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公开(公告)号：US20220112524A1
公开(公告)日：2022-04-14
申请号：US17560753
申请日：2021-12-23
摘要： This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
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2.发明授权公开(公告)号：US10513719B2
公开(公告)日：2019-12-24
申请号：US15094458
申请日：2016-04-08
发明人： Andrew Richard Buller , Sabine Brinkmann-Chen , Michael Herger , David K. Romney , Javier Murciano Calles , Paul van Roye
摘要： This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.
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公开(公告)号：US20180354821A1
公开(公告)日：2018-12-13
申请号：US16107642
申请日：2018-08-21
发明人： Michael R. Hoffmann , Kangwoo Cho
IPC分类号： C02F1/461 , C02F1/467 , C25B11/04 , C02F101/30
CPC分类号： C02F1/46109 , C02F1/4674 , C02F2001/46133 , C02F2001/46138 , C02F2101/30 , C02F2305/023 , C25B11/0405 , C25B11/041 , C25B11/0415 , C25B11/0442 , C25B11/0447 , C25B11/0452 , C25B11/0473 , C25B11/0478 , C25B11/0484
摘要： A water purification anode has a first semiconductor contacting a second semiconductor at a heterojunction. The second semiconductor includes TiO2 and excludes bismuth and niobium. The first semiconductor includes iridium. In some instances, the anode includes a current collector in direct physical contact with the first semiconductor. The anode can be arranged in water such that at least one face of the second semiconductor is in direct physical contact with the water.
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公开(公告)号：US10026560B2
公开(公告)日：2018-07-17
申请号：US13947868
申请日：2013-07-22
摘要： The solar fuels generator includes an ionically conductive separator between a gaseous first phase and a second phase. A photoanode uses one or more components of the first phase to generate cations during operation of the solar fuels generator. A cation conduit is positioned provides a pathway along which the cations travel from the photoanode to the separator. The separator conducts the cations. A second solid cation conduit conducts the cations from the separator to a photocathode.
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公开(公告)号：US20170320792A1
公开(公告)日：2017-11-09
申请号：US15596255
申请日：2017-05-16
发明人： David Leitch , Jay A. Labinger , John E. Bercaw , Yan Choi Lam
CPC分类号： C07C2/74 , C07C2/58 , C07C11/02 , C07C15/12 , C07C2531/24 , C07C2531/28
摘要： A method for coupling an alkane with an alkene using a hydrogen transfer catalyst and an alkene dimerization catalyst to form one or more higher molecular weight hydrocarbons.
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公开(公告)号：US20170037441A1
公开(公告)日：2017-02-09
申请号：US15068521
申请日：2016-03-11
发明人： Frances H. Arnold , Pete Heinzelman
CPC分类号： C12P19/14 , C07K2319/35 , C12N9/2437 , C12P19/02 , C12Y302/01004 , C12Y302/01074 , C12Y302/01091
摘要： The present disclosure relates to CBH I chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.
摘要翻译： 本公开涉及CBH I嵌合融合多肽，编码多肽的核酸和用于产生多肽的宿主细胞。
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公开(公告)号：US09322007B2
公开(公告)日：2016-04-26
申请号：US13554736
申请日：2012-07-20
申请人： Frances H. Arnold , Indira Wu
发明人： Frances H. Arnold , Indira Wu
CPC分类号： C12N9/2437 , C12N15/00 , C12P7/00 , C12P7/10 , C12P19/02 , C12P19/14 , C12P2203/00 , C12Y302/01004 , C12Y302/01091 , Y02E50/16
摘要： The disclosure provides variant Cel6a enzymes having increased thermostability, methods of making and using such polypeptides.
摘要翻译： 本公开提供了具有增加的热稳定性的变体Cel6a酶，制备和使用这些多肽的方法。
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8.发明授权Method and apparatus for detection, identification and quantification of single-and multi-analytes in affinity-based sensor arrays 有权用于基于亲和力的传感器阵列中单分子和多分析物的检测，鉴定和定量的方法和装置公开(公告)号：US09223929B2
公开(公告)日：2015-12-29
申请号：US11376398
申请日：2006-03-14
申请人： Babak Hassibi , Haris Vikalo , Arjang Hassibi
发明人： Babak Hassibi , Haris Vikalo , Arjang Hassibi
IPC分类号： G06F7/60 , G01N33/48 , G01N31/00 , G01N33/50 , G06F19/20 , G06F19/12 , G06F19/24 , G06F19/22
摘要： The disclosure provides methods, device, and systems for analyzing biological array data. In particular, the disclosure provides methods and computer implemented techniques for reducing interference in microarray data, and exploiting it to obtain more accurate readouts.
摘要翻译： 本公开提供用于分析生物阵列数据的方法，装置和系统。 具体地，本公开提供了用于减少微阵列数据干扰的方法和计算机实现的技术，并利用它们获得更准确的读出。
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公开(公告)号：US20130288324A1
公开(公告)日：2013-10-31
申请号：US13750949
申请日：2013-01-25
IPC分类号： C12P7/02
摘要： Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cytochrome P450 BM-3. Preferred cytochrome P450 variants include those having an improved capability to hydroxylate alkanes and epoxidate alkenes comprising less than 8 carbons, and have amino acid substitutions corresponding to V78A, H236Q, and E252G of cytochrome P450 BM-3. Preferred cytochrome P450 variants also include those having an improved hydroxylation activity in solutions comprising co-solvents such as DMSO and THF, and have amino acid substitutions corresponding to T235A, R471A, E494K, and S1024E of cytochrome P450 BM-3.
摘要翻译： 提供了编码细胞色素P450变体的核酸。 细胞色素P450变体具有比相应的野生型或亲本细胞色素P450酶更高的烷烃氧化能力，烯烃氧化能力和/或较高的有机溶剂耐受性。 优选的野生型细胞色素P450是细胞色素P450 BM-3。 优选的细胞色素P450变体包括具有改善含有少于8个碳原子的烷烃和环氧化烯烃羟基化能力以及对应于细胞色素P450 BM-3的V78A，H236Q和E252G的氨基酸取代的那些变体。 优选的细胞色素P450变体还包括在包含共溶剂如DMSO和THF的溶液中具有改善的羟基化活性的那些，并且具有对应于细胞色素P450 BM-3的T235A，R471A，E494K和S1024E的氨基酸取代。
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公开(公告)号：US08299341B2
公开(公告)日：2012-10-30
申请号：US12779780
申请日：2010-05-13
申请人： Julia R. Greer , Michael Burek
发明人： Julia R. Greer , Michael Burek
IPC分类号： H01L21/44
CPC分类号： B81C1/00031 , C25D1/006 , C25D5/022 , Y10T428/2975
摘要： Solid and hollow cylindrical nanopillars with nanoscale diameters are provided. Also provides is a method of making such nanopillars using electron beam lithography followed by the electroplating.
摘要翻译： 提供了具有纳米尺寸直径的固体和中空的圆柱形纳米柱。 还提供了使用电子束光刻，然后进行电镀来制造这样的纳米柱的方法。
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