公开(公告)号：US20240122964A1

公开(公告)日：2024-04-18

申请号：US18541398

申请日：2023-12-15

申请人： Shawn E. WALKER

发明人： Shawn E. WALKER

IPC分类号： A61K31/722 ,  A61K9/00 ,  A61K31/727 ,  A61P31/14 ,  A61P39/00

CPC分类号： A61K31/722 ,  A61K9/0075 ,  A61K31/727 ,  A61P31/14 ,  A61P39/00

摘要： The invention provides methods and compositions for blocking access to, and reducing infiltration into, the brain of a subject through the subject's olfactory nerves, olfactory support structures, or both, of one or more pathogenic or anthropogenic environmental factor by contacting the surface of the olfactory epithelium with a polyanionic polysaccharide-chitosan composition.

公开(公告)号：US11944703B2

公开(公告)日：2024-04-02

申请号：US18365024

申请日：2023-08-03

申请人： Clearside Biomedical, Inc.

发明人： Ronald Yamamoto ,  Stanley R. Conston ,  David Sierra

IPC分类号： A61F9/007 ,  A61F9/00 ,  A61K9/00 ,  A61K9/16 ,  A61K31/717 ,  A61K31/718 ,  A61K31/722 ,  A61K31/728 ,  A61K31/737 ,  A61K47/36 ,  A61M5/31 ,  A61M5/48 ,  A61K9/14

CPC分类号： A61K9/0048 ,  A61F9/0017 ,  A61F9/0026 ,  A61F9/007 ,  A61F9/00736 ,  A61K9/0051 ,  A61K9/1635 ,  A61K31/717 ,  A61K31/718 ,  A61K31/722 ,  A61K31/728 ,  A61K31/737 ,  A61K47/36 ,  A61M5/486 ,  A61K9/14 ,  A61M2005/3103 ,  A61M2210/0612

摘要： An ocular medical injector is provided for drug delivery. A method includes inserting a puncture member of the medical injector into the eye until the puncture member reaches the suprachoroidal space (SCS). The puncture member defines a lumen therethrough. With the puncture member disposed within the SCS, a flexible cannula is advanced distally through the lumen of the puncture member, beyond the distal end portion of the puncture member and along the SCS towards a posterior region of the eye. The flexible cannula has an atraumatic distal tip and defines a lumen therethrough. With the distal tip of the flexible cannula disposed within the SCS beyond a distal end portion of the puncture member, a therapeutic substance is administered to the SCS.

公开(公告)号：US20240100084A1

公开(公告)日：2024-03-28

申请号：US18556096

申请日：2022-04-19

申请人： GLYCOCORE PHARMA SRL

发明人： Lanfranco Callegaro ,  Giulio Bianchini

IPC分类号： A61K31/722 ,  A61K31/136 ,  A61K31/137 ,  A61K31/4178 ,  A61K31/46 ,  A61K31/4745 ,  A61K31/522 ,  A61K31/573 ,  A61K31/58 ,  A61K47/36 ,  A61K47/38 ,  A61P31/14

CPC分类号： A61K31/722 ,  A61K31/136 ,  A61K31/137 ,  A61K31/4178 ,  A61K31/46 ,  A61K31/4745 ,  A61K31/522 ,  A61K31/573 ,  A61K31/58 ,  A61K47/36 ,  A61K47/38 ,  A61P31/14

摘要： The invention discloses a functionalised chitosan, or a salt thereof, used in the treatment of pathologies of the respiratory tract or hepatic pathologies, preferably caused by viral infections. It was indeed observed that said functionalised chitosan or salt thereof was able to act as galectin-modulator, modulating in particular galectin-3, and therefore determining a marked reduction in the inflammatory and fibrotic cascade generated by these viral infections. The invention moreover discloses a pharmaceutical composition, as well as a biomaterial, comprising this functionalised chitosan, or a salt thereof.

