公开(公告)号：WO2022257260A1

公开(公告)日：2022-12-15

申请号：PCT/CN2021/111655

申请日：2021-08-10

Applicant: 河北中化滏恒股份有限公司 ,  有限会社佐藤企画

Inventor： 任建坡 ,  纪烈义 ,  王军生 ,  蒋志强

IPC: C07C13/48 ,  C07C15/24 ,  C07C5/22 ,  C07C5/367 ,  C07C5/42

Abstract: 本发明提供一种1,3－二甲基萘含量少的1,4－二甲基萘的工业制造方法。该1,4－二甲基萘的制造方法中，在酸催化剂的存在下将5－苯基－2－己烯环化，制成粗制1,4－二甲基－1,2,3,4－四氢萘，对将其脱氢而得到的粗制1,4－二甲基萘进行蒸馏精制，该方法中使1,4－二甲基－1,2,3,4－四氢萘中的1,3－二甲基－1,2,3,4－四氢萘浓度相对于1,4－二甲基－1,2,3,4－四氢萘为1.0％以下。

公开(公告)号：WO2022090464A1

公开(公告)日：2022-05-05

申请号：PCT/EP2021/080119

申请日：2021-10-29

Applicant: GIVAUDAN SA

Inventor： CANNELL, Jonathon ,  FINN, Andrew ,  HANSEN, Chad, Allen ,  MARSHALL-HILL, Geoff

IPC: C07C29/80 ,  C07C29/88 ,  C07C35/36 ,  C07C1/24 ,  C07C13/48 ,  A23L27/20 ,  C11B9/02

Abstract: The conversion of nootkatol to nootkatene in a terpene blend is mitigated or prevented by substantially or completely separating the nootkatols such as α-nootkatol from compounds present in the terpene blend that catalyze the chemical reaction of nootkatol to nootkatene, and/or by at least partially neutralizing the compounds present in the terpene blend that catalyze the chemical reaction of nootkatol to nootkatene. Methods of preparing terpene blends, terpene blends, flavour compositions containing the terpene blends, beverages and foodstuffs containing the flavour compositions, fragrance compositions containing the terpene blends, and fragranced products containing the fragrance composition are also disclosed.

公开(公告)号：WO2008124878A1

公开(公告)日：2008-10-23

申请号：PCT/AU2008/000519

申请日：2008-04-14

Applicant: CRYPTOPHARMA PTY LTD ,  STEWART, Alastair ,  BANWELL, Martin ,  LEUNG, Brenda ,  AUGUSTINE, Anu ,  KITCHING, Jacki ,  BILSKI, Tomasz

Inventor： STEWART, Alastair ,  BANWELL, Martin ,  LEUNG, Brenda ,  AUGUSTINE, Anu ,  KITCHING, Jacki ,  BILSKI, Tomasz

IPC: C07C15/12 ,  C07C13/465 ,  C07C205/20 ,  A61K31/015 ,  C07C13/48 ,  C07C251/32 ,  A61K31/025 ,  C07C13/66 ,  C07C251/52 ,  A61K31/04 ,  C07C22/06 ,  C07C251/54 ,  A61K31/15 ,  C07C25/18 ,  C07C251/56 ,  A61K31/36 ,  C07C39/18 ,  C07C251/86 ,  A61K31/365 ,  C07C39/21 ,  C07D231/56 ,  A61K31/416 ,  C07C39/23 ,  C07D271/12 ,  A61P11/06 ,  C07C39/373 ,  C07D317/50 ,  A61P43/00 ,  C07C205/06 ,  C07J41/00 ,  C07C13/19 ,  C07C205/11

CPC classification number: C07C45/68 ,  C07C45/298 ,  C07C45/30 ,  C07C45/59 ,  C07C45/63 ,  C07C45/673 ,  C07C45/71 ,  C07C47/575 ,  C07C49/753 ,  C07C49/84 ,  C07C251/32 ,  C07C251/52 ,  C07C251/54 ,  C07C251/56 ,  C07C251/86 ,  C07D231/56 ,  C07D271/12 ,  C07D317/58

Abstract: The present invention relates to non-steroidal compounds useful in the treatment of inflammatory conditions and pharmaceutical compositions comprising them. A representative example of these compounds is formula (III).

