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公开(公告)号：US20090075228A1
公开(公告)日：2009-03-19
申请号：US12210349
申请日：2008-09-15
IPC分类号： A61C19/06
CPC分类号： A61B5/0088 , A61B2562/0238 , G01N21/64
摘要： Caries located at a position that cannot be directly viewed, such as one of the adjacent surfaces between teeth, can be observed with high contrast, and the spread and the degree of invasion of the caries can be observed. A dental observation apparatus has: an irradiating unit radiating illumination light including an infrared region; a detecting unit separately detecting fluorescence generated from a caries portion by irradiation with the illumination light and scattered light of the illumination light at the tooth; and an image processing unit which forms a fluorescence image based on the fluorescence detected by the detecting unit, which forms a scattered light image capable of identifying a boundary between an enamel layer and a dentine layer, the layers having different scattering properties, based on the intensity of the scattered light detected by the detecting unit, and which combines the fluorescence image and the scattered light image.
摘要翻译： 可以观察到位于不能直接观察的位置的龋齿，例如牙齿之间的相邻表面之一，可以观察到高对比度，并且可以观察到龋齿的蔓延和侵入程度。 牙科观察装置具有：照射单元，其照射包括红外区域的照明光; 检测单元，其通过照射所述照明光和所述照明光的散射光分别检测从龋齿部分产生的荧光; 以及图像处理单元，其基于由检测单元检测到的荧光形成荧光图像，所述荧光图像形成能够识别釉层和牙质层之间的边界的散射光图像，所述散射光图像基于 由检测单元检测到的散射光的强度，并且组合荧光图像和散射光图像。
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公开(公告)号：US07158234B2
公开(公告)日：2007-01-02
申请号：US10808857
申请日：2004-03-25
申请人： Akio Uchiyama , Akihiro Horii , Shuhei Iizuka , Tadashi Hirata , Mitsuhiro Hara , Yoshiyuki Kumada , Kazunari Tokuda
发明人： Akio Uchiyama , Akihiro Horii , Shuhei Iizuka , Tadashi Hirata , Mitsuhiro Hara , Yoshiyuki Kumada , Kazunari Tokuda
CPC分类号： A61B1/07 , A61B1/0008 , A61B1/00165 , A61B1/00172 , A61B1/00183 , A61B5/0066 , A61B5/0084 , B82Y35/00 , G01B9/02002 , G01B9/0205 , G01B9/02064 , G01B9/02091 , G01B2290/35 , G01N21/474 , G01N21/4795
摘要： Before performing observation with an optical scanning probe using a low-coherence light source and the like, a shutter is inserted in a reference light side optical path to create a state wherein interference light does not occur, in which state a reference member is set to a focal position of a converging optical system such that the output of a light detector is maximal by moving the reference member by a driving device at an observation light optical path side of an optical scanning probe, following which the shutter is opened, and the position of a mirror at the reference light side is moved and set such that the output of the light detecting means is maximal, thereby enabling the optical scanning observation apparatus to be set to a state of suitable optical properties, easily and smoothly.
摘要翻译： 在使用低相干光源等的光学扫描探针进行观察之前，将快门插入参考光侧光路中以产生不发生干涉光的状态，在该状态下将基准部件设置为 会聚光学系统的焦点位置，使得光检测器的输出通过在光扫描探针的观察光光路侧处的驱动装置移动参考构件而最大化，随后开启快门，位置 在参考光侧的反射镜的移动和设置使得光检测装置的输出最大，从而使光学扫描观察装置能够容易且平稳地设置为适当的光学特性的状态。
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3.发明申请Objective lens unit, objective lens insertion tool, microscope, objective optical system fixing device, and microscope system 审中-公开物镜单元，物镜插入工具，显微镜，物镜光学系统固定装置和显微镜系统公开(公告)号：US20070097494A1
公开(公告)日：2007-05-03
申请号：US11642436
申请日：2006-12-20
申请人： Kazunari Tokuda , Akihiro Horii , Yoshiyuki Kumada , Mitsuhiro Hara , Tadashi Hirata , Hiroya Fukuyama
发明人： Kazunari Tokuda , Akihiro Horii , Yoshiyuki Kumada , Mitsuhiro Hara , Tadashi Hirata , Hiroya Fukuyama
IPC分类号： G02B21/00
CPC分类号： G02B21/26 , G02B23/2476
摘要： The invention aims to make it unnecessary to reposition an objective lens when repeatedly carrying out examinations. It is possible to carry out in vivo examination of tissue such as cells and muscle tissue or various internal organs, such as the heart, liver, and so forth, of mammals, especially small experimental animals, over a comparatively long period of time. A microscope system having an objective optical system unit and a structure or member for fixing the objective optical system unit to a living body is provided.
