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1.发明授权Graft copolymers of polycationic species and water-soluble polymers, and use therefor 失效聚阳离子种类和水溶性聚合物的接枝共聚物，并用于此
公开(公告)号：US5578442A
公开(公告)日：1996-11-26
申请号：US856137
申请日：1992-03-23
IPC分类号： A01N1/02 , A61K9/127 , A61K9/50 , A61K35/12 , C08G81/00 , C12N5/00 , C12N5/071 , C12N5/077 , C12N11/10
CPC分类号： C12N5/0677 , A01N1/021 , A61K9/1271 , A61K9/5031 , C08G81/00 , C12N5/0006 , C12N5/0012 , A61K2035/122 , A61K2035/128 , C12N2533/30 , C12N2533/32 , C12N2533/40
摘要： In accordance with the present invention, there are provided methods to render cells non-adhesive and/or non-immunogenic with respect to macromolecules typically encountered in culture media or in physiological media. The invention method comprises contacting cells with an effective amount of a composition comprising a polycationic species having water-soluble polymer chains grafted thereon.
摘要翻译： 根据本发明，提供了相对于通常在培养基中或生理介质中遇到的大分子使细胞不粘合和/或非免疫原性的方法。 本发明方法包括使细胞与有效量的组合物接触，所述组合物包含其上接枝有水溶性聚合物链的聚阳离子种类。
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2.发明授权Process for encapsulating biologics using crosslinkable biocompatible encapsulation system 失效使用可交联生物相容性封装系统封装生物制剂的方法
公开(公告)号：US5550178A
公开(公告)日：1996-08-27
申请号：US258769
申请日：1994-06-13
IPC分类号： C12N11/02 , A61K9/16 , A61K9/50 , A61K35/12 , A61K35/39 , C08F290/00 , C08F299/02 , C08G65/332 , C08K5/06 , C08L5/00 , C08L5/04 , C08L71/00 , C08L71/02 , C12N5/00 , C12N11/04 , C08K5/15 , A61K9/14
CPC分类号： C12N11/04 , A61K9/1652 , C08G65/332 , C08L5/04 , C08L71/02 , C12N5/0012 , C08L71/00 , C12N2533/30 , C12N2533/74
摘要： Crosslinked biocompatible compositions comprising an ionically crosslinked component and a covalently crosslinked component for encapsulating biologics are disclosed. In accordance with the present invention, also disclosed are crosslinkable biocompatible mixtures comprising an ionically crosslinkable component and a covalently crosslinkable component. Methods for encapsulating biologics with the crosslinked and cross-linkable biocompatible compositions are provided. Also, retrievable macrocapsules for encapsulating microcapsules or biologics are disclosed.
摘要翻译： 公开了包含离子交联组分和用于封装生物制剂的共价交联组分的交联生物相容性组合物。 根据本发明，还公开了包含可离子交联组分和共价可交联组分的可交联的生物相容性混合物。 提供了用交联和可交联的生物相容性组合物包封生物制剂的方法。 此外，公开了用于封装微胶囊或生物制剂的可回收大囊。
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3.发明授权Graft copolymer of polycationic species and water-soluble polymers, and uses therefor 失效聚阳离子种类和水溶性聚合物的接枝共聚物，用途
公开(公告)号：US5834556A
公开(公告)日：1998-11-10
申请号：US697885
申请日：1996-08-29
IPC分类号： A01N1/02 , A61K9/127 , A61K9/50 , A61K35/12 , C08G81/00 , C12N5/00 , C12N5/071 , C12N5/077 , C08G63/48 , C08G63/91
CPC分类号： C12N5/0677 , A01N1/021 , A61K9/1271 , A61K9/5031 , C08G81/00 , C12N5/0006 , C12N5/0012 , A61K2035/122 , A61K2035/128 , C12N2533/30 , C12N2533/32 , C12N2533/40
摘要： In accordance with the present invention, there are provided methods to render cells non-adhesive and/or non-immunogenic with respect to macromolecules typically encountered in culture media or in physiological media.