Abstract translation: 本发明涉及用于治疗炎性病症的非甾体化合物和包含它们的药物组合物。 这些化合物的代表性实例是式（III）。

公开(公告)号：WO99018075A1

公开(公告)日：1999-04-15

申请号：PCT/JP1998/004426

申请日：1998-10-01

IPC: A61K20060101 ,  A61K31/025 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4409 ,  A61P5/24 ,  C07C20060101 ,  C07C13/48 ,  C07C39/225 ,  C07C39/23 ,  C07C43/20 ,  C07C43/21 ,  C07D20060101 ,  C07D213/16 ,  C07D213/24 ,  C07D213/44 ,  C07D233/54 ,  C07D233/64

CPC classification number: C07D213/30

Abstract: Dihydronaphthalene compounds represented by chemical formula (1), which have an excellent 17 alpha -hydroxylase/C17-20-lyase inhibitory activity, thromboxane A2 synthesis inhibitory activity, and aromatase inhibitory activity and are useful because of these activities as preventives or remedies for various male and female hormone-dependent diseases such as prostatic cancer, prostatic hypertrophy, masculinism, mammary cancer, and mastopathy, myocardial infarct, angina pectoris, and bronchial asthma.

Abstract translation: 由化学式（1）表示的二氢萘化合物，其具有优异的17α-羟化酶/ C17-20-裂解酶抑制活性，凝血恶烷A2合成抑制活性和芳香酶抑制活性，并且由于这些活性作为预防剂或各种药物 男性和女性激素依赖性疾病，如前列腺癌，前列腺肥大，男性主义，乳腺癌和乳腺病，心肌梗塞，心绞痛和支气管哮喘。

公开(公告)号：WO98033752A1

公开(公告)日：1998-08-06

申请号：PCT/US1998/002345

申请日：1998-02-05

IPC: C07C1/32 ,  C07C13/465 ,  C07C13/48 ,  C07C17/35 ,  C07C25/22 ,  C07F7/08 ,  C07F17/00 ,  C07C2/02 ,  C07C19/08 ,  C07C22/00 ,  C07C25/00

CPC classification number: C07F17/00 ,  C07C1/326 ,  C07C17/35 ,  C07C25/22 ,  C07C2602/08 ,  C07C13/465

Abstract: Novel 2-substituted 7-haloindenes and methods for synthesizing such indenes are described. The 2-substituted 7-haloindenes may be coupled with any aryl group to produce a metallocene catalyst intermediate.

Abstract translation: 描述了新的2-取代的7-卤代茚和用于合成这种茚的方法。 2-取代的7-卤代茚可以与任何芳基偶联以产生茂金属催化剂中间体。

公开(公告)号：WO2022165395A1

公开(公告)日：2022-08-04

申请号：PCT/US2022/014658

申请日：2022-02-01

Applicant: THE UNIVERSITY OF TOLEDO

Inventor： ERHARDT, Paul ,  LIU, Shi-He ,  BRUNICARDI, Francis, Charles ,  ANDY, Divya

IPC: A61K31/155 ,  C07C69/74 ,  C07C13/48 ,  C07C13/47 ,  A61P35/00 ,  C07C13/32

Abstract: Stably consolidated compounds assembled from a statin and a metformin analog, and metabolically labile dual prodrugs assembled from the same, methods of making both, and methods of using them to treat metabolic diseases such as cancers are described.

公开(公告)号：WO2016187377A1

公开(公告)日：2016-11-24

申请号：PCT/US2016/033185

申请日：2016-05-19

Applicant: NORTHEASTERN UNIVERSITY

Inventor： BOOTH, Raymond, G.

IPC: C07C13/48 ,  C07C23/36

CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/12 ,  C07C211/42 ,  C07C217/74 ,  C07C2601/08 ,  C07C2602/10

Abstract: This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor in the Gl tract.

Abstract translation: 本发明部分地涉及可用于治疗各种疾病的组合物和方法，所述各种疾病包括与Gl途径中的5-羟色胺受体结合相关的疾病。

公开(公告)号：WO2016028571A3

公开(公告)日：2016-02-25

申请号：PCT/US2015/044876

申请日：2015-08-12

Applicant: CORNELL UNIVERSITY

Inventor： LIN, Gang ,  NATHAN, Carl ,  SINGH, Pradeep, K.

