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    USE OF CATIONIC SURFACTANTS FOR THE PROTECTION AGAINST TOOTH EROSION
    3.
    发明申请
    USE OF CATIONIC SURFACTANTS FOR THE PROTECTION AGAINST TOOTH EROSION 审中-公开
    使用阳离子表面活性剂防止牙齿腐蚀

    公开(公告)号：WO2009101115A1

    公开(公告)日：2009-08-20

    申请号：PCT/EP2009/051587

    申请日：2009-02-11

    Applicant: LABORATORIOS MIRET, S.A. ,  ROCABAYERA BONVILA, Xavier ,  FIGUERAS ROCA, Sergi ,  SEGRET PONS, Roger ,  PIERA EROLES, Eva

    Inventor： ROCABAYERA BONVILA, Xavier ,  FIGUERAS ROCA, Sergi ,  SEGRET PONS, Roger ,  PIERA EROLES, Eva

    IPC: A61Q11/00 ,  A23G4/12

    CPC classification number: A61Q11/00 ,  A23G3/364 ,  A23G3/40 ,  A23G4/066 ,  A23G4/12 ,  A23V2002/00 ,  A61K8/0216 ,  A61K8/44 ,  A61K8/494 ,  A23V2200/312 ,  A23V2200/222

    Abstract: This invention relates to a use of a composition for protecting oral cavity and teeth containing ethyl-Nα-lauroyl-L-arginate HCI (LAE), a corresponding composition and a corresponding method for protecting teeth. Because of nearly epidemic incidence of dental erosion, there is a continuing need for improved products that provide protection against dental erosion. Hence, it is an object of the present invention to protect teeth against dental erosion. Surprisingly, it has been found that ethyl-Nα-lauroyl-L-arginate HCI (LAE) and its salts attach to teeth and provide protection of teeth from erosion especially caused by the action of acid in food products and drinks such as chewing gum and lozenges compositions. Special advantages of this invention are: (a) sustained coating of the teeth by LAE and its homologues; (b) the coating agent provides a source of neutralizing plaque acids by providing sustained base formation. This is because arginines in LAE is degraded by bacteria on tooth in the mouth to produce ammonia. Thus, this chemistry not only provides the coating protection but also generates base to maintain pH balance on a sustained basis; and (c) avoid the use of brushing with abrasive cleansers.

    Abstract translation: 本发明涉及用于保护含有月桂酰-L-精氨酸乙酯钠盐（LAE）的口腔和牙齿的组合物的用途，相应的组合物和相应的保护牙齿的方法。 由于牙齿侵蚀发生几乎流行，因此继续需要提供防止牙齿侵蚀的改良产品。 因此，本发明的目的是保护牙齿免受牙齿侵蚀。 令人惊讶的是，已经发现乙基 - 月桂酰-L-精氨酸盐酸盐（LAE）及其盐附着在牙齿上，并且保护牙齿免受侵蚀，特别是由于酸在食品和饮料中的作用引起的，例如口香糖和 锭剂组合物 本发明的特殊优点是：（a）通过LAE及其同系物持续涂覆牙齿; （b）涂层剂通过提供持续的碱形成提供中和斑块酸源。 这是因为LAE中的精氨酸被口腔中的牙齿上的细菌降解以产生氨。 因此，这种化学不仅提供了涂层保护，而且还产生了基础，以持续地维持pH平衡; 和（c）避免使用磨料清洁剂进行刷牙。

    ANTIVIRAL USE OF CATIONIC SURFACTANT
    6.
    发明申请
    ANTIVIRAL USE OF CATIONIC SURFACTANT 审中-公开
    阳离子表面活性剂的有害使用

    公开(公告)号：WO2008014824A1

    公开(公告)日：2008-02-07

    申请号：PCT/EP2006/065035

    申请日：2006-08-03

    Applicant: LABORATORIOS MIRET, S.A. ,  ROCABAYERA BONVILA, Xavier ,  FIGUERAS ROCA, Sergi ,  SEGRET PONS, Roger

    Inventor： ROCABAYERA BONVILA, Xavier ,  FIGUERAS ROCA, Sergi ,  SEGRET PONS, Roger

    IPC: A61K31/16 ,  A61P31/12

    CPC classification number: A61K31/16

    Abstract: Cationic surfactants derived from the condensation of fatty acids and esterified dibasic amino acids, such as from lauric acid and arginine, in particular the ethyl ester of the lauramide of the arginine monohydrochloride (LAE), may be used for the protection against the growth of the microorganisms. The cationic surfactants of this type are also effective against virus infections. Addition of LAE to cultures of Herpes virus type 1 Vaccinia virus and bovine parainfluenzae 3 virus leads to nearly complete reduction of the virus organisms in these cultures, such effects being observed after 5 and 60 minutes.

