公开(公告)号：US11633384B2

公开(公告)日：2023-04-25

申请号：US17213678

申请日：2021-03-26

申请人： Salix Pharmaceuticals, Inc.

发明人： William Forbes

IPC分类号： A61K31/437 ,  A61K31/08 ,  A61K31/352 ,  A61K31/395 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/606 ,  A61K31/7016 ,  A61K31/785 ,  A61K38/14 ,  A61K38/31 ,  A61K45/06

摘要： The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin.

公开(公告)号：US20230111568A1

公开(公告)日：2023-04-13

申请号：US17913844

申请日：2021-03-24

申请人： Bausch Health Ireland Limited

发明人： Zeev Heimanson ,  Robert J. Israel ,  Thejasvi Ramakrishna ,  Jason Lamar Vittitow

IPC分类号： A61K31/437 ,  A61P1/16 ,  A61P25/28 ,  A61K31/7016 ,  A61K9/20 ,  A61K9/28

摘要： Provided herein are solid dispersions comprising rifaximin and methods of using the same for the treatment of Overt Hepatic Encephalopathy and complications associated with cirrhosis.

公开(公告)号：US20230091701A1

公开(公告)日：2023-03-23

申请号：US17682624

申请日：2022-02-28

申请人： Salix Pharmaceuticals, Inc.

发明人： William Forbes

IPC分类号： A61K31/437 ,  A61K31/7016 ,  A61K45/06 ,  G16H20/10

摘要： The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin. The instant application also provides methods for determining if a subject has a neurological condition or hepatic encephalopathy by determining the critical flicker frequency and/or the venous ammonia level of the subject at two or more time points. The invention further provides methods for treating these subjects.

公开(公告)号：US20230085636A1

公开(公告)日：2023-03-23

申请号：US18049936

申请日：2022-10-26

申请人： Aegis Therapeutics, LLC

发明人： Richard LOWENTHAL ,  Edward T. MAGGIO ,  Robert G. BELL ,  Pratik SHAH

IPC分类号： A61K47/26 ,  A61K31/7016 ,  A61K31/485

摘要： Drug products adapted for nasal delivery comprising formulations with epinephrine and devices comprising such formulations are provided. Methods of treating anaphylaxis with epinephrine products are also provided.

公开(公告)号：US20230071924A1

公开(公告)日：2023-03-09

申请号：US17818591

申请日：2022-08-09

申请人： GINA SLOAN

发明人： GINA SLOAN

IPC分类号： A61K35/745 ,  A61K35/747 ,  A61K38/47 ,  A61K38/46 ,  A61K31/717 ,  A61K31/719 ,  A61K31/7016 ,  A61K31/715 ,  A61K31/7032 ,  A61K47/14 ,  A61K47/12 ,  A61K47/18 ,  A61K47/24 ,  A61P1/14 ,  A61K9/00 ,  A61P31/04 ,  A23K10/18 ,  A23K20/189 ,  A23K50/75

摘要： A probiotic composition comprised of a probiotic, a prebiotic, a complex-starch reducing enzyme, an enzymatic co-factor, and a pH modifier. The probiotic composition facilitates the creation of a biofilm within the GI tract of poultry that outcompetes and excludes pathogens. The probiotic composition can be incorporated into an eggwash and sprayed onto an egg, the sprayed egg developing a stable probiotic population within the GI tract of the pre-hatched chick. The probiotic composition can also be incorporated into poultry feed by applying the probiotic composition as a mash prior to pelleting. The probiotic composition can also be applied post-pelleting as a wet or dry spray, directly onto the pellets. In some instances, the probiotic composition can be added a drinking water source used by poultry as a water additive. Poultry that consume feed or water that contain the probiotic composition develop a stable probiotic population within their GI tracts.

公开(公告)号：US20230047766A1

公开(公告)日：2023-02-16

申请号：US17797785

申请日：2021-02-05

申请人： Sylvian Inc.

