公开(公告)号：US07361637B2

公开(公告)日：2008-04-22

申请号：US11096661

申请日：2005-04-01

申请人： Yuichi Ishida ,  Fumiaki Suzuki ,  Kazuo Murakami

发明人： Yuichi Ishida ,  Fumiaki Suzuki ,  Kazuo Murakami

IPC分类号： A61K38/00

CPC分类号： C12N9/6486 ,  A61K38/00 ,  C07K14/4705 ,  C12Q1/37 ,  C12Y304/23015 ,  G01N2333/96472 ,  G01N2500/00

摘要： There are provided a method for selection of a substance which is capable of controlling activation of prorenin where an adjusting ability of the activation of prorenin by protein-protein interaction in a profragment region of prorenin as indicator is used; a prorenin activation controlling substance having a function of controlling the activation of prorenin based on protein-protein interaction by a profragment region of prorenin; and hypotensor, organ hypertrophy suppressor and arterial thickening suppressor containing the prorenin activation controlling substance as an effective ingredient.

摘要翻译： 提供了一种选择能够控制肾上腺素能活化的物质的方法，其中使用在作为指示剂的肾上腺素的分段区域中通过蛋白质 - 蛋白质相互作用的蛋白质 - 蛋白质相互作用的调节能力; 具有根据蛋白质 - 蛋白质相互作用的蛋白质 - 蛋白质相互作用控制肾上腺素的活化的功能的肾上腺素能激活控制物质; 和低血压，器官肥大抑制剂和含有作为有效成分的肾上腺素激活控制物质的动脉增厚抑制剂。

公开(公告)号：US6159723A

公开(公告)日：2000-12-12

申请号：US417305

申请日：1999-10-13

申请人： Kazuo Murakami ,  Yukio Nakamura ,  Fumiaki Suzuki ,  Yuichi Ishida

发明人： Kazuo Murakami ,  Yukio Nakamura ,  Fumiaki Suzuki ,  Yuichi Ishida

IPC分类号： A61K38/00 ,  A61K39/395 ,  C07K16/40 ,  C12N9/64 ,  C12P21/08 ,  C12N9/96 ,  C07K16/00

CPC分类号： C12N9/6486 ,  A61K38/00 ,  A61K39/395 ,  C07K16/40 ,  C12Y304/23015 ,  A61K2300/00

摘要： Disclosed is a novel renin-active substance by utilizing a anti-peptide antibody capable of specifically recognizing a specific amino acid sequence in the human propenin profragment exemplified, as a typical example, by a complex formed from human prorenin and an anti-peptide antibody capable of specifically recognizing an amino acid sequence consisting of at least 15 amino acid residues located within an amino acid sequence consisting of 33 amino acid residues between the isoleucine residue at the 11th site and the arginine residue at the 43rd site within human propenin profragment having an amino acid sequence consisting of 43 amino acid residues.

摘要翻译： 公开了一种新型的肾素活性物质，其通过利用能够特异性识别人丙烯宁胶束中的特定氨基酸序列的抗肽抗体，作为典型实例，通过由人类肾上腺素形成的复合物和抗肽抗体能力 特异性识别由位于第11个位点的异亮氨酸残基之间的33个氨基酸残基的氨基酸序列中的至少15个氨基酸残基的氨基酸序列和人丙烯蛋白碎片中的第43位的精氨酸残基，其具有氨基 酸序列由43个氨基酸残基组成。

