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    BLOOD PROCESSING APPARATUS WITH CONTROLLED CELL CAPTURE CHAMBER AND METHOD BACKGROUND OF THE INVENTION
    2.
    发明申请
    BLOOD PROCESSING APPARATUS WITH CONTROLLED CELL CAPTURE CHAMBER AND METHOD BACKGROUND OF THE INVENTION 审中-公开
    具有受控细胞室的血液加工装置和方法发明背景

    公开(公告)号：US20070102374A1

    公开(公告)日：2007-05-10

    申请号：US11163969

    申请日：2005-11-04

    申请人： Jeremy Kolenbrander

    发明人： Jeremy Kolenbrander

    IPC分类号： C02F1/38

    CPC分类号： A61M1/3693 ,  A61M1/3692 ,  A61M1/3696 ,  B04B5/0442 ,  B04B2005/0471

    摘要： A centrifuge for separating blood components, and methods for controlling the centrifuge. The apparatus has a fluid separation chamber having a first frustro-conical segment and a second frustro-conical segment. The second segment has a taper such that particles are subjected to substantially equal and opposite centripetal and fluid flow forces. A camera observes fluid flow, and a controller controls the flow. White blood cells are selectively captured within the second segment and are periodically flushed out of the fluid separation chamber. The camera is used to determine the quantity of particles captured. A limited quantity of high density particles, such as red blood cells, may be captured within the first segment before capturing relatively low density particles, such as white blood cells, within the second segment.

    摘要翻译： 用于分离血液成分的离心机和用于控制离心机的方法。 该装置具有流体分离室，其具有第一截锥形段和第二截头圆锥段。 第二段具有锥形，使得颗粒经受基本相等且相对的向心和流体流动力。 摄像机观察流体流动，控制器控制流量。 白细胞被选择性地捕获在第二段内并被周期性地从流体分离室中冲出。 相机用于确定捕获的颗粒数量。 在第二段内捕获相对低密度的颗粒（例如白细胞）之前，可以在第一区段内捕获有限数量的高密度颗粒，例如红细胞。

    Method for processing a blood product with a bag set having a multi-way connector
    4.
    发明授权
    Method for processing a blood product with a bag set having a multi-way connector 有权
    用具有多路连接器的袋装处理血液制品的方法

    公开(公告)号：US07097774B2

    公开(公告)日：2006-08-29

    申请号：US10627029

    申请日：2003-07-24

    申请人： Niclas Högberg ,  Emanuel Hällgren ,  Peter Pihlstedt

    发明人： Niclas Högberg ,  Emanuel Hällgren ,  Peter Pihlstedt

    IPC分类号： B01D21/26 ,  B04B7/12

    CPC分类号： A61M1/3693 ,  A61M1/0209 ,  A61M1/3696 ,  B04B5/0428 ,  B04B2013/006

    摘要： The claimed invention refers to a centrifuge intended for processing blood and blood components and with its function based on the effective utilisation of ring type blood processing bags with associated secondary bags and other accessories. The most outstanding feature of the centrifuge, in accordance with the claimed invention, is that its rotor, at the same intended height of the ring bag (22) inner periphery, shows at least three supports (9–11) arranged along this periphery and intended to locate the ring bag's inner strengthened periphery edge on guide holes at the same time as the centrifuge and its rotor is equipped with a joint rotating inner lid (6) which includes a clamp function (7) that clamps ring bag (22) securely along and between supports (9–11). Furthermore, in the invention these supports (9–11) have, on the one hand, built-in valve functions for communication between the ring bag and the respective secondary bags can be actively controlled and, on the other hand, sterile welding functions for communication between ring bag (22) and the respective secondary bags when interruption and blocking is required.