摘要翻译： 根据本发明，提供了相对于通常在培养基中或生理介质中遇到的大分子使细胞不粘合和/或非免疫原性的方法。
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4.发明授权Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods 失效离子共价交联和可交联的生物相容性封装组合物和方法
公开(公告)号：US5334640A
公开(公告)日：1994-08-02
申请号：US866038
申请日：1992-04-08
IPC分类号： C12N11/02 , A61K9/16 , A61K9/50 , A61K35/12 , A61K35/39 , C08F290/00 , C08F299/02 , C08G65/332 , C08K5/06 , C08L5/00 , C08L5/04 , C08L71/00 , C08L71/02 , C12N5/00 , C12N11/04 , C08K5/15 , A61K9/14
CPC分类号： C12N11/04 , A61K9/1652 , C08G65/332 , C08L5/04 , C08L71/02 , C12N5/0012 , C08L71/00 , C12N2533/30 , C12N2533/74
摘要： Crosslinked biocompatible compositions comprising an ionically crosslinked component and a covalently crosslinked component for encapsulating biologics are disclosed. In accordance with the present invention, also disclosed are crosslinkable biocompatible mixtures comprising an ionically crosslinkable component and a covalently crosslinkable component. Methods for encapsulating biologics with the crosslinked and crosslinkable biocompatible compositions are provided. Also, retrievable macrocapsules for encapsulating microcapsules or biologics are disclosed.
摘要翻译： 公开了包含离子交联组分和用于封装生物制剂的共价交联组分的交联生物相容性组合物。 根据本发明，还公开了包含可离子交联组分和共价可交联组分的可交联的生物相容性混合物。 提供了用交联和可交联的生物相容组合物包封生物制剂的方法。 此外，公开了用于封装微胶囊或生物制剂的可回收大囊。
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5.发明授权
公开(公告)号：US5665383A
公开(公告)日：1997-09-09
申请号：US488804
申请日：1995-06-07
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
CPC分类号： A61K47/48876 , A23L33/40 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/0026 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译： 根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。 生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。 在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。
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公开(公告)号：US5508021A
公开(公告)日：1996-04-16
申请号：US326116
申请日：1994-10-19
申请人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
发明人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
IPC分类号： A61K9/00 , A61K9/50 , A61K9/51 , A61K47/48 , A61K49/18 , A61K49/22 , A61B5/055 , A61B8/13 , A61K49/04
CPC分类号： A61K49/223 , A61K47/48853 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1806 , A61K49/186 , A61K49/1863 , A61K49/1869 , A61K49/222 , Y10S436/806 , Y10T436/24
摘要： In accordance with the present invention compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography. The polymeric shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, polymeric shells of the invention can be used to measure and monitor local oxygen and temperature. Exemplary contrast agents contemplated for use in the practice of the present invention include fluorinated compounds. Fluorinated compounds in general are hydrophobic and as such have limited water solubility. The invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery.
