利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

123 条记录 (耗时 0.026 秒)

    Multilayer pharmaceutical dosage form containing a substance that acts in a modulatory manner with regard to the release of active substances
    9.
    发明申请
    Multilayer pharmaceutical dosage form containing a substance that acts in a modulatory manner with regard to the release of active substances 审中-公开
    含有在活性物质释放方面以调节方式起作用的物质的多层药物剂型

    公开(公告)号：US20060269605A1

    公开(公告)日：2006-11-30

    申请号：US10572963

    申请日：2004-09-15

    申请人： Rosario Lizio ,  Hans-Ulrich Petereit ,  Manfred Assmus ,  Hema Ravishankar

    发明人： Rosario Lizio ,  Hans-Ulrich Petereit ,  Manfred Assmus ,  Hema Ravishankar

    IPC分类号： A61K9/24

    CPC分类号： A61K9/5078 ,  A61K9/5026

    摘要： The invention relates to a multilayer pharmaceutical dosage form for the controlled release of active substances, containing: a) a core layer containing a substance that acts in a modulatory manner with regard to the release of active substances, optionally a neutral core and/or an active substance; b) an inner control layer that influences the release of the substance that acts in a modulatory manner and of the optionally contained active substance from the core layer, containing pharmaceutically useable polymers, waxes, resins and/or proteins; c) an active substance layer containing a pharmaceutical active substance and, optionally, a substance that acts in a modulatory manner; d) an outer control layer containing a (meth)acrylate copolymer or a mixture consisting of a number of (meth)acrylate copolymers comprised of 98 to 85 C1-C4 alkyl esters of (meth)acrylic acid and 2 to 15% by weight of methacrylate monomers with a quaternary ammonium group in the alkyl radical and optionally containing pharmaceutically useable polymers that are insoluble in water, whereby the layers can contain, in addition and in a known manner, pharmaceutically conventional adjuvants.

    摘要翻译： 本发明涉及用于控制释放活性物质的多层药物剂型，其包含：a）核心层，其含有相对于活性物质的释放以调节方式起作用的物质，任选的中性核和/或 活性物质 b）内部控制层，其影响以调节方式起作用的物质的释放，以及含有药学上可用的聚合物，蜡，树脂和/或蛋白质的核心层中任选地含有的活性物质; c）含有药物活性物质和任选的以调节方式作用的物质的活性物质层; d）包含（甲基）丙烯酸酯共聚物的外部控制层或由多个（甲基）丙烯酸酯共聚物组成的混合物，所述（甲基）丙烯酸酯共聚物包含98至85℃1〜 （甲基）丙烯酸的烷基酯和2至15重量％的在烷基中具有季铵基团的甲基丙烯酸酯单体，并且任选地含有不溶于水的药学上可用的聚合物，其中所述层还可以包含 已知的方式，药学上常规的佐剂。

    Core and shell particle for modifying impact resistance of a mouldable poly (meth) acrylate material
    10.
    发明申请
    Core and shell particle for modifying impact resistance of a mouldable poly (meth) acrylate material 失效
    用于改善可塑聚（甲基）丙烯酸酯材料的耐冲击性的核和壳颗粒

    公开(公告)号：US20060147714A1

    公开(公告)日：2006-07-06

    申请号：US10539509

    申请日：2003-10-18

    申请人： Klaus Schultes ,  Reiner Mueller ,  Andreas Spiess ,  Klaus Albrecht ,  Werner Hoess

    发明人： Klaus Schultes ,  Reiner Mueller ,  Andreas Spiess ,  Klaus Albrecht ,  Werner Hoess

    IPC分类号： B32B1/00

    CPC分类号： C08L51/003 ,  C08F265/04 ,  C08F285/00 ,  C08L33/12 ,  C08L33/20 ,  C08L35/06 ,  C08L51/04 ,  C08L55/005 ,  C08L55/02 ,  Y10T428/2998 ,  C08L2666/02 ,  C08L2666/24

    摘要： The present invention relates to a core-shell particle which has a core, a first shell and, where appropriate, a second shell, where: i) the core encompasses, based on its total weight, at least 75.0% by weight of (meth)acrylate repeat units; ii) the first shell has a glass transition temperature below 30° C.; iii) the second shell present where appropriate encompassed, based on its total weight, at lest 75.0% by weight of (meth)acrylate repeat units; iv) the first shell encompasses, based on its total weight, the following constituents; E) from 92.0 to 98.0% by weight of (meth)acrylate repeat units and F) from 2.0 to 8.0% by weight of styrenic repeat units of the general formula (I) where the radicals R1 to R6 are defined according to the Description and the percentages by weight of E) and F) give a total of 100.0% by weight, v) the radius of the core-shell particle inclusive of any second shell present, measured by the Coulter method, is in the range from above 160.0 to 240.0 nm. The present invention further relates to a process for preparing core-shell particles, to a moulding composition comprising core-shell particles, and to the use thereof.

    摘要翻译： 本发明涉及一种具有芯，第一壳和适当的第二壳的核 - 壳颗粒，其中：i）芯基于其总重量包含至少75.0重量％的（甲基） ）丙烯酸酯重复单元; ii）第一壳的玻璃化转变温度低于30℃; iii）适当地包含的第二壳基于其总重量至少为75.0重量％的（甲基）丙烯酸酯重复单元; iv）第一壳基于其总重量包含以下组分; E）为92.0〜98.0重量％的（甲基）丙烯酸酯重复单元，F）2.0〜8.0重量％的通式（I）的苯乙烯重复单元，其中R 1〜 根据描述定义R 6，并且E）和F）的重量百分比总计为100.0重量％，v）包含任何第二壳的核 - 壳颗粒的半径 存在，通过库尔特法测量，在160.0至240.0nm之间的范围内。 本发明还涉及一种制备核 - 壳颗粒的方法，涉及包含核 - 壳颗粒的模塑组合物及其用途。