公开(公告)号：US06900020B2

公开(公告)日：2005-05-31

申请号：US10257050

申请日：2001-04-09

申请人： Yuichi Ishida ,  Fumiaki Suzuki ,  Kazuo Murakami

发明人： Yuichi Ishida ,  Fumiaki Suzuki ,  Kazuo Murakami

IPC分类号： A61K38/00 ,  A61P9/12 ,  C07K14/47 ,  C12N9/64 ,  C12Q1/37 ,  G01N33/53

CPC分类号： C12N9/6486 ,  A61K38/00 ,  C07K14/4705 ,  C12Q1/37 ,  C12Y304/23015 ,  G01N2333/96472 ,  G01N2500/00

摘要： There are provided a method for selection of a substance which is capable of controlling activation of prorenin where an adjusting ability of the activation of prorenin by protein-protein interaction in a profragment region of prorenin as indicator is used; a prorenin activation controlling substance having a function of controlling the activation of prorenin based on protein-protein interaction by a profragment region of prorenin; and hypotensor, organ hypertrophy suppressor and arterial thickening suppressor containing the prorenin activation controlling substance as an effective ingredient.

摘要翻译： 提供了一种选择能够控制肾上腺素能活化的物质的方法，其中使用在作为指示剂的肾上腺素的分段区域中通过蛋白质 - 蛋白质相互作用的蛋白质 - 蛋白质相互作用的调节能力; 具有根据蛋白质 - 蛋白质相互作用的蛋白质 - 蛋白质相互作用控制肾上腺素的活化的功能的肾上腺素能激活控制物质; 和低血压，器官肥大抑制剂和含有作为有效成分的肾上腺素激活控制物质的动脉增厚抑制剂。

公开(公告)号：US20050203021A1

公开(公告)日：2005-09-15

申请号：US11096661

申请日：2005-04-01

申请人： Yuichi Ishida ,  Fumiaki Suzuki ,  Kazuo Murakami

发明人： Yuichi Ishida ,  Fumiaki Suzuki ,  Kazuo Murakami

IPC分类号： A61K38/00 ,  A61P9/12 ,  C07K14/47 ,  C12N9/64 ,  C12Q1/37 ,  A61K38/17 ,  C12Q1/00

CPC分类号： C12N9/6486 ,  A61K38/00 ,  C07K14/4705 ,  C12Q1/37 ,  C12Y304/23015 ,  G01N2333/96472 ,  G01N2500/00

摘要： There are provided a method for selection of a substance which is capable of controlling activation of prorenin where an adjusting ability of the activation of prorenin by protein-protein interaction in a profragment region of prorenin as indicator is used; a prorenin activation controlling substance having a function of controlling the activation of prorenin based on protein-protein interaction by a profragment region of prorenin; and hypotensor, organ hypertrophy suppressor and arterial thickening suppressor containing the said prorenin activation controlling substance as an effective ingredient.

摘要翻译： 提供了一种选择能够控制肾上腺素能活化的物质的方法，其中使用在作为指示剂的肾上腺素的分段区域中通过蛋白质 - 蛋白质相互作用的蛋白质 - 蛋白质相互作用的调节能力; 具有根据蛋白质 - 蛋白质相互作用的蛋白质 - 蛋白质相互作用控制肾上腺素的活化的功能的肾上腺素能激活控制物质; 以及含有所述血管内皮素激活控制物质作为有效成分的低血压，器官肥大抑制剂和动脉增厚抑制剂。

公开(公告)号：US5945512A

公开(公告)日：1999-08-31

申请号：US54260

申请日：1998-04-03

申请人： Kazuo Murakami ,  Yukio Nakamura ,  Fumiaki Suzuki ,  Yuichi Ishida ,  Yasuhiko Hatano

发明人： Kazuo Murakami ,  Yukio Nakamura ,  Fumiaki Suzuki ,  Yuichi Ishida ,  Yasuhiko Hatano

IPC分类号： G01N33/53 ,  A61K39/395 ,  C07K14/47 ,  C07K16/18 ,  C07K16/40 ,  C07K19/00 ,  C12N9/64 ,  G01N33/573 ,  C07K16/00

CPC分类号： C12N9/6486 ,  C07K16/40 ,  C12Y304/23015

摘要： Provided by the present invention are a human prorenin profragment N-terminated peptide antibody capable of specifically recognizing a peptide containing at least 15 amino acid residues from the first leucine residue to the 15th arginine residue in the N-terminated peptide of the human prorenin profragment and a complex of the same with human prorenin. The antibody can be used as a prorenin assay reagent. The human prorenin profragment N-terminated peptide antibody is useful as a reagent for the assay of human prorenin in blood.