IPC: A61K38/02 ,  C07C13/48 ,  C07C15/14

Abstract: The compounds of the present invention are represented by the following compounds having Formula I, where the substituents R1, R4, L, M, X, Y, and s are as defined herein. The compounds of the present invention are also represented by the following compounds having Formula (la), Formula (lb ), or Formula (Ic), where the substituents R1-R4, RX, RY, X, Y, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.

公开(公告)号：WO0151450A3

公开(公告)日：2003-07-10

申请号：PCT/US0101071

申请日：2001-01-12

Applicant: BP CORP NORTH AMERICA INC

Inventor： MACEK JOHN A ,  ROSEN BRUCE I ,  HOLZHAUER JUERGEN K ,  BRAMLET JOHN S ,  LILLWITZ LAWRENCE D ,  SCHNEIDER DAVID J ,  LANG LAWRENCE L ,  PASCHKE EDWARD E ,  WEIS JOHN M ,  VISWANATH YENAMANDRA ,  SAKELLARIDES STEFANOS L

IPC: C07B61/00 ,  C07C2/56 ,  C07C5/22 ,  C07C5/367 ,  C07C7/04 ,  C07C7/14 ,  C07C13/48 ,  C07C15/24 ,  C07C15/44 ,  C07C51/265 ,  C07C63/38 ,  C07C67/08 ,  C07C69/76 ,  C08G63/181 ,  C08G63/189 ,  C08G69/26

CPC classification number: C08G69/265 ,  C07C5/367 ,  C07C67/08 ,  C08G63/189 ,  C08G69/26 ,  C07C15/24 ,  C07C69/76

Abstract: The synthesis of dimethyl-1,5-naphthalenedicarboxylate and polymers and articles formed therefrom is disclosed, as well as applications for dimethyl-1,5-naphthalenedicarboxylate, its corresponding acid 1,5-NDA, and various synthesis intermediates.

Abstract translation: 公开了1,5-萘二甲酸二甲酯及其形成的聚合物和制品的合成，以及1,5-萘二羧酸二甲酯，其相应的酸1,5-萘二甲酸和各种合成中间体的应用。

公开(公告)号：WO0244191A3

公开(公告)日：2003-04-17

申请号：PCT/US0144334

申请日：2001-11-27

Applicant: UNIV CALIFORNIA ,  JACOBS ROBERT S ,  KERR RUSSELL G

Inventor： JACOBS ROBERT S ,  KERR RUSSELL G

IPC: A61P29/00 ,  C07H15/24 ,  A61K31/704 ,  C07C13/48 ,  C07C39/17 ,  C07C49/737 ,  C07C49/753 ,  C07C50/14 ,  C07C50/32 ,  C07C69/14 ,  C07H15/203

CPC classification number: C07H15/24

Abstract: Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula (I) wherein R1 is a hydrogen, alkyl, aryl, hydroxyalkyl, cycloalkyl, cycloalkenyl, carboxylic acid, alkylamino or amide group having from 2 to 20 carbon atoms, R2, R3, and R4 are each independently hydrogen or an acyl residue having from 1 to 6 carbon atoms, R5 is hydrogen, CH3, or CH2OH, and R6 is an organo group such as a hydrocarbon having from 1 to 10 carbon atoms are disclosed. Other seco-pseudopterosins and compounds related to pseudopterosins are disclosed.

Abstract translation: 用于治疗，预防或抑制与炎症，细胞增殖和疼痛相关的疾病和病症的方法，包括施用具有结构式（I）的化合物，其中R 1是氢，烷基，芳基，羟基烷基，环烷基，环烯基， 羧酸，具有2至20个碳原子的烷基氨基或酰胺基，R 2，R 3和R 4各自独立地为氢或具有1至6个碳原子的酰基，R 5为氢，CH 3或CH 2 OH，并且R 6为 公开了具有1至10个碳原子的有机基团。 公开了其他与假飞虱相关的鳞翅目和化合物。