公开(公告)号：US20070179405A1

公开(公告)日：2007-08-02

申请号：US11529614

申请日：2006-09-29

申请人： Jeffrey Emery ,  Craig Litherland ,  Raul Escutia ,  James Pfeiffer ,  Jeffrey Jones

发明人： Jeffrey Emery ,  Craig Litherland ,  Raul Escutia ,  James Pfeiffer ,  Jeffrey Jones

IPC分类号： A61B5/00 ,  G01N27/26 ,  G01N33/487

CPC分类号： A61B5/150984 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150167 ,  A61B5/150229 ,  A61B5/150343 ,  A61B5/150389 ,  A61B5/150396 ,  A61B5/150412 ,  A61B5/150946 ,  A61B5/150954 ,  A61B5/150969 ,  A61B5/151 ,  A61B5/15111 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15148 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15186 ,  A61B5/155 ,  A61B5/157 ,  A61B5/681 ,  A61B5/6824 ,  A61B5/6828 ,  A61B2560/0443 ,  A61B2560/0462 ,  G01N1/14 ,  G01N21/0303 ,  G01N21/77 ,  G01N27/416

摘要： An arrangement includes a housing, a plurality of sampling and analysis sites contained within the housing, each of the sampling and analysis sites having a skin-penetration member having a first end configured to pierce the skin, and an inner lumen in communication with the first end, an actuator operatively associated with the skin-penetration member, and an analyte quantification member in fluid communication with the inner lumen of the skin-penetration member. Integrated devices including such arrangements are also described.

摘要翻译： 一种装置包括壳体，容纳在壳体内的多个采样和分析位置，每个采样和分析位置具有皮肤穿透构件，其具有构造成刺穿皮肤的第一端，以及与第一 与皮肤穿透构件可操作地相关联的致动器以及与皮肤穿透构件的内腔流体连通的分析物定量构件。 还描述了包括这种布置的集成设备。

公开(公告)号：US20070078313A1

公开(公告)日：2007-04-05

申请号：US11239094

申请日：2005-09-30

申请人： Jeffrey Emery ,  Jeffrey Jones ,  Raul Escutia ,  Stephen Yee

发明人： Jeffrey Emery ,  Jeffrey Jones ,  Raul Escutia ,  Stephen Yee

IPC分类号： A61B5/00 ,  B65D81/00

CPC分类号： A61B5/15163 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/15117 ,  A61B5/15153

摘要： Arrangements are provided including a fluid transport tube, or a needle, having a first end and a second end opposite the first end, and a lumen having an inner diameter. At least one fluid transport enhancing projection is disposed in the lumen and extends from the second end toward the first end. A discreet, wearable blood glucose monitor including such arrangements is also described.

摘要翻译： 提供了包括具有第一端和与第一端相对的第二端的流体输送管或针的布置以及具有内径的内腔。 至少一个流体输送增强突起设置在内腔中并且从第二端朝向第一端延伸。 还描述了包括这种布置的谨慎的，可戴式的血糖监测器。

公开(公告)号：US20080077048A1

公开(公告)日：2008-03-27

申请号：US11510784

申请日：2006-08-28

申请人： Raul Escutia ,  Jeffrey L. Emery ,  Craig M. Litherland ,  Jeffrey M. Jones ,  Gregory C. Loney ,  Michael F. Tomasco

发明人： Raul Escutia ,  Jeffrey L. Emery ,  Craig M. Litherland ,  Jeffrey M. Jones ,  Gregory C. Loney ,  Michael F. Tomasco

IPC分类号： A61B5/00

CPC分类号： A61B5/1411 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150748 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15125 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/157

摘要： An integrated monitoring and body fluid sampling device constructed to permit digital as well as alternate-site body fluid sampling and analysis, the device comprising: a housing; at least one skin-penetration member; and a member constructed for the application of circumferential or vacuum pressure to an appendage; wherein the member is detachably or retractably connected to the housing in a manner such that the integrated monitoring and body fluid sampling device can perform digital or alternate-site body fluid sampling and analysis. Additional arrangements and techniques are also described.

摘要翻译： 一种综合监测和体液采样装置，其被构造成允许数字和备用体液采样和分析，所述装置包括：壳体; 至少一个皮肤穿透部件; 以及为了向附属物施加周向或真空压力而构造的构件; 其中所述构件以使得所述综合监测和体液采样装置可以执行数字或替代站点体液采样和分析的方式可拆卸地或可缩回地连接到所述壳体。 还描述了附加的布置和技术。

公开(公告)号：US07004928B2

公开(公告)日：2006-02-28

申请号：US10131268

申请日：2002-04-23

申请人： John Gregory Aceti ,  Sterling Eduard McBride ,  Richard Morgan Moroney, III ,  Christopher Carter Gregory ,  Peter John Zanzucchi

发明人： John Gregory Aceti ,  Sterling Eduard McBride ,  Richard Morgan Moroney, III ,  Christopher Carter Gregory ,  Peter John Zanzucchi

