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公开(公告)号:US20240352461A1
公开(公告)日:2024-10-24
申请号:US18765286
申请日:2024-07-07
申请人: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , SpliSense Ltd.
IPC分类号: C12N15/113 , A61K31/7088 , A61K45/06 , A61P11/00
CPC分类号: C12N15/113 , A61K31/7088 , A61K45/06 , A61P11/00 , C12N2310/11 , C12N2320/31
摘要: The present invention provides oligonucleotides capable of binding to and modulating the splicing of the pre-mRNA of the CFTR gene, including compositions comprising the oligonucleotides, and uses thereof, such as for suppressing the inclusion of a cryptic exon between exon 22 and 23 as a result of the mutation 3849+10 Kb C-to-T, optionally in combination with additional CF therapeutics.
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公开(公告)号:US20240350401A1
公开(公告)日:2024-10-24
申请号:US18756671
申请日:2024-06-27
申请人: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. , LYOTROPIC DELIVERY SYSTEMS LTD
发明人: Nissim GARTI , Sharon GARTI LEVI
IPC分类号: A61K9/00 , A61K9/06 , A61K31/136 , A61K31/723 , A61K47/10 , A61K47/12 , A61K47/44
CPC分类号: A61K9/0014 , A61K9/06 , A61K31/136 , A61K31/723 , A61K47/10 , A61K47/12 , A61K47/44
摘要: The disclosure concerns viscous or gelled delivery systems based on oily nano-domains dispersed in a viscosified/gelled continuous aqueous phase, and suitable for prolonged and/or sustained topical delivery of various active compounds.
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公开(公告)号:US20240315305A1
公开(公告)日:2024-09-26
申请号:US18259825
申请日:2021-12-29
发明人: Ido BRASLAVSKY , Oded SHOSEYOV , Shay SHEMESH , Moshe AKNIN , Yogev NAIIM , Doron COHEN , Omer GENKIN
CPC分类号: A23P20/20 , A23P2020/253 , B33Y10/00 , B33Y30/00 , B33Y40/10
摘要: The invention generally relates to a digital manufacturing system unit for manufacturing a food product, the system unit being a non-partitioned system unit comprising a raw material metering and mixing unit, a food product assembly unit and a food product cooking unit, the system unit being configured and operable to receive one or more customer-specified requirement relating to a food product profile and execute a set of machine instructions specifying a manufacturing process suitable for manufacturing the food product based on the food product profile, thereby manufacturing the food product. The invention also relates to a method for digital manufacturing a food product using such a system.
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公开(公告)号:US20240245067A1
公开(公告)日:2024-07-25
申请号:US18624587
申请日:2024-04-02
发明人: Amos NUSSINOVITCH , Gal SASON
摘要: The present invention relates to a method for forming a protective coating on a plant tissue by applying a first aqueous solution containing a crosslinking agent to a postharvest plant matter having an external surface that includes a first segment which is covered by natural skin and a second segment which has an exposed surface, wherein the first aqueous solution is applied at least upon the exposed surface of the second segment of the postharvest plant matter; and subsequently applying a second aqueous solution comprising a polysaccharide which is susceptible to crosslinking by the crosslinking agent at least upon the exposed surface of the second segment of the postharvest plant matter, thereby forming a protective coating on the exposed surface of the second segment of the postharvest plant matter due to crosslinking of the polysaccharide by the crosslinking agent.
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公开(公告)号:US20240241139A1
公开(公告)日:2024-07-18
申请号:US18563900
申请日:2022-05-25
发明人: Haitham AMAL
CPC分类号: G01N33/6896 , G16H50/20 , G01N2440/14 , G01N2440/26 , G01N2800/28
摘要: The present invention is directed to methods for determining an autism spectrum condition in a subject. Further provided is a kit suitable for determining an autism spectrum condition.
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6.
