公开(公告)号：US20080174859A1

公开(公告)日：2008-07-24

申请号：US11842561

申请日：2007-08-21

申请人： Yoshihisa Tanikawa ,  Tomoaki Sato ,  Ryoji Hyodo

发明人： Yoshihisa Tanikawa ,  Tomoaki Sato ,  Ryoji Hyodo

IPC分类号： G02B21/00

CPC分类号： G02B27/646 ,  A61B5/0059 ,  A61B5/4244 ,  A61B90/20 ,  A61B2503/40 ,  A61B2562/146 ,  G02B21/24

摘要： An in vivo examination apparatus including an objective unit capable of being readily replaced during examination is provided. The in vivo examination apparatus includes a main body, a vibration suppressor configured to suppress vibrations in an examination region of an object under examination, and an objective optical system configured to observe the examination region where the vibrations are suppressed. The objective optical system and the vibration suppressor are attached to the main body. The objective optical system is attachable to and detachable from the main body in a direction crossing an optical-axis direction of the objective optical system.

摘要翻译： 提供一种体内检查装置，其包括能够在检查期间容易地更换的目标单元。 体内检查装置包括：主体，抑制检查对象的检查区域的振动的振动抑制器;以及被配置为观察被抑制振动的检查区域的物镜光学系统。 物镜光学系统和振动抑制器安装在主体上。 物镜光学系统可以在与物镜光学系统的光轴方向交叉的方向上与主体相连接和拆卸。

公开(公告)号：US07675675B2

公开(公告)日：2010-03-09

申请号：US11842561

申请日：2007-08-21

申请人： Yoshihisa Tanikawa ,  Tomoaki Sato ,  Ryoji Hyodo

发明人： Yoshihisa Tanikawa ,  Tomoaki Sato ,  Ryoji Hyodo

IPC分类号： G02B21/00

CPC分类号： G02B27/646 ,  A61B5/0059 ,  A61B5/4244 ,  A61B90/20 ,  A61B2503/40 ,  A61B2562/146 ,  G02B21/24

摘要： An in vivo examination apparatus including an objective unit capable of being readily replaced during examination is provided. The in vivo examination apparatus includes a main body, a vibration suppressor configured to suppress vibrations in an examination region of an object under examination, and an objective optical system configured to observe the examination region where the vibrations are suppressed. The objective optical system and the vibration suppressor are attached to the main body. The objective optical system is attachable to and detachable from the main body in a direction crossing an optical-axis direction of the objective optical system.

摘要翻译： 提供一种体内检查装置，其包括能够在检查期间容易地更换的目标单元。 体内检查装置包括：主体，抑制检查对象的检查区域的振动的振动抑制器;以及被配置为观察被抑制振动的检查区域的物镜光学系统。 物镜光学系统和振动抑制器安装在主体上。 物镜光学系统可以在与物镜光学系统的光轴方向交叉的方向上与主体相连接和拆卸。

公开(公告)号：US07980540B2

公开(公告)日：2011-07-19

申请号：US11730074

申请日：2007-03-29

申请人： Yoshihisa Tanikawa ,  Ryoji Hyodo ,  Kayuri Muraki

发明人： Yoshihisa Tanikawa ,  Ryoji Hyodo ,  Kayuri Muraki

IPC分类号： B23Q3/00

CPC分类号： G02B21/24 ,  G02B21/26 ,  G02B23/2476 ,  Y10S269/909 ,  Y10T29/53961

摘要： Dynamic movement of a specimen in a pressing direction and in directions intersecting the pressing direction is effectively suppressed, while maintaining the viability of the specimen. A stabilizer for in vivo examination that is placed in contact with a biological specimen during examination of the specimen to suppress movement thereof includes a contact-area increasing portion that is provided on a contact surface with the biological specimen and that is configured to increase the contact area with the biological specimen by virtue of a pressure applied during the contact.