IPC分类号： A61M5/00 ,  A61M5/315 ,  A61B5/00 ,  B65D81/00

CPC分类号： A61B5/150984 ,  A61B5/1411 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150076 ,  A61B5/150213 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150526 ,  A61B5/150755 ,  A61B5/15087 ,  A61B5/150969 ,  A61B5/15109 ,  A61B5/15119 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/155 ,  A61B5/157 ,  A61B5/681 ,  A61B5/6833 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0038 ,  A61M2209/088 ,  A61M2230/201 ,  G01N33/491

摘要： The invention relates to analyte monitoring/drug (pharmaceutical agent) delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The electronics portion includes a processor and associated circuitry (e.g., memory, supporting electronics and the like), a motor or the like, a sensor, a power supply (e.g., battery) and optionally an interface. In general, the processor controls the operation of the device and is data communication with the actuator, motor, sensor and interface. The invention provides for autonomous operation, that is, without intervention of the user. The invention can optionally provide for calibration without intervention of the user. The invention can also provide for semi-continuous monitoring for day and night time. The invention can provide for up to four, or more, weeks of operation. The invention can provide for a device that is relative small in size, and therefore unobtrusive. The invention can also provide for device with remote control and interactive electronics. The invention may be also used for the delivery of various pharmaceutical agents including high potency drugs to minimize patient intervention and minimize discomfort.

公开(公告)号：US20070179404A1

公开(公告)日：2007-08-02

申请号：US11529612

申请日：2006-09-29

申请人： Raul Escutia ,  Craig Litherland ,  Jeffrey Emery ,  James Pfeiffer ,  Christo Pamichev

发明人： Raul Escutia ,  Craig Litherland ,  Jeffrey Emery ,  James Pfeiffer ,  Christo Pamichev

IPC分类号： A61B5/00 ,  G01N27/26

CPC分类号： A61B5/150984 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150167 ,  A61B5/150229 ,  A61B5/150343 ,  A61B5/150389 ,  A61B5/150396 ,  A61B5/150412 ,  A61B5/150946 ,  A61B5/150954 ,  A61B5/150969 ,  A61B5/151 ,  A61B5/15111 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15148 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15186 ,  A61B5/155 ,  A61B5/157 ,  A61B5/681 ,  A61B5/6824 ,  A61B5/6828 ,  A61B2560/0443 ,  A61B2560/0462 ,  G01N1/14 ,  G01N21/0303 ,  G01N21/77 ,  G01N27/416

摘要： An arrangement comprises a housing containing one or more components configured for at least one of body fluid sampling and analysis. The arrangement includes a housing containing one or more components configured for at least one of body fluid sampling and analysis, and a body attachment element. The housing and the body attachment element are connected by a quick-release mechanism configured to facilitate removal of the housing from the body attachment element.

摘要翻译： 一种装置包括：壳体，其容纳一个或多个被配置用于体液取样和分析中的至少一个的部件。 该装置包括：壳体，其包含构造成用于体液取样和分析中的至少一个的一个或多个部件，以及主体附接元件。 壳体和身体附接元件通过快速释放机构连接，该快速释放机构构造成便于从身体附接元件移除壳体。

公开(公告)号：US20070083131A1

公开(公告)日：2007-04-12

申请号：US11529613

申请日：2006-09-29

申请人： Raul Escutia ,  Jeffrey Emery ,  Craig Litherland

发明人： Raul Escutia ,  Jeffrey Emery ,  Craig Litherland

IPC分类号： A61B5/00

CPC分类号： A61B5/150984 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150167 ,  A61B5/150229 ,  A61B5/150343 ,  A61B5/150389 ,  A61B5/150396 ,  A61B5/150412 ,  A61B5/150946 ,  A61B5/150954 ,  A61B5/150969 ,  A61B5/151 ,  A61B5/15111 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15148 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15186 ,  A61B5/155 ,  A61B5/157 ,  A61B5/681 ,  A61B5/6824 ,  A61B5/6828 ,  A61B2560/0443 ,  A61B2560/0462 ,  G01N1/14 ,  G01N21/0303 ,  G01N21/77 ,  G01N27/416

摘要： An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes at least one skin-penetration member having a first end configured to pierce the surface of the skin, and a inner lumen in communication with the first end; at least one actuator operatively associated with the at least one skin-penetration member; and at least one catalyst device configured to cause perfusion of body fluid at the sampling site; wherein the at least one actuator is configured to locate the at least one skin-penetration member so as to obstruct the wound opening while transporting body fluid through the inner lumen. Associated methods are also described.

