摘要:
Provided herein in certain embodiments are polypeptide complexes capable of binding to an antigen. Pharmaceutical compositions, method of using the polypeptide complexes are also provided.
摘要:
Provided herein in certain embodiments are polypeptide complexes capable of binding to an antigen. Pharmaceutical compositions, method of using the polypeptide complexes are also provided.
摘要:
A method, optical module, and optical amplifier are configured to detect fiber discontinuities at or near a port from which high powered optical signals are input into a fiber span. These fiber discontinuities can include fiber pinches, and are detected by monitoring for slight changes in a backscatter signal. Detection is quick and efficient based on the backscatter signal being attenuated by the fiber discontinuities twice, namely once as the high powered optical signals and again as the associated backscatter signal of the high powered optical signals returning to the port. Various remedial actions can be taken upon detecting fiber pinches at or near the port.
摘要:
The present disclosure provides high-degree reconfigurable optical add-drop multiplexing (ROADM) systems using bi-directional wavelength selective switches (WSSs) and optical circulators. A single WSS is utilized on each degree of a node in a bi-directional manner, i.e. both ingress and egress share the same WSS. Advantageously, the present invention eliminates conventional splitters/combiners thereby capping intra-node insertion loss to a certain value regardless of the number of degrees. More importantly, the present invention reduces noise penalty associated with high-degree nodes while minimizing cost.
摘要:
The present disclosure relates to streamlining optical module and/or subassembly development, manufacturing, and testing through introducing a memory component within a module and/or subassembly that is utilized with a host module for system calibration and/or configuration. In an exemplary embodiment, the present invention can streamline optical amplifier (EDFA) module and/or subassembly development, manufacturing, and testing. The present invention includes an optical module/sub-assembly without control circuitry, i.e. a “dumb module”, but with a memory that is used to load relevant data from a supplier. This data is utilized to calibrate, test, and configure the optical module/sub-assembly in a host module. The host module includes control circuitry to access this memory in the optical module/sub-assembly and to calibrate, test, configure, and control the optical module/sub-assembly. Advantageously, this additional memory reduces manufacturing time without the disadvantage of adding complexity in the optical module/sub-assembly.
摘要:
The present invention provides a coding gene having the nucleic acid sequence shown as SEQ ID NO:1 and the fusion protein RIG (SEQ ID NO:2) that inhibits osteoclast formation. The present invention also provides the preparation method for the fusion protein RIG as well as synthetic oligo-nucleotide primers, plasmids and host cells used in the method and a medicine having the above fusion protein RIG as active ingredient. The fusion protein RIG in present invention is derived from humanized immunoglobulin and RANKL with a flexible hinge region. RIG can cross link the cell surface receptor RANK and Fcγ 1 to induce a cytosolic inhibitory signal leading to the inhibition of osteoclast formation. The fusion protein RIG in present invention can play an essential role in treating osteoporosis and bone resorption diseases caused by tumor metastasis.
摘要翻译:本发明提供具有SEQ ID NO:1所示的核酸序列和抑制破骨细胞形成的融合蛋白RIG(SEQ ID NO:2)的编码基因。 本发明还提供了融合蛋白RIG的制备方法以及该方法中使用的合成寡核苷酸引物,质粒和宿主细胞以及具有上述融合蛋白RIG作为活性成分的药物。 本发明的融合蛋白RIG衍生自具有柔性铰链区的人源化免疫球蛋白和RANKL。 RIG可以将细胞表面受体RANK和Fcγ1交联以诱导抑制破骨细胞形成的细胞溶质抑制信号。 本发明的融合蛋白RIG可以在治疗由肿瘤转移引起的骨质疏松症和骨吸收疾病中发挥重要作用。
摘要:
A calibration system for a combined Positron Emission Tomography (PET)/Computed Tomography scanner system, may have a support structure carrying a rotation motor driving a phantom, wherein the phantom has at least two phantom rods and the rods are positioned such that they are neither parallel nor connected to each other.
摘要:
This invention generally relates to apparatus and methods for high-throughput, reproducible and inexpensive detection of virus infection using multiplexing technologies such as slide-based, microtiter plate-based and membrane-based microarrays and beads technologies. The apparatus and methods allow simultaneous detection of multiple viral infections in a plurality of test samples.
摘要:
Various embodiments relate to a method of attenuation correction of Positron Emission Tomography (PET) data based on Magnetic Resonance Tomography (MRT) data. A method of at least one embodiment further includes determining further data being indicative of an iterative cycle of a physiological observable of a patient and matching the PET data with the MRT data based on the further data.
摘要:
The present application provides compositions and methods for modulating the activity and quantity of platelets and preventing and treating disorders or diseases associated with abnormal activity and quantity of platelets.