公开(公告)号：US06747797B2

公开(公告)日：2004-06-08

申请号：US09899481

申请日：2001-07-05

申请人： Zhimin Liu ,  Mark S. Wang ,  Jingyu Xu

发明人： Zhimin Liu ,  Mark S. Wang ,  Jingyu Xu

IPC分类号： G02B2728

CPC分类号： G02F1/31 ,  G02F1/093

摘要： A four-port loop optical circulator includes a first, a second, a third and a fourth optical ports for receiving optical beam therein. The circulator further includes a plurality of optical components. The optical components include a walk-off crystal for generating a vertical optical path displacement for a vertical polarized optical beam and for passing a horizontally polarized optical beam therethrough maintaining a same optical path. The optical components also include a vertical displacement device for shifting an optical path along a vertical direction with a predefined vertical displacement for an optical beam transmitted with a particular polarization. The vertical displacement device is coupled to the walk-off crystal for guiding a beam received from the fourth port to project from the first port.

摘要翻译： 四端口环路光环行器包括用于在其中接收光束的第一，第二，第三和第四光端口。 循环器还包括多个光学部件。 光学部件包括用于产生用于垂直偏振光束的垂直光路位移并用于使水平偏振光束通过的走行晶体，其保持相同的光路。 光学部件还包括用于沿着垂直方向移动光路的垂直位移装置，其具有用于以特定偏振传输的光束的预定垂直位移。 垂直位移装置耦合到离散晶体，用于引导从第四端口接收的光束从第一端口突出。

公开(公告)号：US06895129B2

公开(公告)日：2005-05-17

申请号：US10135862

申请日：2002-04-29

申请人： Zhimin Liu ,  Mark S. Wang ,  Shifang Li ,  Wenhui Wang ,  Yanbin Shao

发明人： Zhimin Liu ,  Mark S. Wang ,  Shifang Li ,  Wenhui Wang ,  Yanbin Shao

IPC分类号： G02F1/09 ,  G02F1/31 ,  G02B6/27 ,  G02B5/30

CPC分类号： G02F1/093 ,  G02F1/31

摘要： An optical circulator has a first collimator; a first block of birefringent material; a first compound polarization rotator; a light angle deflector (e.g., Wollaston prism); a second compound polarization rotator; a second block of birefringent material; and a second collimator. Light from the first fiber exits the first collimator along a first path into a first collimated beam that first hits the central plane on a crossing line between the interface and the central plane such that the first collimated beam exits the light angle deflector along a second path substantially parallel to the longitudinal direction and is received by the second fiber. Light from the second fiber exits the second collimator along the second path into a second collimated beam that exits the light angle deflector along a third path and is received by the third fiber.

摘要翻译： 光循环器具有第一准直器; 第一块双折射材料; 第一复合偏振旋转器; 光角偏转器（例如，Wollaston棱镜）; 第二复合偏振旋转器; 第二块双折射材料; 和第二个准直器。 来自第一光纤的光沿着第一路径离开第一准直器进入第一准直光束，该第一准直光束首先在界面和中心平面之间的交叉线上撞击中心平面，使得第一准直光束沿着第二光路离开光角偏转器 基本上平行于纵向并由第二纤维接收。 来自第二光纤的光沿着第二路径离开第二准直仪，进入沿着第三路径离开光角偏转器的第二准直光束，并被第三光纤接收。

公开(公告)号：US07892489B2

公开(公告)日：2011-02-22

申请号：US11754912

申请日：2007-05-29

申请人： Hong Wang ,  Zhimin Liu

发明人： Hong Wang ,  Zhimin Liu

IPC分类号： G01N21/00 ,  G01N21/03 ,  G01J3/44

CPC分类号： G01N21/658

摘要： A micro structure includes a silicon substrate, an adhesion layer on the silicon substrate, a bias layer on the adhesion layer, and structure layers on the adhesion layer. The two or more structure layers comprise different material compositions and a plurality of holes through at least two of the structure layers. Widths of the plurality of holes are in the range of 0.5-500 nm.