公开(公告)号：US11883489B2

公开(公告)日：2024-01-30

申请号：US17021345

申请日：2020-09-15

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

发明人： Billy M. Hargis ,  Neil R. Pumford ,  Marion Morgan ,  Srichaitanya Shivaramaiah ,  Guillermo Tellez-Isaias ,  Amanda Wolfenden

IPC分类号： A61K39/39 ,  A61K8/99 ,  A61K31/722 ,  A61K35/68 ,  A61K39/012 ,  A61K39/02 ,  A61K39/112 ,  A61K39/108 ,  A61K39/08 ,  A61K39/085 ,  A61K39/09 ,  A61K39/12 ,  A61K39/145 ,  A61K39/00 ,  A61K31/7004 ,  C08B37/08 ,  C08L5/08 ,  A61K39/155

CPC分类号： A61K39/39 ,  A61K8/99 ,  A61K31/7004 ,  A61K31/722 ,  A61K35/68 ,  A61K39/012 ,  A61K39/0241 ,  A61K39/0258 ,  A61K39/0275 ,  A61K39/0283 ,  A61K39/08 ,  A61K39/085 ,  A61K39/092 ,  A61K39/099 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  C08B37/003 ,  C08L5/08 ,  A61K2039/521 ,  A61K2039/523 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/55583 ,  A61K2039/575 ,  A61K2039/6087 ,  A61K2039/62 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  Y02A50/30

摘要： Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.

公开(公告)号：US11882832B2

公开(公告)日：2024-01-30

申请号：US17940420

申请日：2022-09-08

申请人： Chinova Bioworks Inc.

发明人： David Brown ,  Tanzina Huq ,  Natasha Dhayagude

IPC分类号： A01N43/16 ,  A23L31/00 ,  A23L2/44 ,  A23L3/3562 ,  A61K8/73 ,  A61K31/722 ,  A61Q17/00

CPC分类号： A01N43/16 ,  A23L2/44 ,  A23L3/3562 ,  A23L31/00 ,  A61K8/736 ,  A61K31/722 ,  A61Q17/005 ,  A23V2002/00

摘要： The present application is directed to antimicrobial compositions comprising chitosan polymers of at least two different average molecular weights (Mws), wherein the Mw of each different chitosan polymer is selected to target a different microorganism as well as method of making and using the compositions and product comprising the compositions.

公开(公告)号：US20230346824A1

公开(公告)日：2023-11-02

申请号：US17918679

申请日：2021-04-14

申请人： SolyPlus GmbH ,  Leopold GmbH

发明人： Andreas VOIGT ,  Richard Dolph ANDERSEN ,  Karl SKRINER

IPC分类号： A23L29/275 ,  A23G4/10 ,  A23L2/52 ,  A61K31/722 ,  A61K31/7004 ,  A61K31/522 ,  A61K9/68 ,  A61P31/14

CPC分类号： A61K31/722 ,  A23G4/10 ,  A23L2/52 ,  A23L29/275 ,  A61K9/0058 ,  A61K31/522 ,  A61K31/7004 ,  A61P31/14

摘要： A composition for use in preventing an infection, or treating an infection, or treating a disease caused by an infection, the composition including a compound selected from the group of chitosan or a salt thereof, galactose, mannose, caffeine, and any combination thereof.

公开(公告)号：US11786547B2

公开(公告)日：2023-10-17

申请号：US16572053

申请日：2019-09-16

申请人： SYNEDGEN, INC.

发明人： Shenda M. Baker ,  William P. Wiesmann ,  Stacy Marie Townsend

IPC分类号： A61K31/722 ,  A61K9/00

CPC分类号： A61K31/722 ,  A61K9/0014 ,  A61K9/0043 ,  A61K9/0053 ,  Y02A50/30

摘要： Described herein are methods of disrupting (e.g., reducing the viscosity of, or dissolving) a preformed biofilm in a subject, the method comprising: administering to the subject an effective amount of a composition comprising a soluble chitosan or derivatized chitosan wherein the soluble chitosan or derivatized chitosan when administered contacts the preformed biofilm, thereby disrupting (e.g., reducing the viscosity of, or dissolving) the preformed biofilm.

