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    LIPID COMPOSITIONS AND USES THEREOF
    2.
    发明申请
    LIPID COMPOSITIONS AND USES THEREOF 有权

    公开(公告)号：US20210392934A1

    公开(公告)日：2021-12-23

    申请号：US16082202

    申请日：2017-03-08

    申请人： ENZYMOTEC LTD.

    发明人： Fabiana BAR-YOSEPH ,  Yael HERZOG

    IPC分类号： A23L33/12 ,  A23L33/00 ,  A61K31/23 ,  A61K9/00

    摘要： The present invention refers to a method for one or both of improving growth in a subject and treating at least one growth problem in a subject. The method comprises administering to the subject an edible lipid composition which comprises a vegetable-derived fat source, wherein the fat source is a triglyceride fat source comprising triglycerides with 13-55% palmitic acid moieties out of the total fatty acids, and wherein the level of palmitic acid moieties at the sn-2 position of the glycerol backbone is at least 30% of total palmitic acid.

    HUMAN MILK FAT SUBSTITUTES
    3.
    发明申请
    HUMAN MILK FAT SUBSTITUTES 审中-公开
    人奶粉替代品

    公开(公告)号：US20160249665A1

    公开(公告)日：2016-09-01

    申请号：US15149278

    申请日：2016-05-09

    申请人： ENZYMOTEC LTD.

    发明人： Avidor SHULMAN ,  Gai BEN DROR ,  Hala LAOUZ ,  Dov YAAKOBI ,  Zohar BAR-ON ,  Gregory BLINDER ,  Iris MEIRI-BENDEK ,  Yael HERZOG

    IPC分类号： A23D7/00 ,  C11C3/08 ,  A23D9/00 ,  C11C3/10

    CPC分类号： A23D9/00 ,  A23L33/115 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  C11C3/08 ,  C11C3/10

    摘要： Disclosed are human milk fat (HMF) substitutes, processes for preparation thereof, uses thereof, and fat blends and formula containing the HMF substitutes. A fat base composition of the invention includes a mixture of vegetable-derived triglycerides, with less than 50% of the fatty acid residues bonded at the sn-2 position being saturated; and/or with the amount of saturated fatty acid residues bonded at the sn-2 position of the glycerol backbone less than about 43.5% of the total amount of the fatty acid residues. Typically, substantially all of the saturated fatty acids bonded at the sn-2 position of the glycerol backbone are palmitic acid residues. Also disclosed are substitute HMF compositions including a blend of at least 25% or at least 30% of the fat base composition of the invention with up to 75%, or respectively up to 70%, of at least one vegetable oil. Processes for preparing the fat base compositions and blend are also disclosed. Further disclosed are infant formulas including the fat base composition or substitute human milk fat composition.

    摘要翻译： 公开了人乳脂肪（HMF）替代品，其制备方法，其用途，以及包含HMF替代物的脂肪共混物和配方。 本发明的脂肪基组合物包括植物来源的甘油三酯的混合物，其中在sn-2位置处键合的少于50％的脂肪酸​​残基是饱和的; 和/或与甘油骨架的sn-2位相连的饱和脂肪酸残基的量小于脂肪酸残基总量的约43.5％。 通常，在甘油骨架的sn-2位上键合的基本上所有的饱和脂肪酸都是棕榈酸残基。 还公开了替代HMF组合物，包括本发明的脂肪基础组合物的至少25％或至少30％的混合物与至多一种植物油的高达75％，或分别高达70％的混合物。 还公开了制备脂肪基础组合物和共混物的方法。 进一步公开的是婴儿配方，包括脂肪组合物或替代人乳脂肪组合物。

    Edible fat composition for enhancing bone strength
    5.
    发明授权
    Edible fat composition for enhancing bone strength 有权
    用于增强骨强度的食用脂肪组合物

    公开(公告)号：US08623825B2

    公开(公告)日：2014-01-07

    申请号：US12671678

    申请日：2008-07-31

    申请人： Fabiana Bar-Yoseph ,  Dori Pelled ,  Yael Lifshitz

    发明人： Fabiana Bar-Yoseph ,  Dori Pelled ,  Yael Lifshitz

    IPC分类号： A61K38/00

    CPC分类号： A61K31/231 ,  A21D2/165 ,  A23D9/00 ,  A23L33/115 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/23 ,  A23V2200/306 ,  A23V2250/18