摘要翻译： 微结构包括硅衬底，硅衬底上的粘合层，粘合层上的偏置层和粘合层上的结构层。 两个或更多个结构层包括不同的材料组成和通过至少两个结构层的多个孔。 多个孔的宽度在0.5〜500nm的范围内。

公开(公告)号：US06469835B1

公开(公告)日：2002-10-22

申请号：US09704113

申请日：2000-10-30

申请人： Zhimin Liu

发明人： Zhimin Liu

IPC分类号： G02B2730

CPC分类号： G02B6/32 ,  G02B27/30

摘要： This invention discloses an optical collimator lens for collimating an incident light. The collimator lens includes an optical transmission rod substantially formed as an elongated cylinder. The optical transmission rod further includes a first end surface formed as a spherical or aspherical end surface and a second end surface opposite the first end-surface. The second end surface formed as an inclined planar surface having an incline angle &thgr; relative to the optical axis of the optical transmission rod for increasing a return loss from the inclined planar surface. In a preferred embodiment, the inclined planar surface has an incline angle of substantially eight degrees or less or more.

摘要翻译： 本发明公开了一种准直入射光的准直透镜。 准直透镜包括基本形成为细长圆筒的光传输杆。 光传输杆还包括形成为球面或非球面端面的第一端面和与第一端面相对的第二端面。 第二端面形成为相对于光传输杆的光轴具有倾斜角θ的倾斜平面，用于增加从倾斜平面的返回损耗。 在优选实施例中，倾斜平面的倾斜角度大致为八度以下。

公开(公告)号：US06400508B1

公开(公告)日：2002-06-04

申请号：US09695766

申请日：2000-10-24

申请人： Zhimin Liu

发明人： Zhimin Liu

IPC分类号： G02B530

CPC分类号： G02B6/272 ,  G02B6/2766 ,  G02B6/29302 ,  G02B6/29386 ,  G02B6/29398

摘要： This invention discloses an optical interleaver. The optical interleaver includes an input port for receiving an input light beam including a plurality of wavelengths represented by &lgr;1, &lgr;2, &lgr;3, . . . , &lgr;n where n is a positive integer. The interleaver further includes a group of optical elements for decomposing the input light beam into a first light beam including a first set of wavelengths represented by &lgr;1, &lgr;3, &lgr;5, . . . , &lgr;n and a second light beam including of a second set of wavelengths represented by &lgr;2, &lgr;4, &lgr;6, . . . , &lgr;n−1, wherein the first light beam and the second light beam transmitted respectively in a first and second optical paths, and the group of optical elements further decomposing and generating two sets of mutually orthogonally polarized and parallel beam-components from the first beam and second beam. The interleaver further includes an incline angle means coupled to the group of optical elements. The incline angle means is used for projecting the two sets of mutually orthogonally polarized and parallel beam-components for the first and second beams respectively with a first incline angle and second incline angle relative to an optical axis of the interleaver. And, the interleaver further includes an output beam-component combining means for combining the mutual orthogonally polarized and parallel beam-components into a first output beam and a second output beam projected with the first and second incline angles respectively relative to the optical axis of the interleaver. In a preferred embodiment, the interleaver further includes a dual fiber collimator having a first optical fiber and a second optical fiber disposed off-axis of the collimator for directly receiving the first output beam and the second output beam projected respectively with the first and second inclined angles.

摘要翻译： 本发明公开了一种光交错器。 光交错器包括用于接收包括由lambd1，lambd2，lambd3表示的多个波长的输入光束的输入端口。 。 。 ，lambdn其中n是正整数。 交织器还包括用于将输入光束分解成包括由lambd1，lambd3，lambd5表示的第一组波长的第一光束的一组光学元件。 。 。 ，lambdn和包含由lambd2，lambd4，lambd6表示的第二组波长的第二光束。 。 。 lambdn-1，其中所述第一光束和所述第二光束分别在第一和第二光路中传输，并且所述光学元件组进一步从所述第一光束分解和产生两组相互正交极化和平行的光束分量 和第二光束。 交织器还包括耦合到该组光学元件的倾斜角度装置。 倾斜角度装置用于相对于交织器的光轴以第一倾斜角度和第二倾斜角度分别投影用于第一和第二光束的两组相互正交偏振和平行光束分量的组。 并且，交织器还包括输出光束分量组合装置，用于将互相正交偏振和平行光束分量组合成第一输出光束和第二输出光束，第一输出光束和第二输出光束分别相对于第一输出光束的光轴投影第一和第二倾斜角度 交织器。 在优选实施例中，交织器还包括具有第一光纤的双光纤准直仪和设置在准直器离轴的第二光纤，用于直接接收第一和第二倾斜的第一输出光束和第二输出光束， 角度。

