公开(公告)号：US20240279275A1

公开(公告)日：2024-08-22

申请号：US18653960

申请日：2024-05-02

申请人： SHENZHEN WINKEY TECHNOLOGY CO., LTD

发明人： WENFENG DING ,  YAN PENG ,  XUE CHEN ,  WENHAO ZHAO ,  XINLIN SUN ,  CHUNQING HUANG ,  FUYI GUAN ,  YU XIAO

IPC分类号： C07K5/083 ,  A61K8/64 ,  A61K38/00 ,  A61P39/06 ,  A61Q19/08

CPC分类号： C07K5/0806 ,  A61K8/64 ,  A61P39/06 ,  A61Q19/08 ,  A61K38/00

摘要： Provided are a peptide derivative and a cosmetic composition or pharmaceutical composition and use thereof. The peptide derivative has a general formula as follows: R1-Gly-Pro-Gln-Gly-Pro-Gln-R2. The peptide derivative is obtained by covalently binding caffeic acid and gallic acid to peptide, respectively; and compared with single caffeic acid, gallic acid and single polypeptide, the peptide derivative has excellent skin photoaging and anti-oxidation effects, and can be applied to the fields of cosmetics, medicines, and the like.

公开(公告)号：US20240254163A1

公开(公告)日：2024-08-01

申请号：US18515100

申请日：2023-11-20

申请人： SUTRO BIOPHARMA, INC.

发明人： Toni KLINE ,  Qun Yin ,  Krishna Bajjuri

IPC分类号： C07K5/083 ,  A61K38/00 ,  A61K47/68 ,  C07K5/02 ,  C07K5/065 ,  C07K9/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/40

CPC分类号： C07K5/0808 ,  A61K47/6817 ,  C07K5/0205 ,  C07K9/003 ,  C07K16/28 ,  C07K16/30 ,  C07K16/40 ,  A61K38/00 ,  A61K47/6855 ,  C07K5/06078 ,  C07K2317/76

摘要： Provided herein are hemiasterlin derivatives, conjugates thereof, compositions comprising the derivatives or conjugates thereof, methods of producing the derivatives and conjugates thereof, and methods of using the derivatives, conjugates, and compositions for the treatment of cell proliferation. The derivatives, conjugates, and compositions are useful in methods of treatment and prevention of cell proliferation and cancer, methods of detection of cell proliferation and cancer, and methods of diagnosis of cell proliferation and cancer. In an embodiment, the hemiasterlin derivatives are according to Formula 1000:




or a pharmaceutically acceptable salt, solvate, or tautomer thereof, wherein Ar, L, W1, W4, W5, SG, and R are as described herein.

公开(公告)号：US11970551B2

公开(公告)日：2024-04-30

申请号：US18184605

申请日：2023-03-15

申请人： WNTRESEARCH AB

发明人： Dennis Henriksen

IPC分类号： C07K7/06 ,  C07K5/083

CPC分类号： C07K7/06 ,  C07K5/081

摘要： The present disclosure relates generally to the field of polypeptide synthesis, and more particularly, to the solution phase synthesis of the Wnt hexapeptide Foxy-5 and protected derivatives and peptide fragments thereof.

公开(公告)号：US11925643B2

公开(公告)日：2024-03-12

申请号：US17057845

申请日：2019-05-23

申请人： MOR RESEARCH APPLICATIONS LTD. ,  BAR ILAN UNIVERSITY

发明人： Edith Hochhauser ,  Arie-Lev Gruzman ,  Elena Trifonov

IPC分类号： A61K31/513 ,  A61K38/06 ,  A61K38/07 ,  A61P9/10 ,  C07D239/47 ,  C07K5/083 ,  C07K5/087 ,  C07K5/103 ,  C07K5/107 ,  C07K5/113

CPC分类号： A61K31/513 ,  A61K38/06 ,  A61K38/07 ,  A61P9/10 ,  C07D239/47 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/1008 ,  C07K5/101 ,  C07K5/1016 ,  C07K5/1021

摘要： Peptides, peptidomimetics and small molecules, collectively referred to as “decoy peptides”, are provided, which interfere with binding to a TIR domain of a toll-like receptor 4 (TLR4), and inhibit a TLR4-induced signaling pathway. These decoy peptides may be useful for treating diseases associated with induction of TLR4 signaling pathway such as a disease or disorder secondary to a cardiovascular disease, sepsis or an inflammatory disease.

公开(公告)号：US20240076281A1

公开(公告)日：2024-03-07

申请号：US18070408

申请日：2022-11-28

申请人： Arvinas Operations, Inc.

