利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

848 条记录 (耗时 0.061 秒)

    GOS PRE-CONDITIONING LACTOBACILLUS STRAINS AND GOS IN FINAL FORMULATION
    4.
    发明公开
    GOS PRE-CONDITIONING LACTOBACILLUS STRAINS AND GOS IN FINAL FORMULATION 审中-公开

    公开(公告)号：US20240156886A1

    公开(公告)日：2024-05-16

    申请号：US18549669

    申请日：2022-03-11

    申请人： SOCIETE DES PRODUITS NESTLE S.A.

    发明人： FLORAC DE BRUYN ,  BERTRAND BOURQUI ,  GUENOLEE ELIANE MARIE PRIOULT ,  STEPHANE DUBOUX

    IPC分类号： A61K35/747 ,  C12N1/20 ,  C12N1/38 ,  C12R1/23

    CPC分类号： A61K35/747 ,  C12N1/20 ,  C12N1/38 ,  C12N2500/34 ,  C12R2001/23

    摘要： The invention herein relates generally to enhancing the survival and activity of probiotic Lactobacillus strains in mammals. Lactobacillus strain comprising a LacS transporter sequence having a sequence identity of at least 70% to SEQ ID NO: 1, and/or comprising a GH42 B-gal sequence, wherein the Lactobacillus strain is not a Lactobacillus reuteri strain. The invention comprises methods for cultivating and manufacturing probiotic Lactobacillus strains, and products containing such strains. In more detail the GC present invention relates to a composition comprising probiotic Lactobacillus strains, obtained by a step of growing the bacteria in a medium comprising galacto-oligosaccharides (GOS) (“pre-conditioning”), and administering said pre-conditioned bacteria together with GOS in the final product. The inventors have found that such method induces a boost in the beneficial effects of the probiotic bacteria, such as survival in the gastrointestinal tract.

    CRYPTIC METABOLITES AND METHOD FOR ACTIVATING SILENT BIOSYNTHETIC GENE CLUSTERS IN DIVERSE MICROORGANISMS
    8.
    发明申请
    CRYPTIC METABOLITES AND METHOD FOR ACTIVATING SILENT BIOSYNTHETIC GENE CLUSTERS IN DIVERSE MICROORGANISMS 有权

    公开(公告)号：US20230123785A1

    公开(公告)日：2023-04-20

    申请号：US18072800

    申请日：2022-12-01

    申请人： The Trustees of Princeton University

    发明人： Mohammad R. SEYEDSAYAMDOST ,  Fei XU ,  Yihan WU ,  Leah BUSHIN ,  Katherine Davis

    IPC分类号： G01N33/68 ,  C07K9/00 ,  C12N1/20 ,  C12N1/38 ,  C12P19/56 ,  C12P21/00 ,  C12Q1/18

    摘要： Microorganisms are prolific producers of natural products, a group of molecules that make up the majority of drugs approved by the FDA in the past 35 years. After decades of mining, the low-hanging fruit has been picked and so discovery of drug-like molecules from microorganisms has come to a near-halt. The reason for this lack of productivity is that most biosynthetic pathways that give rise to natural products are not active under typical laboratory growth conditions. These so-called ‘cryptic’ or ‘silent’ pathways are a major source of new bioactive molecules and methods that reliably activate them could have a profound impact on drug discovery. Disclosed herein is a rapid genetics-free method for eliciting and detecting cryptic metabolites using an imaging mass spectrometry-based approach. An organism of choice is challenged with elicitors from a small molecule library. The molecules elicited are then imaged by mass spec, which allows for rapid identification of cryptic metabolites. These are then isolated and characterized. Employing the disclosed approach activated production of cryptic glycopeptides from an actinomycete bacterium. The molecules that result, the keratinimicins and keratinicyclins, are metabolites with important structural features. At least two of these, keratinimicins B and C, are highly bioactive against several pathogenic strains. This approach will allow for rapid activation and identification of cryptic metabolites from diverse microorganisms in the future.

    METHOD FOR PROMOTING GROWTH OF GAS-FERMENTED MICROORGANISMS
    9.
    发明申请
    METHOD FOR PROMOTING GROWTH OF GAS-FERMENTED MICROORGANISMS 有权

    公开(公告)号：US20230091009A1

    公开(公告)日：2023-03-23

    申请号：US17896103

    申请日：2022-08-26

    申请人： HARBIN INSTITUTE OF TECHNOLOGY, SHENZHEN

    发明人： LU LU ,  Yongjie Yu ,  Ruijie Yang

    IPC分类号： C12N1/20 ,  C12N1/38

    摘要： The present invention relates to a method for promoting growth of gas-fermented microorganisms, comprising the following steps: S1. ultrasonically blending a surfactant and a culture medium, then adding a fluorine-containing alkyl compound to a mixture, and ultrasonically processing the mixture to obtain a perfluorocarbon nanoemulsion; S2. inoculating a bacterial suspension into the perfluorocarbon nanoemulsion, and introducing simultaneously a mixed gas to obtain a precursor; S3. cultivating the precursor in a shaker, wherein the precursor has a diameter of bubbles of 2.0-4.2 mm, and the bubbles have the total volume of less than 40 ml. Under these conditions, the microorganisms have a high utilization rate of the gas, can grow and metabolize more quickly, and can obtain bacteria and products more quickly. Compared with a traditional culture system, addition of a mass transfer material can promote gas mass transfer. Therefore, the gas consumption is small, and the cost is low.

    Controlled growth of microorganisms
    10.
    发明授权
    Controlled growth of microorganisms 有权

    公开(公告)号：US11427800B2

    公开(公告)日：2022-08-30

    申请号：US16227371

    申请日：2018-12-20

    申请人： Syngulon SA

    发明人： Philippe Gabant

    IPC分类号： C12N1/12 ,  A61K36/06 ,  A61K35/74 ,  A61K36/02 ,  C12N1/16 ,  C12N1/20 ,  C07K14/195 ,  C12N1/38 ,  A01N63/50

    摘要： It can be useful to regulate the growth of microbial cells. Some embodiments herein provide genetically engineered microbial cells that can produce bacteriocins to control the growth of microbial cells. In some embodiments, microbial cells are contained within a desired environment. In some embodiments, contaminating microbial cells are neutralized. In some embodiments, a first microbial cell type regulates the growth of a second microbial cell type so as to maintain a desired ratio of the two cell types.