公开(公告)号：US09457047B2

公开(公告)日：2016-10-04

申请号：US14037420

申请日：2013-09-26

申请人： Whitehead Institute ,  Massachusetts Institute of Technology ,  Boston University ,  The General Hospital Corporation

发明人： Ifat Rubin-Bejerano ,  Gerald R. Fink ,  Claudia Abeijon ,  Daniel S. Kohane ,  Jason E Fuller ,  Robert S. Langer

IPC分类号： A61K39/395 ,  A61K31/716 ,  A61K45/06 ,  A61K36/09 ,  C08B37/00 ,  A61K36/064 ,  A61K47/48 ,  C08J3/12

CPC分类号： A61K31/716 ,  A61K9/1647 ,  A61K36/064 ,  A61K36/09 ,  A61K39/0011 ,  A61K39/385 ,  A61K39/39 ,  A61K45/06 ,  A61K47/61 ,  A61K47/6843 ,  A61K47/6921 ,  A61K2039/55583 ,  A61K2039/572 ,  C08B37/0024 ,  C08J3/126 ,  C08J3/128 ,  C08J2300/16 ,  C08J2325/06 ,  C08J2367/04 ,  C08J2400/16 ,  C08J2405/00

摘要： This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.

摘要翻译： 本发明涉及β-1-6-葡聚糖，包含其的组合物和装置及其在调节免疫应答中的用途。 本发明某些实施方案的β-1-6-葡聚糖富含O-乙酰化基团和/或与固体支持物缀合或与靶向部分连接。

公开(公告)号：US20140030277A1

公开(公告)日：2014-01-30

申请号：US14037420

申请日：2013-09-26

申请人： Whitehead Institute ,  The General Hospital Corporation d/b/a Massachusetts General Hospital ,  Boston University ,  Massachusetts Institute of Technology

发明人： Ifat Rubin-Bejerano ,  Gerald R. Fink ,  Claudia Abeijon ,  Daniel S. Kohane ,  Jason E. Fuller ,  Robert S. Langer

IPC分类号： A61K31/716 ,  A61K45/06

CPC分类号： A61K31/716 ,  A61K9/1647 ,  A61K36/064 ,  A61K36/09 ,  A61K39/0011 ,  A61K39/385 ,  A61K39/39 ,  A61K45/06 ,  A61K47/61 ,  A61K47/6843 ,  A61K47/6921 ,  A61K2039/55583 ,  A61K2039/572 ,  C08B37/0024 ,  C08J3/126 ,  C08J3/128 ,  C08J2300/16 ,  C08J2325/06 ,  C08J2367/04 ,  C08J2400/16 ,  C08J2405/00

摘要： This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.

摘要翻译： 本发明涉及β-1-6-葡聚糖，包含其的组合物和装置及其在调节免疫应答中的用途。 本发明的某些实施方案的β-1-6-葡聚糖富含O-乙酰化基团和/或与固体支持物缀合或连接至靶向部分。

公开(公告)号：US20160257098A1

公开(公告)日：2016-09-08

申请号：US15030613

申请日：2014-10-27

申请人： TIPA CORP. LTD

发明人： Daphna NISSENBAUM ,  Tal NEUMAN ,  Dori PELLED ,  Shai GARTY ,  Nili KONIECZNY

IPC分类号： B32B27/08 ,  C08J5/18 ,  B32B27/30 ,  B65D65/46 ,  B32B27/36

CPC分类号： B32B27/08 ,  B32B7/12 ,  B32B27/22 ,  B32B27/306 ,  B32B27/36 ,  B32B27/365 ,  B32B2250/02 ,  B32B2250/03 ,  B32B2250/04 ,  B32B2250/05 ,  B32B2250/40 ,  B32B2255/10 ,  B32B2255/205 ,  B32B2262/06 ,  B32B2262/062 ,  B32B2262/065 ,  B32B2262/067 ,  B32B2262/10 ,  B32B2262/101 ,  B32B2262/105 ,  B32B2262/106 ,  B32B2262/108 ,  B32B2264/06 ,  B32B2264/067 ,  B32B2264/10 ,  B32B2264/104 ,  B32B2264/105 ,  B32B2264/107 ,  B32B2270/00 ,  B32B2307/31 ,  B32B2307/54 ,  B32B2307/546 ,  B32B2307/704 ,  B32B2307/7163 ,  B32B2307/7244 ,  B32B2307/7246 ,  B32B2307/7265 ,  B32B2307/73 ,  B32B2307/732 ,  B32B2439/70 ,  B65D65/466 ,  C08J5/18 ,  C08J2300/16 ,  C08J2367/02 ,  C08J2367/04 ,  C08J2400/16 ,  C08J2467/04