发明人： Yimin QIAN ,  Hanqing DONG ,  Jing WANG

IPC分类号： C07D401/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5386 ,  A61K31/551 ,  A61K38/05 ,  A61K38/06 ,  A61K45/06 ,  A61K47/54 ,  A61P15/00 ,  A61P35/00 ,  C07D401/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D498/10 ,  C07K5/078 ,  C07K5/083

CPC分类号： C07D401/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5386 ,  A61K31/551 ,  A61K38/05 ,  A61K38/06 ,  A61K45/06 ,  A61K47/54 ,  A61K47/545 ,  A61P15/00 ,  A61P35/00 ,  C07D401/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D498/10 ,  C07K5/06165 ,  C07K5/0806 ,  C07K5/06034

摘要： The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end at least one of a Von Hippel-Lindau ligand, a cereblon ligand, inhibitors of apoptosis proteins ligand, mouse double-minute homolog 2 ligand, or a combination thereof, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

公开(公告)号：US11912787B2

公开(公告)日：2024-02-27

申请号：US17422494

申请日：2020-01-22

申请人： DERMAFIRM, INC.

发明人： Hoon Cha ,  Young Il Kwon ,  Sang Cheol Han ,  Jin Wook Kim ,  Mi Young Lee ,  Ga Hee Hur

IPC分类号： C07K7/06 ,  C07K19/00 ,  A61K38/06 ,  A61K38/08 ,  A61K8/64 ,  A61Q19/08 ,  A61P17/00 ,  C07K5/083 ,  C07K5/103 ,  A61K38/00

CPC分类号： C07K5/0806 ,  A61K8/64 ,  A61Q19/08 ,  C07K5/1008 ,  C07K19/00 ,  A61K38/00

摘要： Proposed is a peptide for skin anti-aging and anti-wrinkle, comprising a glycine-histidine-lysine tripeptide and polyarginine linked to the carboxy-terminus of the tripeptide, and a composition for skin anti-aging and anti-wrinkle comprising the peptide. The peptide and composition may enter the cytoplasm more rapidly and efficiently than a conventional GHK tripeptide, and may exhibit skin anti-aging and anti-wrinkle effects similar to those of the GHK tripeptide even at a lower concentration than that of the GHK tripeptide.

公开(公告)号：US11912786B2

公开(公告)日：2024-02-27

申请号：US17389171

申请日：2021-07-29

申请人： Sanford Burnham Prebys Medical Discovery Institute

发明人： Nicholas David Peter Cosford ,  Mitchell Dennis Vamos

IPC分类号： C07D281/04 ,  A61K31/554 ,  C07K5/083 ,  C07D498/04 ,  C07D513/04 ,  C07D487/04 ,  C07D487/14 ,  C07D498/10 ,  A61K38/00

CPC分类号： C07K5/0806 ,  C07D487/04 ,  C07D487/14 ,  C07D498/04 ,  C07D498/10 ,  C07D513/04 ,  A61K38/00

摘要： Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

公开(公告)号：US11773135B2

公开(公告)日：2023-10-03

申请号：US17505544

申请日：2021-10-19

申请人： Rajendra Sahai Bhatnagar

发明人： Rajendra Sahai Bhatnagar

IPC分类号： C07K5/10 ,  C07K5/083 ,  C07K7/06 ,  A61K38/00

CPC分类号： C07K5/10 ,  C07K5/0806 ,  C07K7/06 ,  A61K38/00

摘要： Peptides and methods of use thereof, are disclosed for use in treating various disease and disorders, including inflammation, pain, oral mucositis, oral lesions, and cancer. The Peptides modulate the activity of the transcription factor NF κB.

公开(公告)号：US11723944B2

公开(公告)日：2023-08-15

申请号：US17322493

申请日：2021-05-17

申请人： California Institute of Technology ,  Indi Molecular, Inc.

发明人： Blake Farrow ,  James R. Heath ,  Heather Dawn Agnew

IPC分类号： A61K38/00 ,  C07B59/00 ,  A61K38/12 ,  A61K38/06 ,  C07K7/52 ,  C07K5/083 ,  A61K38/08 ,  C07K7/06 ,  G01N33/531 ,  A61K47/60 ,  C07K7/08 ,  G16B5/00

CPC分类号： A61K38/005 ,  A61K38/06 ,  A61K38/08 ,  A61K38/12 ,  A61K47/60 ,  C07B59/008 ,  C07K5/0808 ,  C07K7/06 ,  C07K7/08 ,  C07K7/52 ,  G01N33/531 ,  A61K38/00 ,  C07B2200/05 ,  C07K2319/01 ,  C07K2319/70 ,  G01N2333/33 ,  G16B5/00 ,  Y02A50/30

摘要： The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.

公开(公告)号：US20230017637A1

公开(公告)日：2023-01-19

申请号：US17367484

申请日：2021-07-05

申请人： Biohaven Therapeutics Ltd.

发明人： Jay Edward Wrobel ,  Allen B. Reitz ,  Jeffery Claude Pelletier ,  Garry Robert Smith ,  Haiyan Bian

IPC分类号： A61K31/428 ,  A61P25/00 ,  A61P25/28 ,  A61K38/06 ,  C07K5/083 ,  C07K5/087 ,  C07D277/82 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K38/05 ,  A61K45/06 ,  C07D417/12 ,  C07K5/062 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20

摘要： Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.