摘要翻译： 本发明提供了一种能够特异性识别含有至少15个氨基酸残基的肽的人肾上腺素蛋白片段化N-末端肽抗体，其中人源肾上腺素破坏的N-末端肽中的第一亮氨酸残基至第15位精氨酸残基， 与人类prorenin相同的复合物。 该抗体可用作肾上腺素能测定试剂。 人肾上腺皮质激素N-封端肽抗体可用作血液中人血管内皮素的测定试剂。

公开(公告)号：US08846552B2

公开(公告)日：2014-09-30

申请号：US13062132

申请日：2009-09-03

申请人： Masahiko Miyauchi ,  Yuichi Ishida ,  Toshio Ogasawara ,  Rikio Yokota

发明人： Masahiko Miyauchi ,  Yuichi Ishida ,  Toshio Ogasawara ,  Rikio Yokota

IPC分类号： B32B5/26 ,  B05D3/10 ,  C08G73/10 ,  C08K5/3415 ,  C09D179/08 ,  C09J5/02 ,  D04H3/14 ,  D04H3/16 ,  C07D209/48 ,  C08L79/08 ,  C08F290/06 ,  C07D487/04 ,  C08F299/00 ,  C08F299/02 ,  C08J5/24 ,  C08K7/02

CPC分类号： C08F290/065 ,  C07D209/48 ,  C07D487/04 ,  C08F299/00 ,  C08F299/02 ,  C08G73/1042 ,  C08G73/105 ,  C08G73/1071 ,  C08J5/24 ,  C08J2379/08 ,  C08K7/02 ,  C08L79/08 ,  C09D179/08 ,  Y10T428/24994 ,  Y10T428/24995 ,  Y10T442/2631 ,  Y10T442/671 ,  Y10T442/69

摘要： A novel terminally modified imide oligomer having excellent solubility in organic solvents, excellent solution storage stability, and excellent molding properties such as low melt viscosity. Also, a varnish obtained by dissolving the terminally modified imide oligomer in an organic solvent; a cure product obtained by using the terminally modified imide oligomer and having excellent thermal and mechanical characteristics such as heat resistance, elastic modulus, tensile strength at break and tensile elongation at break; a prepreg; and a fiber-reinforced laminate. The soluble terminally modified imide oligomer is represented by general formula (1). In the formula, R1 and R2 each represents a divalent aromatic diamine residue; R3 and R4 each represents a tetravalent aromatic tetracarboxylic acid residue; R5 and R6 each represents a hydrogen atom or a phenyl group, with R5 or R6 being a phenyl group; m and n satisfy the following relations: m≧1, n≧0, 1≦m+n≦20 and 0.05≦m/(m+n)≦1; and the repeating units may be arranged in blocks or randomly.

摘要翻译： 一种在有机溶剂中具有优异溶解性的新型末端改性酰亚胺低聚物，优异的溶液保存稳定性，以及优异的成型性能如熔融粘度低。 另外，将末端改性酰亚胺低聚物溶解在有机溶剂中得到的清漆; 通过使用末端改性的酰亚胺低聚物得到的固化产物，具有优异的耐热性，弹性模量，断裂拉伸强度和断裂拉伸伸长率等热和机械特性。 预浸料 和纤维增强层压板。 可溶性末端改性酰亚胺低聚物由通式（1）表示。 在该式中，R 1和R 2各自表示二价芳族二胺残基; R3和R4各自表示四价芳族四羧酸残基; R5和R6各自表示氢原子或苯基，R5或R6是苯基; m和n满足以下关系：m≥1，n≥0,1＆nlE; m + n＆nlE; 20和0.05＆nlE; m /（m + n）＆nlE; 1; 并且重复单元可以以块或随机方式排列。