摘要翻译： 根据本发明，提供了包含聚合物壳内的成像剂的组合物。 本发明组合物可用作例如磁共振成像（MRI），超声检查和X射线计算机断层摄影的造影剂。 聚合物外壳直径通常为约2微米。 因此，这些材料由于网状上游系统（RES）或单核吞噬细胞（MNP）系统在静脉注射后迅速清除而具有器官特异性。 此外，本发明的聚合物壳可用于测量和监测局部氧气和温度。 考虑用于本发明实践的示例性造影剂包括氟化合物。 氟化合物通常是疏水性的，因此具有有限的水溶性。 本发明方法允许以适于准备输送的生物相容形式制备这些化合物。
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7.发明授权Composition useful for in vivo delivery of biologics and methods employing same 失效可用于体内递送生物制剂的组合物和使用其的方法
公开(公告)号：US5498421A
公开(公告)日：1996-03-12
申请号：US200235
申请日：1994-02-22
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
IPC分类号： A23L33/00 , A61K9/00 , A61K9/50 , A61K9/51 , A61K47/30 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/00 , A61K38/00 , A61K9/127
CPC分类号： A61K9/0026 , A23L33/40 , A61K47/48869 , A61K47/48876 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译： 根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。 生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。 在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。
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8.发明授权Macrocapsules prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor 失效由可交联的多糖，聚阳离子和/或脂质制备的大胶囊并用于其中
公开(公告)号：US5846530A
公开(公告)日：1998-12-08
申请号：US475175
申请日：1995-06-07
申请人： Patrick Soon-Shiong , Neil P. Desai , Paul A. Sandford , Roswitha A. Heintz , Soebianto Sojomihardjo
发明人： Patrick Soon-Shiong , Neil P. Desai , Paul A. Sandford , Roswitha A. Heintz , Soebianto Sojomihardjo
IPC分类号： A61K9/50 , A61F13/00 , A61F13/02 , A61K9/127 , A61K9/16 , A61K47/30 , A61L15/00 , A61L15/58 , A61L24/04 , A61L24/08 , A61L26/00 , A61L27/38 , C08B37/00 , C08B37/08 , C08F2/50 , C08F290/00 , C08F290/08 , C08F290/10 , A61K9/62 , A61K9/56 , A61K9/64
CPC分类号： C08F290/00 , A61F13/02 , A61K9/1273 , A61K9/1635 , A61K9/1652 , A61L24/04 , A61L24/08 , A61L26/0009 , A61L26/0023 , A61L27/3804 , B82Y5/00 , C08B37/00 , C08B37/003 , C08B37/0072 , C08B37/0084 , C08F290/08 , C08F290/10 , A61F2013/00157 , A61F2013/00229 , A61F2013/00574 , A61F2013/00625 , A61F2013/00638 , A61F2013/0068 , A61F2013/00748 , A61F2013/00876 , A61F2013/00906 , A61F2013/0091 , Y10S514/866 , Y10S514/893 , Y10S514/962 , Y10S514/963 , Y10T428/2984
摘要： The present invention relates to a new form of biocompatible materials (e.g., lipids, polycations, polysaccharides) which are capable of undergoing free radical polymerization, e.g., by using certain sources of light; methods of modifying certain synthetic and naturally occurring biocompatible materials to make polymerizable microcapsules containing biological material coated with said polymerizable materials, composites of said polymerizable materials, methods of making microcapsules and encapsulating biological materials therein, and apparatus for making microcapsules containing biological cells (particularly islets of Langerhans) coated with polymerizable alginate or with a composite thereof (e.g., alginate and PEG). The present invention also relates to drug delivery systems relating to the foregoing, as well as bioadhesives and wound dressings made utilizing the foregoing technology.
摘要翻译： 本发明涉及能够经历自由基聚合的新形式的生物相容性材料（例如脂质，聚阳离子，多糖），例如通过使用某些光源; 改变某些合成和天然存在的生物相容性材料以制备包含用所述可聚合材料涂覆的生物材料的可聚合微胶囊的方法，所述可聚合材料的复合材料，制备微胶囊的方法和包封生物材料的方法，以及用于制备含有生物细胞（特别是胰岛）的微胶囊的装置 的朗格汉斯）涂覆有可聚合的藻酸盐或其复合物（例如藻酸盐和PEG）。 本发明还涉及与上述相关的药物递送系统，以及利用上述技术制备的生物粘合剂和伤口敷料。
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9.发明授权Gel compositions prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor 失效由交联性多糖，聚阳离子和/或脂质制备的凝胶组合物及其用途
公开(公告)号：US5700848A
