Spherical beads for use in producing pharmaceutically active pellets

    公开(公告)号:US12115259B2

    公开(公告)日:2024-10-15

    申请号:US17281442

    申请日:2019-09-27

    IPC分类号: A61K9/16

    摘要: Improved spherical beads that may be used in producing pharmaceutically active pellets by depositing a pharmaceutically active agent on the surface of said spherical beads. The spherical beads includes a pharmaceutically acceptable carrier material, including:



    a) at least 60 wt. % of phosphoric acid calcium salt and
    b) up to 40 wt. % of organic material.




    Greater than or equal to 90 wt % of the spherical beads have a particle size in the range of from 90 μm to 1200 μm. The spherical beads have:



    a bulk density of at least or more than 1000 g/l,
    a specific surface area of at most or less than 10 m2/g, and
    a hardness of at least or more than 600 g/mm2. Also included is a method for producing such spherical beads and to pharmaceutically active pellets being prepared by depositing a pharmaceutically active agent on the surface of the spherical beads.

    Lubricant for the hot forming of metals

    公开(公告)号:US11485929B2

    公开(公告)日:2022-11-01

    申请号:US17310710

    申请日:2020-02-21

    摘要: A lubricant for the hot forming of metals, with respect to the solid constituents, contains at least the following constituents: 55 to 85 wt % of a solid lubricating agent comprising a mixture of talc and a potassium mica, wherein the ratio of talc to potassium mica in the solid lubricating agent is 2.0 to 5.0, 10 to 30 wt % of an adhesive agent selected from a polyvinyl acetate, sodium water glass and dextrin or a mixture of same, 2 to 10 wt % of a thickener selected from hydroxy cellulose, hydroxyethyl cellulose, hydroxyproply cellulose, carboxymethyl cellulose, methyl cellulose, ethyl cellulose, methylethyl cellulose, hydroxyethylmethyl cellulose, hydroxypropylmethyl cellulose, ethylhydroxymethyl cellulose, carboxymethylhydroxy cellulose, dextrin, starch, organically modified bentonite, smectite and xanthan gum, 0 to 10 wt % of further auxiliary agents, and not more than 10 wt % of graphite.

    Graphite-free high-temperature lubricant
    9.
    发明申请
    Graphite-free high-temperature lubricant 有权
    无石墨高温润滑剂

    公开(公告)号:US20100298181A1

    公开(公告)日:2010-11-25

    申请号:US12308440

    申请日:2007-06-22

    IPC分类号: C10M169/04

    摘要: A high-temperature lubricant for the hot processing of metals comprising a mixture of fine-powder materials. To provide a high-temperature lubricant having good trickle and flow characteristics for dissolving scale on heated metal surfaces, which applied in powder form permits good coverage of the metal surface and which even after prolonged storage under production conditions still has good trickle and flow characteristics without severe lump formation and which avoids the use of graphite, in accordance with the invention it is proposed that the mixture includes at least the following constituents (a) a secondary and/or tertiary calcium phosphate compound, (b) a fatty acid or a fatty acid salt, (c) boric acid, a boric acid salt (borate) and/or a mineral containing boric acid salt (borate), and (d) condensed alkali metal phosphates, and wherein the constituents of the mixture have a mean grain size of ≦150 μm and the lubricant does not contain any addition of graphite.

    摘要翻译: 用于热处理金属的高温润滑剂,包括细粉末材料的混合物。 为了提供具有良好的涓流和流动特性的高温润滑剂,用于将粉末溶解在加热的金属表面上,以粉末形式施加,可以很好地覆盖金属表面,并且即使在生产条件下长时间储存​​后仍然具有良好的涓流和流动特性,而没有 严重的团块形成并且避免使用石墨,根据本发明,提出混合物至少包括以下组分(a)仲和/或叔磷酸钙化合物,(b)脂肪酸或脂肪酸 酸性盐,(c)硼酸,硼酸盐(硼酸盐)和/或含硼酸盐(硼酸盐)的矿物,和(d)浓缩的碱金属磷酸盐,其中混合物的组分具有平均粒度 的≦̸ 150μm,润滑剂不含任何石墨添加。

    Pigment For Laser-Writable Plastic Materials And Use Thereof
    10.
    发明申请
    Pigment For Laser-Writable Plastic Materials And Use Thereof 有权
    用于激光可塑塑料的颜料及其用途

    公开(公告)号:US20090036585A1

    公开(公告)日:2009-02-05

    申请号:US11665363

    申请日:2005-10-14

    IPC分类号: C01B25/37 C08K3/22

    摘要: A pigment for laser-writable plastic materials in the form of particulate, light-sensitive compounds which under the influence of laser light change their color and/or lead to a color change in the plastic material is characterized in that the pigments include at least one salt-like compound including at least two different cations or a compound mixture which can be reacted to afford at least one such salt-like compound with at least two different cations, wherein at least one of the cations is selected from a group (A) of the elements Ti, Cr, Mn, Fe, Co, Ni, Cu, Zn, Y, Zr, Nb, Mo, Ag, Sn, Sb, La, Pr, Ta, W and Ce and at least one further cation is selected from a group (B) of the elements of the 3rd to 6th periods of the main groups II and III, the 5th to 6th periods of the main group IV and the 4th to 5th periods of the secondary group III to VIII and the lanthanides of the periodic system of elements. The invention also includes plastic materials containing the pigment or the compound mixture.

    摘要翻译: 在激光影响下,颗粒状,光敏化合物形式的激光可写塑性材料的颜料改变其颜色和/或导致塑性材料的颜色变化,其特征在于颜料包括至少一种 包含至少两种不同阳离子的盐状化合物或可以与至少两种不同阳离子反应得到至少一种这样的盐状化合物的化合物混合物,其中至少一种阳离子选自(A) 元素Ti,Cr,Mn,Fe,Co,Ni,Cu,Zn,Y,Zr,Nb,Mo,Ag,Sn,Sb,La,Pr,Ta,W和Ce中的至少一种, 主要组别二,三组第三至第六期要素组(B),第四组第五至第六期,第三至第八组第四至第五次,第 元素的周期性系统。 本发明还包括含有颜料或化合物混合物的塑料材料。