-
公开(公告)号:US5260444A
公开(公告)日:1993-11-09
申请号:US977173
申请日:1992-11-16
IPC分类号: C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D405/12
CPC分类号: C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要: The present invention provides dihydropyridine derivatives represented by the following formula (I) ##STR1## and salts thereof. They have extremely strong, slow and long-acting vasodilating action and antihypertensive action with less adverse effects so that they are useful as therapeutic agents for cardiovascular diseases.
摘要翻译: 本发明提供由下式(I)表示的二氢吡啶衍生物及其盐。 它们具有极强,缓慢和长效的血管舒张作用和抗高血压作用,副作用较少,因此它们可用作心血管疾病的治疗剂。
-
公开(公告)号:US5208245A
公开(公告)日:1993-05-04
申请号:US696704
申请日:1991-05-07
IPC分类号: C07D405/12 , A61K31/44 , A61K31/443 , A61K31/4433 , A61P9/00 , A61P9/08 , A61P9/12 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14
CPC分类号: C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要: The present invention provides dihydropyridine derivatives represented by the following formula (I) ##STR1## and salts thereof. They have extremely strong, slow and long-acting vasodilating action and antihypertensive action with less adverse effects so that they are useful as therapeutic agents for cardiovascular diseases.
-
公开(公告)号:US4879223A
公开(公告)日:1989-11-07
申请号:US186075
申请日:1988-04-25
IPC分类号: C07K14/485 , C12P21/02
CPC分类号: C07K14/485 , C12P21/02
摘要: A protein having nonprotein amino acids can be produced by a method which comprises providing a protein-producing organism with a nutrient containing nonprotein amino acids, cells being cultured to produce the protein in a medium containing the nonprotein amino acids, in which method expression of a gene coding for the protein is induced under conditions in which normal cell growth is suppressed.
-
公开(公告)号:US4876335A
公开(公告)日:1989-10-24
申请号:US67798
申请日:1987-06-30
申请人: Akio Yamane , Tatsuro Kawasoe , Noriko Tsukumo , Kenichi Miyoshi
发明人: Akio Yamane , Tatsuro Kawasoe , Noriko Tsukumo , Kenichi Miyoshi
摘要: A poly-labelled oligonucleotide having a plurality of labels, comprising labels carried on a polylysine and having the polylysine introduced on the extension from 5'- and/or 3'-end through phosphate group is useful as a probe for hybridization.
摘要翻译: 具有多个标记的多标记寡核苷酸可用作杂交探针,所述多标记寡核苷酸包含在聚赖氨酸上携带的标记,并且在5'-和/或3'末端通过磷酸基的延伸引入聚赖氨酸。
-
公开(公告)号:US4849336A
公开(公告)日:1989-07-18
申请号:US855710
申请日:1986-04-25
申请人: Kenichi Miyoshi , Masanori Suzuki , Toru Fuwa
发明人: Kenichi Miyoshi , Masanori Suzuki , Toru Fuwa
IPC分类号: C07H19/16 , C07H19/20 , C07H21/00 , G01N33/535
CPC分类号: C07H19/16 , C07H19/20 , C07H21/00 , G01N33/535 , Y10S435/81
摘要: Biotin- or 2,4-dinitrophenyl-oligodeoxyribonucleotide derivative represented by the formula shown below and its preparation method is disclosed: ##STR1## wherein: R is ##STR2## m and n are each 0 or a natural number; R.sup.1 is a straight or branched hydrocarbon residue; and B is a base constituting the nucleotide (in which when a plural number of B exist, they may be either identical or different). This compound is useful for use as a nonradioactive affinity probe for nucleic acid or a primer.
-
公开(公告)号:US4667025A
公开(公告)日:1987-05-19
申请号:US790658
申请日:1985-10-24
申请人: Kenichi Miyoshi , Toru Fuwa
发明人: Kenichi Miyoshi , Toru Fuwa
IPC分类号: B01D15/08 , B01J20/281 , C07H21/00 , C07H21/04 , G01N30/88
摘要: An oligonucleotide derivative having an amino group protected with an eliminatable group bonded through a phosphate group and a spacer with an appropriate length to the 5'-end of an oligonucleotide protected suitably at the 3'-hydroxyl group and the base moiety of the nucleotide, and an immobilized oligonucleotide derivative having a Sepharose carrier bonded to the amino group in place of said protective group are disclosed. Methods for production of these derivatives are also disclosed.
