公开(公告)号：US5252692A

公开(公告)日：1993-10-12

申请号：US617177

申请日：1990-11-23

申请人： Jan Lovy ,  Vladimir A. Stoy

发明人： Jan Lovy ,  Vladimir A. Stoy

IPC分类号： C08F8/32 ,  C08F220/52

CPC分类号： C08F8/32 ,  C08F2800/10 ,  C08F2810/20

摘要： Novel amphoteric acrylic and methacrylic copolymers are described comprising cationic units of pendant N-substituted amidine and anionic units of acrylic or methacrylic acid and/or acidic groups carried by substituents of N-acrylamide, N-methacrylamide, N-acrylamidine or N-methacrylamidine. One preferred embodiment is a copolymer in which at least some types of functional groups are organized in blocks. Particularly preferred are blocks of pendant nitrile groups. Preferred compositions have the said N-substituents of the amides and/or amidines containing polar groups other than primary amines. Particularly preferred polar groups are tertiary amines, quaternary ammonium salts, hydroxyls and sulfonic acid. These copolymers may optionally be convalently or physically crosslinked and swellable rather than soluble in water. A method of preparing said amphoteric acrylic and methacrylic copolymers is described comprising the reaction of selected polymers with a multitude of pendant CN groups in mutual 1,3 positions with a primary amine in presence of water. One preferred method is the reaction of CN groups with the primary amine and water in the presence of a solvent of the said polymer and/or in the presence of a basic catalyst. The particularly preferred embodiment is a reaction of CN groups containing polymer dissolved in a mixture of the polymer solvent, a primary amine, water and an optional basic catalyst.

摘要翻译： 描述了新型两性丙烯酸和甲基丙烯酸共聚物，其包括N-取代脒侧基的阳离子单元和由N-丙烯酰胺，N-甲基丙烯酰胺，N-丙烯酰脒或N-甲基脒基的取代基所携带的丙烯酸或甲基丙烯酸和/或酸性基团的阴离子单元。 一个优选实施方案是其中至少一些类型的官能团以块形式组织的共聚物。 特别优选的是侧基腈基团。 优选的组合物具有除伯胺之外的含有极性基团的酰胺和/或脒的所述N-取代基。 特别优选的极性基团是叔胺，季铵盐，羟基和磺酸。 这些共聚物可以任选地是共价的或物理上交联的和可溶胀的而不是可溶于水。 描述制备所述两性丙烯酸和甲基丙烯酸共聚物的方法，其包括在存在水的情况下，将选定的聚合物与多个相互1,3位的侧基CN基团与伯胺反应。 一种优选的方法是在所述聚合物的溶剂存在下和/或在碱性催化剂的存在下，CN基团与伯胺和水的反应。 特别优选的实施方案是含有聚合物的CN基团溶解在聚合物溶剂，伯胺，水和任选的碱性催化剂的混合物中的反应。

公开(公告)号：US5217026A

公开(公告)日：1993-06-08

申请号：US864472

申请日：1992-04-06

申请人： George P. Stoy ,  Vladimir A. Stoy

发明人： George P. Stoy ,  Vladimir A. Stoy

IPC分类号： A61M25/00

CPC分类号： A61M25/0045 ,  A61M25/0009 ,  A61M25/09 ,  A61M2025/09083 ,  A61M2025/09091 ,  A61M2025/09108 ,  Y10S524/916

摘要： The present invention guidewire involves an elongated, non-hydrogel core element forming an inner part of the device, and an integral outside tubular layer of elastomeric hydrogel ("hydrogel sleeve"). This outer hydrogel layer has unique physical characteristics. They are (a) Gradient of chemical composition with increasing concentration of polar groups in the outward direction away from the core element; (b) Gradient of swelling in contact with water with water content increasing in the outward direction away from the core element; (c) Compressive stress in the outer hydrophilic layer causing the hydrogel in that layer to swell to a water content lower than its equilibrium value in a free-swelling state; and, optionally, (d) Inward-directed radial stress pushing the outside hydrogel layer constantly against the inner core element. The present invention also involves the methods of making these guidewires, including melt extrusion directly onto the core element, coagulation from solution, in situ hydrogel polymer formation, and tubing extrusion followed by consequent shrink-fit over the core.