摘要翻译： 在保持试样的活力的同时，有效地抑制试样在按压方向和与挤压方向交叉的方向上的动态运动。 用于在检查试样以抑制其运动时与生物样品接触的体内检查的稳定剂包括设置在与生物样本接触表面并且被配置为增加接触的接触面积增加部分 通过在接触期间施加的压力与生物样品的区域。

公开(公告)号：US20070236783A1

公开(公告)日：2007-10-11

申请号：US11730074

申请日：2007-03-29

申请人： Yoshihisa Tanikawa ,  Ryoji Hyodo ,  Kayuri Muraki

发明人： Yoshihisa Tanikawa ,  Ryoji Hyodo ,  Kayuri Muraki

IPC分类号： G02B21/00

CPC分类号： G02B21/24 ,  G02B21/26 ,  G02B23/2476 ,  Y10S269/909 ,  Y10T29/53961

摘要： Dynamic movement of a specimen in a pressing direction and in directions intersecting the pressing direction is effectively suppressed, while maintaining the viability of the specimen. A stabilizer for in vivo examination that is placed in contact with a biological specimen during examination of the specimen to suppress movement thereof includes a contact-area increasing portion that is provided on a contact surface with the biological specimen and that is configured to increase the contact area with the biological specimen by virtue of a pressure applied during the contact.

摘要翻译： 在保持试样的活力的同时，有效地抑制试样在按压方向和与挤压方向交叉的方向上的动态运动。 用于在检查试样以抑制其运动时与生物样品接触的体内检查的稳定剂包括设置在与生物样本接触表面并且被配置为增加接触的接触面积增加部分 通过在接触期间施加的压力与生物样品的区域。

公开(公告)号：US20080174765A1

公开(公告)日：2008-07-24

申请号：US11842496

申请日：2007-08-21

申请人： Yoshihisa Tanikawa ,  Tomoaki Sato

发明人： Yoshihisa Tanikawa ,  Tomoaki Sato

IPC分类号： G01N21/00

CPC分类号： G02B21/367 ,  G02B21/26

摘要： An examination apparatus is provided, the examination apparatus being capable of preventing difficulty in observing a specimen because of light emitted from markers. The examination apparatus includes a first image-acquisition unit configured to detect a movement related to a first image of light generated at a first region of the specimen; a second image-acquisition unit configured to observe a second image of light generated at a second region of the specimen; and a driving unit configured to cause the second image be to formed at substantially the same position in the second image-acquisition unit on the basis of a detection signal of the first image-acquisition unit. The first image includes at least an image that is different from the second image, and the driving unit controls the image position of the second image on the basis of the detection signal of the first image.

摘要翻译： 提供一种检查装置，该检查装置能够防止由于从标记物发出的光而观察样本的困难。 检查装置包括第一图像获取单元，被配置为检测与在样本的第一区域处产生的光的第一图像相关的移动; 第二图像获取单元，被配置为观察在所述样本的第二区域处产生的光的第二图像; 以及驱动单元，被配置为基于第一图像获取单元的检测信号使第二图像形成在第二图像获取单元中的基本相同的位置处。 第一图像至少包括与第二图像不同的图像，并且驱动单元基于第一图像的检测信号来控制第二图像的图像位置。

公开(公告)号：US07864413B2

公开(公告)日：2011-01-04

申请号：US11840449

申请日：2007-08-17

申请人： Yoshihisa Tanikawa ,  Tomoaki Sato ,  Ikuko Sakai

发明人： Yoshihisa Tanikawa ,  Tomoaki Sato ,  Ikuko Sakai

IPC分类号： G02B21/36

CPC分类号： G02B21/367

摘要： An examination apparatus that observes a specimen in a stationary state while suppressing the blurring caused by a control delay. The apparatus includes a first optical system and a second optical system for imaging light produced in a specimen, a first image-acquisition unit with a plurality of first image-acquisition devices for detecting an image formed by the first optical system, a second image-acquisition unit with a second image-acquisition device for acquiring an image formed by the second optical system, and a driving unit that causes the images to be formed at the same position in the second image-acquisition unit. The value obtained by dividing the pixel size Y of the first image-acquisition devices by the magnification X of the first optical system is smaller than the value obtained by dividing the pixel size Y′ of the second image-acquisition device by the magnification X′ of the second optical system.