公开(公告)号：US11752101B2

公开(公告)日：2023-09-12

申请号：US17711495

申请日：2022-04-01

申请人： CLEARSIDE BIOMEDICAL, INC.

发明人： Ronald Yamamoto ,  Stanley R. Conston ,  David Sierra

IPC分类号： A61F9/007 ,  A61F9/00 ,  A61M5/31 ,  A61K9/00 ,  A61K9/16 ,  A61K31/717 ,  A61K31/718 ,  A61K31/722 ,  A61K31/728 ,  A61K31/737 ,  A61K47/36 ,  A61M5/48 ,  A61K9/14

CPC分类号： A61K9/0048 ,  A61F9/007 ,  A61F9/0017 ,  A61F9/0026 ,  A61F9/00736 ,  A61K9/0051 ,  A61K9/1635 ,  A61K31/717 ,  A61K31/718 ,  A61K31/722 ,  A61K31/728 ,  A61K31/737 ,  A61K47/36 ,  A61M5/486 ,  A61K9/14 ,  A61M2005/3103 ,  A61M2210/0612

摘要： An ocular medical injector is provided for drug delivery. A method includes inserting a puncture member of the medical injector into the eye until the puncture member reaches the SCS. The puncture member defines a lumen therethrough. With the puncture member disposed within the SCS, a flexible cannula is advanced distally through the lumen of the puncture member, beyond the distal end portion of the puncture member and along the SCS towards a posterior region of the eye. The flexible cannula has an atraumatic distal tip and defines a lumen therethrough. With the distal tip of the flexible cannula disposed within the SCS beyond a distal end portion of the puncture member, a therapeutic substance is administered to the SCS.

公开(公告)号：US11717541B2

公开(公告)日：2023-08-08

申请号：US17220455

申请日：2021-04-01

申请人： SIDR, LLC

发明人： Scott P. Noel ,  William Brian Austin ,  Alex Greene ,  John Kirk Shumpert

IPC分类号： A61K36/185 ,  A61K35/644 ,  A23K20/163 ,  A23K50/20 ,  A23K10/30 ,  A61P1/04 ,  A61K9/00 ,  A61K31/722 ,  A61K31/733 ,  A61K36/61 ,  A61K45/06

CPC分类号： A61K35/644 ,  A23K10/30 ,  A23K20/163 ,  A23K50/20 ,  A61K9/0053 ,  A61K9/0056 ,  A61K31/722 ,  A61K31/733 ,  A61K36/185 ,  A61K36/61 ,  A61K45/06 ,  A61P1/04

摘要： The invention provides compositions comprising chitosan, manuka honey and one or more additional components that promotes digestive health (e.g., inulin, probiotics) for the treatment and prevention of gastric ulcers (esophageal, stomach, or duodenum) in a mammal (e.g., equine).

公开(公告)号：US20230142823A1

公开(公告)日：2023-05-11

申请号：US17940420

申请日：2022-09-08

申请人： Chinova Bioworks Inc.

发明人： David Brown ,  Tanzina Huq ,  Natasha Dhayagude

IPC分类号： A01N43/16 ,  A23L31/00 ,  A23L2/44 ,  A23L3/3562 ,  A61K8/73 ,  A61K31/722 ,  A61Q17/00

CPC分类号： A01N43/16 ,  A23L31/00 ,  A23L2/44 ,  A23L3/3562 ,  A61K8/736 ,  A61K31/722 ,  A61Q17/005 ,  A23V2002/00

摘要： The present application is directed to antimicrobial compositions comprising chitosan polymers of at least two different average molecular weights (Mws), wherein the Mw of each different chitosan polymer is selected to target a different microorganism as well as method of making and using the compositions and product comprising the compositions.