-
公开(公告)号：US20250066797A1
公开(公告)日：2025-02-27
申请号：US18673055
申请日：2024-05-23
Applicant: Mammoth Biosciences, Inc.
Inventor： Lucas Benjamin HARRINGTON , William Douglass WRIGHT , Pei-Qi LIU , Benjamin Julius RAUCH , Wiputra Jaya HARTONO , Bridget Ann Paine MCKAY , Danuta Sastre PHIPPS , Yuxuan ZHENG , Nerea SANVISENS , Sean CHEN , David PAEZ-ESPINO
Abstract: Provided herein, in certain embodiments, are programmable nucleases, guide nucleic acids, and complexes thereof. Certain programmable nucleases provided herein comprise a RuvC domain. Also provided herein are nucleic acids encoding said programmable nucleases and guide nucleic acids. Also provided herein are methods of genome editing, methods of regulating gene expression, and methods of detecting nucleic acids with said programmable nucleases and guide nucleic acids.
-
公开(公告)号：US20240409893A1
公开(公告)日：2024-12-12
申请号：US18732352
申请日：2024-06-03
Applicant: Mammoth Biosciences, Inc.
Inventor： Subhadra JAYARAMAN RUKMINI , Pei-Qi LIU , Lucas Benjamin HARRINGTON , Pooja KYATSANDRA NARENDRA
IPC: C12N5/0783 , C07K16/28 , C12N9/22 , C12N15/11 , C12N15/90
Abstract: Provided herein are viral vectors comprising nucleotide sequences for production of an effector protein, guide nucleic acids for targeting modification of select genes to abrogate allogeneic immune reactions of T cells, and a donor nucleic acid encoding a chimeric antigen receptor (CAR), and uses thereof. Due to the small nature of the effector proteins provided herein, the viral vectors provided herein have ample room for all needed components for the efficient and robust production of CAR T cells from allogeneic donors. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the generation of “off-the-self” CAR T cells.
-
公开(公告)号：US20240384247A1
公开(公告)日：2024-11-21
申请号：US18669081
申请日：2024-05-20
Applicant: Mammoth Biosciences, Inc.
Inventor： Aaron DELOUGHERY , Benjamin RAUCH , Clarissa Oriel RHINES , Stepan TYMOSHENKO , Fnu YUNANDA , Lucas Benjamin HARRINGTON
Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
-
公开(公告)号：US20240359180A1
公开(公告)日：2024-10-31
申请号：US18541650
申请日：2023-12-15
Applicant: Mammoth Biosciences, Inc.
Inventor： Timothy James PATNO , Phillip You Fai LEE , Benjamin Andrew BLIZARD , Xin MIAO , Jacob LESINSKI , Ryan A. BROWN , Daniel Thomas DRZAL , Sarah Jane SHAPIRO , Joshua BAIK , Janice Sha CHEN , James Paul BROUGHTON , Clare Louise FASCHING , Jesus CHING , Sonal JAIN , Deepika VERMA , Matthew VEROSLOFF , Devin SPRATT , Nicholas John FANTIN
IPC: B01L3/00
CPC classification number: B01L3/502761 , B01L2200/0647 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0663 , B01L2300/161 , B01L2300/1805 , B01L2400/06
Abstract: The present disclosure provides various systems, diagnostic devices, and methods for nucleic acid analysis. The systems, devices, and methods allow for the analysis of nucleic acids, in a sample, via programmable nuclease-based assays. Provided are systems comprising an instrument and a cartridge allowing for point of care use. The systems, devices, and methods described herein can be configured for multiplexed detection of nucleic acids in a single sample.
-
公开(公告)号：US20240294970A1
公开(公告)日：2024-09-05
申请号：US18334327
申请日：2023-06-13
Applicant: Mammoth Biosciences, Inc.
