中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

20 records (took 0.016 seconds)

    Suture device
    1.
    发明授权
    Suture device 有权

    公开(公告)号：US10058324B2

    公开(公告)日：2018-08-28

    申请号：US14358136

    申请日：2012-11-16

    Applicant: Stichting VU-VUMC

    Inventor： Rianne Irene Van Loenen ,  Micha Ilan Paalman ,  Alexander Arnold Frederik Adriaan Veenhof

    IPC: A61B17/04 ,  A61B17/12

    CPC classification number: A61B17/0469 ,  A61B2017/047 ,  A61B2017/0472 ,  F04C2270/0421

    Abstract: A suture device includes a needle operating device movable longitudinally with respect to a housing between at least an insertion position and a needle transfer position. The needle operating device includes an elongate operating element arranged extending from a distal end of the housing to or near a housing proximal end. A needle holder connected at a distal end of the operating element holds two or more needles, with free ends directed in proximal direction. The holder is movable with respect to a protection device between at least a protecting position shielding the free ends, and a non-protecting position for the same. A needle receive device at a distal end of the housing receives the free ends when the operating device is moved to the transfer position. In at least the insertion position the holder and the protection device are spaced longitudinally from the housing to receive a tissue therebetween.

    System and method for network synchronization and frequency dissemination
    7.
    发明授权
    System and method for network synchronization and frequency dissemination 有权
    网络同步和频率传播的系统和方法

    公开(公告)号：US09331844B2

    公开(公告)日：2016-05-03

    申请号：US14119688

    申请日：2012-05-24

    Applicant: Roeland Johannus Marie Wilhelm Nuijts ,  Jeroen Cornelis Jean Koelemeij

    Inventor： Roeland Johannus Marie Wilhelm Nuijts ,  Jeroen Cornelis Jean Koelemeij

    IPC: H04J14/00 ,  H04L7/00 ,  H04J3/06 ,  H04J14/02

    CPC classification number: H04L7/0075 ,  H04J3/0682 ,  H04J14/02 ,  H04J14/0272 ,  H04J14/0275

    Abstract: Distribution of reference frequency and timing information in a network involves determining latency between a first and second node from time delay between transmission of a reference frequency and timing signal and reception of an optical return timing signal in response. In a network with pairs of first and second optical fibers in optical fiber connections between network nodes, for transmission of optical data signals separately in mutually opposite directions between the network nodes respectively, provisions are made to transmit the reference frequency and timing signal and the resulting optical return signal via the same fiber, one in the same direction as the unidirectional data signal over that fiber and the other upstream. Repeaters between the nodes may be modified to pass such signals upstream and downstream. In an embodiment wherein the network provides for an optical supervisory channel, the optical filters for combining the optical supervisory channel signal with the unidirectional data signal and separating the optical supervisory channel signal from the unidirectional data signal are used to combine and separate the reference frequency and timing signal and to pass the optical return timing signal. For this purpose, further optical filters may be added outside the main optical data channel to combine and separate the reference frequency and timing signal and the optical supervisory channel and to pass the optical return signal back to the filter that separates the optical supervisory channel signal from the data signal.

    Abstract translation: 参考频率和定时信息在网络中的分布涉及从响应于参考频率的传输和定时信号之间的时间延迟以及接收光学返回定时信号来确定第一和第二节点之间的等待时间。 在网络节点之间的光纤连接中具有成对的第一和第二光纤的网络中，为了分别在网络节点之间彼此相反的方向上分别传输光数据信号，提供传输参考频率和定时信号，并且由此得到 通过相同光纤的光返回信号，一个在与该光纤上的单向数据信号相同的方向上，另一个在上游。 节点之间的中继器可以被修改以在上游和下游传递这样的信号。 在网络提供光学监控信道的实施例中，用于将光监控信道信号与单向数据信号组合并将光监控信道信号与单向数据信号分离的滤光器用于组合和分离参考频率和 定时信号并通过光学返回定时信号。 为此，可以将另外的光学滤波器添加到主光学数据通道外部，以组合和分离参考频率和定时信号和光学监控通道，并将光学返回信号传回到将光学监控通道信号与 数据信号。

