公开(公告)号：US20230212472A1

公开(公告)日：2023-07-06

申请号：US18157198

申请日：2023-01-20

申请人： SI Group, Inc.

发明人： Kelly S. Chichak ,  Joseph T. Doane ,  Brian Christofel ,  Elliott W. Shanklin

IPC分类号： C10L1/198 ,  C10L10/16 ,  C10L1/195 ,  C07C39/06 ,  C07C39/15 ,  C10G75/04 ,  C10G75/02 ,  C10G71/00 ,  C08L61/06 ,  C08G8/10 ,  C08G8/08

CPC分类号： C10L1/1981 ,  C10L10/16 ,  C10L1/195 ,  C07C39/06 ,  C07C39/15 ,  C10G75/04 ,  C10G75/02 ,  C10G71/00 ,  C08L61/06 ,  C08G8/10 ,  C08G8/08 ,  C10G2300/80 ,  C10G2300/206

摘要： In one embodiment, an alkylphenol copolymer is disclosed wherein the copolymer comprises at least one alkylphenol monomer and the alkylphenol copolymer exhibits the following: an oscillation displacement Θ of greater than 0 at a temperature of −5° C. in a first oscillation temperature sweep and an oscillation displacement Θ in a second oscillation temperature sweep within 25% of the oscillation displacement Θ in the first oscillation temperature sweep at a temperature of −5° C. In a further embodiment, a petroleum composition is disclosed wherein the composition comprises a petroleum source and a macromolecular compound wherein the macromolecular compound exhibits the following: an oscillation displacement Θ of greater than 0 at a temperature of −10° C. in a first oscillation temperature sweep, and an oscillation displacement Θ in a second oscillation temperature sweep within 25% of the oscillation displacement Θ in the first oscillation temperature sweep at a temperature of −10° C.

公开(公告)号：US11479528B2

公开(公告)日：2022-10-25

申请号：US16496355

申请日：2018-03-20

申请人： TAIPEI MEDICAL UNIVERSITY

发明人： Jing-ping Liou ,  Che-ming Teng ,  Shiow-lin Pan

IPC分类号： C07C235/60 ,  C07C49/835 ,  A61K9/00 ,  C07D295/135 ,  C07D295/192 ,  C07D213/75 ,  C07D209/08 ,  C07D471/04 ,  C07D231/56 ,  C07D487/04 ,  C07D215/38 ,  C07D261/20 ,  C07C233/75 ,  C07C311/21 ,  C07C39/15 ,  A61P35/00

摘要： This disclosure is related to aromatic compounds of formula (I), and methods of their use in treating medical conditions associated with Heat Shock Protein-90 (HSP90), e.g., cancer. Compounds of formula (I) have the following structure: Also disclosed are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US11434190B2

公开(公告)日：2022-09-06

申请号：US16472882

申请日：2017-12-21

申请人： The University of Queensland

发明人： Mathias Francois ,  Johannes Zuegg ,  Jeroen Overman ,  Sreeman Kumar Mamidyala ,  Angela Aguslyarti Salim ,  Frank Roger Fontaine ,  Matthew Allister Cooper ,  Robert John Capon ,  Avril Alexis Barbara Robertson

IPC分类号： C07C63/66 ,  C07C39/15 ,  C07C43/215 ,  C07C63/331 ,  C07C233/65 ,  A61P35/00

摘要： Disclosed are compounds of a formula provided herein that show efficacy in the inhibition of SOX18 protein activity, and in particular with respect to the ability of SOX18 to bind DNA and/or particular protein partners. Further, methods of treating angiogenesis- and/or lymphangiogenesis-related diseases, disorders or conditions, such as cancer metastasis and vascular cancers, are provided herein.

公开(公告)号：US20200247739A1

公开(公告)日：2020-08-06

申请号：US16488185

申请日：2018-02-21

申请人： Mitsubishi Gas Chemical Company, Inc.

发明人： Yasushi MIKI ,  Takashi MAKINOSHIMA ,  Masatoshi ECHIGO

IPC分类号： C07C39/17 ,  C07C39/15 ,  G03F7/022 ,  G03F7/00 ,  G03F7/16 ,  G03F7/09 ,  G03F7/004

摘要： The present invention provides a compound, a resin and a composition that are excellent in solvent solubility, are applicable to a wet process, are excellent in heat resistance and etching resistance, and are useful for forming a film for lithography. The present invention also provides pattern formation methods using the composition. The present invention further provides a method for purifying the compound and the resin. A composition comprising a compound having a specific structure and/or a resin having a constituent unit derived from the compound is used.

公开(公告)号：US20200172459A1

公开(公告)日：2020-06-04

申请号：US16639202

申请日：2018-08-16

申请人： THE UNIVERSITY OF SYDNEY

发明人： Tristan Reekie ,  Michael Scott ,  Michael Kassiou

IPC分类号： C07C37/50 ,  C07C39/15 ,  C07D311/94 ,  C07D311/80 ,  C07D311/58

摘要： method for decarboxylating a carboxylated phytocannabinoid compound of Formula I to form a phytocannabinoid compound of Formula II: Formula I Formula II wherein: R1 is selected from the group consisting of: substituted or unsubstituted C1-C5 alkyl; R2 is selected from the group consisting of: OH or O, and R3 is selected from the group consisting of: a substituted or unsubstituted cyclohexene, a substituted or unsubstituted C2-C8 alkene, or a substituted or unsubstituted C2-C8 dialkene; or R2 is O, and R2 and R3 together form a ring structure in which R2 is an internal ring atom; wherein the method includes heating a reaction mixture comprising the carboxylated phytocannabinoid compound and a polar aprotic solvent in the presence of a LiCl for a time sufficient to decarboxylate at least a portion of the carboxylated phytocannabinoid compounds and form the phytocannabinoid compound.