    摘要翻译： 所要求保护的发明是指旨在用于处理血液和血液成分的离心机，并且其功能基于有效利用具有相关次级袋和其它附件的环型血液处理袋。 根据要求保护的发明，离心机的最突出的特征是其在环袋（22）内周边的相同预期高度处的转子显示出沿着这个周边布置的至少三个支撑件（9-11） 旨在将离心机和其转子配备有接合旋转内盖（6）的同时定位在引导孔上的环袋的内部加强的周边边缘，其包括夹紧功能（7），该夹紧功能（7）牢固地夹紧环形袋（22） 在支撑（9-11）之间和之间。 此外，在本发明中，这些支撑件（9-11）一方面可以主动地控制环袋和相应的次级袋之间的连通的内置阀功能，另一方面，用于 当需要中断和阻塞时，环袋（22）和各个次级袋之间的通信。

    Method for fluid separation devices using a fluid pressure balanced configuration
    5.
    发明授权
    Method for fluid separation devices using a fluid pressure balanced configuration 失效
    使用流体压力平衡配置的流体分离装置的方法

    公开(公告)号：US07094197B2

    公开(公告)日：2006-08-22

    申请号：US10709079

    申请日：2004-04-12

    申请人： Dennis J Hlavinka ,  Thomas J. Felt

    发明人： Dennis J Hlavinka ,  Thomas J. Felt

    IPC分类号： B01D21/26

    CPC分类号： B04B5/0442 ,  A61M1/0231 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  B04B5/0428 ,  B04B7/08 ,  B04B9/08 ,  B04B2005/045 ,  B04B2005/0464 ,  B04B2009/143

    摘要： A method for separating a composite fluid into components in a centrifugal fluid separation system. The system includes a rotor that has a composite fluid containment area, an inlet channel, a peripheral separation channel, outlet channels and separated component collection areas, which together form a processing area. The separation channel may be semi-spiraled. The inlet channel may connect to the center of the separation channel and an outlet channel may connect to each end of the separation channel. The outlet channels have different heights. The ends of the separation channels may have different heights. The separation channels may have extensions. The rotor may have multiple processing areas. The collection areas may be pockets slanted radially outwardly and downwardly. A motor may produce a rotating magnetic field, which co-acts with a magnetically reactive material in the rotor. A disposable bag and tubing system may be used in a processing area of the rotor.

    摘要翻译： 一种将复合流体分离成离心流体分离系统中的组分的方法。 该系统包括具有复合流体容纳区域，入口通道，周边分离通道，出口通道和分离的部件收集区域的转子，它们一起形成处理区域。 分离通道可以是半螺旋的。 入口通道可以连接到分离通道的中心，并且出口通道可以连接到分离通道的每一端。 出口通道具有不同的高度。 分离通道的端部可以具有不同的高度。 分离通道可以具有扩展。 转子可以具有多个处理区域。 收集区域可以是径向向外和向下倾斜的袋。 电动机可以产生与转子中的磁反应性材料共同作用的旋转磁场。 可以在转子的处理区域中使用一次性袋和管道系统。

    Use of visible light at wavelengths of 500 nm and higher to pathogen reduce blood and blood components
    6.
    发明申请
    Use of visible light at wavelengths of 500 nm and higher to pathogen reduce blood and blood components 有权
    使用波长为500 nm以上的可见光对病原体会降低血液和血液成分

    公开(公告)号：US20050282143A1

    公开(公告)日：2005-12-22

    申请号：US11154503

    申请日：2005-06-15

    申请人： Raymond Goodrich ,  Matthew Platz ,  Christopher Martin

    发明人： Raymond Goodrich ,  Matthew Platz ,  Christopher Martin

    IPC分类号： A01N1/02 ,  A61K31/50 ,  A61L2/00 ,  A61M1/36

    CPC分类号： A61K41/0019 ,  A61K31/50 ,  A61L2/0011 ,  A61L2/0082 ,  A61M1/3683

    摘要： This invention is directed towards a method of using visible light at wavelengths of at least 500 nm and above in combination with a sensitizer having a flavin moiety to reduce any pathogens that may be contained in blood and blood components. By exposing the blood and blood components to light of 500 nm and higher, only the sensitizer that is bound to nucleic acids of the pathogens will be activated, thus destroying the sensitizer-pathogenic nucleic acid complex. Because unbound sensitizer is not activated at this wavelength, damage to blood and blood components caused by photolysis of unbound sensitizer may be avoided.

