公开(公告)号：US20230000927A1

公开(公告)日：2023-01-05

申请号：US17941352

申请日：2022-09-09

申请人： JangoBio, LLC

发明人： Craig S. Atwood ,  Sivan Vadakkadath Meethal

IPC分类号： A61K35/545 ,  A61K35/52 ,  A61K35/55 ,  A61P5/24 ,  A61P5/06 ,  C07K14/59 ,  A61K35/54 ,  A61K35/15 ,  A61K31/568 ,  A61K31/566 ,  A61K31/57

摘要： Methods are described for differentiating stem and post-natal cells into sex hormone-producing cells that can be administered to a patient autologously or allogeneically in order to maintain in balance, or rebalance, their hypothalamic-pituitary-gonadal (HPG) axis.

公开(公告)号：US20210386792A1

公开(公告)日：2021-12-16

申请号：US17416340

申请日：2018-12-19

申请人： Dong Ha BHANG

发明人： Dong Ha Bhang ,  Sandra Sonsuk Ryeom

IPC分类号： A61K35/52 ,  A61K35/44 ,  C12N5/076 ,  A61P15/00

摘要： Maintenance of adult tissues depends on stem cell self-renewal in local niches. Spermatogonial stem cells (SSC) are germline adult stem cells necessary for spermatogenesis and fertility. The present invention relates utilization of testicular endothelial cells (TECs) in the SSC niche producing glial cell line-derived neurotrophic factor (GDNF) and other factors to support human and mammal SSCs in long-term culture. The present invention also relates to utilization of five factors sufficient for long-term maintenance of human and mammal SSC colonies in feeder-free cultures. Male cancer survivors after chemotherapy are often infertile since SSCs are highly susceptible to cytotoxic injury. Transplantation of TECs alone is used to restore spermatogenesis in mice after chemotherapy-induced depletion of SSCs.

公开(公告)号：US20190133736A1

公开(公告)日：2019-05-09

申请号：US16239315

申请日：2019-01-03

申请人： Inguran, LLC

发明人： Hein van der Steen ,  Gregg Bevier

IPC分类号： A61D19/02 ,  A61K35/52 ,  A61B6/00 ,  A61B1/04 ,  A61B1/313 ,  A61B6/12

CPC分类号： A61D19/027 ,  A61B1/04 ,  A61B1/3132 ,  A61B6/12 ,  A61B6/485 ,  A61K35/52

摘要： The invention relates to methods of increasing genetic merit of swine by establishing a plurality of mating subtypes for a line of swine, and determining a percentage of progeny that are male for each of the mating subtypes, or a percentage of progeny that are female for each of the mating subtypes, that would result, relative to a control, in an increase in genetic merit in the line; the invention further relates to sorting a sperm cell sample from a male swine in one of the mating subtypes into one or more subpopulations of sperm cells, wherein a majority of sperm cells in a subpopulation of sperm cells bear X chromosomes or Y chromosomes, and inseminating one or more female swine in the one of the mating subtypes with the subpopulation of sperm cells to achieve the percentage of progeny that are male, or the percentage of progeny that are female, determined to increase genetic merit relative to the control.

公开(公告)号：US10278798B2

公开(公告)日：2019-05-07

申请号：US15314330

申请日：2015-05-27

申请人： IMV TECHNOLOGIES

发明人： Eric Schmitt

IPC分类号： A61D19/00 ,  A61D19/02 ,  A01N1/02 ,  A61D19/04 ,  A61K35/52

摘要： The system comprises a straw and a liquid dilution medium. The straw comprises a tube (11) extending between a first end and a second end and comprises a gas-permeable, liquid-tight plug, said plug being arranged in the tube (11) in the vicinity of the first end of same and extending between a first end turned towards the first end of the tube (11) and a second end turned towards the second end of the tube (11). Said plug comprises an element (14) impregnated with a reagent (22) at least in the vicinity of a first end turned towards the second end of the tube (11). The liquid medium is provided to produce, by mixing, in predefined conditions, the liquid substance (21). The reagent (22) and the medium(27) are configured such that, when the substance (21) comes into contact with the first end of the impregnated element (14), it forms a hydrogel.

