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    PROCESS FOR THE PREPARATION OF STROBILURIN INTERMEDIATES
    11.
    发明申请
    PROCESS FOR THE PREPARATION OF STROBILURIN INTERMEDIATES 审中-公开
    制备骨髓素中间体的方法

    公开(公告)号：WO00034229A1

    公开(公告)日：2000-06-15

    申请号：PCT/EP1999/009705

    申请日：1999-12-09

    IPC分类号： C07B61/00 ,  C07C45/00 ,  C07C49/233 ,  C07C249/04 ,  C07C249/08 ,  C07C249/12 ,  C07C251/48

    CPC分类号： C07C249/08 ,  C07C45/54 ,  C07C49/233 ,  C07C251/48

    摘要： The present invention relates to a novel improved process and intermediates for the process of preparing the oxime intermediates of formula (II) wherein R1 is hydrogen, fluoro or chloro, and R2 is methyl, ethyl, methoxy, ethoxy, trifluoromethyl, trifluoromethoxy, cyano, fluoro, chloro or bromo. The novel process comprises diazotizing an aniline of formula (VI) reacting the resulting diazonium salt with isopropenylacetate of formula (X) and reacting the resulting ketone of formula (XI) with an organic nitrite in the presence of hydrogene chloride, and methylating the resulting ketooxime of formula (VIII) with a methylating agent and reacting the resulting O-methyl ketooxime of formula (IX) with hydroxylamine. The compounds of formula (II) are intermediates for highly active fungicides from the class of the strobilurins.

    摘要翻译： 本发明涉及制备式（II）的肟中间体的方法和中间体，其中R1是氢，氟或氯，R2是甲基，乙基，甲氧基，乙氧基，三氟甲基，三氟甲氧基，氰基， 氟，氯或溴。 该新方法包括使式（Ⅵ）的苯胺重氮化，使得到的重氮盐与式（X）的异丙烯基乙酸酯反应，并使所得的式（Ⅺ）酮与有机亚硝酸酯在氯化氢存在下反应，并使所得酮肟甲基化 （VIII）与甲基化剂反应，并使所得的式（IX）的O-甲基酮肟与羟胺反应。 式（II）化合物是来自嗜球果伞素类的高活性杀真菌剂的中间体。

    PROCESSES FOR THE HYDROGENATION OF α,β-UNSATURATED KETONES
    17.
    发明申请
    PROCESSES FOR THE HYDROGENATION OF α,β-UNSATURATED KETONES 审中-公开
    氢化不饱和酮的方法

    公开(公告)号：WO2008057915A1

    公开(公告)日：2008-05-15

    申请号：PCT/US2007/083295

    申请日：2007-11-01

    申请人： ALBEMARLE CORPORATION ,  BELMONT, Stephen, E.

    发明人： BELMONT, Stephen, E.

    IPC分类号： C07C45/62

    CPC分类号： C07C45/62 ,  C07C49/233

    摘要： The catalytic hydrogenation of α,β-unsaturated ketones R 1 -CH=CH-CO-R 2 in which R 1 and R 2 independently of one another represent straight-chain or branched C 1 -C 12 -alkyl or C 2 -C 12 -hydroxyalkyl, straight-chain or branched C 2 -C 12 -alkenyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkenyl, C 7 -C 14 -aralkyl or C 6 -C 12 -aryl, where at least one of R 1 and R 2 is monosubstituted to trisubstituted by halogen, to give the respective saturated ketones R 11 -CH2-CH2-CO-R 12 in which R 11 and R 12 assume the meaning of R 1 and R 2 with the exception that alkenyl and cycloalkenyl are hydrogenated to the respective alkyl or cycloalkyl, wherein the hydrogenation process comprises combining the α,β-υnsaturated ketones and a reaction medium comprising a C 4 -C 10 alcohol and water in about a 1:2 to about a 2:1 mass ratio, and the hydrogenation is earned out in the presence of (i) basic substance comprising organic amine, (ii) Ni-containing catalyst, and (iii) organic sulphur compound.

    摘要翻译： α，β-不饱和酮R 1 -CH = CH-CO-R 2的催化氢化，其中R 1和R 2 > 2个彼此独立地表示直链或支链C 1 -C 12 - C 1 -C 12 - 烷基或C 2 -C 2 - 直链或支链C 2 -C 12亚烷基，C 3 -C 12亚烷基，C 3 -C 12亚烷基， C 8 - 环烷基，C 3 -C 8 - 环烯基，C 7 -C 14 - 芳烷基或C 6 -C 12 - 芳基，其中R 1和R 2中的至少一个是 由卤素单取代至三取代，得到相应的饱和酮R 11 -CH 2 -CH 2 -CO-R 12，其中R 11和R 24 假设R 1和R 2的含义除了烯基和环烯基被氢化成各自的烷基或环烷基之外，其中氢化 方法包括将α，β-不饱和酮和反应介质组合物组合 是以大约1:2至大约2:1的质量比形成C 4 -C 10 - 醇和水，并且在（ i）包含有机胺的基本物质，（ii）含Ni催化剂和（iii）有机硫化合物。

    A NOVEL SYNTHETIC ROUTE FOR OBTAINING 1-(4-CHLOROPHENYL)-4,4-DIMETHYL-PENTANE-3-ONE
    20.
    发明申请
    A NOVEL SYNTHETIC ROUTE FOR OBTAINING 1-(4-CHLOROPHENYL)-4,4-DIMETHYL-PENTANE-3-ONE 审中-公开
    用于获得1-（4-氯苯基）-4,4-二甲基 - 戊烷-3-酮的新型合成路线

    公开(公告)号：WO00044703A2

    公开(公告)日：2000-08-03

    申请号：PCT/IL2000/000063

    申请日：2000-01-30

    IPC分类号： C07C45/68 ,  C07C49/00

    CPC分类号： C07C45/68 ,  C07C49/233

    摘要： 1-(4-chlorophenyl)-4,4-dimethyl-pentane-3-one of formula (I) is prepared by the alkylation of pinacolone (3,3-dimethyl-2-butanone) with p-chlorobenzylchloride where the pinacolone is used both as a reagent and the solvent. The alkylation is done under either Phase Transfer Catalysis conditions in the presence of a base or in the presence of a strong base.

    摘要翻译： 式（I）的1-（4-氯苯基）-4,4-二甲基 - 戊烷-3-酮通过频哪酮（3,3-二甲基-2-丁酮）与对氯苄基氯化物的烷基化来制备， 用作试剂和溶剂。 烷基化在相转移催化条件下在碱存在下或在强碱存在下进行。