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    Method and device for collecting suspended particles
    2.
    发明授权
    Method and device for collecting suspended particles 失效
    用于收集悬浮颗粒的方法和装置

    公开(公告)号：US07879214B2

    公开(公告)日：2011-02-01

    申请号：US11568895

    申请日：2005-05-06

    申请人： Thomas Schnelle ,  Torsten Muller ,  Jorg Kentsch ,  Frank Grom ,  Martin Stelzle

    发明人： Thomas Schnelle ,  Torsten Muller ,  Jorg Kentsch ,  Frank Grom ,  Martin Stelzle

    IPC分类号： B03C5/02

    CPC分类号： B03C5/026

    摘要： A description is given of methods for collecting particles (1, 2) which are suspended in a liquid, including the following steps: providing the liquid containing the suspended particles (1, 2) in a compartment (10) having lateral surfaces (11), wherein at least one electrode (21) is arranged on at least one of the lateral surfaces (11), and generating high-frequency electric fields by means of the at least one electrode (21) so as to form at least one circulating flow (30), by means of which the particles (1, 2) are guided to at least one predetermined collecting area (40) in the compartment (10), wherein the flow (30) is formed in such a way that at least one branch of the flow runs along a longitudinal extent of the at least one electrode (21), and the flow (30) circulates about an axis (31) which is oriented perpendicular to the respectively adjacent lateral surface (11) with the electrode (21). Corresponding devices for collecting particles are also described.

    摘要翻译： 给出了用于收集悬浮在液体中的颗粒（1,2）的方法的描述，包括以下步骤：将含有悬浮颗粒（1,2）的液体提供在具有侧表面（11）的隔室（10）中， ，其中至少一个电极（21）布置在所述侧表面（11）中的至少一个上，并且通过所述至少一个电极（21）产生高频电场，以便形成至少一个循环流 （30），所述颗粒（1,2）通过所述颗粒（1,2）被引导到所述隔室（10）中的至少一个预定收集区域（40），其中所述流动（30）形成为使得至少一个 流动的分支沿着至少一个电极（21）的纵向延伸，并且流动（30）围绕垂直于相邻的侧表面（11）的电极（21）的轴线（31）循环 ）。 还描述了用于收集颗粒的相应装置。

    Methods and apparatus for image analysis using threshold compactness features
    3.
    发明授权
    Methods and apparatus for image analysis using threshold compactness features 有权
    使用阈值紧密度特征的图像分析方法和装置

    公开(公告)号：US09443129B2

    公开(公告)日：2016-09-13

    申请号：US14221929

    申请日：2014-03-21

    申请人： PerkinElmer Cellular Technologies Germany GmbH

    发明人： Peet Kask

    IPC分类号： G06K9/00 ,  G06T7/00

    CPC分类号： G06K9/00147 ,  G06K9/0014 ,  G06T7/11 ,  G06T7/136 ,  G06T2207/30024

    摘要： A new family of morphological features, referred to herein as threshold compactness features, is provided, useful for automated classification of objects, such as cells, in images. In one embodiment, one or more thresholds and/or binary masks are applied to an image, and one or more provisional objects within a cell in the image are automatically identified. The threshold compactness of the cell is computed as a function of area S of the one or more provisional objects and border length P of the one or more provisional objects. Computation of threshold compactness allows cells in an image to be distinguished and characterized. Compared to previous techniques, the methods and apparatus described herein are more robust and computationally efficient.

    摘要翻译： 提供了一种新的形态特征家族，这里称为阈值紧密度特征，用于对图像中的诸如细胞的物体进行自动分类。 在一个实施例中，将一个或多个阈值和/或二进制掩码应用于图像，并且图像中的单元格内的一个或多个临时对象被自动识别。 根据一个或多个临时对象的面积S和一个或多个临时对象的边界长度P来计算小区的阈值紧密度。 阈值紧密度的计算允许区分和表征图像中的单元。 与以前的技术相比，本文描述的方法和装置更加鲁棒和计算有效。

    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR GENERATING AND USING UNBINNED IMAGE DATA
    4.
    发明公开
    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR GENERATING AND USING UNBINNED IMAGE DATA 审中-公开

    公开(公告)号：US20240119556A1

    公开(公告)日：2024-04-11

    申请号：US17956639

    申请日：2022-09-29

    申请人： PerkinElmer Cellular Technologies Germany GmbH

    发明人： Kaupo Palo ,  Peet Kask

    IPC分类号： G06T3/40

    CPC分类号： G06T3/40

    摘要： Disclosed herein are methods, systems, and computer-readable media for generating and using unbinned image data, characterized by (a) receiving image data corresponding to an image; (b) generating the unbinned image data by performing an unbinning operation on the received image data, wherein the unbinning operation is characterized by conditions of invertibility and smoothness; and (c) using the unbinned image data for either: (i) displaying a version of the image based on the unbinned image data; and/or (ii) performing image processing.

    Methods and devices for separating particles in a liquid flow
    6.
    发明授权
    Methods and devices for separating particles in a liquid flow 有权
    用于分离液体流中的颗粒的方法和装置

    公开(公告)号：US09149813B2

    公开(公告)日：2015-10-06

    申请号：US13586988

    申请日：2012-08-16

    申请人： Torsten Müller ,  Thomas Schnelle ,  Rolf Hagedorn

    发明人： Torsten Müller ,  Thomas Schnelle ,  Rolf Hagedorn

    IPC分类号： G01N27/447 ,  B03C5/00

    CPC分类号： B03C5/005

    摘要： Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.