    METHOD OF ANALYSING A BLOOD SAMPLE OF A SUBJECT FOR THE PRESENCE OF A DISEASE MARKER
    8.
    发明申请
    METHOD OF ANALYSING A BLOOD SAMPLE OF A SUBJECT FOR THE PRESENCE OF A DISEASE MARKER 审中-公开
    分析疾病标志物存在的病人血液样本的方法

    公开(公告)号：US20140199693A1

    公开(公告)日：2014-07-17

    申请号：US14006089

    申请日：2012-01-16

    Applicant: Thomas Wurdinger ,  Rolf Jonas Nilsson

    Inventor： Thomas Wurdinger ,  Rolf Jonas Nilsson

    IPC: C12Q1/68

    CPC classification number: C12Q1/6834 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

    Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

    Abstract translation: 本发明涉及一种分析患者血液样本中疾病标志物存在的方法，所述方法包括以下步骤：a）从所述血液样品中的未核化血细胞提取核酸，以提供无核细胞提取的 核酸级分，以及b）分析所述无核细胞提取的核酸级分是否存在疾病标志物，其中所述疾病标志物是所述受试者的细胞基因中的疾病特异性突变，或其中所述疾病标记 是所述受试者的细胞的基因的疾病特异性表达谱。

    Method for prognosticating the clinical response of a patient to B-lymphocyte inhibiting or depleting therapy
    9.
    发明授权
    Method for prognosticating the clinical response of a patient to B-lymphocyte inhibiting or depleting therapy 有权
    预测患者对B淋巴细胞抑制或消耗性治疗的临床反应的方法

    公开(公告)号：US08580528B2

    公开(公告)日：2013-11-12

    申请号：US12905625

    申请日：2010-10-15

    Applicant: Cornelis Lammert Verweij ,  Paul-Peter Tak

    Inventor： Cornelis Lammert Verweij ,  Paul-Peter Tak

    IPC: G01N33/53

    CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K2317/24 ,  C12Q2600/106 ,  G01N33/6866 ,  G01N2800/52

    Abstract: The invention relates to methods for predicting a clinical response to B-lymphocyte inhibiting or depleting therapies (BCIDT) using expression levels of genes of the Type I INF pathway. In another aspect, the invention relates to a method for evaluating a pharmacological effect of a treatment with B-lymphocyte inhibiting or depleting therapy. More in particular, the invention relates to a method for prognosticating the clinical response of a patient to treatment with a soluble BCID or TCID agent, said method comprising the steps of obtaining at least two samples from said patient wherein a first sample has not been exposed to a soluble BCID or TCID agent and wherein at least a second sample has been exposed to a soluble BCID or TCID agent, determining the level of an IFN-I type response in said at least two samples, comparing the level of the IFN-I type response in said first sample with the level of the IFN-I type response in said at least second sample and prognosticating said clinical response from said comparison.

    Abstract translation: 本发明涉及使用I型INF途径的基因的表达水平预测对B淋巴细胞抑制或消耗性治疗（BCIDT）的临床应答的方法。 另一方面，本发明涉及用于评估B淋巴细胞抑制或消耗性治疗的治疗药理作用的方法。 更具体地，本发明涉及一种用于预测患者用可溶性BCID或TCID剂治疗的临床反应的方法，所述方法包括以下步骤：从所述患者获得至少两个样品，其中第一样品未暴露 涉及可溶性BCID或TCID试剂，并且其中至少第二样品已经暴露于可溶性BCID或TCID试剂，确定所述至少两个样品中IFN-I型应答的水平，比较IFN-1的水平 在所述第一样品中，所述至少第二个样品中的IFN-I型应答水平，并从所述比较预测所述临床反应。

Patent Agency Ranking