公开(公告)日：1997-12-23
申请号：US472191
申请日：1995-06-07
申请人： Patrick Soon-Shiong , Neil P. Desai , Paul A. Sandford , Roswitha A. Heintz , Soebianto Sojomihardjo
发明人： Patrick Soon-Shiong , Neil P. Desai , Paul A. Sandford , Roswitha A. Heintz , Soebianto Sojomihardjo
IPC分类号： A61K9/50 , A61F13/00 , A61F13/02 , A61K9/127 , A61K9/16 , A61K47/30 , A61L15/00 , A61L15/58 , A61L24/04 , A61L24/08 , A61L26/00 , A61L27/38 , C08B37/00 , C08B37/08 , C08F2/50 , C08F290/00 , C08F290/08 , C08F290/10 , C12N11/04
CPC分类号： C08F290/00 , A61F13/02 , A61K9/1273 , A61K9/1635 , A61K9/1652 , A61L24/04 , A61L24/08 , A61L26/0009 , A61L26/0023 , A61L27/3804 , B82Y5/00 , C08B37/00 , C08B37/003 , C08B37/0072 , C08B37/0084 , C08F290/08 , C08F290/10 , A61F2013/00157 , A61F2013/00229 , A61F2013/00574 , A61F2013/00625 , A61F2013/00638 , A61F2013/0068 , A61F2013/00748 , A61F2013/00876 , A61F2013/00906 , A61F2013/0091 , Y10S514/866 , Y10S514/893 , Y10S514/962 , Y10S514/963 , Y10T428/2984
摘要： The present invention relates to a new form of biocompatible materials (e.g., lipids, polycations, polysaccharides) which are capable of undergoing free radical polymerization, e.g., by using certain sources of light; methods of modifying certain synthetic and naturally occurring biocompatible materials to make polymerizable microcapsules containing biological material coated with said polymerizable materials, composites of said polymerizable materials, methods of making microcapsules and encapsulating biological materials therein, and apparatus for making microcapsules containing biological cells (particularly islets of Langerhans) coated with polymerizable alginate or with a composite thereof (e.g., alginate and PEG). The present invention also relates to drug delivery systems relating to the foregoing, as well as bioadhesives and wound dressings made utilizing the foregoing technology.
摘要翻译： 本发明涉及能够经历自由基聚合的新形式的生物相容性材料（例如脂质，聚阳离子，多糖），例如通过使用某些光源; 改变某些合成和天然存在的生物相容性材料以制备包含用所述可聚合材料涂覆的生物材料的可聚合微胶囊的方法，所述可聚合材料的复合材料，制备微胶囊的方法和包封生物材料的方法，以及用于制备含有生物细胞（特别是胰岛）的微胶囊的装置 的朗格汉斯），其涂覆有可聚合的藻酸盐或其复合物（例如藻酸盐和PEG）。 本发明还涉及与上述相关的药物递送系统，以及利用上述技术制备的生物粘合剂和伤口敷料。
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10.发明授权Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging 失效用于制备用于医学成像的含氟碳聚合物壳的方法
公开(公告)号：US5505932A
公开(公告)日：1996-04-09
申请号：US478986
申请日：1995-06-06
申请人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
发明人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
CPC分类号： A61K49/223 , A61K47/48853 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1806 , A61K49/186 , A61K49/1863 , A61K49/1869 , A61K49/222 , Y10S436/806 , Y10T436/24
摘要： In accordance with the present invention, compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography. The polymeric shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, polymeric shells of the invention can be used to measure and monitor local oxygen and temperature. Exemplary contrast agents contemplated for use in the practice of the present invention include fluorinated compounds. Fluorinated compounds in general are hydrophobic and as such have limited water solubility. The invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery.
摘要翻译： 根据本发明，提供了包含聚合物壳内的成像剂的组合物。 本发明组合物可用作例如磁共振成像（MRI），超声检查和X射线计算机断层摄影的造影剂。 聚合物外壳直径通常为约2微米。 因此，这些材料由于网状上游系统（RES）或单核吞噬细胞（MNP）系统在静脉注射后迅速清除而具有器官特异性。 此外，本发明的聚合物壳可用于测量和监测局部氧气和温度。 考虑用于本发明实践的示例性造影剂包括氟化合物。 氟化合物通常是疏水性的，因此具有有限的水溶性。 本发明方法允许以适于准备输送的生物相容形式制备这些化合物。
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