摘要翻译： 本发明的目的是在重复执行检查时不需要重新定位物镜。 可以在比较长的时间内对哺乳动物，特别是小型实验动物等细胞，肌肉组织或各种内部器官（如心脏，肝脏等）的组织进行体内检查。 提供了一种具有物镜光学系统单元和用于将物镜光学系统单元固定到生物体的结构或构件的显微镜系统。
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4.发明申请公开(公告)号：US20120014925A1
公开(公告)日：2012-01-19
申请号：US12837780
申请日：2010-07-16
申请人： Yoshiyuki Kumada , Shuguang Zhang
发明人： Yoshiyuki Kumada , Shuguang Zhang
IPC分类号： A61K35/32 , C07K7/06 , C07K7/08 , A61K38/00 , A61M5/31 , A61K38/06 , A61K38/10 , A61P1/02 , A61P19/08 , C07K5/093 , C07K5/103 , A61K38/08
CPC分类号： C07K14/00 , A61K38/00 , A61K38/07 , A61L27/227 , A61L27/24 , A61L27/3804 , A61L27/3834 , A61L27/3865 , A61L2430/12 , C07K5/101 , C07K7/06 , C07K7/08 , C07K14/001 , C07K2319/735
摘要： The invention relates to a novel class of self-assembling peptides, compositions thereof, methods for the preparation thereof and methods of use thereof. The invention also encompasses methods for tissue regeneration, increasing the production of extracellular matrix proteins, and methods of treatment comprising administering self-assembling peptides.
摘要翻译： 本发明涉及一类新型自组装肽，其组合物，其制备方法及其使用方法。 本发明还包括用于组织再生，增加细胞外基质蛋白质的产生的方法和包括施用自组装肽的治疗方法。
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公开(公告)号：US20080027345A1
公开(公告)日：2008-01-31
申请号：US11630318
申请日：2005-06-21
申请人： Yoshiyuki Kumada , Toshimitsu Musha
发明人： Yoshiyuki Kumada , Toshimitsu Musha
IPC分类号： A61B5/0476
CPC分类号： A61B5/0478
摘要： The labor involved in cleaning for each examination is reduced, the examination can be carried out hygienically, and the convenience of use is improved. An electrode apparatus for detecting brain waves which is arranged in contact with the scalp and which detects brain wave signals is provided. The electrode apparatus for detecting brain waves comprises a rod-shaped electrode apparatus main body having an electrode disposed at the tip thereof, a cap which is mountable on the tip of the electrode apparatus main body and which has an elastic member which contains an electrolyte and which is disposed making close contact so as to cover the electrode, and a connection means which detachably connects the cap to the electrode apparatus main body.
摘要翻译： 每次检查所涉及的劳动力减少，可以进行卫生检查，提高使用便利性。 提供一种用于检测与头皮接触并且检测脑波信号的脑波的电极装置。 用于检测脑电波的电极装置包括：杆状电极装置主体，其具有设置在其前端的电极，盖可安装在电极装置主体的前端，并且具有包含电解质的弹性构件， 其被设置为紧密接触以覆盖电极;以及连接装置，其将盖可拆卸地连接到电极装置主体。
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6.发明授权公开(公告)号：US08741833B2
公开(公告)日：2014-06-03
申请号：US12837780
申请日：2010-07-16
申请人： Yoshiyuki Kumada , Shuguang Zhang
发明人： Yoshiyuki Kumada , Shuguang Zhang
CPC分类号： C07K14/00 , A61K38/00 , A61K38/07 , A61L27/227 , A61L27/24 , A61L27/3804 , A61L27/3834 , A61L27/3865 , A61L2430/12 , C07K5/101 , C07K7/06 , C07K7/08 , C07K14/001 , C07K2319/735
摘要： The invention relates to a novel class of self-assembling peptides, compositions thereof, methods for the preparation thereof and methods of use thereof. The invention also encompasses methods for tissue regeneration, increasing the production of extracellular matrix proteins, and methods of treatment comprising administering self-assembling peptides.
