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    CARBONYL DERIVATIVES HAVING A C3 SYMMETRY, THEIR PREPARATION AND USES THEREOF
    56.
    发明申请
    CARBONYL DERIVATIVES HAVING A C3 SYMMETRY, THEIR PREPARATION AND USES THEREOF 审中-公开
    具有C3对称性的羰基衍生物及其制备及其用途

    公开(公告)号：WO2010038252A2

    公开(公告)日：2010-04-08

    申请号：PCT/IT2009000449

    申请日：2009-10-02

    Applicant: UNIV ROMA ,  BAGALA RAMPAZZO LILIANA ,  MATIELLO LEONARDO

    Inventor： BAGALA RAMPAZZO LILIANA ,  MATIELLO LEONARDO

    IPC: C07C49/675 ,  C07C45/46 ,  C09K11/06 ,  H01L51/50

    CPC classification number: H01L51/0058 ,  C07C45/28 ,  C07C45/46 ,  C07C49/675 ,  C07C49/788 ,  C07C49/792 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1048 ,  H01L51/5048 ,  H05B33/14 ,  Y02E10/549 ,  Y02P70/521

    Abstract: The invention relates to 1,3,5-benzene derivatives and corresponding radical-anions and radical-cations of the general formula (I): wherein: Z is a group chosen from among C=O, CONH, CONR, CONAr; m is an integer >0, preferably m = 1; A is a group chosen from among the radicals of: biphenylene, carbazole, fluoranthene, fluorene, dibenzothiofene, dibenzofurane, fluorenone, bifluorenylidene, triphenylene, cyclooctatetraene (COT), dibenzocyclooctatetraene (DBCOT), coronene, acenaphtylene, triptycene, azulene, benzo(ghi)fluoranthene, 2-phenyl-l,3,4-oxadiazole, anthracene. R and Ar are alkyl and aryl respectively and have the meaning indicated herein below. The invention also relates to the method for synthesizing said compounds and to their use in particular as components of matrices in the molecular electronics, spintronics and telecom fields.

    Abstract translation: 本发明涉及通式（I）的1,3,5-苯衍生物和相应的自由基阴离子和自由基：其中：Z是选自C = O，CONH，CONR，CONAr; m是整数> 0，优选m = 1; A是选自以下的基团：亚联苯基，咔唑，荧蒽，芴，二苯并噻嗯，二苯并呋喃，芴酮，二芴基，三亚苯，环辛四烯（COT），二苯并环辛四烯（DBCOT），咔唑，苊烯，三萜烯，薁，苯并（ghi ）荧蒽，2-苯基-1,3,4-恶二唑，蒽。 R和Ar分别为烷基和芳基，具有下文所示的含义。 本发明还涉及用于合成所述化合物的方法及其在分子电子学，自旋电子学和电信领域中特别用作基质的组分的用途。

    HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE
    60.
    发明申请
    HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE 审中-公开
    杂环化合物，其制备和使用

    公开(公告)号：WO1996015099A1

    公开(公告)日：1996-05-23

    申请号：PCT/DK1994000421

    申请日：1994-11-09

    Applicant: NOVO NORDISK A/S ,  PELLICCIARI, Roberto ,  LUNEIA, Roberto ,  LOMBARDI, Grazia ,  MORONI, Flavio

    Inventor： NOVO NORDISK A/S

    IPC: C07C229/46

    CPC classification number: C07D257/04 ,  C07C17/2637 ,  C07C45/30 ,  C07C45/46 ,  C07C61/39 ,  C07C63/49 ,  C07C229/50 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/42 ,  C07D307/84 ,  C07D333/68 ,  C07C22/04 ,  C07C47/546 ,  C07C49/84 ,  C07C49/792

    Abstract: The present invention relates to therapeutically active heterocyclic compounds of formula (I) wherein n is 0, 1 or 2; and X is -O-, -S, -N(R )- or -CH2-; and R is H, NH2, NHR or OH; and R and R independently are H, COOH, COOR , CONH2, CONHR , CON(R )2, CONHSO2R or tetrazole; and R is H, OH, NH2, NHR , CF3, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, C3-6-cycloalkyl, phenyl or C1-4-alkoxy; and R is H, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, phenyl or C3-6-cycloalkyl; and ring A can be partly or completely saturated or aromatic, or a salt thereof with a pharmaceutically acceptable acid or base, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system related to the metabotropic glutamate receptor system.

    Abstract translation: 本发明涉及式（I）的治疗活性杂环化合物，其中n为0,1或2; 并且X是-O - ， - S，-N（R 5） - 或-CH 2 - ; 并且R 1是H，NH 2，NHR 5或OH; R 2和R 3独立地是H，COOH，COOR 5，CONH 2，CONHR 5，CON（R 5）2，CONHSO 2 R 5或四唑; 和R 4是H，OH，NH 2，NHR 5，CF 3，C 1-8烷基，C 2-8 - 烯基，C 2-8 - 炔基，C 3-6 - 环烷基，苯基或C 1-4 - 烷氧基 ; R 5为H，C 1-8 - 烷基，C 2-8 - 烯基，C 2-8 - 炔基，苯基或C 3-6 - 环烷基; 并且环A可以是部分或完全饱和的或芳族的，或其与药学上可接受的酸或碱的盐，其制备方法和包含该化合物的药物组合物。 该新化合物可用于治疗与代谢型谷氨酸受体系统相关的中枢神经系统疾病。

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