摘要翻译： 本发明的导丝涉及形成装置的内部的细长的非水凝胶芯元件和弹性体水凝胶（“水凝胶套”）的整体的外部管状层。 该外部水凝胶层具有独特的物理特征。 它们是（a）化学成分的梯度随着极性基团浓度越来越远离核心元素的向外方向; （b）与水接触的膨胀梯度，水分含量沿远离核心元件的向外方向增加; （c）外层亲水层中的压缩应力使得该层中的水凝胶在游离溶胀状态下膨胀至低于其平衡值的水含量; 和（d）向内的径向应力将外部水凝胶层不断地推靠在内芯元件上。 本发明还涉及制造这些导线的方法，包括直接熔融挤出到芯元件上，从溶液凝结，原位水凝胶聚合物形成和管材挤出，随后在芯上收缩配合。

公开(公告)号：US5159360A

公开(公告)日：1992-10-27

申请号：US556329

申请日：1990-07-17

申请人： Vladimir A. Stoy ,  Jan Lovy ,  George P. Stoy

发明人： Vladimir A. Stoy ,  Jan Lovy ,  George P. Stoy

IPC分类号： G02B1/04 ,  G02C7/04

CPC分类号： G02B1/043 ,  G02C7/04

摘要： The present invention contact lens is a soft, disposable lens which, under eye wearer conditions, changes one or more characteristics essential for comfortable use, at a predetermined time to initiate disposal thereof by the user. This lens, under wear conditions, changes, for example, at least its base curve redius and its deformability as a consequence of a change in hydrophilicity of at least a portion of the contact lens material. This hydrophilicity change may be achieved by various means, e.g. degradation of crosslinking bridges or conversion of less hydrophilic groups to groups having greater hydrophilicity. In one preferred embodiment, the conversion is achieved by hydrolysis of selected functional (hydrophobic) groups into hydrophilic groups.

摘要翻译： 本发明的隐形眼镜是一种柔软的一次性透镜，其在眼睛佩戴者的条件下，在预定的时间改变用于舒适使用所必需的一个或多个特征以开始用户的处置。 这种透镜在磨损条件下，例如由于隐形眼镜材料的至少一部分的亲水性变化而至少改变其基线曲线及其变形能力。 这种亲水性变化可以通过各种方式实现，例如， 交联桥的降解或较少亲水基团转化为具有较大亲水性的基团。 在一个优选的实施方案中，通过将选择的官能（疏水）基团水解成亲水基团来实现转化。

公开(公告)号：US5218039A

公开(公告)日：1993-06-08

申请号：US43327

申请日：1987-04-28

申请人： Vladimir Stoy ,  Jan Lovy

发明人： Vladimir Stoy ,  Jan Lovy

IPC分类号： A01N25/04 ,  A23C9/152 ,  A23L1/03 ,  A23L1/24 ,  A23L1/308 ,  A61K8/04 ,  A61K8/06 ,  A61K8/73 ,  A61K8/81 ,  A61K9/00 ,  A61K9/107 ,  A61K47/32 ,  A61L27/52 ,  A61Q19/00 ,  B01F17/00 ,  C08J3/02 ,  C08L33/18 ,  C09D5/02 ,  C09G1/04 ,  C09K3/00

CPC分类号： A61K8/042 ,  A23L27/60 ,  A23L33/25 ,  A61K47/32 ,  A61K8/06 ,  A61K8/73 ,  A61K8/8141 ,  A61K9/0014 ,  A61K9/107 ,  A61L27/52 ,  A61Q19/00 ,  B01F17/005 ,  C09D5/02 ,  C09G1/04

摘要： Stable emulsions and dispersions of both the water-in-oil and oil-in-water types are prepared by subjecting mixtures of the two phases to shear stress in the presence of nitrile group-containing copolymers capable of forming hydrogels containing at least 90% by weight of water at room temperature.

