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    MICROCHANNEL ARRAY AND METHOD FOR PRODUCING THE SAME, AND BLOOD MEASURING METHOD EMPLOYING IT
    4.
    发明申请
    MICROCHANNEL ARRAY AND METHOD FOR PRODUCING THE SAME, AND BLOOD MEASURING METHOD EMPLOYING IT 审中-公开
    MICROCHANNEL ARRAY AND METHOD FOR PRODUCTION THE SAME，和BLOOD MEASURING METHODWORKING IT

    公开(公告)号：US20090149345A1

    公开(公告)日：2009-06-11

    申请号：US11908047

    申请日：2006-03-01

    申请人： Taiji Nishi ,  Motohiro Fukuda ,  Go Tazaki ,  Seiichi Kanai ,  Takenori Kitani ,  Naoto Fukuhara

    发明人： Taiji Nishi ,  Motohiro Fukuda ,  Go Tazaki ,  Seiichi Kanai ,  Takenori Kitani ,  Naoto Fukuhara

    IPC分类号： C40B30/10 ,  C40B40/00 ,  C40B50/00

    CPC分类号： G01N33/80 ,  B01L3/502707 ,  B01L3/502746 ,  B01L2300/0681 ,  B01L2300/0816 ,  G01N33/56972

    摘要： A microchannel array, a method of manufacturing the same, and a blood test method. The microchannel array is formed by joining first and second substrates, each including a fluid inlet and outlet on their surfaces. An internal space structure connects the fluid inlet and outlet, and includes an upstream flow channel connected with the fluid inlet, a downstream flow channel connected with the fluid outlet with a gap therebetween, and a micro flow channel connecting the upstream and downstream flow channels. A minimum distance from a center of a sectional surface of the micro flow channel to a side wall of the micro flow channel is smaller than that of the upstream and downstream flow channels. Each surface of the first and second substrates includes grooves for creating the upstream and downstream flow channels, and the surface of the second substrate has grooves for creating the micro flow channel.

    摘要翻译： 微通道阵列，其制造方法和血液检查方法。 微通道阵列通过接合第一和第二基底而形成，每个基底在其表面上包括流体入口和出口。 内部空间结构连接流体入口和出口，并且包括与流体入口连接的上游流动通道，与流体出口连接的下游流动通道，其间具有间隙，以及连接上游和下游流动通道的微流动通道。 从微流动通道的截面的中心到微流动通道的侧壁的最小距离小于上游和下游流动通道的最小距离。 第一和第二基板的每个表面包括用于产生上游和下游流动通道的槽，并且第二基板的表面具有用于产生微流动通道的凹槽。

    Method of culturing cells under regulation in the extension direction
    5.
    发明授权
    Method of culturing cells under regulation in the extension direction 有权
    在延伸方向调节细胞的方法

    公开(公告)号：US09005970B2

    公开(公告)日：2015-04-14

    申请号：US11813720

    申请日：2006-01-11

    申请人： Ryosuke Nishio ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita ,  Seiichi Kanai ,  Takenori Kitani

    发明人： Ryosuke Nishio ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita ,  Seiichi Kanai ,  Takenori Kitani

    IPC分类号： C12M1/12 ,  C12M1/32 ,  C12N5/02 ,  C12M1/22

    CPC分类号： C12M25/06 ,  C12M23/12 ,  C12N5/0657 ,  C12N2533/30 ,  C12N2535/00

    摘要： [PROBLEMS] Relating to a bioassay method with the use of cultured cells and cell culture for a therapeutic purpose in the case of determining the efficacy of a drug or the like or examining the toxicity thereof, it is intended to provide a method of culturing cells under regulation in the extension direction and a cell culture plate. [MEANS FOR SOLVING PROBLEMS] A cell culture plate having a plural number of side walls (1) and a plural number of space structures (3) for providing cultured cells which are formed by the side walls (1), wherein the side walls (1) are provided with openings (2) so that the space structures (3) are linked together. By using this cell culture plate, a method of culturing cells under regulation in the extension direction can be provided.

    摘要翻译： [问题]关于在确定药物等的功效或检查其毒性的情况下使用培养细胞和细胞培养物进行生物测定方法的目的是提供培养细胞的方法 在延伸方向调节和细胞培养板。 解决问题的手段具有多个侧壁（1）和多个用于提供由侧壁（1）形成的培养细胞的多个空间结构（3）的细胞培养板，其中侧壁 1）设置有开口（2），使得空间结构（3）连接在一起。 通过使用该细胞培养板，可以提供在延伸方向的调节下培养细胞的方法。

    METHOD OF CULTURING CELLS UNDER REGULATION IN THE EXTENSION DIRECTION
    8.
    发明申请
    METHOD OF CULTURING CELLS UNDER REGULATION IN THE EXTENSION DIRECTION 有权
    培养细胞在扩展方向调节方法

