公开(公告)号：US11753423B2

公开(公告)日：2023-09-12

申请号：US17689178

申请日：2022-03-08

Applicant: MMAG Co., Ltd. ,  National Institute of Advanced Industrial Science and Technology

Inventor： Hirotaka Nagata ,  Nobuto Minowa ,  Nozomu Nakanishi ,  Katsuya Shimura ,  Tadahiro Fujitani

IPC: C07F9/08

CPC classification number: C07F9/08

Abstract: A method for producing methyldichlorophosphane, the method including: allowing methane and phosphorus trichloride to react in the presence of an additive using a metal compound, or a metal compound carried on a carrier, or both thereof.

公开(公告)号：US10689579B2

公开(公告)日：2020-06-23

申请号：US16276878

申请日：2019-02-15

Applicant: International Business Machines Corporation

Inventor： Brandon M. Kobilka ,  Joseph Kuczynski ,  Jacob T. Porter ,  Jason T. Wertz

IPC: C09K21/12 ,  C08K5/5313 ,  C08K5/5317 ,  C08K5/5337 ,  C08K5/372 ,  C07F9/12 ,  C07F9/14 ,  C07F9/145 ,  C07F9/24 ,  C07F9/40 ,  C07F9/42 ,  C07F9/44 ,  C09K21/14 ,  C08K5/52 ,  C08K5/5399 ,  C07C15/04 ,  C07F9/08

Abstract: A flame-retardant vanillin-derived small molecule, a process for forming a flame-retardant polymer, and an article of manufacture comprising a material that contains the flame-retardant vanillin-derived small molecule are disclosed. The flame-retardant vanillin-derived small molecule can be synthesized from vanillin obtained from a bio-based source, and can have at least one phosphoryl or phosphonyl moiety with phenyl, allyl, or thioether substituents. The process for forming the flame-retardant polymer can include reacting a diol vanillin derivative and a flame-retardant phosphorus-based molecule to form the flame-retardant vanillin-derived small molecule, and binding the flame-retardant vanillin-derived small molecule to a polymer. The material in the article of manufacture can be flame-retardant, and contain the flame-retardant vanillin-derived small molecules. Examples of materials that can be in the article of manufacture can include resins, plastics, adhesives, polymers, etc.

公开(公告)号：US10251982B2

公开(公告)日：2019-04-09

申请号：US15429835

申请日：2017-02-10

Applicant: BioInteractions Ltd.

Inventor： Fanny Burrows ,  John E. Mckendrick ,  Alan Rhodes ,  Simon J. Onis ,  Shivpal S. Sandhu

IPC: C08F18/22 ,  A61L33/00 ,  C08F222/02 ,  A61L27/34 ,  A61L31/10 ,  C07F9/10 ,  C07F9/6574 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16 ,  A61L33/06 ,  C08F230/02 ,  C07F9/09 ,  C08F220/18 ,  C08F220/28 ,  C09D133/14 ,  G02B1/04 ,  C07F9/40 ,  C07F9/06 ,  C07F9/08 ,  C07F9/32 ,  C07F9/36 ,  C08F130/02 ,  C08F122/02 ,  C08F30/02 ,  C08F8/40 ,  C08F8/30 ,  C08F16/14 ,  C08F216/14 ,  C08F116/14

Abstract: New ampholyte biomaterial compounds containing ampholyte moieties are synthesized and integrated into polymeric assemblies to provide hydrophilic polymers exhibiting improved biocompatibility, haemocompatibility, hydrophilicity non-thrombogenicity, anti-bacterial ability, and mechanical strength, as well as suitability as a drug delivery platform.