    摘要翻译： 本发明涉及使用波长为500nm以上的可见光与具有黄素部分的敏化剂组合以减少血液和血液成分中可能含有的任何病原体的方法。 通过将血液和血液成分暴露于500nm以上的光，只有与病原体的核酸结合的敏化剂才能被活化，从而破坏致敏致病核酸复合物。 因为未激活敏感剂在这个波长下，可能会避免由未结合的敏化剂的光解造成的血液和血液成分的损害。

    Apparatus and method for separating a volume of composite liquid into at least two components
    8.
    发明申请
    Apparatus and method for separating a volume of composite liquid into at least two components 有权
    将体积的复合液体分离成至少两个组分的装置和方法

    公开(公告)号：US20050045567A1

    公开(公告)日：2005-03-03

    申请号：US10783831

    申请日：2004-02-20

    申请人： Brian Holmes ,  Peter Pihlstedt ,  Geert Waeg

    发明人： Brian Holmes ,  Peter Pihlstedt ,  Geert Waeg

    IPC分类号： A61M1/36 ,  B04B5/04 ,  B04B13/00 ,  C02F1/38

    CPC分类号： A61M1/3693 ,  A61M1/0209 ,  A61M1/3696 ,  A61M1/3698 ,  A61M2205/331 ,  B01D21/262 ,  B01D2221/10 ,  B04B5/0428 ,  B04B5/0442 ,  B04B13/00 ,  B04B2013/006

    摘要： A method for separating a volume of a composite liquid into at least a first component and a second component is performed in a centrifuge cooperating with a separation bag containing the volume of composite liquid. The separation bag is connected to at least a first component bag and a second component bag. The separation bag is spun so as to centrifuge the volume of composite liquid and cause the sedimentation of the at least first and second components. When the at least first and second components have sedimented, the first component is transferred at at least one first transfer flow rate into the first component bag. When the first component has been transferred into the first component bag, the second component is transferred into the intermediate component bag at at least one second transfer flow rate that is different from the at least one first transfer flow rate.

    摘要翻译： 在与包含复合液体体积的分离袋配合的离心机中进行将复合液体的体积分离成至少第一成分和第二成分的方法。 分离袋连接到至少第一组分袋和第二组分袋。 旋转分离袋以离心复合液体的体积并引起至少第一和第二组分的沉降。 当至少第一和第二组分沉淀时，第一组分以至少一个第一转移流速转移到第一组分袋中。 当第一组分转移到第一组分袋中时，第二组分以不同于至少一个第一转移流速的至少一个第二转移流速转移到中间组分袋中。

    Methods and apparatuses for blood component separation
    9.
    发明申请
    Methods and apparatuses for blood component separation 有权
    血液成分分离方法和装置

    公开(公告)号：US20040104182A1

    公开(公告)日：2004-06-03

    申请号：US10648559

    申请日：2003-08-25

    申请人： Gambro, Inc.

    发明人： Brian M. Holmes ,  Johan-Petter Hagstrom ,  Per-Olov Lundberg ,  Geert Van Waeg ,  Peter Nordgren

    IPC分类号： B04B001/00

    CPC分类号： B04B13/00 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/025 ,  A61M1/26 ,  A61M1/262 ,  A61M1/3633 ,  A61M1/3639 ,  A61M1/3641 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/3698 ,  A61M2205/331 ,  B04B5/0428 ,  B04B5/0442 ,  B04B2005/045 ,  B04B2005/0478 ,  B04B2013/006

    摘要： A system for separating a composite fluid into component parts thereof, including: a centrifuge having a rotor with a separation space and at least two valve members disposed thereon and a container set having a separation container adapted to be disposed in the separation space of the rotor and first and second collection containers connected to the separation container by a first and a second tubes. The tubes are adapted to be disposed in operative relationship with the valve members so that flow through the tubes may be controlled thereby. Three components of the composite fluid may be separated therefrom by the present system and two components may be moved to the collection containers. The container set may further include a third collection container connected to the separation container by a tube, and a third component may thus be moved to this third container.

    摘要翻译： 一种将复合流体分离成其组成部分的系统，包括：具有分离空间的转子和设置在其上的至少两个阀构件的离心机和具有适于设置在转子的分离空间中的分离容器的容器组 以及通过第一和第二管连接到分离容器的第一和第二收集容器。 管适于与阀构件成可操作的关系，从而可以控制通过管的流动。 复合流体的三个组分可以通过本系统与其分离，并且两个组分可以移动到收集容器中。 容器组还可以包括通过管连接到分离容器的第三收集容器，并且因此第三组分可以移动到第三容器。