    摘要： Disclosed is describes a method of increasing bone strength and/or increasing bone resistance to bending and/or improving bone architecture and/or maintaining bone status in a human, comprising administering to said human a composition comprising a fat source, wherein said fat source is a triglyceride fat source comprising triglycerides with 15-55% palmitic acid moieties out of the total fatty acids, and wherein the level of palmitic acid moieties at the sn-2 position of the glycerol backbone is at least 30% (w/w) of total palmitic acid. Said method is particularly intended for subjects at risk of impaired bone strength. Further disclosed is said fat source, as well as food articles and a commercial package comprising the same.

    摘要翻译： 公开了一种增加骨强度和/或增加骨抗性以改善骨架构和/或改善人体骨骼状态的方法，包括对所述人施用包含脂肪源的组合物，其中所述脂肪来源是 甘油三酸酯脂肪源包括在总脂肪酸中具有15-55％的棕榈酸部分的甘油三酸酯，并且其中在甘油骨架的sn-2位置处的棕榈酸部分的水平为至少30％（w / w） 总棕榈酸。 所述方法特别适用于具有骨强度受损的风险的受试者。 进一步公开的是脂肪源，以及食品和包含该食品的商业包装。

    Lipids containing omega-3 and omega-6 fatty acids
    6.
    发明授权
    Lipids containing omega-3 and omega-6 fatty acids 有权
    含有ω-3和ω-6脂肪酸的脂质

    公开(公告)号：US08470345B2

    公开(公告)日：2013-06-25

    申请号：US12590893

    申请日：2009-11-16

    申请人： Gai Ben Dror ,  Dorit Platt ,  Orly Farkash ,  Rassan Zuabi ,  Zohar Bar-On ,  Avidor Shulman ,  Dori Pelled

    发明人： Gai Ben Dror ,  Dorit Platt ,  Orly Farkash ,  Rassan Zuabi ,  Zohar Bar-On ,  Avidor Shulman ,  Dori Pelled

    IPC分类号： A61K31/685 ,  A61P25/00

    CPC分类号： A61K31/685 ,  A21D2/32 ,  A23D7/013 ,  A23D9/013 ,  A23L33/12 ,  A23V2002/00 ,  A23V2200/322 ,  A23V2250/1882 ,  A23V2250/1942 ,  A23V2250/1842

    摘要： A lipid preparation including a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The preparation possesses an improved bioactivity, and is useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes.

    摘要翻译： 一种包含甘油磷脂或盐的缀合物及其衍生物，特别是磷脂酰丝氨酸（PS），磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰肌醇（PI），磷脂酰甘油（PG）和磷脂酸（PA） - 不饱和脂肪酸（PUFA）酰基，特别是长链多不饱和脂肪酸（LC-PUFA）酰基如ω-3和/或ω-6酰基，其中所述PUFA与所述甘油磷脂共价结合。 该制剂具有改善的生物活性，并且可用于治疗各种认知和精神状况和障碍，并用于维持脑相关系统和过程的正常功能。

    Human Milk Fat Substitutes
    9.
    发明申请
    Human Milk Fat Substitutes 有权
    人乳脂肪替代品

    公开(公告)号：US20080193624A1

    公开(公告)日：2008-08-14

    申请号：US11912946

    申请日：2006-04-27

    申请人： Avidor Shulman ,  Gai Ben Dror ,  Hala Laouz ,  Dov Yaakobi ,  Zohar Bar-On ,  Gregory Blinder ,  Iris Meiri-Bendek ,  Yael Herzog

    发明人： Avidor Shulman ,  Gai Ben Dror ,  Hala Laouz ,  Dov Yaakobi ,  Zohar Bar-On ,  Gregory Blinder ,  Iris Meiri-Bendek ,  Yael Herzog

    IPC分类号： A23D9/00 ,  A23L2/38

    CPC分类号： A23D9/00 ,  A23L33/115 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  C11C3/08 ,  C11C3/10