公开(公告)号：US20150353471A1

公开(公告)日：2015-12-10

申请号：US14508960

申请日：2014-10-07

Applicant: Baylor College of Medicine

Inventor： Changyi Chen ,  Qizhi YAO ,  Jian-Ming LU

IPC: C07C205/37 ,  C07F9/08 ,  C07C217/58 ,  C07F7/18 ,  C07C69/017 ,  C07D317/62 ,  C07D317/64 ,  C07C323/16 ,  C07C69/02

CPC classification number: C07C205/37 ,  A61K31/09 ,  A61K31/11 ,  A61K31/137 ,  A61K31/222 ,  A61K31/275 ,  A61K31/357 ,  A61K31/385 ,  A61K31/4166 ,  A61K31/426 ,  A61K31/661 ,  C07C205/43 ,  C07C205/44 ,  C07C207/04 ,  C07C217/58 ,  C07C239/12 ,  C07C251/48 ,  C07C305/24 ,  C07C323/16 ,  C07D317/62 ,  C07D317/64 ,  C07F7/1804 ,  C07F9/12

Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as compositions, methods for their use for treating disorders, mediated at least in part, by xanthine oxidase.

Abstract translation: 提供了小分子黄嘌呤氧化酶抑制剂，以及组合物，其用于治疗至少部分由黄嘌呤氧化酶介导的病症的方法。

公开(公告)号：US08889760B2

公开(公告)日：2014-11-18

申请号：US13074537

申请日：2011-03-29

Applicant: Aleksey V. Kurdyumov ,  Dale G. Swan

Inventor： Aleksey V. Kurdyumov ,  Dale G. Swan

IPC: C07F9/08 ,  C07F9/12 ,  C07C49/786 ,  C07F9/145 ,  C07F9/40 ,  A61L17/14 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  C07F7/10 ,  C07F7/18 ,  C08F2/48

CPC classification number: C09D7/63 ,  A61L17/145 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L2400/18 ,  A61L2420/02 ,  C07F7/10 ,  C07F7/1804 ,  C07F7/184 ,  C07F9/06 ,  C07F9/12 ,  C07F9/145 ,  C07F9/4025 ,  C07F9/4084 ,  C08F2/48 ,  C08K5/51 ,  C08K5/5419 ,  C08K5/544 ,  C09D7/1233

Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.

Abstract translation: 本文描述了分子式为Photo1-LG-Photo2的可降解连接剂，其中Photo1和Photo2独立地表示至少一个光反应性基团，LG代表包含一个或多个硅原子或一个或多个磷原子的连接基团。 可降解交联剂包括至少一个光反应基团和连接基团之间的共价键，其中至少一个光反应基团和连接基团之间的共价键被至少一个杂原子中断。 还描述了用可降解的连接剂，涂覆的支撑表面和医疗装置涂覆支撑表面的方法。

公开(公告)号：US20120010407A1

公开(公告)日：2012-01-12

申请号：US13241037

申请日：2011-09-22

Applicant: Hui Li ,  Thilo J. Heckrodt ,  Yan Chen ,  Vanessa Taylor ,  Rajinder Singh ,  Pingyu Ding ,  Rose Yen

Inventor： Hui Li ,  Thilo J. Heckrodt ,  Yan Chen ,  Vanessa Taylor ,  Rajinder Singh ,  Pingyu Ding ,  Rose Yen

IPC: C07F9/08

CPC classification number: C07D413/12 ,  A61K31/155 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/54 ,  A61K31/541 ,  A61K31/5415 ,  A61K31/55 ,  A61K31/551 ,  A61K31/635 ,  A61K31/675 ,  A61K45/06 ,  C07D401/14 ,  C07D403/12 ,  C07D413/04 ,  C07D413/14 ,  C07D419/14 ,  C07D451/02 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/08 ,  C07D498/04 ,  C07F9/65583

Abstract: Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.

