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    Method of treating patients with diabetes
    4.
    发明授权
    Method of treating patients with diabetes 失效
    治疗糖尿病患者的方法

    公开(公告)号：US5879709A

    公开(公告)日：1999-03-09

    申请号：US076339

    申请日：1998-05-11

    申请人： Patrick Soon-Shiong ,  Neil P. Desai ,  Roswitha E. Heintz

    发明人： Patrick Soon-Shiong ,  Neil P. Desai ,  Roswitha E. Heintz

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/52 ,  A61K9/48 ,  A61K9/50 ,  C12N11/00

    CPC分类号： A61K9/0024 ,  A61K9/2081 ,  Y10S514/866

    摘要： The present invention is directed to a method of treating a patient with diabetes by implanting an improved macrocapsule containing living islet cells in the patient. The improved macrocapsules encapsulate microcapsules containing islet cells, to make the system more biocompatible by decreasing the surface area and surface roughness of microencapsulated biological materials; increasing stability of microencapsulated islet cells; enhancing cytoprotectivity by increasing diffusion distance of encapsulated islet cells from cytotoxins secreted in vivo; providing retrievability of microencapsulated material; and providing a system of sustained release of the cellular products.

    摘要翻译： 本发明涉及一种通过在患者体内植入含有活体胰岛细胞的改进的大囊剂来治疗糖尿病患者的方法。 改进的大囊封装含有胰岛细胞的微胶囊，通过减少微胶囊生物材料的表面积和表面粗糙度使系统更具生物相容性; 提高微囊化胰岛细胞的稳定性; 通过增加封装的胰岛细胞从体内分泌的细胞毒素的扩散距离来增强细胞保护性; 提供微囊化材料的可回收性; 并提供一种持续释放细胞产品的系统。

    Microencapsulation of cells
    5.
    发明授权
    Microencapsulation of cells 失效
    细胞的微胶囊化

    公开(公告)号：US5762959A

    公开(公告)日：1998-06-09

    申请号：US343594

    申请日：1994-11-29

    申请人： Patrick Soon-Shiong ,  Roswitha E. Heintz ,  Gudmund Skjak-Braek

    发明人： Patrick Soon-Shiong ,  Roswitha E. Heintz ,  Gudmund Skjak-Braek

    IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K35/39 ,  B01J13/02 ,  C12N11/04 ,  A61K9/48 ,  G01M3/02

    CPC分类号： A61K9/1652 ,  A61K35/39 ,  A61K9/5073 ,  B01J13/02 ,  C12N11/04

    摘要： In accordance with the present invention, it has been discovered that a major reason for the failure to achieve successful in vivo transplantation in large mammalian species has been flaws associated with the design of microcapsules taught in the prior art, flaws in the method of making such microcapsules, and a lack of tests to determine if a given microcapsule will be successful. In accordance with the present invention, a number of functional properties which must be met by a microcapsule in order to achieve successful in vivo transplantation in large animal models have been identified. These properties include (i) a mechanically stable capsule core, (ii) a mechanically strong capsule membrane (i.e., the membrane must be of sufficient strength to prevent capsule disruption), (iii) the absence of excess exposed positively-charged PLL (which leads to fibrosis), and (iv) an adequate level of diffusion of the entrapped biologically active material out of the capsule.

    摘要翻译： PCT No.PCT / US93 / 05122 Sec。 371日期1994年12月23日第 102（e）日期1994年12月23日PCT提交1993年5月28日PCT公布。 公开号WO93 / 24112 PCT 日期1993年12月9日根据本发明，已经发现，在大型哺乳动物物种中未能实现成功的体内移植的主要原因是与现有技术教导的微胶囊的设计相关的缺陷， 制备这种微胶囊的方法，以及缺乏确定给定微胶囊是否成功的试验。 根据本发明，已经确定了为了在大型动物模型中实现成功的体内移植而必须由微胶囊满足的许多功能特性。 这些性质包括（i）机械稳定的胶囊核心，（ii）机械强力的胶囊膜（即膜必须具有足够的强度以防止胶囊破裂），（iii）不存在过量暴露的带正电荷的PLL 导致纤维化），和（iv）被捕获的生物活性物质从胶囊中的适当水平的扩散。

    Physiological cell separation and method of separating cells using same
    8.
    发明授权
    Physiological cell separation and method of separating cells using same 失效
    生理细胞分离及使用该细胞分离细胞的方法

    公开(公告)号：US5739033A

    公开(公告)日：1998-04-14

    申请号：US486404

    申请日：1995-06-05

    申请人： Patrick Soon-Shiong

    发明人： Patrick Soon-Shiong

    IPC分类号： A61K35/12 ,  C12N5/00 ,  C12N5/071

    CPC分类号： C12N5/0676 ,  A61K35/12

    摘要： An aqueous composition, initially present as a two-phase gradient, useful for separation of two cell types, such as islet cells from acinar cells, is disclosed, as well as a method of separating the cells. The composition is comprised of a water soluble, metabolically inert substance which maintains density, osmolarity and pH in the presence of cells, and a physiological cold storage solution comprising viscosity modifiers to increase the viscosity and osmotically active impermeant agents for suppressing cold-induced cellular edema, and also comprising a physiological solution capable of maintaining viable cells. These solutions are present in various combinations in a concentration sufficient to provide a first solution with a density greater than both cell types in their natural state, and less than the second cell type after incubation in said solution, and a second solution having a density less than that of both cell types. The system is allowed to stand or is centrifuged to separate the cells.

    摘要翻译： 公开了最初作为两相梯度存在的含水组合物，其用于分离两种细胞类型，例如来自腺泡细胞的胰岛细胞，以及分离细胞的方法。 该组合物由在细胞存在下保持密度，渗透压和pH的水溶性代谢惰性物质和包含粘度调节剂以增加粘度的生理冷藏溶液和用于抑制冷诱导的细胞水肿的渗透活性渗透剂 并且还包含能够维持活细胞的生理溶液。 这些溶液以各种组合存在，其浓度足以提供密度大于其天然状态的细胞类型的第一溶液，并且在所述溶液中孵育后小于第二细胞类型，并且具有密度较小的第二溶液 比两种细胞类型。 使系统静置或离心分离细胞。