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    Lectin-derived progenitor cell preservation factors and methods of use
    5.
    发明申请
    Lectin-derived progenitor cell preservation factors and methods of use 审中-公开
    凝集素衍生的祖细胞保存因子及使用方法

    公开(公告)号：US20050060779A1

    公开(公告)日：2005-03-17

    申请号：US10929743

    申请日：2004-08-30

    申请人： M. Colucci ,  Maarten Chrispeels ,  Jeffrey Moore

    发明人： M. Colucci ,  Maarten Chrispeels ,  Jeffrey Moore

    IPC分类号： C12N15/09 ,  A61K35/12 ,  C07K14/42 ,  C12N5/0789 ,  C12N5/10 ,  C12N15/90 ,  A01H5/00 ,  C07H21/04 ,  C12N9/24 ,  C12N5/04

    CPC分类号： C12N15/90 ,  A61K38/00 ,  A61K2035/124 ,  C07K14/42 ,  C12N5/0647 ,  C12N2501/26 ,  C12N2501/59

    摘要： The invention relates to an isolated nucleic acid molecule that encodes a protein that is effective to preserve progenitor cells, such as hematopoietic progenitor cells. The nucleic acid comprises a sequence defined by SEQ ID NO:1, a homolog thereof, or a fragment thereof. The encoded protein has an amino acid sequence that comprises a sequence defined by SEQ ID NO:2, a homolog thereof or a fragment thereof that contains an amino acid sequence TNNVLQVT. Methods of using the encoded protein for preserving progenitor cells in vitro, ex vivo, and in vivo are also described. The invention, therefore, include methods such as myeloablation therapies for cancer treatment wherein myeloid reconstitution is facilitated by means of the specified protein. Other therapeutic utilities are also enabled through the invention, for example, expanding progenitor cell populations ex vivo to increase chances of engraftation, improving conditions for transporting and storing progenitor cells, and facilitating gene therapy to treat and cure a broad range of life-threatening hematologic diseases.

    摘要翻译： 本发明涉及分离的核酸分子，其编码有效保留祖细胞的蛋白质，例如造血祖细胞。 核酸包含由SEQ ID NO：1定义的序列，其同系物或其片段。 编码的蛋白质具有包含由SEQ ID NO：2定义的序列的氨基酸序列，其含有氨基酸序列TNNVLQVT的同源物或其片段。 还描述了使用编码的蛋白质在体外，离体和体内保存祖细胞的方法。 因此，本发明包括诸如用于癌症治疗的骨髓消融治疗的方法，其中通过指定的蛋白质促进骨髓重建。 通过本发明也可实现其它治疗用途，例如，离体扩增祖细胞群以增加移植的机会，改善运输和储存祖细胞的条件，以及促进基因治疗以治疗和治愈广泛的危及生命的血液学 疾病

    Composition and method for preserving progenitor cells
    6.
    发明申请
    Composition and method for preserving progenitor cells 失效
    用于保存祖细胞的组合物和方法

    公开(公告)号：US20040229206A1

    公开(公告)日：2004-11-18

    申请号：US10737180

    申请日：2003-12-15

    申请人： ImClone Systems incorporated

    发明人： Jeffrey G. Moore

    IPC分类号： A01N001/02 ,  C07K007/06

    CPC分类号： C07K14/415 ,  A01N1/0226 ,  A61K38/00

    摘要： The invention relates to a protein material which is effective to preserve progenitor cells, such as hematopoietic progenitor cells. The protein has an amino acid sequence comprising AQSLSFSFTKFD (SEQ ID NO:1) and a molecular weight of about 12-20 kD, or has an amino acid sequence comprising VVAVEFD (SEQ ID NO:3) and a molecular weight of about 15-20 kD. Heterodimers of the protein are described, and multimers thereof. Methods of using the protein of the invention for preserving progenitor cells in vitro, ex vivo, and in vivo are also described. The invention, therefore, include methods such as myeloablation therapies for cancer treatment wherein myeloid reconstitution is facilitated by means of the specified protein. Other therapeutic utilities are also enabled through the invention, for example, expanding progenitor cell populations ex vivo to increase chances of engraftation, improving conditions for transporting and storing progenitor cells, and facilitated gene therapy to treat and cure a broad range of life-threatening hematologic diseases.