Inventor： Jesus CHING , James Paul BROUGHTON , Janice Sha CHEN , Sarah Jane SHAPIRO , Elizabeth Mae HAWKINS , Sonal JAIN , Lior KREINDLER , Sophia HUBBELL
IPC: C12Q1/6823 , C12N15/10 , C12Q1/44 , C12Q1/6806 , C12Q1/6844 , G01N21/64
CPC classification number: C12Q1/6823 , C12N15/1096 , C12Q1/44 , C12Q1/6806 , C12Q1/6844 , G01N21/6428 , G01N2021/6432 , G01N2333/922
Abstract: Described herein are methods, devices, and compositions for immobilization of biomolecules in diagnostic assays onto a surface. The methods, devices, and compositions may utilize or comprise a plurality of different non-naturally occurring guide nucleic acids. Each of the different non-naturally occurring guide nucleic acids may be immobilized to a surface at a known location identified with the particular non-naturally occurring guide nucleic acid, Alternatively, or in combination, a plurality of programmable nucleases may be immobilized to the surface at each of the known locations. Optionally, the methods, devices, and compositions may utilize or comprise a plurality of reporters immobilized to the surface in proximity to each of the different non-naturally occurring guide nucleic acids and/or programmable nucleases at each of the known locations.
-
Patent Agency Ranking
公开(公告)号：US12077775B2
公开(公告)日：2024-09-03
申请号：US18333467
申请日：2023-06-12
Applicant: Mammoth Biosciences, Inc.
Inventor： Aaron Deloughery , Matan Drory Retwitzer , Lucas Benjamin Harrington , Wiputra Jaya Hartono , Alexander Richard Neckelmann , David Paez-Espino , Benjamin Julius Rauch , Clarissa Oriel Rhines , Stepan Tymoshenko , Fnu Yunanda , William Douglass Wright
CPC classification number: C12N15/907 , C12N9/22 , C12N15/11 , C12N15/86 , C12N2750/14143
Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
-
公开(公告)号：US20240271113A1
公开(公告)日：2024-08-15
申请号：US18585306
申请日：2024-02-23
Applicant: Mammoth Biosciences, Inc.
CPC classification number: C12N9/22 , A61K38/00 , C12N15/111 , C12N15/86 , C07K2319/09 , C12N2750/14143
Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
-
8.发明公开公开(公告)号：US20240226327A9
公开(公告)日：2024-07-11
申请号：US18469512
申请日：2023-09-18
Applicant: Mammoth Biosciences, Inc.
Inventor： Timothy Robert ABBOTT , Aaron DELOUGHERY , David PAEZ-ESPINO , Benjamin Julius RAUCH
CPC classification number: A61K48/005 , C12N9/1241 , C12N15/11
Abstract: Provided herein are compositions, systems, and methods comprising effector proteins, effector partners, and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and/or engineering of nucleic acids.
-
公开(公告)号：US20240084401A1
公开(公告)日：2024-03-14
申请号：US17938640
申请日：2022-10-06
Applicant: Mammoth Biosciences, Inc.
Inventor： Matthew VEROSLOFF , Clare FASCHING , Carley Gelenter HENDRIKS , Xin MIAO , James Paul BROUGHTON , Lucas Benjamin HARRINGTON , Janice Sha CHEN
IPC: C12Q1/689 , C12N9/22 , C12Q1/6806 , C12Q1/6816 , C12Q1/6844
CPC classification number: C12Q1/689 , C12N9/22 , C12Q1/6806 , C12Q1/6816 , C12Q1/6844 , C12N2310/20
Abstract: Provided herein, in certain embodiments, are various methods, reagents, and devices for detection of multiple target nucleic acids in a sample, or multiple segments of a target nucleic acid in a sample, using a programmable nuclease. In certain embodiments, the present disclosure provides compositions of pools of guide nucleic acids, programmable nucleases, and detector nucleic acids and methods of using said compositions for detection of different segments of one target nucleic acid or different target nucleic acids in a sample.
-
公开(公告)号：US20240084275A1
公开(公告)日：2024-03-14
申请号：US18336718
申请日：2023-06-16
Applicant: Mammoth Biosciences, Inc.
Inventor： Lucas Benjamin HARRINGTON , Pei-Qi LIU , Subhadra JAYARAMAN RUKMINI
CPC classification number: C12N9/22 , C12N15/102 , C12N2310/20
Abstract: Disclosed herein, in certain embodiments, are methods of inducing cell cycle arrest, apoptosis, cell death, or a combination thereof, in a cell or population of cells. Also disclosed herein are methods of treating a disease or condition in an individual in need thereof comprising inducing cell cycle arrest, apoptosis, cell death, or a combination thereof in a population of cells in the individual. The cell or population of cells may comprise a nucleic acid sequence associated with a disease or condition, including an autoimmune disease, cancer, or an infectious disease. The methods described herein generally comprise contacting cells with a CRISPR-associated protein and a guide nucleic acid.
-
-
-
-
-
-
-
-
-
Search Results
53
records
(took 0.022 seconds)