发明人： Victor Stone

IPC分类号： A61K31/7016 ,  A61P25/28 ,  G01N30/72 ,  A61P9/10

摘要： A method for treating vasospasm may include measuring cerebrospinal fluid (CSF) to obtain a baseline biomarker value. The method may include administering a first dose of a trehalose solution. The method may include draining the CSF to maintain a current intracranial pressure (ICP). The method may include measuring a trehalose concentration in the CSF. The method may include measuring a biomarker value in the CSF. The method may end based on a determination that the measured biomarker value indicates a predetermined biomarker concentration.

公开(公告)号：US20230046275A1

公开(公告)日：2023-02-16

申请号：US17849328

申请日：2022-06-24

申请人： University of Louisville Research Foundation, Inc.

发明人： Ori BRAUN ,  Martin G. O'TOOLE ,  Shlomit SCHAAL

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K31/7016 ,  A61K47/26 ,  A61P27/02

摘要： Methods of reducing oxidative damage to an eye of a subject are provided. Aspects of the method include intravitreal injection an antioxidant composition consisting essentially of a non-reducing sugar or a hydrate thereof. In some embodiments, the non-reducing sugar is trehalose. The methods can further include surgical removal of at least a portion of the subject's vitreous humor during a vitrectomy. Also provided are ophthalmic compositions, kits and pre-loaded injection devices for use in vitrectomy surgery which find use in the subject methods.

公开(公告)号：US20220395520A1

公开(公告)日：2022-12-15

申请号：US17821282

申请日：2022-08-22

申请人： GLYCOM A/S

发明人： Nikolay KHANZHIN ,  Markus JONDELIUS HEDEROS ,  Louise Kristine VIGSNÆS ,  Bruce MCCONNELL

IPC分类号： A61K31/702 ,  C12P19/04 ,  C12P1/04 ,  C12N9/10 ,  A61K31/716 ,  A61P31/04 ,  A61K31/7016 ,  A61K31/7032 ,  C07H1/00

摘要： A mixture of human milk oligosaccharides that comprises or consists essentially of a) LNTri II, LNT, pLNH II and optionally lactose, or b) LNTri II, LNnT, pLNnH and optionally lactose, and is useful for preventing or treating viral or bacterial, intestinal and respiratory infections and for modulating the human gastrointestinal microbiota to increase Bifidobacterium abundance. A process for preparing the mixture and methods of crystallizing LNnT and LNT is also described.

公开(公告)号：US20220387463A1

公开(公告)日：2022-12-08

申请号：US17765059

申请日：2020-09-29

申请人： Seelos Therapeutics, Inc.

发明人： Raj Mehra ,  Warren Wasiewski ,  Gopal Krishna

IPC分类号： A61K31/7016 ,  A61P3/00

摘要： The present disclosure relates to methods of treating or alleviating one or more symptoms of mucopolysaccharidoses in a subject, via administering a trehalose formulation to the subject.

公开(公告)号：US20220362273A1

公开(公告)日：2022-11-17

申请号：US17302819

申请日：2021-05-12

申请人： Northwestern University ,  Case Western Reserve University

发明人： Kurt Q. Lu

IPC分类号： A61K31/7016 ,  A61K31/593 ,  A61K31/436 ,  A61K31/585 ,  A61K31/341 ,  A61K31/549 ,  A61K31/522 ,  A61K36/28 ,  A61K9/00 ,  A61P17/02

摘要： In an aspect of the present application, a composition for preventing or treating skin damage in skin of a mammalian subject in need thereof can include at least one autophagy promoter and at least one diuretic. The at least one autophagy promoter and the at least one diuretic, in combination, can each be present in an amount sufficient to prevent or treat the skin damage. In another aspect, the present application includes a method for preventing or treating skin damage in skin of a mammalian subject in need thereof whereby the composition can be administered to the subject in a therapeutically effective amount to prevent or treat the skin damage.