公开(公告)号：US5149052A

公开(公告)日：1992-09-22

申请号：US120947

申请日：1987-11-16

申请人： Vladimir A. Stoy ,  George P. Stoy

发明人： Vladimir A. Stoy ,  George P. Stoy

IPC分类号： B29C33/00 ,  B29C43/02 ,  B29C45/00 ,  B29C67/06 ,  B29D11/00

CPC分类号： B29C33/0038 ,  B29C43/02 ,  B29C45/0001 ,  B29C67/06 ,  B29D11/00057 ,  B29K2105/0064 ,  B29L2011/0016 ,  B29L2031/7532 ,  Y10S425/808

摘要： A method and apparatus for precision molding soluable polymers is disclosed, in order to form an exact and precisely shaped product, such as contact lenses and surgical implants. A preferred mold for forming contact lenses includes a female part having an indentation and a sharp circumferential edge surrounding the indentation. The mold also includes a male part which is adapted to contact the sharp circumferential edge of the female part to form the molding cavity between the indentation of the female part and the male part. A semi-permeable gate is formed between the female part and the male part for introducing coagulating fluid into the molding cavity while preventing the escape of the polymer solution from the molding cavity. The semi-permeable gate allows the diffusion of the coagulating fluid into the molding cavity at a faster rate than the rate of diffusion of solvent out of the molding cavity. The polymer solution is coagulated by the influx of the coagulating fluid into the polymer solution which causes both the coagulation and swelling of the polymer solution. Swelling of the polymer solution coagulates the solution under pressure within the molding cavity to form a precisely shaped product. Coagulation proceeds under pressure since the solvent diffuses out of the semi-permeable gate at a slower rate than the diffusion of the coagulating fluid into the molding cavity.

摘要翻译： 公开了一种用于精密模制可溶性聚合物的方法和设备，以便形成精确和精确成形的产品，例如隐形眼镜和手术植入物。 用于形成隐形眼镜的优选模具包括具有凹陷的凹形部分和围绕凹口的尖锐周边边缘。 该模具还包括凸形部分，该凸形部分适于接触凹形部分的尖锐的周边边缘，以在母体部分的凹陷和凸形部分之间形成模制腔。 在阴部件和阳部件之间形成半透水门，用于将凝结流体引入模腔中，同时防止聚合物溶液从模腔中逸出。 半渗透门允许凝固流体以比溶剂扩散出模腔更快的速率扩散到模腔中。 聚合物溶液通过凝结流体流入聚合物溶液而凝结，导致聚合物溶液的凝结和溶胀。 聚合物溶液的溶胀在模腔内的压力下凝结溶液以形成精确成型的产品。 凝结在压力下进行，因为溶剂以比凝固流体扩散到模腔中更慢的速率从半透性浇口扩散出来。

公开(公告)号：US5066091A

公开(公告)日：1991-11-19

申请号：US493102

申请日：1990-03-12

申请人： George P. Stoy ,  Francis T. Delahanty ,  Vladimir A. Stoy

发明人： George P. Stoy ,  Francis T. Delahanty ,  Vladimir A. Stoy

IPC分类号： B29C35/04 ,  B29C61/00 ,  B29C61/06 ,  G02B6/38

CPC分类号： G02B6/3803 ,  B29C61/003 ,  B29C61/06 ,  B29C35/049 ,  Y10T428/1328

摘要： The present invention is directed to a device and method for precise positioning, or alignment of two or more articles with respect to each other. The device comprises a Unistructural Mass of Inherent Memory Polymer with two or more internal cavities which have inherent shapes with at least one cross-sectional configuration which is congruent to a cross-sectional configuration shape of the said article(s) in the positioned or aligned position(s). The unistructural mass cavities have cross-sectional configurations which are the same or smaller than those corresponding to the positions of the articles. The unistructural mass also includes at least one separate access cavity. It is deformed such that the articles can be readily inserted into the corresponding cavities. Once the articles are inserted into their corresponding cavities, the inherent memory polymer is returned to its inherent shape by non-mechanical stimulus to force the articles into precisely defined position and inspectional or operational access to the article(s) at or near the alignment portions is available through the separate access hole.