公开(公告)号：US20120010173A1

公开(公告)日：2012-01-12

申请号：US13256875

申请日：2010-03-03

Applicant: Yves Rene Johanna Paul Gonnissen ,  Jody Firmin Marceline Voorspoels

Inventor： Yves Rene Johanna Paul Gonnissen ,  Jody Firmin Marceline Voorspoels

IPC: A61K31/675 ,  A61K31/683 ,  C07J43/00 ,  A61P31/10 ,  C07F9/146 ,  C07F9/24 ,  C07F9/08 ,  C07F9/6518 ,  A61K31/685

CPC classification number: C07F9/65583 ,  A61K31/675 ,  C07F9/6518

Abstract: The invention relates to a compound of formula (I) and the salts, N-oxides, quaternary amines, and stereoisomers thereof, wherein R1 to R8 are as defined in the claims. The invention further relates to intermediates and methods for the preparation of the compounds of formula (I). The invention also relates to the compounds of formula (I) for use as a medicament, particularly for the prevention or treatment of fungal infections.

Abstract translation: 本发明涉及式（I）化合物及其盐，N-氧化物，季胺及其立体异构体，其中R 1至R 8如权利要求中所定义。 本发明还涉及制备式（I）化合物的中间体和方法。 本发明还涉及用作药物，特别是用于预防或治疗真菌感染的式（I）化合物。

公开(公告)号：US20110313182A1

公开(公告)日：2011-12-22

申请号：US13221458

申请日：2011-08-30

Applicant: Rathindra N. Bose

Inventor： Rathindra N. Bose

IPC: C07F9/08

CPC classification number: C07F15/0086 ,  A61K31/6615 ,  A61K31/663 ,  A61K31/665 ,  A61K33/24

Abstract: The present invention provides phosphaplatins, stable isolated monomeric phosphato complexes of platinum (II) and (IV), and methods of use thereof for treating cancers, including cisplatin- and carboplatin-resistant cancers. Unlike cisplatin, these complexes do not readily undergo hydrolysis and are quite soluble and stable in aqueous solutions. Moreover, these complexes—unlike cisplatin, carboplatin, and related platinum-based anti-cancer agents—do not bind DNA. Rather, data suggests that phosphaplatins trigger overexpression of fas and fas-related transcription factors and some proapoptotic genes such as Bak and Bax. Nevertheless, the complexes exhibit tremendous cytotoxicity towards cancer cells. Thus, the present invention provides novel platinum anticancer agents that have a different molecular target than those in the art.

Abstract translation: 本发明提供了磷酸铂蛋白，铂（II）和（IV）的稳定的分离的单体磷酸复合物及其用于治疗癌症的方法，包括顺铂和卡铂耐药性癌症。 与顺铂不同，这些复合物不容易经历水解，并且在水溶液中是非常可溶的和稳定的。 此外，这些复合物 - 不像顺铂，卡铂和相关的铂类抗癌剂 - 不结合DNA。 相反，数据表明磷酸蛋白酶引发fas和fas相关转录因子的过度表达以及一些促细胞凋亡基因如Bak和Bax。 然而，复合物对癌细胞表现出巨大的细胞毒性。 因此，本发明提供了与本领域相比具有不同分子靶标的新型铂抗癌剂。

公开(公告)号：US20100254931A1

公开(公告)日：2010-10-07

申请号：US12734405

申请日：2007-10-30

Applicant: Changguo Wang ,  Evelyn Su

Inventor： Changguo Wang ,  Evelyn Su

IPC: A61K8/55 ,  C07F9/08 ,  A61Q5/12

CPC classification number: A61Q5/12 ,  A61K8/55 ,  A61Q5/02

Abstract: Use of long carbon chain quaternary ammonium salt phosphoric acid ester of formula (I) as conditioner for hair.

Abstract translation: 使用式（I）的长碳链季铵盐磷酸酯作为头发的调理剂。

公开(公告)号：US07745655B1

公开(公告)日：2010-06-29

申请号：US10505879

申请日：2002-11-28

Applicant: Cornelia Borgmann

Inventor： Cornelia Borgmann

IPC: C07F9/08

CPC classification number: C07F9/65746 ,  C07F9/65744

Abstract: The present invention relates to a process for preparing bisphosphites which contain dioxaphosphorinone units.

Abstract translation: 本发明涉及一种制备含有二氧磷基荧光酮单元的二亚磷酸酯的方法。