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1.发明申请公开(公告)号：US20100003258A1
公开(公告)日：2010-01-07
申请号：US12494965
申请日：2009-06-30
申请人： Zhigang Weng , William M. Winston, JR. , Lyne Breault , Kristan Meetze , Solly Weiler , Jeno Gyuris
发明人： Zhigang Weng , William M. Winston, JR. , Lyne Breault , Kristan Meetze , Solly Weiler , Jeno Gyuris
IPC分类号： A61K39/395 , C07K16/28 , C12N15/13 , C12N15/85 , C12N5/16 , C12P21/02 , A61P35/00 , C12N5/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： Monoclonal antibodies that bind and inhibit activation of fibroblast growth factor receptor 3 (FGFR3) are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of FGFR3.
摘要翻译： 公开了结合并抑制成纤维细胞生长因子受体3（FGFR3）活化的单克隆抗体。 抗体可用于治疗与FGFR3的激活相关的细胞增殖性疾病和病症，包括某些形式的癌症。
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公开(公告)号：US08187601B2
公开(公告)日：2012-05-29
申请号：US12494965
申请日：2009-06-30
申请人： Zhigang Weng , William M. Winston, Jr. , Lyne Breault , Kristan Meetze , Solly Weiler , Jeno Gyuris
发明人： Zhigang Weng , William M. Winston, Jr. , Lyne Breault , Kristan Meetze , Solly Weiler , Jeno Gyuris
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： Monoclonal antibodies that bind and inhibit activation of fibroblast growth factor receptor 3 (FGFR3) are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of FGFR3.
摘要翻译： 公开了结合并抑制成纤维细胞生长因子受体3（FGFR3）活化的单克隆抗体。 抗体可用于治疗与FGFR3的激活相关的细胞增殖性疾病和病症，包括某些形式的癌症。
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公开(公告)号：US20110256154A1
公开(公告)日：2011-10-20
申请号：US13082852
申请日：2011-04-08
申请人： Sylvie Vincent , William M. Winston, JR. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Botega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
发明人： Sylvie Vincent , William M. Winston, JR. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Botega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
IPC分类号： A61K39/395 , C07H21/00 , C12P21/00 , C12N15/63 , C12N1/00 , C12N5/10 , C07K16/28 , A61P35/00
CPC分类号： C07K16/32 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
摘要翻译： 公开了结合并抑制表皮生长因子受体相关成分ErbB3 / HER3活化的单克隆抗体。 抗体可用于治疗与ErbB3 / HER3的激活相关的细胞增殖性疾病和病症，包括某些形式的癌症。
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公开(公告)号：US08481687B2
公开(公告)日：2013-07-09
申请号：US13082852
申请日：2011-04-08
申请人： Sylvie Vincent , William M. Winston, Jr. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Bottega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
发明人： Sylvie Vincent , William M. Winston, Jr. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Bottega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
IPC分类号： C07K16/28
CPC分类号： C07K16/32 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
摘要翻译： 公开了结合并抑制表皮生长因子受体相关成分ErbB3 / HER3活化的单克隆抗体。 抗体可用于治疗与ErbB3 / HER3的激活相关的细胞增殖性疾病和病症，包括某些形式的癌症。
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公开(公告)号：US08603478B2
公开(公告)日：2013-12-10
申请号：US13177071
申请日：2011-07-06
申请人： Kerry Whalen , Steve Bottega , Andrea Boudrow , Lyne Breault , Ting Chen , James Gifford , May Han , Jinwei Jiang , Lorena Lerner , Qing Liu , Kristan Meetze , Sylvie Vincent , Solly Weiler , William M. Winston, Jr. , Jeno Gyuris
发明人： Kerry Whalen , Steve Bottega , Andrea Boudrow , Lyne Breault , Ting Chen , James Gifford , May Han , Jinwei Jiang , Lorena Lerner , Qing Liu , Kristan Meetze , Sylvie Vincent , Solly Weiler , William M. Winston, Jr. , Jeno Gyuris
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d' Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON.
摘要翻译： 公开了结合并抑制人RON（Recepteur d'Origine Nantais）活化的单克隆抗体。 抗体可用于治疗与RON活化相关的特定形式的癌症。
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公开(公告)号：US20120027773A1
公开(公告)日：2012-02-02
申请号：US13177071
申请日：2011-07-06
申请人： Kerry Whalen , Steve Botega , Andrea Boudrow , Lyne Breault , Ting Chen , James Gifford , May Han , Jinwei Jiang , Lorena Lerner , Qing Liu , Kristan Meetze , Sylvie Vincent , Solly Weiler , William M. Winston, JR. , Jeno Gyuris
发明人： Kerry Whalen , Steve Botega , Andrea Boudrow , Lyne Breault , Ting Chen , James Gifford , May Han , Jinwei Jiang , Lorena Lerner , Qing Liu , Kristan Meetze , Sylvie Vincent , Solly Weiler , William M. Winston, JR. , Jeno Gyuris
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , A61P35/00 , C12N1/21 , C12P21/00 , C12N5/09 , C07K16/40 , C12N5/10
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d' Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON.
摘要翻译： 公开了结合并抑制人RON（Recepteur d'Origine Nantais）活化的单克隆抗体。 抗体可用于治疗与RON活化相关的特定形式的癌症。
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公开(公告)号：US08575318B2
公开(公告)日：2013-11-05
申请号：US13589652
申请日：2012-08-20
申请人： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
发明人： May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US20080108565A1
公开(公告)日：2008-05-08
申请号：US11757059
申请日：2007-06-01
申请人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人： William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号：US20110236377A1
公开(公告)日：2011-09-29
申请号：US13051474
申请日：2011-03-18
申请人： May Han , S. Kirk Wright , William M. Winston, JR. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
发明人： May Han , S. Kirk Wright , William M. Winston, JR. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
IPC分类号： A61K39/395 , C12N5/02 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。
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公开(公告)号：US20110229462A1
公开(公告)日：2011-09-22
申请号：US13051481
申请日：2011-03-18
申请人： William M. Winston, JR. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人： William M. Winston, JR. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
IPC分类号： A61K39/395 , A61P35/00 , C12N5/09
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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