摘要翻译： 本发明涉及一种用于相对于彼此精确定位或对准两个或多个物件的装置和方法。 该装置包括具有两个或更多个内部空腔的固有存储器聚合物的非结构质量，所述内部空腔具有固有形状，其具有至少一个截面形状，其与位于或对准的所述制品的横截面构造形状一致 职位。 非结构质量腔具有与对应于物品的位置相对应的横截面构型。 非结构质量还包括至少一个单独的进入腔。 其变形使得物品可以容易地插入到相应的空腔中。 一旦物品被插入其相应的空腔中，固有的记忆聚合物通过非机械刺激返回到其固有的形状，以迫使制品进入精确限定的位置，并且在对准部分处或附近检查或操作地进入物品 可通过单独的入口孔获得。

公开(公告)号：US4828705A

公开(公告)日：1989-05-09

申请号：US925347

申请日：1986-10-31

申请人： Yatin B. Thakore ,  Karen L. Swanson ,  Vladimir A. Stoy

发明人： Yatin B. Thakore ,  Karen L. Swanson ,  Vladimir A. Stoy

IPC分类号： A61K9/28 ,  B01D61/14 ,  B01D61/18 ,  B01D61/22 ,  B01D63/00 ,  B01D65/02 ,  B01D65/08 ,  B01D69/02 ,  B01D69/12

CPC分类号： B01D61/142 ,  A61K9/284 ,  B01D69/02 ,  B01D69/12

摘要： Pressure-dependent anisotropic behavior is provided by a size selective separation membrane system having two successive porous layers. The first layer is a soft, elastic, effectively porous material, and the second layer is a substantially rigid porous material. When positive pressure presses the first layer against the second layer, the second layer serves as a rigid support, and the first layer is compressed to reduce its effective pore size. The first layer material is characterized by sufficient compressibility, that, when a pressure differential of 100 psi is applied across the thickness of the system, the effective flow rate is reduced by a factor of at least 20 compared to the flow rate when 100 psi is exerted in the opposite direction. A substance can be separated from a liquid mixture using the membrane system by: positioning the second layer of the membrane system in contact with the mixture; exerting pressure on the mixture to force liquid with the substance first through the pores of the rigid layer and the soft layer of the system; and reversing the flow through the membrane system by exerting pressure on the resulting filtrate, in a manner to compress the soft material sufficiently to reduce the pore size to prevent passage of the substance. The membrane system is manufactured by coagulating the layers from polymers in solution.

摘要翻译： 压力依赖的各向异性行为由具有两个连续多孔层的尺寸选择性分离膜系统提供。 第一层是柔软的，弹性的，有效的多孔材料，第二层是基本刚性的多孔材料。 当正压力将第一层压在第二层上时，第二层用作刚性支撑体，并且第一层被压缩以减小其有效孔径。 第一层材料的特征在于具有足够的压缩性，当在整个系统的厚度上施加100psi的压力差时，当100psi为100psi时，与流速相比，有效流速降低至少20倍 施加在相反的方向。 可以使用膜系统将物质与液体混合物分离，方法是将膜系统的第二层与混合物接触; 对混合物施加压力以迫使液体与物质首先通过刚体层和系统的软层的孔; 并通过对所得滤液施加压力来反转通过膜系统的流动，以充分压缩软材料以减小孔径以防止物质通过。 膜系统通过从溶液中的聚合物凝结层来制造。

公开(公告)号：US4731079A

公开(公告)日：1988-03-15

申请号：US935224

申请日：1986-11-26

申请人： Vladimir Stoy

发明人： Vladimir Stoy

IPC分类号： A61F2/16 ,  A61L27/00 ,  A61L27/52 ,  B29C61/06 ,  B29D11/02 ,  A45C13/10

CPC分类号： A61F2/16 ,  A61F2/1616 ,  A61F2/1664 ,  A61L27/52 ,  B29C61/06 ,  B29D11/023 ,  A61F2/1613 ,  A61L2430/16 ,  B29L2011/0041

摘要： There is provided a novel intraocular lens and mode of insertion therefore. The lens is of conventional shape and dimensions but is made of polymeric material having a softening point in the range of body temperature. The lens, prior to insertion is dimensionally reduced to enable introduction thru a small incision by compression or by axial extension. The deformed lens is frozen in this configuration by cooling the lens below its softening temperature. The cooled, deformed lens is then inserted into the eye. The action of body heat, optionally supplemented by various non-harmful methods, permits the lens to regain its original configuration within the eye.