公开(公告)号:US20240197197A1
公开(公告)日:2024-06-20
申请号:US18286618
申请日:2022-04-13
发明人: Aviv MEZER , Shir FILO
CPC分类号: A61B5/055 , A61B5/0037 , A61B5/0042 , G01R33/50
摘要: A method of detecting iron-related entities in a region of interest, is disclosed. The method may comprise: receiving at least two Magnetic Resonance Imaging (MRI) signals from each of at least two different locations in the region of interest; calculating at least four MRI parameters from the MRI signals; and determining a presence of at least two different iron-related entities in the region of interest based on the at least four MRI parameters.
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7.
公开(公告)号:US20240166541A1
公开(公告)日:2024-05-23
申请号:US18283019
申请日:2022-03-20
发明人: Amos NUSSINOVITCH , Jaap VAN RIJN
IPC分类号: C02F3/10 , A01K63/04 , C02F3/00 , C02F3/08 , C02F3/28 , C02F101/34 , C02F103/20
CPC分类号: C02F3/108 , A01K63/04 , C02F3/085 , C02F3/106 , C02F3/2806 , C02F2003/001 , C02F2101/34 , C02F2103/20 , C02F2303/02 , C02F2305/06
摘要: The present invention provides a method for the removal of noxious taste or odor compounds (TOCs) from water of an aquaculture system, the method comprising contacting the water with a carrier comprising: a hydrophobic agent being configured to adsorb said TOCs; and a hydrocolloid, wherein the carrier is adapted for the colonization of microorganisms which are capable of degrading said TOCs. Further provided is a recirculating aquaculture system (RAS) for maintaining aquaculture species, comprising, inter alia, a reactor comprising a plurality of carriers comprising a hydrophobic agent configured to adsorb TOCs, and a hydrocolloid.
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公开(公告)号:US20240159678A1
公开(公告)日:2024-05-16
申请号:US18549192
申请日:2022-03-10
发明人: Nir BAR-GILL , Yoav NINIO , Uri BANIN , Nir WAISKOPF
IPC分类号: G01N21/64
CPC分类号: G01N21/6486 , G01N2021/6419
摘要: A non-magnetic method is disclosed for determining presence and/or concentration of at least one radical species in a sample.
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公开(公告)号:US20240131080A1
公开(公告)日:2024-04-25
申请号:US18537944
申请日:2023-12-13
IPC分类号: A61K35/545 , A61K8/64 , A61Q19/00 , C12N5/073 , C12N15/86
CPC分类号: A61K35/545 , A61K8/64 , A61Q19/00 , C12N5/0605 , C12N15/86 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/00 , C12N2513/00 , C12N2533/92 , C12N2740/15043
摘要: A method of generating an induced trophoblast stem cell (iTSC) from a human cell is provided. Accordingly there is provided a method comprising expressing within a human cell GATA3 and OCT4 transcription factors, under conditions which allow generation of an iTSC from the cell. Also provided is a method of rejuvenating and/or de-differentiating a human cell. Also provided are nucleic acid constructs, protein preparation, isolated human cells, human iTSCs, rejuvenated cells and de-differentiated cells.
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公开(公告)号:US11952431B2
公开(公告)日:2024-04-09
申请号:US18089067
申请日:2022-12-27
申请人: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD.
IPC分类号: A61K9/14 , A61K31/03 , A61K31/4196 , A61K31/4439 , A61K47/64 , A61K47/69 , A61P11/00 , B82Y5/00 , B82Y30/00 , C07K5/12 , C07K7/06 , C07K7/08 , C07K14/00 , C07K17/08 , C12N5/16
CPC分类号: C07K17/08 , A61K31/03 , A61K31/4196 , A61K31/4439 , A61K47/6937 , C07K7/06 , C07K7/08 , B82Y5/00 , B82Y30/00
摘要: Disclosed are peptides that specifically bind to neutrophils and uses thereof for neutrophil-targeted delivery of drugs or diagnostic agents in medical conditions including cancer as well as infectious, inflammatory and autoimmune diseases or disorders.
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