摘要： Disclosed is a biodegradable sheet comprising at least one layer which is a direct contact layer, intended to successfully contact materials, such as liquids, while maintaining the mechanical properties of the sheet and to extend the biodegradable sheet shelf life. The direct contact layer may comprise a hydrophobic polymer selected from poly(epsilon-caprolactone) (PCL) polyhydroxybutyrate (PHB), Polydioxanone (PDO) polyglycolic acid (PGA), polybutylene succinate (PBS), polybutylene succinate adipate (PBS A), poly lactic acid (PL A), polybutylene adipate terphtalate (PBAT), polyhydroxyalkanoates (PHA), such as polyhydroxybutyrates (PHB), polyhydroxyvalerates (PHV), and polyhydroxybutyrate-hydroxyvalerate copolymers (PHBV) or any mixture thereof. The biodegradable sheet may further comprise surface treated nanoclay particles, PVOH grafted with a crosslinker and PBS or PBS A The biodegradable sheet may further include at least one metalized, biodegradable, laminate layer.

摘要翻译： 公开了一种生物可降解片材，其包含至少一层直接接触层，其旨在成功地接触材料例如液体，同时保持片材的机械性能并延长生物降解片材的保存期限。 直接接触层可以包括选自聚（ε-己内酯）（PCL）聚羟基丁酸酯（PHB），聚二恶烷酮（PDO）聚乙醇酸（PGA），聚丁二酸丁二醇酯（PBS），聚丁二酸丁二醇酯己二酸酯（PBS A），聚 乳酸（PL A），聚己二酸丁二醇酯（PBAT），聚羟基链烷酸酯（PHA），如聚羟基丁酸酯（PHB），聚羟基戊酸酯（PHV）和聚羟基丁酸酯 - 羟基戊酸酯共聚物（PHBV）或其任何混合物。 生物降解性片材还可以包含表面处理的纳米粘土颗粒，用交联剂和PBS或PBS A接枝的PVOH。生物降解性片材还可以包括至少一种金属化的，可生物降解的层压层。

公开(公告)号：US20120178836A1

公开(公告)日：2012-07-12

申请号：US13349365

申请日：2012-01-12

申请人： Suzanne A. Maher ,  Kenneth Ng ,  Tony Chen ,  Florian Wanivenhaus

发明人： Suzanne A. Maher ,  Kenneth Ng ,  Tony Chen ,  Florian Wanivenhaus

IPC分类号： C08F116/06 ,  C08J9/26

CPC分类号： C08J9/26 ,  A61L27/16 ,  A61L27/58 ,  A61L2430/06 ,  A61L2430/24 ,  C08J3/005 ,  C08J2201/046 ,  C08J2329/04 ,  C08J2400/16 ,  C08L29/00 ,  C08L29/04

摘要： The present invention relates to a method of manufacture of an interconnected porous non-biodegradable polymer implant suitable for implantation into a mammal for the treatment, repair or replacement of defects or injury in musculoskeletal tissue, wherein the mechanical properties of the implant can be controlled by varying the concentration of the non-biodegradable polymer and/or varying the duration and number of freeze-thaw cycles and the interconnected porous non-biodegradable polymer implant has sufficient percent porosity and pore diameter to facilitate integration of cells and attachment within the mammal via ingrowth of surrounding tissue. The present invention also relates to an implant manufactured by the method.

摘要翻译： 本发明涉及一种制造适合于植入哺乳动物的互连的多孔不可生物降解的聚合物植入物的方法，用于治疗，修复或替换肌肉骨骼组织中的缺陷或损伤，其中植入物的机械性质可由 改变不可生物降解的聚合物的浓度和/或改变冷冻 - 融化循环的持续时间和数量，并且互连的多孔不可生物降解的聚合物植入物具有足够的孔隙率和孔径百分比，以促进细胞的整合和通过向内生长在哺乳动物内的附着 的周围组织。 本发明还涉及通过该方法制造的植入物。

公开(公告)号：US07993745B2

公开(公告)日：2011-08-09

申请号：US12375170

申请日：2007-07-24

申请人： Junichi Narita ,  Hiroyuki Wakaki

发明人： Junichi Narita ,  Hiroyuki Wakaki

IPC分类号： B32B17/10

CPC分类号： C08J5/18 ,  C08J2300/16 ,  C08J2367/04 ,  C08J2400/16 ,  C08L67/04 ,  C08L2205/025 ,  Y10S428/91 ,  Y10T428/269 ,  Y10T428/31786

摘要： The object of the present invention is to provide a polylactic acid stretched film having biodegradability and excelling in transparency and heat resistance. The main feature is characterized in that a polylactic acid stretched film is composed of a polylactic acid composition containing poly-L-lactic acid and poly-D-lactic acid in which a peak ratio (peak 1/peak 2) of a peak height (peak 1) of a maximum endothermic peak of endothermic peaks within a range of 150 to 200° C. to a peak height (peak 2) of a maximum endothermic peak of endothermic peaks within a range of 205 to 240° C. in DSC measurements is equal to or less than 0.2.