公开(公告)号：US09807986B2

公开(公告)日：2017-11-07

申请号：US15083269

申请日：2016-03-28

申请人： Rui Hou ,  Yuwei Wang ,  Huifang Liang ,  Zhanguo Zhang ,  Zhimin Liu ,  Binhao Zhang ,  Bixiang Zhang ,  Xiaoping Chen

发明人： Rui Hou ,  Yuwei Wang ,  Huifang Liang ,  Zhanguo Zhang ,  Zhimin Liu ,  Binhao Zhang ,  Bixiang Zhang ,  Xiaoping Chen

IPC分类号： A01K67/027 ,  A61K49/00 ,  G01N33/50 ,  C12N5/09 ,  C12N9/02

CPC分类号： A01K67/0271 ,  A01K2207/12 ,  A01K2227/105 ,  A01K2267/0331 ,  C12N5/0693 ,  C12N9/0069 ,  C12Y113/12007

摘要： A method for establishing an animal model of hepatocellular carcinoma (HCC) bone metastasis, the method including: 1) establishing 97H and LM3 cell clones with stable expression of firefly luciferase (LUC); 2) allowing HCC cells to form bone metastasis in nude mice via intratibial injection; 3) reproducing HCC bone metastasis in nude mice via intracardiac injection of tumor cells; and 4) isolating a sub-population of tumor cells that targets metastasis to bone. The 97H and the LM3 are highly metastatic HCC cell lines transfected with luciferase gene. BALB/cA-nu mice are 4-5 weeks old and maintained in laminar flow cabinets under SPF conditions and received human care throughout an entire study. A cell number for intratibial injection is 0.5×106, and a cell number for intracardiac injection is 1×106.

公开(公告)号：US07384792B1

公开(公告)日：2008-06-10

申请号：US10852787

申请日：2004-05-24

申请人： Hong Wang ,  Zhimin Liu

发明人： Hong Wang ,  Zhimin Liu

IPC分类号： G01N21/03 ,  G01N33/558 ,  B32B3/02 ,  B32B7/12 ,  H01J9/04

CPC分类号： G01N21/658 ,  G01J3/44 ,  Y10T428/218 ,  Y10T428/28

摘要： A method to fabricate an optical scattering probe and the method includes the steps of a) depositing an conductive layer on a substrate followed by depositing a noble metal layer on top of the conductive layer and then an aluminum layer on top the noble metal layer; b) anodizing the aluminum layer to form a porous aluminum oxide layer having a plurality of pores; and c) etching the plurality of pores through the aluminum oxide layer and the noble metal layer for forming a nano-hole array. In a preferred embodiment, the step of etching the plurality of pores through the aluminum oxide layer and the noble metal layer further comprising a step of widening the pores followed by removing the aluminum oxide layer for forming a plurality of noble metal column on top of the conductive layer.

摘要翻译： 一种制造光散射探针的方法，包括以下步骤：a）在衬底上沉积导电层，然后在导电层的顶部沉积贵金属层，然后在贵金属层顶上沉积铝层; b）阳极氧化铝层以形成具有多个孔的多孔氧化铝层; 以及c）通过氧化铝层和用于形成纳米孔阵列的贵金属层蚀刻多个孔。 在优选实施例中，通过氧化铝层和贵金属层蚀刻多个孔的步骤还包括扩大孔的步骤，随后除去用于形成多个贵金属柱的氧化铝层 导电层。

公开(公告)号：US06870988B2

公开(公告)日：2005-03-22

申请号：US10690735

申请日：2003-10-21

申请人： Zhimin Liu

发明人： Zhimin Liu

IPC分类号： G02B6/28 ,  G02B6/32

CPC分类号： G02B6/2852 ,  G02B6/2848

摘要： This invention discloses an optical collimator that includes a built-in tap-out projection optical arrangement for projecting a portion of an incoming beam to a tap-out beam-transmission fiber. In one of the preferred embodiments, the built-in tap-out projection optical arrangement further includes a front surface having an incline angle for projecting a portion of an incoming beam to a tap-out beam transmission fiber. In another preferred embodiment, the built-in tap-out projection optical arrangement further includes a prism having a pair of inclined front surfaces for projecting the incoming beam into an output beam and a tap out beam. In yet another preferred embodiment, the built-in tap-out projection optical arrangement further includes a partially reflective front surface and a reflective mirror projecting the incoming beam into an output beam and a tap out beam. This invention disclosure a dual beam collimator that provides two parallel each other beam with adjustable distance between them in the same diameter as single beam collimator. The dual beam collimator can be expanded into multiple beam collimator also.