    摘要翻译： 本发明涉及一种有效保留祖细胞的蛋白质材料，例如造血祖细胞。 该蛋白质具有包含AQSLSFSFTKFD（SEQ ID NO：1）和约12-20kD的分子量的氨基酸序列，或具有包含VVAVEFD（SEQ ID NO：3）和分子量为约15〜 20 kD。 蛋白质的异源二聚体被描述，其多聚体。 还描述了使用本发明的蛋白质在体外，离体和体内保存祖细胞的方法。 因此，本发明包括诸如用于癌症治疗的骨髓消融治疗的方法，其中通过指定的蛋白质促进骨髓重建。 还可通过本发明实现其它治疗用途，例如，离体扩增祖细胞群以增加移植的机会，改善运输和储存祖细胞的条件，以及促进基因治疗治疗和治愈广泛的危及生命的血液学 疾病

    HUMAN ANTIBODIES SPECIFIC TO KDR AND USES THEREOF
    9.
    发明申请
    HUMAN ANTIBODIES SPECIFIC TO KDR AND USES THEREOF 有权
    人类抗体特异性及其用途

    公开(公告)号：US20090142358A1

    公开(公告)日：2009-06-04

    申请号：US12234203

    申请日：2008-09-19

    申请人： Zhenping Zhu

    发明人： Zhenping Zhu

    IPC分类号： A61K39/395 ,  C12N5/08 ,  A61P35/00

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

    摘要： The invention provides an antibodies that bind to KDR with an affinity comparable to or higher than human VEGF, and that neutralizes activation of KDR. Antibodies include whole immunoglobulins, monovalent Fabs and single chain antibodies, multivalent single chain antibodies, diabodies, triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells that encode and express these antibodies. The invention further provides a method of neutralizing the activation of KDR, a method of inhibiting angiogenesis in a mammal and a method of inhibiting tumor growth in a mammal.

    摘要翻译： 本发明提供以与人VEGF相当或高于人VEGF的亲和力结合KDR的抗体，并且中和KDR的活化。 抗体包括整个免疫球蛋白，单价Fab和单链抗体，多价单链抗体，双抗体，三抗体和单结构域抗体。 本发明还提供编码和表达这些抗体的核酸和宿主细胞。 本发明还提供了中和KDR活化的方法，抑制哺乳动物血管发生的方法和抑制哺乳动物肿瘤生长的方法。

    Human antibodies specific to KDR and uses thereof
    10.
    发明授权
    Human antibodies specific to KDR and uses thereof 有权
    针对KDR的人抗体及其用途

    公开(公告)号：US07498414B2

    公开(公告)日：2009-03-03

    申请号：US10506997

    申请日：2003-03-04

    申请人： Zhenping Zhu

    发明人： Zhenping Zhu

    IPC分类号： C07K16/00

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

    摘要： The invention provides an antibodies that bind to KDR with an affinity comparable to or higher than human VEGF, and that neutralizes activation of KDR. Antibodies include whole immunoglobulins, monovalent Fabs and single chain antibodies, multivalent single chain antibodies, diabodies, triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells that encode and express these antibodies. The invention further provides a method of neutralizing the activation of KDR, a method of inhibiting angiogenesis in a mammal and a method of inhibiting tumor growth in a mammal.

    摘要翻译： 本发明提供以与人VEGF相当或高于人VEGF的亲和力结合KDR的抗体，并且中和KDR的活化。 抗体包括整个免疫球蛋白，单价Fab和单链抗体，多价单链抗体，双抗体，三抗体和单结构域抗体。 本发明还提供编码和表达这些抗体的核酸和宿主细胞。 本发明还提供了中和KDR活化的方法，抑制哺乳动物血管发生的方法和抑制哺乳动物肿瘤生长的方法。