    摘要翻译： 描述了用于在流体微系统（100）的隔室（30）中分离颗粒（20,21,22）的方法和装置，其中液体（10）的运动，其中颗粒（20,21,22 ）以预定的流动方向悬挂通过隔室（30），并产生偏转电位，其中至少一部分颗粒（20,21,22）在偏转方向上相对于液体移动 被设想为进一步产生至少一个聚焦电位，使得至少一部分颗粒在高频电场的作用下通过介电电泳相对于液体的偏转方向移动，并且引导颗粒 在不同的流动区域（11,12）中发生不同的电，磁或几何特性。

    Methods and Apparatus for Image Analysis and Modification Using Fast Sliding Parabola Erosian
    7.
    发明申请
    Methods and Apparatus for Image Analysis and Modification Using Fast Sliding Parabola Erosian 审中-公开
    使用快速滑动抛物线爱沙尼亚图像分析和修改的方法和装置

    公开(公告)号：US20130064468A1

    公开(公告)日：2013-03-14

    申请号：US13230433

    申请日：2011-09-12

    申请人： Peet Kask ,  Kaupo Palo

    发明人： Peet Kask ,  Kaupo Palo

    IPC分类号： G06K9/44

    CPC分类号： G06T5/30 ,  G06T2207/10004 ,  G06T2207/10016

    摘要： Methods and apparatus are provided for image analysis and modification using a fast sliding parabola erosion. The methods include selecting a scan line in an image and performing a unidirectional left-hand pass followed by a unidirectional right-hand pass. The unidirectional passes are performed as loops with increasing distance. By utilizing simple unidirectional left-hand and right-hand passes along a scan line in an image, the erosion procedure is greatly simplified and computation times are significantly reduced.

    摘要翻译： 提供了使用快速滑动抛物线侵蚀进行图像分析和修改的方法和装置。 所述方法包括在图像中选择扫描线并执行单向左手通过，然后进行单向右手通过。 单向通路以距离增加的循环执行。 通过沿图像中的扫描线利用简单的单向左手和右手通道，大大简化了侵蚀过程，并大大减少了计算时间。

    Methods and Apparatus for Fast Identification of Relevant Features for Classification or Regression
    8.
    发明申请
    Methods and Apparatus for Fast Identification of Relevant Features for Classification or Regression 有权
    用于快速识别分类或回归相关特征的方法和装置

    公开(公告)号：US20130064441A1

    公开(公告)日：2013-03-14

    申请号：US13230377

    申请日：2011-09-12

    申请人： Peet Kask

    发明人： Peet Kask

    IPC分类号： G06K9/00

    CPC分类号： G06K9/00147 ,  G06K9/623

    摘要： In various embodiments, methods and apparatus are provided for automated selection of features of cells useful for classifying cell phenotype. The methods include determining a signal-to-noise ratio (S/N) for each of a plurality of pairs of features, rather than S/N for individual features. The approach is capable of quickly identifying a small set of features of imaged cells that are most relevant for classification of a desired cell phenotype from among a very large number of features. The small group of relevant features can then be used to more efficiently and more accurately classify phenotype of unidentified cells.

    摘要翻译： 在各种实施方案中，提供了用于自动选择可用于分类细胞表型的细胞特征的方法和装置。 所述方法包括为多个特征对中的每一个确定信噪比（S / N），而不是为各个特征确定S / N。 该方法能够从非常大量的特征中快速鉴定与所需细胞表型的分类最相关的成像细胞的一小部分特征。 然后可以将小组相关特征用于更有效和更准确地分类未鉴定细胞的表型。

    Method and Device for Handling Sedimenting Particles
    9.
    发明申请
    Method and Device for Handling Sedimenting Particles 审中-公开
    处理沉淀颗粒的方法和装置

    公开(公告)号：US20080296157A1

    公开(公告)日：2008-12-04

    申请号：US12088009

    申请日：2006-09-27

    申请人： Gunter Bauer ,  Torsten Muller ,  Thomas Schnelle

    发明人： Gunter Bauer ,  Torsten Muller ,  Thomas Schnelle

    IPC分类号： B01D35/06 ,  B03C5/02 ,  B03C1/30 ,  B03C1/02

    CPC分类号： B03C1/288 ,  B01L3/021 ,  B01L3/0275 ,  B01L2200/0631 ,  B01L2200/0668 ,  B01L2300/0645 ,  B01L2400/0415 ,  B01L2400/043 ,  B03C5/026 ,  B03C2201/26 ,  G01N35/0098

    摘要： The invention relates to a method for handling particles (1, 2) that are suspended in a carrier liquid (3). The method includes the following steps: the carrier liquid (3) is received with the particles (1, 2) in a liquid siphoning device (10) including at least one siphoning opening (11), electrical and/or magnetic separating fields are generated in the liquid siphoning device (10), a sedimentation movement of the particles (1, 2) is created in the liquid, each particle having a sedimentation speed that depends on the action of the separating fields on the particle (1, 2) and the particles (1, 2) forming a plurality of particle fractions (5, 6) according to the sedimentation speeds thereof, and the particle fractions (5, 6) are separately extracted from the liquid siphoning device (10). The invention also relates to a handling device (100) for handling suspended particles (1, 2).

    摘要翻译： 本发明涉及一种处理悬浮在载体液体（3）中的颗粒（1,2）的方法。 该方法包括以下步骤：载体液体（3）在包括至少一个虹吸孔（11）的液体虹吸装置（10）中与颗粒（1,2）一起接收，产生电和/或磁分离场 在液体虹吸装置（10）中，在液体中产生颗粒（1,2）的沉降运动，每个颗粒的沉降速度取决于颗粒（1,2）上的分离场的作用和 从液体虹吸装置（10）分别提取根据其沉降速度形成多个颗粒部分（5,6）和颗粒部分（5,6）的颗粒（1,2）。 本发明还涉及一种用于处理悬浮颗粒（1,2）的处理装置（100）。