摘要:
Aspects of the present disclosure include reconfigurable integrated circuits for characterizing particles of a sample in a flow stream. Reconfigurable integrated circuits according to certain embodiments are programmed to calculate parameters of a particle in a flow stream from detected light; compare the calculated parameters of the particle with parameters of one or more particle classifications; classify the particle based on the comparison between the parameters of the particle classifications and the calculated parameters of the particle; and adjust one or more parameters of the particle classifications based on the calculated parameters of the particle. Methods for characterizing particles in a flow stream with the subject integrated circuits are also described. Systems and integrated circuit devices programmed for practicing the subject methods, such as on a flow cytometer, are also provided.
摘要:
Described herein is a gas detection system (5) including a housing (10) having an inlet (20) in fluid communication with an atmosphere; an analyzer (25) within the housing (20) and configured to detect and measure a gas species in the atmosphere using a gas sensor (37); and a pneumatic system (60) contained within the housing (10) and in fluid communication with the inlet (20) to draw an air sample from the atmosphere. The pneumatic system (60) includes a pump (15); a low flow branch (65) in fluid communication with the pump (15) and having an airflow sensor (90) and a first orifice (85); and a high flow branch (70) in fluid communication with the pump (15) and having a second orifice (95). Such a system is particularly suitable for remote sampling because it prevents the high flow needed for remote sampling to be directed towards the gas sensor withstanding only low flow. Related apparatus, systems, methods and/or articles are described.
摘要:
The present invention relates to diagnostic devices incorporating electrode modules and fluidics for performing chemical analyses. The invented devices consist of a sensor array formed on an electrode module, the sensor array being contained within a fluidic housing. The electrode module is a laminate of a perforated epoxy foil and a photo-formed metal foil with sensor membranes deposited into the perforations. The fluidic housing is an element consisting of a plastic card-like body with fluidic conduits and a sealed fluid reservoir contained in a foil-lined cavity.
摘要:
Flow cytometry concepts are modified to enable dynamic characterizations of particles to be obtained using optical scattering data. Particles in flow will be introduced into a sample volume. Light scattered by a particle in the sample volume is collected and analyzed. What differentiates the concepts disclosed herein from conventional flow cytometry is the use of an acoustic source that is disposed to direct acoustic energy into the sample volume. As the particle passes through the sample volume, it responds to the acoustic energy, causing changes in the light scattered by the particle. Those changes, which are not measured during conventional flow cytometry, can be analyzed to determine additional physical properties of the particle.
摘要:
A chemical analyser analyses a sample for a target chemical. The sample and reagent are added to a measurement cell until a detectable change is observed. A reference compound, which does not take part in the reaction between the target chemical and reagent, is added to the reagent. By measuring the concentration of the reference compound, the amount of reagent used may be determined. In one embodiment, a mechanism introduces the sample, adds reagent, mixes, cleans, and flushes the measurement cell, which incorporates a longitudinal chamber having inlets for the sample and reagent and an outlet for measured sample/reagent mixtures. A detector located in or adjacent to the chamber between the inlets and outlet and a piston movable in the chamber carries seals such that movement of a piston sequentially opens the inlets and expels the fluid. The analyzer also includes a device that delivers reagent to a measurement cell.
摘要:
A method and apparatus for interfacing a plurality of gas measurement systems, including a mainstream and a sidestream gas measurement system, to a host system via an interface unit. The present invention also pertains to a sidestream gas measurement system that output signals emulating the signals output by a mainstream gas measurement system or portion thereof, so that the sidestream gas measurement system can seamlessly communicate with a host system configured to communicate only a mainstream gas measurement system or a portion thereof.
摘要:
Single or multi-cell reservoir sensors with single illumination sources and one or more detectors per cell unit have an arrangement whereby a gaseous, vapor or liquid sample enters the cell body and interacts with a sensing solution to detect and quantify a given species. Entrance of the sample into the sensor is through an opening in the cell body which may be covered with a membrane to contain the sensing reagent and to presort the species entering the cell. Reservoir cells can be used with organic, inorganic or biochemical sensing materials. A variety of sensors as alcohol, drugs of abuse, organic halides, cyanide and inorganic ions are provided.
摘要:
A flow cell for a colour measurement system is described that includes a body with a fluid inlet and a fluid outlet linked by a fluid pathway. An entrance window for allowing light transmission into the flow cell is provided, along with a coupler configured to couple a light source to the flow cell. The entrance window is fixedly coupled to the body of the flow cell, and the coupler is carried by a coupler mount that attaches to the body of the flow cell independently of the entrance window.
摘要:
A cell survival rate determining device includes a distribution acquisition unit acquiring a particle size distribution in a solution containing particles including cultured cells; a classification unit classifying the particles into a small particle group and a large particle group using a predetermined threshold in the distribution; a ratio calculation unit calculating the value of a ratio between the number of particles belonging to the small particle group and the number of particles belonging to the large particle group; and a survival rate determination unit determining the survival rate of the cultured cells from the value of the ratio using a pre-acquired relationship between the ratio and cell survival rate.
摘要:
The flow cell of the present application simultaneously monitors and measures light absorbance and fluorescence of particles in a flowing liquid. The flow cell comprises a housing having a light input face, an absorbance output face and first and second emission output faces; a fluid flow section within the housing that comprises a bottom funnel through which fluid enters the flow cell, a core chamber into which fluid flows from the bottom funnel, and a top funnel into which fluid flows from the core chamber, wherein the bottom and top funnels each comprise a first end which extends at an angle to a second end that is wider in diameter than the first end, and said second end of each is adjacent to and aligned with the core chamber; and a center section within the housing center having a recess formed therein which houses the core chamber of the fluid flow section, wherein said center section comprises a first pair of opposing channels formed in the light input face and the absorbance output face, respectively, and a second pair of opposing channels formed in the first emission output face and the second emission output face and which are perpendicular to the first pair of opposing channels, and wherein the first pair of opposing channels and second pair of opposing channels are in communication with the core chamber. An apparatus comprising the flow cell is also provided.