摘要翻译: 具有通过磷酸基团键合的可消除基团保护的氨基的寡核苷酸衍生物和适当长度的寡核苷酸衍生物,其适当长度保护在核苷酸的3'-羟基和碱基部分适当保护的寡核苷酸的5'-末端, 公开了具有与氨基键合的Sepharose载体代替所述保护基团的固定化寡核苷酸衍生物。 还公开了这些衍生物的制备方法。
-
公开(公告)号:US6001633A
公开(公告)日:1999-12-14
申请号:US952671
申请日:1998-03-31
IPC分类号: C12N15/867 , C12N7/00 , C12N5/00 , C12N7/02
CPC分类号: C12N15/86 , C12N2740/13043 , C12N2740/13052
摘要: An objective of the present invention is to provide a packaging cell for preparing a retrovirus having a high viral titer. The cell producing a recombinant retrovirus is constructed by introducing, the Polyoma virus early region gene together with a recombinant plasmid or a recombinant retrovirus free from any replication origin derived from Polyoma virus into a packaging cell for preparing a recombinant retrovirus.
摘要翻译: PCT No.PCT / JP96 / 01484第 371日期1998年3月31日 102(e)1998年3月31日PCT PCT 1996年5月31日PCT公布。 第WO96 / 38545号公报 日期1996年12月5日本发明的目的是提供一种用于制备具有高病毒滴度的逆转录病毒的包装细胞。 产生重组逆转录病毒的细胞通过将多瘤病毒早期区域基因连同重组质粒或不含任何来源于多瘤病毒的复制起点的重组逆转录病毒一起引入用于制备重组逆转录病毒的包装细胞来构建。
-
公开(公告)号:US5939542A
公开(公告)日:1999-08-17
申请号:US931072
申请日:1997-09-15
CPC分类号: C12Q1/6881
摘要: A probe set is provided which can assay larger amounts of samples in a simpler manner and enables typing of all HLA-DR types currently known to be present in Japanese. The probe set comprises part or all of oligonucleotides having the following sequences 1 to 16 or complementary strands thereof:sequence 1: CGGTTGCTCGGAAAGATGCATCsequence 2: ACACTCCCTCTTTGGCTGsequence 3: GGCCGGGTGGACAACTACsequence 4: ATGTTTAACCTGCTCCAAsequence 5: CCTGATGAGGAGTACTGGAAsequence 6: AGCTACTGCGCTTCGACsequence 7: CGTAGAGTACTCCAAGAAsequence 8: CTTATACTTACCCTGCCAsequence 9: AGACAGGCGGGCCCTsequence 10: TCAAACTTATCCTGCTTCsequence 11: AAACTTAACCTCCTCCAAsequence 12: ACTCTACGTCTGAGTGTCsequence 13: ACGGGTGAGTGTTATTTCsequence 14: GACCTCCTGGAAGACAGGsequence 15: ACATCCTGGAAGACGAGCsequence 16: CCCGTAGTTGTGTCTGCA.