    公开(公告)号：US20090017540A1

    公开(公告)日：2009-01-15

    申请号：US11813720

    申请日：2006-01-11

    申请人： Ryosuke Nishio ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita ,  Seiichi Kanai ,  Takenori Kitani

    发明人： Ryosuke Nishio ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita ,  Seiichi Kanai ,  Takenori Kitani

    IPC分类号： C12N5/02 ,  C12M3/00

    CPC分类号： C12M25/06 ,  C12M23/12 ,  C12N5/0657 ,  C12N2533/30 ,  C12N2535/00

    摘要： [Problems]Relating to a bioassay method with the use of cultured cells and cell culture for a therapeutic purpose in the case of determining the efficacy of a drug or the like or examining the toxicity thereof, it is intended to provide a method of culturing cells under regulation in the extension direction and a cell culture plate.[Means for Solving Problems]A cell culture plate having a plural number of side walls (1) and a plural number of space structures (3) for providing cultured cells which are formed by the side walls (1), wherein the side walls (1) are provided with openings (2) so that the space structures (3) are linked together. By using this cell culture plate, a method of culturing cells under regulation in the extension direction can be provided.

    摘要翻译： [问题]关于在确定药物等的功效或检查其毒性的情况下使用培养细胞和细胞培养物进行生物测定方法的治疗目的，旨在提供培养细胞的方法 在延伸方向调节和细胞培养板。 解决问题的手段具有多个侧壁（1）和多个用于提供由侧壁（1）形成的培养细胞的空间结构（3）的细胞培养板，其中侧壁 1）设置有开口（2），使得空间结构（3）连接在一起。 通过使用该细胞培养板，可以提供在延伸方向的调节下培养细胞的方法。

    Microchannel array
    9.
    发明授权
    Microchannel array 有权
    微通道阵列

    公开(公告)号：US07432110B2

    公开(公告)日：2008-10-07

    申请号：US11659952

    申请日：2005-08-04

    申请人： Yuji Kikuchi ,  Mitsutoshi Nakajima ,  Taiji Nishi ,  Motohiro Fukuda

    发明人： Yuji Kikuchi ,  Mitsutoshi Nakajima ,  Taiji Nishi ,  Motohiro Fukuda

    IPC分类号： G01N1/18

    CPC分类号： B01L3/502761 ,  B01F3/0807 ,  B01F5/0453 ,  B01F5/0456 ,  B01F13/0059 ,  B01L3/502707 ,  B01L2200/0668 ,  B01L2300/0816 ,  C12M23/16 ,  Y10T436/25375

    摘要： A microchannel array according to the present invention includes a first substrate 1, and a second substrate 11 bonded to the first substrate 1. Two sets, that is, a set of a first through-hole 9, a first recess 7, and a first groove 8 and a set of a second through-hole 4, a second recess 2, and a second groove 3 are formed on the first substrate 1. The different sets are separated by a partition 5. A cell differentation/proliferation speed after micro-injection can be increased by using such microchannel array.

    摘要翻译： 根据本发明的微通道阵列包括第一基板1和结合到第一基板1的第二基板11。 两组，即一组第一通孔9，第一凹槽7和第一凹槽8以及一组第二通孔4，第二凹槽2和第二凹槽3形成在 第一基板1。 不同的集合由分区5分隔。 通过使用这种微通道阵列可以增加微注射后的细胞分化/增殖速度。

    Micro channel array
    10.
    发明申请
    Micro channel array 有权
    微通道阵列

    公开(公告)号：US20070276972A1

    公开(公告)日：2007-11-29

    申请号：US11659952

    申请日：2005-08-04

    申请人： Yuji Kikuchi ,  Mitsutoshi Nakajima ,  Taiji Nishi ,  Motohiro Fukuda

    发明人： Yuji Kikuchi ,  Mitsutoshi Nakajima ,  Taiji Nishi ,  Motohiro Fukuda

    IPC分类号： G06F13/00

    CPC分类号： B01L3/502761 ,  B01F3/0807 ,  B01F5/0453 ,  B01F5/0456 ,  B01F13/0059 ,  B01L3/502707 ,  B01L2200/0668 ,  B01L2300/0816 ,  C12M23/16 ,  Y10T436/25375

    摘要： A microchannel array according to the present invention includes a first substrate 1, and a second substrate 11 bonded to the first substrate 1. Two sets, that is, a set of a first through-hole 9, a first recess 7, and a first groove 8 and a set of a second through-hole 4, a second recess 2, and a second groove 3 are formed on the first substrate 1. The different sets are separated by a partition 5. A cell differentation/proliferation speed after micro-injection can be increased by using such microchannel array.

    摘要翻译： 根据本发明的微通道阵列包括第一基板1和接合到第一基板1的第二基板11.两组，即一组第一通孔9，第一凹槽7和第一基板11。 凹槽8和一组第二通孔4，第二凹槽2和第二凹槽3形成在第一基底1上。不同的组由分隔体5分隔开。微孔之后的细胞分化/ 可以通过使用这种微通道阵列来增加注射。