摘要翻译： 一种在抑制由控制延迟引起的模糊的同时在静止状态下观察样本的检查装置。 该装置包括第一光学系统和用于对在样本中产生的光进行成像的第二光学系统，具有用于检测由第一光学系统形成的图像的多个第一图像获取装置的第一图像获取单元， 获取单元，具有用于获取由第二光学系统形成的图像的第二图像获取装置，以及使图像形成在第二图像获取单元中的相同位置的驱动单元。 通过将第一图像采集装置的像素大小Y除以第一光学系统的倍率X而获得的值小于通过将第二图像获取装置的像素尺寸Y'除以倍率X'而获得的值， 的第二光学系统。

公开(公告)号：US07804642B2

公开(公告)日：2010-09-28

申请号：US11913833

申请日：2006-05-16

申请人： Nobuyuki Nagasawa ,  Masahiro Oba ,  Tetsuya Koike ,  Yoshihisa Tanikawa ,  Yujin Arai

发明人： Nobuyuki Nagasawa ,  Masahiro Oba ,  Tetsuya Koike ,  Yoshihisa Tanikawa ,  Yujin Arai

IPC分类号： G02B21/06

CPC分类号： G02B21/002 ,  G02B21/008 ,  G02B21/365

摘要： A scanning examination apparatus 1 is provided, the apparatus including a detachable objective lens 6 or 6′, a scanner 3 for two-dimensionally scanning light F from a specimen 100 focused by the objective lens 6 or 6′, a scanner control device 13 for controlling the operation of the scanner 3, and an optical detector 9 for detecting light scanned by the scanner 3, wherein the scanner control device 13 changes the scanning direction of the light F depending on an image formation mode of the light F at the objective lens 6 or 6′ which is attached.

摘要翻译： 提供了一种扫描检查装置1，该装置包括一个可拆卸的物镜6或6'，用于从由物镜6或6'聚焦的样本100二维地扫描光F的扫描器3，用于 控制扫描仪3的操作，以及用于检测由扫描器3扫描的光的光学检测器9，其中扫描仪控制装置13根据物镜上的光F的图像形成模式改变光F的扫描方向 6或6'。

公开(公告)号：US20070167842A1

公开(公告)日：2007-07-19

申请号：US11640921

申请日：2006-12-19

申请人： Yoshihisa Tanikawa ,  Tadashi Hirata ,  Yasuaki Natori ,  Chika Nakajima ,  Yoshihiro Kawano

发明人： Yoshihisa Tanikawa ,  Tadashi Hirata ,  Yasuaki Natori ,  Chika Nakajima ,  Yoshihiro Kawano

IPC分类号： A61B6/00

CPC分类号： A61B1/045 ,  A61B1/043 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084

摘要： An object is to easily and reliably reach an examination site. The present invention provides an examination method of carrying out in-vivo examination using an in-vivo examination apparatus capable of fluorescence examination and reflected-light examination and includes the steps of setting a reference position so as to set an examination site by carrying out reflected-light examination, switching from reflected-light examination to fluorescence examination, and moving from the reference position to the examination site.