摘要翻译: 提供了一种探针组,其可以以更简单的方式测定更大量的样品,并且能够打印目前已知以日语存在的所有HLA-DR类型。 探针组包含具有以下序列1至16或其互补链的部分或全部寡核苷酸:序列1:CGGTTGCTCGGAAAGATGCATC序列2:ACACTCCCTCTTTGGCTG序列3:GGCCGGGTGGACAACTAC序列4:ATGTTTAACCTGCTCCAA序列5:CCTGATGAGGAGTACTGGAA序列6:AGCTACTGCGCTTCGAC序列7:CGTAGAGTACTCCAAGAA序列 8:CTTATACTTACCCTGCCA序列9:AGACAGGCGGGCCCT序列10:TCAAACTTATCCTGCTTC序列11:AAACTTAACCTCCTCCAA序列12:ACTCTACGTCTGAGTGTC序列13:ACGGGTGAGTGTTATTTC序列14:GACCTCCTGGAAGACAGG序列15:ACATCCTGGAAGACGAGC序列16:CCCGTAGTTGTGTCTGCA。
-
公开(公告)号:US5913729A
公开(公告)日:1999-06-22
申请号:US835489
申请日:1997-04-08
申请人: Yoshio Kajimura
发明人: Yoshio Kajimura
CPC分类号: A01G1/00
摘要: Efficient methods for cultivating garlic plants are disclosed. Bulbils, which are smaller but available in a larger number per plant than cloves, are used in: a first method for cultivating garlic plant, wherein bulbils of a garlic plant are planted in spring for cultivation after stored for wintering at a temperature not inducing fleshy clove formation; a second method of cultivating garlic plants, wherein a garlic plant in which fleshy clove formation may have been induced (e.g., one which has been exposed to a low temperature in winter) is warmed to negate the state of fleshy clove formation, then the bulbils thereof are planted in spring for cultivation; and a third method of cultivating garlic plants, wherein a garlic plant which has been harvested in the Southern Hemisphere and has not wintered is transported to the Northern Hemisphere, and the bulbils thereof are planted in spring for cultivation. According to the methods of the present invention, a garlic plant which has been planted in spring continues vegetative growth without withering its epigeal part during summer when the day length is long, efficiently yielding bulbs comparable to those obtained by conventional cultivation from cloves.
摘要翻译: 公开了培育大蒜植物的有效方法。 使用较小但比丁香更多的植物的鳞茎,用于:栽培大蒜植物的第一种方法,其中大蒜植物的鳞茎被种植在春季用于培养,在不诱导肉质的温度下储存以进行越冬 丁香形成; 第二种培养大蒜植物的方法,其中可能诱导肉桂丁香形成的大蒜植物(例如,冬季暴露于低温的大蒜植物)被加热以消除肉丁状腺形成的状态,然后将球茎 春季种植; 以及栽培大蒜植物的第三种方法,其中已经在南半球收获并且没有烧结的大蒜植物被运送到北半球,并且将其鳞茎种植在春季用于培养。 根据本发明的方法,在春季种植的大蒜植物在夏天持续营养生长而不枯萎其表面部分,有效地产生与通过常规栽培从丁香获得的灯泡相当的灯泡。
-
10.
公开(公告)号:US5654322A
公开(公告)日:1997-08-05
申请号:US386649
申请日:1995-02-10
申请人: Terukage Hirata , Nobuya Sakae , Koichi Tamura , Masayasu Okuhira , Hirotaka Amano , Masaharu Yokomoto , Jun Nomiyama
发明人: Terukage Hirata , Nobuya Sakae , Koichi Tamura , Masayasu Okuhira , Hirotaka Amano , Masaharu Yokomoto , Jun Nomiyama
IPC分类号: C07D261/14 , C07D263/48 , C07D277/42 , C07D277/82 , C07D285/08 , C07D417/10 , A61K31/41
CPC分类号: C07D285/08 , C07D261/14 , C07D263/48 , C07D277/42 , C07D277/82 , C07D417/10
摘要: This invention relates to a biphenylmethane derivative represented by the formula (1): ##STR1## wherein A represents a group ##STR2## in which R.sup.1, X, Y, Z and B are as defined in the Specification. The compounds have potent angiotensin II antagonist activity and anti-hypertensive effect. They have therapeutic utility for circulatory diseases such as hypertension, heart diseases and cerebral apoplexy.
摘要翻译: 本发明涉及由式(1)表示的联苯甲烷衍生物:其中A表示基团,其中R 1,X,Y,Z和B如本说明书中所定义。 该化合物具有有效的血管紧张素II拮抗剂活性和抗高血压作用。 它们具有循环系统疾病如高血压,心脏病和脑中风的治疗效用。
-
-
-
-
-
-
-
-
-