公开(公告)号：US08391007B2

公开(公告)日：2013-03-05

申请号：US12536996

申请日：2009-08-06

申请人： Mitsuo Hashimoto ,  Kazuaki Yazawa ,  Yuichi Ishida ,  Hiroyuki Ryoson

发明人： Mitsuo Hashimoto ,  Kazuaki Yazawa ,  Yuichi Ishida ,  Hiroyuki Ryoson

IPC分类号： H05K7/20 ,  F28D15/02

CPC分类号： H05K7/208 ,  F28D15/0233 ,  F28F2245/02 ,  F28F2245/04 ,  H01L2924/0002 ,  Y10T29/4935 ,  H01L2924/00

摘要： According to an embodiment, there is provided a heat spreader including an evaporation portion, a first condenser portion, a working fluid, and a first flow path. The evaporation portion is arranged in a first position. The first condenser portion is arranged in a second position, the second position being arranged apart from and higher than the first position. The working fluid evaporates from a liquid phase to a gas phase in the evaporation portion, and condenses from the gas phase to the liquid phase in the first condenser portion. The first flow path is made of a nanomaterial, has hydrophobicity on a surface, and causes the working fluid condensed to the liquid phase in the first condenser portion to flow to the evaporation portion by a gravitational force.

摘要翻译： 根据一个实施例，提供了一种散热器，其包括蒸发部分，第一冷凝器部分，工作流体和第一流动路径。 蒸发部分布置在第一位置。 第一冷凝器部分布置在第二位置，第二位置被布置成与第一位置分开并高于第一位置。 工作流体在蒸发部分中从液相蒸发到气相，并在第一冷凝器部分中从气相冷凝成液相。 第一流路由纳米材料制成，在表面上具有疏水性，并使第一冷凝器部分中冷凝到液相的工作流体通过重力流向蒸发部分。

公开(公告)号：US20100254088A1

公开(公告)日：2010-10-07

申请号：US12730593

申请日：2010-03-24

申请人： Yuichi Ishida ,  Mitsuo Hashimoto ,  Kazuaki Yazawa ,  Hiroyuki Ryoson ,  Tatsuhiko Shigemoto

发明人： Yuichi Ishida ,  Mitsuo Hashimoto ,  Kazuaki Yazawa ,  Hiroyuki Ryoson ,  Tatsuhiko Shigemoto

IPC分类号： H05K7/20 ,  F28D15/00 ,  B21D53/02

CPC分类号： H05K7/203 ,  F28D15/02 ,  F28D15/046 ,  F28F23/00 ,  G06F1/20 ,  G06F2200/201 ,  Y10T29/4935

摘要： According to an embodiment of the present invention, there is provided a heat transport device including a working fluid, an evaporation portion, a condenser portion, a flow path portion, and an area. The working fluid includes pure water and an organic compound bearing a hydroxyl group. The evaporation portion causes the working fluid to evaporate from a liquid phase to a vapor phase. The condenser portion communicates with the evaporation portion, and causes the working fluid to condense from the vapor phase to the liquid phase. The flow path portion causes the working fluid condensed in the condenser portion to the liquid phase to flow to the evaporation portion. The area is made of a carbon material and provided on at least one of the evaporation portion, the condenser portion, and the flow path portion.

摘要翻译： 根据本发明的实施例，提供了一种包括工作流体，蒸发部分，冷凝器部分，流路部分和区域的热传输装置。 工作流体包括纯水和带有羟基的有机化合物。 蒸发部分使工作流体从液相蒸发成气相。 冷凝器部与蒸发部连通，使工作流体从气相冷凝成液相。 流路部使冷凝部冷凝的液相流向蒸发部。 该区域由碳材料制成并且设置在蒸发部分，冷凝器部分和流动路径部分中的至少一个上。

公开(公告)号：US20060257661A1

公开(公告)日：2006-11-16

申请号：US11490069

申请日：2006-07-21

申请人： Hiroki Naito ,  Yuichi Ishida ,  Masayuki Suzuki ,  Keiko Furukawa ,  Katsuyuki Hironaka