摘要翻译： 本发明涉及一类新型自组装肽，其组合物，其制备方法及其使用方法。 本发明还包括用于组织再生，增加细胞外基质蛋白质的产生的方法和包括施用自组装肽的治疗方法。
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公开(公告)号：US20090171181A1
公开(公告)日：2009-07-02
申请号：US11658441
申请日：2005-07-15
申请人： Yoshiyuki Kumada , Toshimitsu Musha
发明人： Yoshiyuki Kumada , Toshimitsu Musha
IPC分类号： A61B5/0478
CPC分类号： A61B5/0478 , A61B5/4088
摘要： It is possible for the tips of all the electrodes to make contact with the scalp with greater reliability even with respect to different subjects, by adaptation to individual differences in the heads of subjects, and the functional status of the brain can be detected with greater accuracy. A brain function detection apparatus is provided which has a hat-shaped apparatus main body for mounting on the head of a subject, a plurality of electrodes for detecting brain wave signals, which are mounted in the apparatus main body separated from each other at intervals, and which are arranged in contact with the scalp, and the apparatus main body has a plurality of holder pieces in which at least one electrode is mounted, a bendable belt for linking the holder pieces, and a holder piece interval-adjusting apparatus for adjusting the distance between the holder pieces.
摘要翻译： 所有电极的尖端都可以通过适应受试者头部的个体差异，即使相对于不同的受试者也可以更高的可靠性与头皮接触，并且可以以更高的精度检测大脑的功能状态 。 提供一种脑功能检测装置，其具有用于安装在被检体头部的帽状装置主体，安装在设备主体中的多个用于检测脑波信号的电极，其间隔隔开， 并且其设置成与头皮接触，并且设备主体具有多个保持件，其中安装有至少一个电极，用于连接保持件的可弯曲带，以及用于调节保持件的间隔调节装置 支架之间的距离
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8.发明申请Objective lens unit, objective lens insertion tool, microscope, objective optical system fixing device, and microscope system 审中-公开物镜单元，物镜插入工具，显微镜，物镜光学系统固定装置和显微镜系统公开(公告)号：US20050094260A1
公开(公告)日：2005-05-05
申请号：US10964866
申请日：2004-10-14
申请人： Kazunari Tokuda , Akihiro Horii , Yoshiyuki Kumada , Mitsuhiro Hara , Tadashi Hirata , Hiroya Fukuyama
发明人： Kazunari Tokuda , Akihiro Horii , Yoshiyuki Kumada , Mitsuhiro Hara , Tadashi Hirata , Hiroya Fukuyama
CPC分类号： G02B21/26 , G02B23/2476
摘要： The invention aims to make it unnecessary to reposition an objective lens when repeatedly carrying out examinations. It is possible to carry out in vivo examination of tissue such as cells and muscle tissue or various internal organs, such as the heart, liver, and so forth, of mammals, especially small experimental animals, over a comparatively long period of time. A microscope system having an objective optical system unit and a structure or member for fixing the objective optical system unit to a living body is provided.
摘要翻译： 本发明的目的是在重复执行检查时不需要重新定位物镜。 可以在比较长的时间内对哺乳动物，特别是小型实验动物等细胞，肌肉组织或各种内部器官（如心脏，肝脏等）的组织进行体内检查。 提供了一种具有物镜光学系统单元和用于将物镜光学系统单元固定到生物体的结构或构件的显微镜系统。
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