摘要翻译： 本发明公开了一种光学准直器，其包括内置的出口投射光学装置，用于将入射光束的一部分投影到出射光束传输光纤。 在一个优选实施例中，内置的出口投影光学装置还包括具有倾斜角的前表面，用于将入射光束的一部分投射到出射光束传输光纤。 在另一优选实施例中，内置的出口投射光学装置还包括具有一对倾斜前表面的棱镜，用于将入射光束投射到输出光束和出射光束中。 在另一个优选实施例中，内置的出口投影光学装置还包括部分反射的前表面和将入射光束投影到输出光束和出射光束中的反射镜。 本发明公开了一种双光束准直仪，其提供两个彼此平行的彼此的光束，它们之间具有与单光束准直器相同直径的可调距离。 双光束准直仪也可扩展成多光束准直仪。

公开(公告)号：US06370287B1

公开(公告)日：2002-04-09

申请号：US09510120

申请日：2000-02-22

申请人： Zhimin Liu

发明人： Zhimin Liu

IPC分类号： G02B600

CPC分类号： G02F1/093 ,  G02B6/2746

摘要： This invention discloses an optical circulator. The optical circulator includes a first set of optical components having a birefringent crystal, a pair of half wave plates and the Faraday rotator to separate and then polarize the light beam into projection-direction ready polarization components. These projection-direction ready polarization components are suitable for entering into a projection-direction optical-processing-optical device, e.g., a Wollaston prism, to generate the projecting-to-exit-port beam components. The circulator then employs a set of reciprocal components of the first set of optical components to carry out reciprocal polarization rotations and beam component merging processes to transmit an output beam to the exit port by projecting the beam components and the merged beam along the projecting-to-exit port direction.

摘要翻译： 本发明公开了一种光循环器。 光循环器包括具有双折射晶体的第一组光学部件，一对半波片和法拉第旋转器，用于将光束分离，然后将光束偏振成投影方向准备偏振分量。 这些投影方向准备偏振分量适于进入诸如Wollaston棱镜的投影方向光学处理光学装置，以产生投射到出射光束分量。 循环器然后采用第一组光学部件的一组倒数分量来执行倒数偏振旋转和光束分量合并过程，以通过将光束分量和合并光束投影到投影光束的投影到投影光束 - 端口方向。

公开(公告)号：US07242469B2

公开(公告)日：2007-07-10

申请号：US10987842

申请日：2004-11-12

申请人： Hong Wang ,  Zhimin Liu

发明人： Hong Wang ,  Zhimin Liu

IPC分类号： G01J3/44

CPC分类号： G01J3/44 ,  G01N21/658 ,  G08B21/12

摘要： New and improved applications of Raman Scattering are disclosed. These applications may be implemented with or without using an enhanced nano-structured surface that is trademarked as the RamanNanoChip™ disclosed in a pending patent. As a RamanNanoChip™ provides much higher sensitivity in SERS compared with conventional enhance surface, broader scopes of applications are now enabled and can be practically implemented as now disclosed in this application. Furthermore, a wide range of applications is achievable as new and improved Raman sensing applications. By applying the analysis of Raman scattering spectrum, applications can be carried out to identify unknown chemical compositions to perform the tasks of homeland security; food, drug and drinking materials safety; early disease diagnosis; environmental monitoring; industrial process monitoring, precious metal and gem authentications, etc.

摘要翻译： 公开了拉曼散射的新的和改进的应用。 这些应用可以在使用或不使用商标为未决专利中公开的RamanNanoChip TM的增强型纳米结构化表面的情况下实现。 由于与传统增强表面相比，RamanNanoChip（TM）在SERS中提供了更高的灵敏度，因此现在可以实现更广泛的应用范围，并且可以实际实现，如本应用中所公开的。 此外，作为新的和改进的拉曼传感应用可以实现广泛的应用。 通过应用拉曼散射光谱分析，可以应用于识别未知化学成分来执行国土安全任务; 食品，药品和饮料安全; 早期疾病诊断; 环境监测; 工业过程监控，贵金属和宝石认证等