公开(公告)号：US20180344652A1

公开(公告)日：2018-12-06

申请号：US15778380

申请日：2016-11-23

申请人： ASSOCIATION FOR THE ADVANCEMENT OF TISSUE ENGINEERING CELL BASED TECHNOLOGIES & THERAPIES

发明人： Sílvia CRISTINA ARAÚJO VIEIRA ,  Joaquim MIGUEL ANTUNES DE OLIVEIRA ,  Rui LUÍS GONÇALVES DOS REIS ,  Joana CATARINA DA SILVA CORREIA

IPC分类号： A61K9/50 ,  A61K9/48 ,  A61K9/00 ,  A61K35/52 ,  A61K35/39 ,  A61P35/00 ,  A61P1/18 ,  A61P3/10 ,  A61P3/04 ,  A61P15/08

CPC分类号： A61K9/5036 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/4858 ,  A61K9/4875 ,  A61K9/5052 ,  A61K35/12 ,  A61K35/39 ,  A61K35/52 ,  A61L27/26 ,  A61L27/36 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2400/06 ,  A61P1/18 ,  A61P3/04 ,  A61P3/10 ,  A61P15/08 ,  A61P35/00 ,  C08L5/00 ,  C08L89/00

摘要： The present disclosure relates to a composition of at least one predominantly positively charged polyelectrolyte polymer and at least one predominantly negatively charged polyelectrolyte polymer, a preferred composition comprises poly-L-lysine and a gellan gum, preferably a methacrylate gellan gum. The present subject-matter further relates to methods for generating composition of the present disclosure and to uses of a mixture according to the disclosure for biomedical applications such as cellular and acellular systems for tissue engineering and regenerative medicine applications or as drug delivery systems, for the treatment of several diseases namely diabetes mellitus.

公开(公告)号：US10092504B2

公开(公告)日：2018-10-09

申请号：US15343984

申请日：2016-11-04

申请人： REGENICS AS

发明人： Runhild Gammelsaeter ,  Jan Remmereit

IPC分类号： A61K35/60 ,  A61K35/12 ,  A61K35/52 ,  A61K35/54 ,  C12N5/00 ,  C12N5/02 ,  A61K8/98 ,  A61K8/67 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q7/00 ,  A61Q19/02

摘要： The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. In preferred embodiments, the methods and agents comprise active extracts produced from fish eggs. The invention further provides processes for making active fish egg extracts.

公开(公告)号：US20180161137A1

公开(公告)日：2018-06-14

申请号：US15853010

申请日：2017-12-22

申请人： Inguran, LLC

发明人： Hein van der Steen ,  Gregg Bevier

IPC分类号： A61D19/02 ,  A61K35/52 ,  A61B6/00 ,  A61B6/12 ,  A61B1/313 ,  A61B1/04

CPC分类号： A61D19/027 ,  A61B1/04 ,  A61B1/3132 ,  A61B6/12 ,  A61B6/485 ,  A61K35/52

摘要： The invention relates to methods of increasing genetic merit of swine by establishing a plurality of mating subtypes for a line of swine, and determining a percentage of progeny that are male for each of the mating subtypes, or a percentage of progeny that are female for each of the mating subtypes, that would result, relative to a control, in an increase in genetic merit in the line; the invention further relates to sorting a sperm cell sample from a male swine in one of the mating subtypes into one or more subpopulations of sperm cells, wherein a majority of sperm cells in a subpopulation of sperm cells bear X chromosomes or Y chromosomes, and inseminating one or more female swine in the one of the mating subtypes with the subpopulation of sperm cells to achieve the percentage of progeny that are male, or the percentage of progeny that are female, determined to increase genetic merit relative to the control.

公开(公告)号：US20180051252A1

公开(公告)日：2018-02-22

申请号：US15633283

申请日：2017-06-26

申请人： LUTERION CO., LTD.

