-
公开(公告)号:US20240358824A1
公开(公告)日:2024-10-31
申请号:US18194864
申请日:2023-04-03
申请人: PULMOTECT, INC. , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , BAYLOR COLLEGE OF MEDICINE
发明人: BURTON DICKEY , SCOTT EVANS , BRIAN GILBERT , DIANE MARKESICH , MICHAEL TUVIM , BRENTON SCOTT
IPC分类号: A61K39/39 , A61K9/00 , A61K31/215 , A61K31/24 , A61K31/7056 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K39/00 , A61K45/06
CPC分类号: A61K39/39 , A61K9/0078 , A61K31/215 , A61K31/24 , A61K31/7056 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , A61K2039/55561 , Y02A50/30
摘要: Embodiments are directed to compositions and methods for treating viral infections.
-
公开(公告)号:US20240309088A1
公开(公告)日:2024-09-19
申请号:US18392623
申请日:2023-12-21
申请人: Genentech, Inc.
发明人: Yvonne CHEN , Mark DENNIS , David DORNAN , Kristi ELKINS , Jagath Reddy JUNUTULA , Andrew POLSON , Bing ZHENG
IPC分类号: C07K16/28 , A61K31/537 , A61K38/05 , A61K39/00 , A61K39/395 , A61K45/06 , A61K47/68 , A61K51/10 , C07K16/30 , G01N33/574
CPC分类号: C07K16/2803 , A61K31/537 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6867 , A61K51/1027 , C07K16/3061 , G01N33/57492 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , Y02A50/30
摘要: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
-
公开(公告)号:US20240307482A1
公开(公告)日:2024-09-19
申请号:US18735024
申请日:2024-06-05
发明人: Siak Khim TAN
IPC分类号: A61K38/08 , A61K9/00 , A61K9/06 , A61K31/728 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/39
CPC分类号: A61K38/08 , A61K9/0014 , A61K9/06 , A61K31/728 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/39
摘要: Compositions for dermal delivery of a topical solution and methods for using such compositions are described herein. The compositions may contain extracellular matrix components and therapeutic peptides.
-
公开(公告)号:US20240307481A1
公开(公告)日:2024-09-19
申请号:US18606224
申请日:2024-03-15
IPC分类号: A61K38/05 , A61K31/01 , A61K31/047 , A61K31/09 , A61K31/145 , A61K31/198 , A61K31/51 , A61K38/06
CPC分类号: A61K38/05 , A61K31/01 , A61K31/047 , A61K31/09 , A61K31/145 , A61K31/198 , A61K31/51 , A61K38/063
摘要: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to unit dose compositions comprising (a) N-acetyl carnosine or a pharmaceutically acceptable salt thereof; (b) S-acetyl glutathione or a pharmaceutically acceptable salt thereof; (c) pterostilbene or a pharmaceutically acceptable salt thereof; (d) N-acetyl cysteine or a pharmaceutically acceptable salt thereof; (e) lutein or a pharmaceutically acceptable salt thereof; (f) taurine or a pharmaceutically acceptable salt thereof; (g) thiamine or a pharmaceutically acceptable salt thereof; (h) lycopene or a pharmaceutically acceptable salt thereof; and (i) zeaxanthin or a pharmaceutically acceptable salt thereof. In one aspect, the unit dose compositions improve eye function in a subject. In another aspect, the unit dose compositions treat or prevent eye disease is a subject.
-
公开(公告)号:US20240301427A1
公开(公告)日:2024-09-12
申请号:US18670885
申请日:2024-05-22
发明人: Yuji Kondo , Jianxin Fu , Hua Wang , Klaas Wierenga , Patrick M. Gaffney , Lijun Xia
IPC分类号: C12N15/113 , A61K31/155 , A61K31/18 , A61K31/192 , A61K31/26 , A61K31/4045 , A61K31/436 , A61K31/575 , A61K38/05 , A61K38/07 , A61K38/08 , A61K45/06 , A61P19/08 , C12N15/64
CPC分类号: C12N15/1137 , A61K31/155 , A61K31/18 , A61K31/192 , A61K31/26 , A61K31/4045 , A61K31/436 , A61K31/575 , A61K38/05 , A61K38/07 , A61K38/08 , A61P19/08 , C12N15/64 , A61K45/06
摘要: The present invention includes a method of treating a bone disease caused by a intracellular protein trafficking defect comprising: identifying a subject having the bone disease caused by the intracellular protein trafficking defect in a membrane bound transcription factor peptidase, site 1 (MBTPS1) gene; and providing the subject with an effective amount of a composition that bypasses or corrects a defect in MBTPS1 gene expression, gene splicing, or corrects protein trafficking defects in the endoplasmic reticulum and to the lysosome.