    Abstract translation: 衍生自脂肪酸和酯化的二元氨基酸（例如月桂酸和精氨酸），特别是精氨酸一盐酸盐（LAE）的月桂酰胺的乙酯的缩合产生的阳离子表面活性剂可用于防止生长 微生物。 这种阳离子表面活性剂对于病毒感染也是有效的。 在1型疱疹病毒和牛副流感病毒3病毒的培养物中添加LAE导致这些培养物中病毒生物体的几乎完全减少，在5和60分钟后观察到这种效应。

    PRESERVATIVE SYSTEMS COMPRISING CATIONIC SURFACTANTS
    9.
    发明申请
    PRESERVATIVE SYSTEMS COMPRISING CATIONIC SURFACTANTS 审中-公开
    包含阳离子表面活性剂的防腐剂系统

    公开(公告)号：WO2007014580A1

    公开(公告)日：2007-02-08

    申请号：PCT/EP2005/053735

    申请日：2005-08-01

    Applicant: LABORATORIOS MIRET, S.A. ,  MIRET CARCELLER, Jordi ,  FIGUERAS ROCA, Sergi ,  SEGRET PONS, Roger

    Inventor： MIRET CARCELLER, Jordi ,  FIGUERAS ROCA, Sergi ,  SEGRET PONS, Roger

    IPC: A61K8/44 ,  A23L3/00 ,  A61K8/49 ,  A61Q19/10

    CPC classification number: A61Q19/10 ,  A23B4/20 ,  A23B4/24 ,  A23B7/154 ,  A23B7/157 ,  A23L3/3508 ,  A23L3/3517 ,  A23L3/3526 ,  A23L3/3544 ,  A23L3/358 ,  A61K8/44 ,  A61K8/442 ,  A61K8/4946 ,  A61K2800/524 ,  A61Q19/00 ,  Y02A40/944

    Abstract: Preservative systems on the basis of cationic surfactants are known i n the art, a typical example of such cationic surfactants is the ethyl ester of the lauramide of arginine monohydrochloride ( LAE ) (2). Besides the chloride form the corresponding bromide and sulphate salts are known. It was found that other salts of the cationic surfactants display excellent properties, such as the salts oflactic acid, glutamic acid and acetic acid. It was further found that the combination of the cationic surfactants with at least one salt of an organic or inorganic acid displayed an excellent preservative action. A further preservative system with favourable properties was the combination of the cationic surfactants with at least one ester compound, amide or enzyme inhibitor. Also the combination of the cationic surfactant with a further cationic molecule such as ethyl arginate, glucosamine or chitosan led to an effective preservative system. A further effective preservative system turned out to be the cationic surfactant in encapsulated form.

    Abstract translation: 基于阳离子表面活性剂的防腐剂体系是本领域已知的，这种阳离子表面活性剂的典型实例是精氨酸一盐酸盐（LAE）的月桂酰胺的乙酯（2）。 除了氯化物形式之外，已知相应的溴化物和硫酸盐。 发现阳离子表面活性剂的其它盐显示出优异的性质，例如乳酸，谷氨酸和乙酸的盐。 进一步发现阳离子表面活性剂与有机或无机酸的至少一种盐的组合显示出优异的防腐作用。 阳离子表面活性剂与至少一种酯化合物，酰胺或酶抑制剂的组合具有良好性能的另外的防腐剂体系。 此外，阳离子表面活性剂与另外的阳离子分子如精氨酸乙酯，葡糖胺或壳聚糖的组合导致有效的防腐剂体系。 另一种有效的防腐剂体系证明是封装形式的阳离子表面活性剂。

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