    摘要： Disclosed are human milk fat (HMF) substitutes, processes for their preparation, uses thereof and fat blends and infants formulae containing them. A fat base composition of the invention comprises a mixture of vegetable-derived triglycerides, with less than 50% of the fatty acid residues bonded at the sn-2 position being saturated; and/or with the amount of saturated fatty acid residues bonded at the sn-2 position of the glycerol backbone less than about 43.5% of the total amount of saturated fatty acid residues. Typically, substantially all of the saturated fatty acids bonded at the sn-2 position of the glycerol backbone are palmitic acid residues. Also disclosed are substitute HMF compositions comprising a blend of at least 25% or at least 30% of the said fat base composition of the invention with up to 75%, or respectively up to 70%, of at least one vegetable oil. Processes for preparing the fat base compositions and blend are also disclosed. Further disclosed are infant formulas comprising the fat base composition or substitute human milk fat composition.

    摘要翻译： 公开了人乳脂肪（HMF）替代品，其制备方法，其用途和含有它们的脂肪混合物和婴儿配方。 本发明的脂肪基组合物包含植物来源的甘油三酯的混合物，其中在sn-2位置处键合的少于50％的脂肪酸​​残基是饱和的; 和/或与在甘油骨架的sn-2位键合的饱和脂肪酸残基的量小于饱和脂肪酸残基总量的约43.5％。 通常，在甘油骨架的sn-2位上键合的基本上所有的饱和脂肪酸都是棕榈酸残基。 还公开了替代HMF组合物，其包含本发明所述脂肪基础组合物的至少25％或至少30％的共混物与至多一种植物油的至多75％，或分别达70％的混合物。 还公开了制备脂肪基础组合物和共混物的方法。 进一步公开的是包含脂肪基础组合物或替代人乳脂肪组合物的婴儿配方食品。

    Process for the production of phospholipids
    10.
    发明授权
    Process for the production of phospholipids 有权
    磷脂生产工艺

    公开(公告)号：US07034168B2

    公开(公告)日：2006-04-25

    申请号：US10700320

    申请日：2003-11-03

    申请人： Sobhi Basheer ,  Rassan Zuabi ,  Avidor Shulman ,  Neta Scheinman

    发明人： Sobhi Basheer ,  Rassan Zuabi ,  Avidor Shulman ,  Neta Scheinman

    IPC分类号： C07F9/02

    CPC分类号： C07F9/10 ,  C12P7/6481 ,  C12P9/00 ,  C12P13/001 ,  C12P13/06

    摘要： A new enzymatic process for preparing 1,2-diacylated phospholipids using an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced according to the esterification/transesterification process are obtainable in high yield and purity and carry identical desired carboxylic acid, preferably fatty acid, acyl groups at the sn-1 and sn-2 positions. The process involves esterification/transesterification (acylation) of a glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of the above mentioned appropriate enzyme preparation. The process of the invention further relates to a process for the production of 1-acyl-2-lyso-glycerophospholipid, preferably 2-lyso-PC by reacting glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of a sn-1 specific phospholipase (PLA1 or PLA1,2) and a solvent, in a microaqueous medium.

    摘要翻译： 使用在微水反应体系中sn-1和sn-2位点具有磷酰化活性的酶制剂来制备1,2-二酰化磷脂的新的酶法。 更具体地，根据酯化/酯交换方法生产的1,2-二酰基磷脂可以高产率和纯度获得，并且在sn-1和sn-2位置携带相同的所需羧酸，优选脂肪酸酰基。 该方法包括在上述合适的酶制剂存在下，将所需羧酸，优选脂肪酸或其衍生物的甘油磷脂，优选甘油磷酸胆碱（GPC）进行酯化/酯交换（酰化）。 本发明的方法还涉及通过使甘油磷脂，优选甘油磷酰胆碱（GPC）与所需羧酸（优选脂肪酸）反应来生产1-酰基-2-溶血甘油磷脂，优选2-溶血甘油磷酸的方法， 或其衍生物在sn-1特异性磷脂酶（PLA 1 / PLA 2 N 2）和溶剂存在下在微水介质中。