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公开(公告)号：US12037571B2
公开(公告)日：2024-07-16
申请号：US17252977
申请日：2019-05-09
发明人： Takeyuki Mogi
CPC分类号： C12M23/50 , C12M21/08 , C12M23/06 , C12M23/44 , C12M27/16 , C12N5/0062 , C12N5/0693 , C12N11/02 , C12N2513/00 , C12N2537/00
摘要： A method of producing a cell structure includes applying a magnetic field, in a container (40), to a plurality of culture carriers to arrange the culture carriers. The culture carriers include at least one of a carrier (10) and a cell holding carrier (30), the carrier (10) having a magnetic portion (12), formed only in a part of the carrier (10), and a cell holder (11). The method also includes culturing cells (20) held on the cell holder (11) while maintaining the culture carriers in the arranged state.
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公开(公告)号：US20240218537A1
公开(公告)日：2024-07-04
申请号：US18603491
申请日：2024-03-13
发明人： Manoj KUMAR , Prakash Chandra SAHOO , Srikanth SANDIPAM , Suresh Kumar PURI , Sankara Sri Venkata RAMAKUMAR
IPC分类号： C25B11/073 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C12N1/20 , C12N11/02 , C25B3/00 , C25B11/043 , H01M8/16
CPC分类号： C25B11/073 , C12N1/20 , C12N11/02 , C25B3/00 , C25B11/043 , H01M8/16 , B82Y5/00 , B82Y15/00 , B82Y30/00
摘要： The present disclosure provides a ready-to-use bio-electrode stable for long term storage and a process of constructing the same. The process for construction of bio-electrode for electro-biocatalysis comprising of: selection of an electro-active bacteria; enrichment of said electro-active bacteria in a nutrient rich medium; separation of said electro-active bacterial cells from said nutrient rich medium; selection of an electrode material; surface modification of said electrode material; layering the surface modified electrode material with conductive material; layering the surface modified electrode material with an electro-active bacterial cells along with biofilm inducing agents and stabilizing agents; conditioning the electro-active bacterial cells layered electrode; incubating the electrode obtained with an immobilizing agent along with conductive material; and conditioning the electrode with micronutrients to obtain a bio-electrode.
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公开(公告)号：US11969246B2
公开(公告)日：2024-04-30
申请号：US18319085
申请日：2023-05-17
发明人： Samson Chen , Axel Scherer , Dvin I. Adalian , Peter Petillo , Muhammad Musab Jilani , Xiomara L. Madero , Deepan Kishore Kumar
IPC分类号： C12N11/14 , A61B5/145 , A61B5/1459 , A61B5/1486 , C12N9/02 , C12N11/02 , G01N27/327
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1459 , C12N9/0004 , C12N11/02 , C12N11/14 , G01N27/3272 , C12Y101/01001 , C12Y101/03003 , C12Y101/03005 , C12Y101/03007 , C12Y101/03008 , C12Y101/0301 , C12Y101/03011 , C12Y101/03012 , C12Y101/03015 , C12Y101/03016 , C12Y101/03018 , C12Y101/03019 , C12Y101/0302 , C12Y101/03023 , C12Y101/03027 , C12Y101/03029 , C12Y101/0303 , C12Y101/03037 , C12Y101/03038 , C12Y101/0304 , C12Y101/03041
摘要： A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
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公开(公告)号：US11920126B2
公开(公告)日：2024-03-05
申请号：US16363052
申请日：2019-03-25
申请人： Ecovative Design LLC
发明人： Damen Schaak
IPC分类号： C12N11/02 , A01G18/10 , A23K10/18 , A23K40/30 , C12N1/00 , C12N1/02 , C12N1/14 , C12N1/20 , C12N9/80 , C12N9/88 , C12N11/14 , C12N15/00 , C12N15/52 , C12N15/74 , C12N15/76 , C12N15/80 , C12R1/07 , C12R1/125 , C12R1/465
CPC分类号： C12N11/02 , A01G18/10 , A23K10/18 , A23K40/30 , C12N1/00 , C12N1/02 , C12N1/14 , C12N1/205 , C12N9/80 , C12N9/88 , C12N11/14 , C12N15/00 , C12N15/52 , C12N15/746 , C12N15/76 , C12N15/80 , C12R2001/07 , C12R2001/125 , C12R2001/465 , C12Y305/01041 , C12Y402/01001
摘要： The process of making a biocomposite material utilize a bacterial species and a fungal species in an agricultural feedstock composed of a substrate of non-nutrient discrete particles and a nutrient material wherein the bacterial species imparts mechanical properties to the biocomposite material and the fungal species binds the biocomposite material. Both bacterium and fungus can be genetically engineered to produce desired properties within the microbial communities.