发明人： Hiroki Naito ,  Yuichi Ishida ,  Masayuki Suzuki ,  Keiko Furukawa ,  Katsuyuki Hironaka

IPC分类号： B32B1/00

CPC分类号： C09K11/7792 ,  B82Y30/00 ,  C09K11/025 ,  C09K11/7734 ,  D01F1/04 ,  Y10S977/811 ,  Y10S977/834 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2998

摘要： Crystalline superfine particles capable of emitting light depending upon a time-rate-of-change of a stress and controlled in grain size in the range from 5 nm to 100 nm are complexed with another material such as resin. The crystalline superfine particles are manufactured by using aggregates of molecules, i.e. inverted micelles, which orient hydrophilic groups of surfactant molecules inward and hydrophobic groups outward in a nonpolar solvent and which contain metal ions of a metal for forming the crystalline superfine particles dissolved in water inside the inverted micelles. Alternatively, they are manufactured by using inverted micelles enveloping precursor superfine particles, in which precursor superfine particles are enveloped in water inside the inverted micelles. The crystalline superfine particles are excellent in dispersibility in another material to be complexed, enhanced in emission efficiency and usable to make a transparent stress emission material. The complex material obtained is used to manufacture artificial light-emitting hair structures, artificial light-emitting skin, artificial light-emitting bodies, artificial light-emitting fabrics, and others.

摘要翻译： 能够根据应力的变化时间变化发光并在5nm〜100nm的范围内控制晶粒尺寸的结晶超微粒与另一种材料如树脂复合。 结晶超细颗粒通过使用分子的聚集体即反胶束来制造，所述分子将表面活性剂分子的亲水基团向内取向，并且疏水基团在非极性溶剂中向外定向并且含有金属的金属离子，以形成溶解在水中的结晶超细颗粒 反胶束。 或者，它们通过使用反胶束包封前体超细颗粒来制造，其中前体超细颗粒被包封在反胶束内的水中。 结晶超细颗粒在另一种复合材料中的分散性优异，发光效率提高，可用于制造透明应力发射材料。 所得的复合材料用于制造人造发光毛发结构，人造发光皮，人造发光体，人造发光织物等。

公开(公告)号：US06577039B2

公开(公告)日：2003-06-10

申请号：US09739224

申请日：2000-12-18

申请人： Yuichi Ishida ,  Naomi Nagasawa ,  Masayuki Suzuki ,  Takaaki Ami ,  Teiichiro Nishimura

发明人： Yuichi Ishida ,  Naomi Nagasawa ,  Masayuki Suzuki ,  Takaaki Ami ,  Teiichiro Nishimura

IPC分类号： A61F208

CPC分类号： A61F2/08 ,  A61F2002/0894 ,  F03G7/005

摘要： A driving system using an intercalation substance as a novel mechanochemical system includes an actuator using the intercalation substance and driven by exchange of solutions or by changing concentration of a solution, and a solution supplier that supplies the actuator with the driving solution or solutions. The actuator is composed of one or more cylindrical or fiber-shaped elements each extending in the expanding and contracting direction of the intercalation substance, or one or more film-shaped or plate-shaped elements each having a major surface extending vertically of the expanding and contracting direction of the intercalation substance. The driving system is used as artificial muscle, for example.

摘要翻译： 使用插层物质作为新型机械化学系统的驱动系统包括使用插层物质并通过交换溶液或改变溶液浓度驱动的致动器以及为致动器供应驱动溶液或解决方案的解决方案供应商。 致动器由一个或多个圆柱形或纤维形元件组成，每个元件沿插入物质的膨胀和收缩方向延伸，或者一个或多个膜形或板状元件，每个元件或板状元件都具有垂直于膨胀物体的垂直方向延伸的主表面， 插层物质的收缩方向。 驾驶系统例如用作人造肌肉。