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    SUBSTITUED OXAZOLES AND THIAZOLES AS HPPAR ALPHA AGONISTS
    72.
    发明申请
    SUBSTITUED OXAZOLES AND THIAZOLES AS HPPAR ALPHA AGONISTS 审中-公开
    作为HPPAR ALPHA AGONISTS的替代奥沙唑和噻唑

    公开(公告)号：WO02050047A1

    公开(公告)日：2002-06-27

    申请号：PCT/EP2001/014886

    申请日：2001-12-18

    IPC: A61K31/426 ,  A61P1/14 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P29/00 ,  A61P43/00 ,  C07D277/20 ,  C07D277/22 ,  C07D277/24 ,  C07D277/26 ,  C07D277/58

    CPC classification number: C07D277/24 ,  C07D277/26

    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof wherein X is O or S; X is O or S; X is S or O; R and R are independently H, methyl, or halogen; R and R are independently H or C1-3 alkyl or R and R may, together with the carbon atom to which they are bonded, form a 3-5 membered cycloalkyl ring; R and R are independently H, C1-3 alkyl, or allyl; each R is independently halogen, C1-6 straight or branched alkyl, or CF3; and y is 0, 1, 2, 3, 4 or 5 act as hPPAR alpha agonists.

    Abstract translation: 式（I）化合物及其药学上可接受的盐，溶剂合物和可水解的酯，其中X是O或S; X 1是O或S; X是S或O; R 1和R 2独立地是H，甲基或卤素; R 4和R 5独立地为H或C 1-3烷基或R 4和R 5可以与它们所键合的碳原子一起形成3-5元环烷基环; R 6和R 7独立地为H，C 1-3烷基或烯丙基; 每个R 3独立地是卤素，C 1-6直链或支链烷基或CF 3; y为0,1,2,3,4或5作为hPPARα激动剂。

    LINKER ARMS FOR NANOCRYSTALS AND COMPOUNDS THEREOF
    73.
    发明申请
    LINKER ARMS FOR NANOCRYSTALS AND COMPOUNDS THEREOF 审中-公开
    关于纳米晶体及其化合物的链接

    公开(公告)号：WO0190716A3

    公开(公告)日：2002-04-04

    申请号：PCT/US0116739

    申请日：2001-05-24

    Applicant: UNIV VANDERBILT

    Inventor： ROSENTHALL SANDRA J ,  TOMLINSON IAN D ,  KIPPENY TADD

    IPC: C07C323/12 ,  C07C323/16 ,  C07D209/16 ,  C07D277/24 ,  C07D277/26 ,  C07D295/135 ,  C07D451/02 ,  C07D451/14 ,  G01N33/58 ,  C07C43/205 ,  A61K31/095 ,  C07C323/25

    CPC classification number: C07D295/135 ,  B82Y15/00 ,  C07C323/12 ,  C07C323/16 ,  C07D209/16 ,  C07D277/24 ,  C07D277/26 ,  C07D451/02 ,  C07D451/14 ,  G01N33/588

    Abstract: This invention generally relates to nanocrystal compounds, and linker arm for nanocrystal compounds that attach the nanocrystals to the organic compounds. The nanocrystal compound comprises a nanocrystal, linker arm, and organic compound. Preferably, the organic compound is a biologically active compound that can provide a fluorescent sensor. Preferably, the linker arm is a polyether chain with an attachment point for the nanocrystal and an attachment point for the organic compound. Specifically, the nanocrystal is attached to the linker arm through a R group and the organic compound is attached to the linker arm through a R2 group.R is a bond or is selected from the group consisting of: SH, O(CH2(n)O)nSH, NH(CH2(n)O)nSH, NH(CH2(n)NH)SH, S(CH2(n)O)nSH, and S(CH2(n)S)SH. n is 1-10, with S being attached to the nanocrystal. R2 is a bond or selected from the group consisting of carbonyl, NH, S, CONH, COO, S, C1-10 alkyl, carbamate, and thiocarbamate.

    Abstract translation: 本发明一般涉及将纳米晶体附着到有机化合物上的纳米晶体化合物和用于纳米晶体化合物的连接臂。 纳米晶体化合物包括纳米晶体，连接臂和有机化合物。 优选地，有机化合物是可以提供荧光传感器的生物活性化合物。 优选地，连接臂是具有纳米晶体的附着点和有机化合物的附着点的聚醚链。 具体地，纳米晶体通过R基团连接到连接臂上，有机化合物通过R 2基团连接到连接臂上.R是键或选自：SH，O（CH 2（n） O）nSH，NH（CH 2（n）O）n SH，NH（CH 2（n）NH）SH，S（CH 2（n）O）n SH和S（CH 2（n） n是1-10，其中S连接到纳米晶体上。 R2是选自羰基，NH，S，CONH，COO，S，C 1-10烷基，氨基甲酸酯和硫代氨基甲酸酯的键。

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