent impurity diffusion regions, and a second gate electrode provided on each impurity diffusion region of the third layer. The impurity diffusion region forms the charge storage region of the CCD and the third layer between the two mutually adjacent impurity diffusion regions forms the potential barrier region of the CCD.
摘要:
A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要:
An object of the present invention is to perform the clustering and assembling of nucleic acid base sequences at a high speed. Partial sequences 102 are extracted from each input sequence 101 and entered into a fixed-length partial sequence table 103. In the case where a sequence overlapping with a consensus sequence 104 is searched while making reference to the fixed-length partial sequence table 103 and consequently a partial sequence 102, which exactly matches with a sequence defined by a fixed length window 105 scanning along the consensus sequence, is found to be present, whether the whole input sequence can be assembled or not is determined by comparing the sequences. If it is possible to assemble the sequences, they are assembled into a consensus sequence and also joined into the same cluster. The clustering and assembling are performed by repeatedly processing this procedure based on greedy method until no unprocessed input nucleic acid base sequence is left.
摘要:
The present invention provides: proteins suppressing or promoting the aggregation or deposition of amyloid-β protein; polynucleotides encoding the proteins; a method for screening a compound suppressing or promoting the aggregation or deposition of amyloid-β protein; and therapeutic agents for treating or preventing Alzheimer's diseases comprising a compound that regulates the activity of a protein suppressing or promoting the aggregation or deposition of amyloid-β protein.