-
公开(公告)号:US20240299484A1
公开(公告)日:2024-09-12
申请号:US18601590
申请日:2024-03-11
发明人: Ralf Jäger , Martin Purpura , Shawn D. Wells , Kylin Liao
IPC分类号: A61K38/05 , A61K31/198 , A61K31/522 , A61K45/06 , A61P3/04 , A61P3/06 , A61P29/00 , A61P37/04 , A61P43/00
CPC分类号: A61K38/05 , A61K31/198 , A61K31/522 , A61K45/06 , A61P3/04 , A61P3/06 , A61P29/00 , A61P37/04 , A61P43/00
摘要: Disclosed herein are compositions and methods for promoting weight loss and/or preventing or obesity; improving athletic performance/endurance; improving muscle function; improving cognitive function; promoting weight management; improving cardiovascular health; improving blood flow; reducing inflammation; and/or immune modulation. In certain aspects, the disclosed method comprises administering a composition to a subject comprising combinations of dileucine and paraxanthine and/or dileucine and L-arginine and/or dileucine and leucine.
-
公开(公告)号:US12031136B2
公开(公告)日:2024-07-09
申请号:US16758339
申请日:2018-10-23
发明人: Yuji Kondo , Jianxin Fu , Hua Wang , Klaas Wierenga , Patrick M. Gaffney , Lijun Xia
IPC分类号: A61K31/192 , A61K31/155 , A61K31/18 , A61K31/26 , A61K31/4045 , A61K31/436 , A61K31/575 , A61K38/05 , A61K38/07 , A61K38/08 , A61P19/08 , C12N15/113 , C12N15/64 , A61K45/06
CPC分类号: C12N15/1137 , A61K31/155 , A61K31/18 , A61K31/192 , A61K31/26 , A61K31/4045 , A61K31/436 , A61K31/575 , A61K38/05 , A61K38/07 , A61K38/08 , A61P19/08 , C12N15/64 , A61K45/06
摘要: The present invention includes a method of treating a bone disease caused by a intracellular protein trafficking defect comprising: identifying a subject having the bone disease caused by the intracellular protein trafficking defect in a membrane bound transcription factor peptidase, site 1 (MBTPS1) gene; and providing the subject with an effective amount of a composition that bypasses or corrects a defect in MBTPS1 gene expression, gene splicing, or corrects protein trafficking defects in the endoplasmic reticulum and to the lysosome.
-
公开(公告)号:US20240207255A1
公开(公告)日:2024-06-27
申请号:US18419894
申请日:2024-01-23
申请人: Celgene Corporation
发明人: Matthew D. Alexander , Gerald D. Artman , Gordon L. Bray , James Carmichael , Soraya Carranico , Brian E. Cathers , Matthew D. Correa , Joshua Hansen , Courtney G. Havens , Timothy S. Kercher , Antonia Lopez-Girona , Xiaoling Lu , Hon-Wah Man , Mark A. Nagy , Rama K. Narla , Joseph R. Piccotti , Daniel W. Pierce , Paula A. Tavares-Greco , Brandon W. Whitefield , Lilly L. Wong , Nanfei Zou
IPC分类号: A61K31/496 , A61K31/573 , A61K31/69 , A61K38/05 , A61P35/00 , A61P35/02 , C07D401/04
CPC分类号: A61K31/496 , A61K31/573 , A61K38/05 , A61P35/00 , A61P35/02 , C07D401/04 , A61K31/69 , A61K2300/00
摘要: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.
-
公开(公告)号:US12016896B2
公开(公告)日:2024-06-25
申请号:US17532285
申请日:2021-11-22
申请人: CORNELL UNIVERSITY
发明人: Gang Lin , Carl Nathan , Pradeep K. Singh
IPC分类号: A61K38/05 , A61K31/165 , A61K31/42 , A61K38/02 , C07C237/06 , C07C237/12 , C07C237/22 , C07C271/22 , C07C311/14 , C07C311/19 , C07D209/18 , C07D261/18 , C07K5/06
CPC分类号: A61K38/05 , A61K31/165 , A61K31/42 , A61K38/02 , C07C237/06 , C07C237/12 , C07C237/22 , C07C271/22 , C07C311/14 , C07C311/19 , C07D209/18 , C07D261/18 , C07K5/06 , C07C2601/02
摘要: The compounds of the present invention are represented by the following compounds having Formula I:
where the substituents R1, R4, L, M, X, Y, and s are as defined herein. The compounds of the present invention are also represented by the following compounds having Formula (Ia), Formula (Ib), or Formula (Ic):
where the substituents R1-R4, Rx, Ry, X, Y, and s are as defined herein.
These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.-
公开(公告)号:US12005046B2
公开(公告)日:2024-06-11
申请号:US17164654
申请日:2021-02-01
发明人: Jay Edward Wrobel , Allen B. Reitz , Jeffrey Claude Pelletier , Garry Robert Smith , Haiyan Bian
IPC分类号: A61K31/428 , A61K9/00 , A61K9/16 , A61K9/20 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K38/05 , A61K38/06 , A61K39/00 , A61K45/06 , A61P25/00 , A61P25/28 , A61P35/00 , C07D277/82 , C07D417/12 , C07K5/062 , C07K5/083 , C07K5/087
CPC分类号: A61K31/428 , A61K9/006 , A61K9/1617 , A61K9/2004 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K38/05 , A61K38/06 , A61K39/4636 , A61K45/06 , A61P25/00 , A61P25/28 , A61P35/00 , C07D277/82 , C07D417/12 , C07K5/06026 , C07K5/0806 , C07K5/0808 , C07K5/0812 , A61K2300/00
摘要: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
-
-
-
-
-
-
-
-
-