摘要翻译： 用于从在采样部位的皮肤表面产生的伤口开口产生体液样本的装置包括至少一个皮肤穿透部件，其具有构造成刺穿皮肤表面的第一端和与皮肤表面连通的内腔 第一端 与所述至少一个皮肤穿透构件可操作地相关联的至少一个致动器; 以及至少一个催化剂装置，其构造成在取样部位引起体液灌注; 其中所述至少一个致动器构造成定位所述至少一个皮肤穿透构件，以便在将体液输送通过所述内腔时阻塞所述伤口的开口。 还描述了相关方法。

公开(公告)号：US07052652B2

公开(公告)日：2006-05-30

申请号：US10394230

申请日：2003-03-24

申请人： Peter J. Zanzucchi ,  Sterling E. McBride

发明人： Peter J. Zanzucchi ,  Sterling E. McBride

IPC分类号： G01N21/78

CPC分类号： A61B5/1459 ,  A61B5/1411 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/151 ,  A61B5/157 ,  G01N21/03 ,  G01N21/359 ,  G01N21/7703 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/54373 ,  G01N2021/0325 ,  G01N2021/0346 ,  Y10T436/144444

摘要： Arrangements for the detection of the presence and/or concentration of an analyte in a sample of bodily fluid include diffuse transmission, diffuse reflection and edge or waveguide illumination arrangements. A vertical flow assay arrangement and/or technique is also disclosed, and includes a detection component that can be in the form of an array of optical detection elements. A number of assay pad constructions are described which may include at least one or more of the following components: a prefilter component, a reflective component, a membrane component, a reagent component, a mesh component, and a component to prevent lateral spreading.

公开(公告)号：US06923764B2

公开(公告)日：2005-08-02

申请号：US10347620

申请日：2003-01-22

申请人： John Gregory Aceti ,  Zvi Gerald Loewy ,  Richard Morgan Moroney, III ,  Christopher Carter Gregory ,  Peter John Zanzucchi

发明人： John Gregory Aceti ,  Zvi Gerald Loewy ,  Richard Morgan Moroney, III ,  Christopher Carter Gregory ,  Peter John Zanzucchi

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1459 ,  A61B5/15 ,  A61B5/151 ,  A61B5/157

CPC分类号： A61B5/157 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/150511 ,  A61B5/150755 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15153 ,  A61B5/15163 ,  G06F19/00

摘要： Provided is an analyte monitoring device having a housing, the device comprising: a plurality of needles, each having a tip, a retracted position, a position wherein the tip is extended from the housing a distance adapted to pierce skin; an electrically or spring powered needle pushing apparatus movable to separately engage each of the needles to move each from the retracted position to the extended position; an energy source located within the housing; a plurality of analysis sites comprising an analysis preparation, each adapted to receive liquid from the needles to wet the analysis preparation; one or more light sources adapted to direct light at the analysis sites; one or more light detectors adapted to receive light from the analysis sites; and a processor.

摘要翻译： 提供了一种具有壳体的分析物监测装置，该装置包括：多个针，每个针具有尖端，缩回位置，其中尖端从壳体延伸适合于刺穿皮肤的距离; 电动或弹簧动力的推针装置，其可移动以分别接合每个针，以使其从缩回位置移动到延伸位置; 位于壳体内的能源; 多个分析位点，包括分析制剂，每个分析制剂适于从针头接收液体以润湿分析制剂; 适于在分析场所引导光的一个或多个光源; 一个或多个适于从分析位置接收光的光检测器; 和处理器。

公开(公告)号：US20070078358A1

公开(公告)日：2007-04-05

申请号：US11239123

申请日：2005-09-30

申请人： Raul Escutia ,  Jeffrey Emery

发明人： Raul Escutia ,  Jeffrey Emery

IPC分类号： A61B5/00

CPC分类号： A61B5/150343 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/151 ,  A61B5/15117 ,  A61B5/15153 ,  A61B5/15163

摘要： Arrangements are provided including a base having a bore disposed therein extending from a first surface of the base through a second surface of the base, a fluid transport tube having a first end, a second end opposite the first end, and a lumen having an inner diameter, at least the second end of the tube being received within the bore of the base, and at least one fluid transport enhancing groove having at least a first section disposed in the second surface of the base and in fluid communication with the bore.

摘要翻译： 提供了一种布置，其具有设置在其中的孔的基部，其从基部的第一表面延伸穿过基部的第二表面;流体输送管，其具有第一端，与第一端相对的第二端和具有内部 所述管的至少第二端容纳在所述基座的孔内，以及至少一个流体输送增强凹槽，所述至少一个流体输送增强槽至少具有设置在所述基部的第二表面中并与所述孔流体连通的第一部分。

公开(公告)号：US20060281187A1

公开(公告)日：2006-12-14

申请号：US11239122

申请日：2005-09-30

申请人： Jeffrey Emery ,  Carole Stivers

发明人： Jeffrey Emery ,  Carole Stivers

IPC分类号： G01N31/22

CPC分类号： A61B5/157 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/150358 ,  A61B5/155 ,  A61B5/6802 ,  A61B5/681 ,  A61B5/6831 ,  A61B2562/0295 ,  G01N21/78 ,  G01N33/523 ,  G01N33/54373 ,  G01N33/66 ,  G01N2021/752 ,  Y10S435/895

摘要： Disclosed are devices, arrangements and methods for quantifying the concentration of an analyte present in bodily fluid, including: an assay pad having at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot upon reaction with the analyte; a light source; a detector array; a processor; and a memory in communication with the processor, the memory comprising: (a) at least one value indicative of one or more of: (i) the level of hematocrit contained in the sample; (ii) the volume of the sample applied to the assay pad; or (iii) imperfections present in the reaction spot; and (b) at least one algorithm for calculating the concentration of the analyte contained in the sample.