公开(公告)号：US20200170907A1

公开(公告)日：2020-06-04

申请号：US16780018

申请日：2020-02-03

申请人： Unigen, Inc.

发明人： Qi Jia ,  Ji-Fu Zhao

IPC分类号： A61K8/34 ,  A61K8/49 ,  C07C41/32 ,  C07C41/26 ,  A61Q19/02 ,  C07C43/23 ,  C07D321/12 ,  C07C215/74 ,  C07C49/835 ,  C07C45/67 ,  C07C39/367 ,  C07C39/15 ,  A61K31/704 ,  A61K31/40 ,  A61K31/357 ,  A61K31/09 ,  A61K31/085 ,  A61K31/05 ,  A61K31/015 ,  A61K8/97 ,  A61K8/31

摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

公开(公告)号：US20200002307A1

公开(公告)日：2020-01-02

申请号：US16489258

申请日：2018-02-28

申请人： Mitsubishi Gas Chemical Company, Inc.

发明人： Naoya UCHIYAMA ,  Junya HORIUCHI ,  Takashi MAKINOSHIMA ,  Masatoshi ECHIGO

IPC分类号： C07D311/82 ,  C07D311/78 ,  C08G8/20 ,  C07D405/04 ,  C07C39/15 ,  C08G8/04 ,  C07C39/14

摘要： A method for purifying a material, the method comprising: a step of preparing a solution comprising a solvent and at least one material selected from the group consisting of a compound represented by the following formula (1A) and a resin having a structure represented by the following formula (2A); and a step of purification in which the solution is passed through a filter: wherein, X represents an oxygen atom, a sulfur atom, a single bond, or non-crosslinked state; Ra represents a 2n-valent group having 1 to 40 carbon atoms or a single bond; each Rb independently represents one of various functional groups; each m is independently an integer of 0 to 9; n is an integer of 1 to 4; and each p is independently an integer of 0 to 2; provided that at least one Rb represents a group comprising one selected from a hydroxyl group and a thiol group, and all m cannot be 0 at the same time; wherein, X, Ra, Rb, n and p are the same as defined in the formula (1A); Rc represents a single bond or an alkylene group having 1 to 40 carbon atoms; each m2 is independently an integer of 0 to 8; provided that at least one Rb represents a group comprising one or more selected from a hydroxyl group and a thiol group, and all m2 cannot be 0 at the same time.

公开(公告)号：US20190270712A1

公开(公告)日：2019-09-05

申请号：US16319957

申请日：2017-07-28

申请人： Vectus Biosystems Limited

发明人： Karen Annette DUGGAN

IPC分类号： C07D239/26 ,  C07D237/08 ,  C07D213/56 ,  C07D277/30 ,  C07C233/11 ,  C07D263/44 ,  C07C215/54 ,  C07D207/408 ,  C07D261/14 ,  C07D401/10 ,  C07D403/10 ,  C07C39/15 ,  A61P11/00

摘要： The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.

公开(公告)号：US10359701B2

公开(公告)日：2019-07-23

申请号：US15565018

申请日：2016-04-07

申请人： Mitsubishi Gas Chemical Company, Inc.

发明人： Kana Okada ,  Takashi Makinoshima ,  Masatoshi Echigo ,  Go Higashihara ,  Atsushi Okoshi

IPC分类号： C07C39/15 ,  C07C261/02 ,  C07D311/78 ,  C09D165/00 ,  C09D173/00 ,  G03F7/11 ,  G03F7/039 ,  G03F7/16 ,  H01L21/308 ,  G03F7/20 ,  G03F7/32 ,  G03F7/38

摘要： A material for forming an underlayer film for lithography, in which a compound represented by the following formula (0) is used. (in formula (0), each X independently represents an oxygen atom or a sulfur atom, or a non-crosslinked state, R1 represents a 2n-valent group having 1 to 30 carbon atoms, or a single bond, each R0 independently represents a straight, branched or cyclic alkyl group having 1 to 30 carbon atoms, an aryl group having 6 to 30 carbon atoms, a straight, branched or cyclic alkenyl group having 2 to 30 carbon atoms, a thiol group, a halogen group, a nitro group, an amino group, a carboxylic acid group or a hydroxyl group, the alkyl group, the alkenyl group and the aryl group each optionally include a cyanato group, a thiol group, a halogen group, a nitro group, an amino group, a carboxylic acid group, a hydroxyl group, an ether bond, a ketone bond or an ester bond, each m1 is independently an integer of 0 to 4, in which at least one m1 is an integer of 1 to 4, each m2 is independently an integer of 0 to 3, n is an integer of 1 to 4, and each p is independently 0 or 1.)

公开(公告)号：US10329311B1

公开(公告)日：2019-06-25

申请号：US15927264

申请日：2018-03-21

申请人： OLON S.p.A.

发明人： Federico Gassa ,  Lazzaro Feliciani ,  Alberto Mazza ,  Marco Quaroni ,  Mara Sada ,  Giorgio Bertolini

IPC分类号： C07F5/02 ,  C07C39/205 ,  B01J27/053 ,  B01J23/44 ,  B01J23/42 ,  C07C39/15 ,  C07C37/02 ,  B01J27/232

CPC分类号： C07F5/027 ,  B01J23/42 ,  B01J23/44 ,  B01J27/053 ,  B01J27/232 ,  C07B47/00 ,  C07C37/02 ,  C07C39/15 ,  C07C39/205 ,  C07C255/50 ,  C07F5/025

摘要： The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):