摘要翻译： 本发明的目的是提供具有生物降解性和透明性和耐热性优异的聚乳酸拉伸膜。 其主要特征在于，聚乳酸拉伸膜由含有聚L-乳酸和聚-D-乳酸的聚乳酸组合物构成，其中峰高（峰1 /峰2） 在150至200℃的范围内的吸热峰的最大吸热峰的峰值1）与在DSC测量中在205至240℃范围内的吸热峰的最大吸热峰的峰高（峰2） 等于或小于0.2。

公开(公告)号：US20180251619A1

公开(公告)日：2018-09-06

申请号：US15972714

申请日：2018-05-07

申请人： JSP Corporation

发明人： Mitsuru Shinohara ,  Masaharu Oikawa

IPC分类号： C08J9/18 ,  C08J9/16 ,  C08J9/232 ,  C08J9/12 ,  C08J9/00

CPC分类号： C08J9/18 ,  C08J9/0061 ,  C08J9/122 ,  C08J9/16 ,  C08J9/232 ,  C08J2203/06 ,  C08J2205/052 ,  C08J2323/14 ,  C08J2323/16 ,  C08J2400/16 ,  C08J2409/06 ,  C08J2423/14 ,  C08J2423/16 ,  C08J2453/02 ,  C08J2467/00 ,  C08J2467/04

摘要： The present invention relates to polyolefin resin expanded beads containing multi-layer expanded beads containing a core layer in a foamed state containing a polyolefin resin and a cover layer coated on the core layer, the cover layer containing a mixed resin of a polyolefin resin (A) and at least one resin (B) selected from a polystyrene resin and a polyester resin, and the mixed resin having a weight ratio (A/B) of the polyolefin resin (A) and the resin (B) of from 15/85 to 90/10, and a composite laminated body using an expanded beads molded body thereof, and the expanded beads molded body is excellent in solvent resistance and also excellent in adhesiveness to a thermosetting resin on the surface of the molded body, and can provide a composite laminated body excellent in productivity with a thermosetting resin.

公开(公告)号：US20180051151A1

公开(公告)日：2018-02-22

申请号：US15556561

申请日：2016-03-03

申请人： BANDO CHEMICAL INDUSTRIES, LTD.

发明人： Tomohito ICHIKI ,  Saki JINDAI

IPC分类号： C08J9/00 ,  C08J9/18

CPC分类号： C08J9/0066 ,  C08J9/0061 ,  C08J9/122 ,  C08J9/18 ,  C08J9/34 ,  C08J2201/03 ,  C08J2203/06 ,  C08J2203/08 ,  C08J2205/044 ,  C08J2205/046 ,  C08J2205/052 ,  C08J2300/16 ,  C08J2323/06 ,  C08J2323/12 ,  C08J2367/04 ,  C08J2400/104 ,  C08J2400/16 ,  C08J2401/02 ,  C08J2423/06 ,  C08J2423/12 ,  C08J2423/26 ,  C08J2427/18 ,  C08J2467/04

摘要： The present invention provides a foamable resin composition excellent in terms of the dispersibility and moldability. The foamable resin composition containing: from 30 to 80 wt % of a polyolefin; from 3 to 40 wt % of a polylactic acid; from 1 to 20 wt % of a modified polyolefin containing a carbonyl group in a molecule; from 10 to 40 wt % of a layered silicate; and from 0.01 to 0.5 wt % of a filler, the polyolefin containing at least one of polypropylene and polyethylene, the filler having a density different from the density of the layered silicate by at least 0.20 g/cm3.