摘要翻译： 目的是轻松可靠地到达考场。 本发明提供使用能够进行荧光检查和反射光检查的体内检查装置进行体内检查的检查方法，包括以下步骤：设定参考位置，以便通过进行反射 光线检查，从反射光检查切换到荧光检查，从参考位置移动到检查点。

公开(公告)号：US20060017920A1

公开(公告)日：2006-01-26

申请号：US11182782

申请日：2005-07-18

申请人： Atsuhiro Tsuchiya ,  Yoshihiro Kawano ,  Yoshihisa Tanikawa ,  Tadashi Hirata

发明人： Atsuhiro Tsuchiya ,  Yoshihiro Kawano ,  Yoshihisa Tanikawa ,  Tadashi Hirata

IPC分类号： G01J3/30

CPC分类号： G01N21/6458 ,  G02B21/002 ,  G02B21/0064 ,  G02B21/0076 ,  G02B21/0084 ,  G02B21/16

摘要： The invention reduces the loss of fluorescence intensity obtained from a specimen to acquire clear fluorescence images when irradiating the specimen with ultrashort-pulse laser light produced by a laser light source. The invention provides a laser-scanning examination apparatus including a laser light source for producing ultrashort-pulse laser light; a laser light source for producing continuous-wave laser light; a measurement head including an optical scanning unit for scanning the laser light on a specimen and an objective optical system; an imaging unit for detecting return light from the specimen in response to the ultrashort-pulse laser light; and an imaging unit for detecting return light from the specimen in response to the continuous-wave laser light. The laser light sources and one imaging unit are connected to the measurement head by an optical fiber, and the other imaging unit is connected to the measurement head by another optical fiber with a larger core diameter.

摘要翻译： 本发明减少了从样品获得的荧光强度的损失，以便在用激光光源产生的超短脉冲激光照射样品时获得清晰的荧光图像。 本发明提供了一种激光扫描检查装置，其包括用于产生超短脉冲激光的激光光源; 用于产生连续波激光的激光源; 测量头，包括用于扫描样本上的激光的光学扫描单元和物镜光学系统; 用于响应于超短脉冲激光来检测来自样本的返回光的成像单元; 以及用于响应于连续波激光来检测来自样本的返回光的成像单元。 激光光源和一个成像单元通过光纤连接到测量头，另一个成像单元通过具有较大芯直径的另一光纤连接到测量头。

公开(公告)号：US20050211872A1

公开(公告)日：2005-09-29

申请号：US11085047

申请日：2005-03-22

申请人： Yoshihiro Kawano ,  Tadashi Hirata ,  Tatsuo Nakata ,  Yoshihisa Tanikawa

发明人： Yoshihiro Kawano ,  Tadashi Hirata ,  Tatsuo Nakata ,  Yoshihisa Tanikawa

IPC分类号： G02B21/00 ,  G02B23/26 ,  G02B7/04

CPC分类号： G02B21/0048 ,  G02B21/004 ,  G02B21/0076

摘要： The invention provides an optical-scanning examination apparatus with a simple configuration, in which the resolution of acquired images can be freely changed and in which the fluorescence image intensity and examination depth can be adjusted to suit the purpose of examination. The optical-scanning examination apparatus includes a light source unit; a focusing lens for forming a first intermediate image of excitation light; an imaging lens; a first objective lens; an optical fiber bundle; a second objective lens; and an imaging unit for imaging return light that returns via the second objective lens, the optical fiber bundle, the first objective lens, and the imaging lens. In addition, a scanning mirror device, which is disposed at the first intermediate image position, is formed of a plurality of mirrors that simultaneously receive the first intermediate image and that can be selectively turned on and off.

摘要翻译： 本发明提供了一种具有简单结构的光学扫描检查装置，其中可以自由地改变所获取的图像的分辨率，并且可以调整荧光图像强度和检查深度以适应检查的目的。 光扫描检查装置包括：光源单元; 用于形成激发光的第一中间图像的聚焦透镜; 成像透镜; 第一个物镜; 光纤束; 第二个物镜; 以及用于对通过第二物镜，光纤束，第一物镜和成像透镜返回的返回光成像的成像单元。 此外，设置在第一中间图像位置的扫描镜装置由同时接收第一中间图像并且可以选择性地打开和关闭的多个反射镜形成。