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公开(公告)号：US11820975B2
公开(公告)日：2023-11-21
申请号：US15533250
申请日：2015-12-09
CPC分类号： C12N11/02 , C12N5/069 , C12N5/0697 , C12Q1/02 , C12N5/0605 , C12N2502/08 , C12N2502/28 , C12N2503/04 , C12N2506/45
摘要： An in vitro population of human brain endothelial cells (hBECs) expressing claudin-5, occludin, ZO-1 and GLUT-1 and expressing one or more of FZD7, WNT7A, WNT7B, APCDD1, STRA6 and ZO-3 is provided. A blood brain barrier (BBB) comprising the hBECs and use of the BBB for analyzing permeability characteristics of a test agent are provided.
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6.发明授权公开(公告)号：US11795483B2
公开(公告)日：2023-10-24
申请号：US16438081
申请日：2019-06-11
CPC分类号： C12P7/56 , C12N11/02 , C12N11/14 , B82Y5/00 , B82Y15/00 , C12Y102/01012 , C12Y102/02003 , C12Y207/01002 , C12Y207/01011 , C12Y401/02013 , C12Y503/01001 , C12Y503/01009
摘要： A nanoplatelet serves as a substrate for immobilizing enzymes involved in consecutive reactions as a cascade. This results in a significant increase in the rate of catalysis as well as final product yield compared to non-immobilized enzymes or enzymes immobilized to quantum dots.
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公开(公告)号：US20230250413A1
公开(公告)日：2023-08-10
申请号：US18012979
申请日：2021-10-05
发明人： Shigeki MIZUSHIMA
摘要： The present invention addresses the objective of providing a novel, reproducible plant-based enzyme-immobilization carrier that is biodegradable and imposes a low environmental load and is also harmless for the human body. The technical concept of the present invention was achieved with the discovery, in response to the objective, that a prescribed porous body based on plant protein, e.g., from soy, functions as an enzyme-immobilization carrier.
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8.发明公开公开(公告)号：US20230227806A1
公开(公告)日：2023-07-20
申请号：US18126459
申请日：2023-03-26
发明人： David BARAM , Rachel DIAMANT , David DABOUSH
IPC分类号： C12N11/02 , C12N1/20 , A61K35/747 , C12N11/12 , C12N11/14 , A61K35/74 , C12N11/04 , A61K9/14 , A61K35/741
CPC分类号： C12N11/02 , C12N1/20 , A61K35/747 , C12N11/12 , C12N11/14 , A61K35/74 , C12N11/04 , A61K9/141 , A61K35/741 , A61K2035/11
摘要： The present invention provides a method, wherein the method forms a biofilm, wherein the biofilm comprises a population of at least one bacterial strain attached to particles, wherein the biofilm is configured to colonize a gut of a subject in need thereof for at least five days, when ingested by the subject, the method comprising: a. obtaining a population comprising at least one strain of bacteria; b. inoculating a growth medium containing particles with the population comprising at least one strain of bacteria; c. incubating the particles with the population comprising at least one bacterial strain for a time sufficient for the population of at least one strain of bacteria to attach to the particles; and d. culturing the population comprising at least one strain of bacteria attached to the particles in a growth medium, for a time sufficient to form a biofilm.
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公开(公告)号：US20230148451A9
公开(公告)日：2023-05-11
申请号：US16932777
申请日：2020-07-19
申请人： Biomason, Inc
CPC分类号： C04B20/1092 , C12P3/00 , C12Y305/01005 , C12N11/14 , B05D1/02 , C12N11/02 , C04B12/00 , C04B28/10 , Y02W30/97 , C04B2103/0001
摘要： The invention is directed to compositions and methods for the manufacture of pigmented solids structures for which can be used for construction and/or decoration. Manufacturing comprises fixing one or more pigments to an aggregate material such as crushed rock, stone or sand. The pigmented aggregate is incubated with urease or urease producing microorganisms, an amount of a nitrogen source such as urea, and an amount of calcium source such as calcium chloride forming calcite bridges between particles of aggregate. The resulting solid has a hardness and colorfastness for most any construction material. Using selected aggregate and pigment, the process also provides for the manufacture of simulated-stone materials such as clay or granite bricks or blocks, marble counter-tops, and more. The invention is also directed to composition containing microorganisms and pigment as kits that can be added to most any aggregate materials.
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公开(公告)号：US20230085686A1
公开(公告)日：2023-03-23
申请号：US17904530
申请日：2021-02-19
申请人： Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4TEC
发明人： Carlos FERREIRA GUIMARÃES , Luca GASPERINI , Alexandra Margarida PINTO MARQUES , Rui Luis GONÇALVES DOS REIS
摘要： The present disclosure relates to a hydrogel fibre comprising an ionic hydrogel and a second component in a plurality of compartments, wherein the second component is selected from a second hydrogel, a hydrophilic solution, or a mixture thereof. It is also disclosed the method to obtain the aforesaid hydrogel fibres. This disclosure also relates to a composition comprising the hydrogel fibres and a suitable carrier, and an article/kit, a bundle, a mesh or a membrane comprising the hydrogel fibre. A composition comprising an ionic hydrogel and a second component for use in medicine administered in a hydrogel fibre comprising a plurality of compartments is also disclosed.
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