公开(公告)号：US20170029591A1

公开(公告)日：2017-02-02

申请号：US15223837

申请日：2016-07-29

申请人： JSP Corporation

发明人： Takuya CHIBA ,  Masaharu OIKAWA

IPC分类号： C08J9/232 ,  B29C43/00 ,  B29C44/34 ,  C08J9/18 ,  C08J9/12

CPC分类号： C08J9/232 ,  B29C43/003 ,  B29C44/3461 ,  B29K2067/046 ,  B29K2105/048 ,  B32B5/18 ,  C08J9/0061 ,  C08J9/122 ,  C08J9/18 ,  C08J2201/03 ,  C08J2201/034 ,  C08J2203/06 ,  C08J2205/044 ,  C08J2205/052 ,  C08J2205/10 ,  C08J2207/00 ,  C08J2300/16 ,  C08J2367/04 ,  C08J2400/16 ,  C08J2423/04 ,  C08J2423/06 ,  C08J2423/10 ,  C08J2467/04 ,  C08L67/04 ,  C09D167/04 ,  C08L23/02

摘要： The present invention provides expanded polylactic acid resin beads, in which each bead is composed of a core layer that is in an expanded state and contains a crystalline polylactic acid resin, and a coating layer that coats the core layer and contains a mixed resin of an amorphous polylactic acid resin and a crystalline polyolefin resin, wherein the content of the crystalline polyolefin resin in the coating layer is 3% by weight or more and less than 50% by weight. The expanded polylactic acid resin beads can stably produce a molded article of expanded polylactic acid resin beads excellent in fusibility of the expanded polylactic acid resin beads therein and also excellent in solvent resistance.

摘要翻译： 本发明提供了膨胀聚乳酸树脂珠粒，其中每个珠粒由扩展状态的核心层组成并含有结晶聚乳酸树脂，和涂覆层包覆核心层并含有 无定形聚乳酸树脂和结晶聚烯烃树脂，其中涂层中结晶聚烯烃树脂的含量为3重量％以上且小于50重量％。 膨胀聚乳酸树脂珠粒可以稳定地制备发泡聚乳酸树脂珠的易熔性优异且耐溶剂性优异的膨胀聚乳酸树脂珠粒的成型体。

公开(公告)号：US09527967B2

公开(公告)日：2016-12-27

申请号：US14648816

申请日：2013-12-02

申请人： Akzo Nobel Chemicals International B.V.

发明人： Paul Albert Iacobucci ,  Wilhelm Klaas Frijlink

IPC分类号： C08J3/22 ,  C08J9/00 ,  C08J9/40 ,  C08K5/14 ,  C08J3/00 ,  C08J3/20

CPC分类号： C08J3/22 ,  C08J3/005 ,  C08J3/203 ,  C08J3/226 ,  C08J9/00 ,  C08J9/40 ,  C08J2201/03 ,  C08J2367/04 ,  C08J2400/16 ,  C08J2457/00 ,  C08J2467/04 ,  C08J2487/00 ,  C08K5/14

摘要： Masterbatch comprising one or more organic peroxides in liquid form, dispersed in a polymeric matrix comprising at least 50 wt % of a bioresin, wherein the polymeric matrix has a porosity, expressed as percentage of voids on the volume of the matrix, of 2.5-70 vol % and the concentration of water in the masterbatch is kept to 2000 ppm or less, based on the total weight of the masterbatch.

公开(公告)号：US20160168450A1

公开(公告)日：2016-06-16

申请号：US14907907

申请日：2014-07-23

申请人： KUREHA CORPORATION ,  SUMITOMO BAKELITE CO., LTD.

发明人： Takuma Kobayashi ,  Hiroyuki Sato ,  Takeo Takahashi ,  Fumihiro Maeda ,  Yasushi Arita ,  Masakatsu Asami

IPC分类号： C09K8/72 ,  C08K5/42 ,  C08J3/20

CPC分类号： C09K8/725 ,  C08G85/00 ,  C08J3/12 ,  C08J3/203 ,  C08J3/226 ,  C08J2300/14 ,  C08J2367/02 ,  C08J2367/04 ,  C08J2371/14 ,  C08J2400/16 ,  C08J2467/02 ,  C08J2467/04 ,  C08K5/42 ,  C08K5/435 ,  C08L101/16 ,  E21B43/267 ,  C08L67/00

摘要： An acid curing agent inclusion according to the present invention contains an acid curing agent having an acidic group; and a polyester. The acid curing agent exists in a state that the acidic group thereof is blocked by a compound having reactivity with the acidic group. This makes it possible to provide an acid curing agent inclusion capable of preparing a resin composition which can reliably cure an acid curable resin at a required place, and a method for producing (preparing) such an acid curing agent inclusion.

摘要翻译： 根据本发明的酸性固化剂夹杂物含有具有酸性基团的酸性固化剂; 和聚酯。 酸固化剂以酸性基团与酸性基团具有反应性的化合物封闭的状态存在。 这使得可以提供能够制备能够可靠地固化所需位置的酸固化树脂的树脂组合物的酸固化剂夹杂物，以及制备（制备）这种酸固化剂夹杂物的方法。