发明人： Won Cheol Choi ,  Young Ah Kwon ,  Suk Hoon Choi ,  Chang Hoon Choi

IPC分类号： C12N5/078 ,  C12N5/076 ,  C12N13/00 ,  A61K35/14 ,  A61K35/52

CPC分类号： C12N5/0634 ,  A61K35/14 ,  A61K35/20 ,  A61K35/28 ,  A61K35/38 ,  A61K35/52 ,  C12N5/061 ,  C12N13/00 ,  C12N2529/00

摘要： The present disclosure relates to luterial, which is a mitochondrial-like unidentified nano-sized particle derived from a body fluid, and to a method for isolating the same.

公开(公告)号：US20160137975A1

公开(公告)日：2016-05-19

申请号：US14904396

申请日：2014-07-10

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Cyril Yeshwant Ramathal ,  Jens Dumuthy-Durruthy ,  Renee A. Reijo Pera ,  Kyle E. Orwig

IPC分类号： C12N5/076 ,  A61K9/00 ,  A61K35/52 ,  C12N5/074 ,  A61K35/545

CPC分类号： C12N5/061 ,  A61K9/0034 ,  A61K35/52 ,  A61K35/545 ,  C12N5/0696 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2506/02 ,  C12N2506/1307 ,  C12N2506/45 ,  C12N2510/00

摘要： Methods are provided for the generation of male germ cells from somatic cells. Included are methods of non-integrative reprogramming for germ cell differentiation with a reduced risk of neoplasia during in vivo differentiation by the inclusion of VASA with the reprogramming factors. Also included are methods of generating male germ cells from reprogrammed pluripotent cells by direct injection of the reprogrammed cells into the seminiferous tubules. In some embodiments the somatic cells are derived from a male with oligospermia or azoospermia, which may be the result of a genetic abnormality in Azoospermia Factor (AZF) region.

摘要翻译： 提供用于从体细胞产生雄性生殖细胞的方法。 包括生物细胞分化的非综合重编程方法，通过包含VASA与重编程因子在体内分化过程中瘤形成风险降低。 还包括通过将重编程细胞直接注射到生精小管中从重编程的多能细胞产生雄性生殖细胞的方法。 在一些实施方案中，体细胞衍生自具有精子不足或无精子症的雄性，这可能是无精症因子（AZF）区域遗传异常的结果。

公开(公告)号：US20150258149A1

公开(公告)日：2015-09-17

申请号：US14508763

申请日：2014-10-07

申请人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

发明人： Yanhe Lue ,  Ronald S. Swerdloff ,  Peter Yiwen Liu ,  Krista Erkkila ,  Christina Wang

IPC分类号： A61K35/52 ,  A61K31/568

CPC分类号： A61K35/52 ,  A01K67/0271 ,  A61K31/568 ,  A61K35/28 ,  A61K35/51 ,  A61K35/545

摘要： This invention pertains to the discovery that stem cells (e.g., bone marrow stem cells) transplanted directly into a testicular environment are transdifferentiated into bona fide Sertoli cells, and/or Leydig cells, and/or and germ cells. This provides a mechanism for the treatment of male infertility and/or testosterone deficiency. Thus, in one embodiment, this invention provides a method of treating infertility or testosterone deficiency in a male mammal. The method typically involves implanting stem cells into the testes of the mammal whereby the stem cells differentiate into germ cells and/or Sertoli cells and/or Leydig cells thereby reducing infertility and/or testosterone deficiency.

摘要翻译： 本发明涉及直接移植到睾丸环境中的干细胞（例如，骨髓干细胞）被转分化为真正的支持细胞和/或Leydig细胞和/或生殖细胞的发现。 这提供了治疗男性不育症和/或睾酮缺乏症的机制。 因此，在一个实施方案中，本发明提供了治疗男性哺乳动物不育症或睾酮缺乏症的方法。 该方法通常包括将干细胞植入哺乳动物的睾丸中，由此干细胞分化成生殖细胞和/或支持细胞和/或莱迪格细胞从而减少不育症和/或睾酮缺乏症。