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40 条记录 (耗时 0.031 秒)

    MODIFIED MICROORGANISM FOR IMPROVED PRODUCTION OF SUCCINATE
    11.
    发明公开
    MODIFIED MICROORGANISM FOR IMPROVED PRODUCTION OF SUCCINATE 审中-公开

    公开(公告)号：EP3502241A1

    公开(公告)日：2019-06-26

    申请号：EP17209645.5

    申请日：2017-12-21

    申请人： BASF SE

    发明人： HOFF, Birgit ,  BOEHMER, Nico ,  HAEFNER, Stefan ,  SCHROEDER, Hartwig ,  ZELDER, Oskar ,  WITTMANN, Christoph ,  SCHROER, Anna Christine

    IPC分类号： C12N9/02 ,  C12P7/46

    摘要： The present invention relates to a process of producing an organic compound, the process comprising
    I) cultivating a genetically modified microorganism in a culture medium comprising at least one assimilable carbon source to allow the genetically modified microorganism to produce the organic compound,
    II) recovering the organic compound from the fermentation broth obtained in process step I), wherein the genetically modified microorganism comprises
    A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the udhA -gene, compared to the original microorganism that has not been genetically modified,

    and wherein the original microorganism belongs to the family Pasteurellaceae.
    The present invention also relates to a genetically modified microorganism and to the use thereof for the fermentative production of an organic compound from at least one assimilable carbon source.

    THE USE OF GLYCEROL WITH LIMITED FEED OF CARBOHYDRATES FOR FERMENTATION
    12.
    发明公开
    THE USE OF GLYCEROL WITH LIMITED FEED OF CARBOHYDRATES FOR FERMENTATION 审中-公开
    佛罗伦萨VERBENRENZTERZUFÜHRUNGVON KOHLENHYDRATEN ZUR FERMENTIERUNG

    公开(公告)号：EP3119898A1

    公开(公告)日：2017-01-25

    申请号：EP15711141.0

    申请日：2015-03-18

    申请人： BASF SE

    发明人： DANTAS COSTA, Esther ,  ZELDER, Oskar ,  SCHRÖDER, Hartwig ,  HAEFNER, Stefan ,  KRAWCZYK, Joanna Martyna ,  VON ABENDROTH, Gregory ,  RIEDELE, Christian ,  RENZ, Torsten

    IPC分类号： C12P7/46 ,  C12N9/04 ,  C12N9/10 ,  C07K14/285

    CPC分类号： C12N9/0006 ,  C07K14/285 ,  C12N9/1029 ,  C12P7/46 ,  C12Y101/01027 ,  C12Y203/01054

    摘要： The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).

    摘要翻译： 本发明涉及通过发酵生产有机酸的方法，包括以下工艺步骤：I）在作为可同化碳源进料的培养基中培养微生物甘油和另外的碳质化合物，以使微生物 产生有机酸，从而得到包含有机酸的发酵液; II）从方法步骤I）中获得的发酵液中回收有机酸或其盐; 其中，至少在处理步骤I）中的一段时间内，进一步的碳质化合物（CRc.c;以g / l / h）的消耗速率低于进一步的碳质化合物的最大理论消耗速率 （CRc.c.max;以g每升/小时计）。

    PROCESSES AND RECOMBINANT MICROORGANISMS FOR THE PRODUCTION OF CADAVERINE
    14.
    发明公开
    PROCESSES AND RECOMBINANT MICROORGANISMS FOR THE PRODUCTION OF CADAVERINE 审中-公开
    VERFAHREN UND REKOMBINANTER MIKROORGANISMUS ZUR HERSTELLUNG VON CADAVERIN

    公开(公告)号：EP2513302A1

    公开(公告)日：2012-10-24

    申请号：EP10795316.8

    申请日：2010-12-15

    申请人： BASF SE

    发明人： SCHRÖDER, Hartwig ,  JEONG, Weol Kyu ,  SERWE, Annegret ,  ZELDER, Oskar

    IPC分类号： C12N9/88 ,  C12P13/00 ,  C12R1/15

    CPC分类号： C12N9/88 ,  C12P13/001

    摘要： The present invention relates to the use of recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine, as well as to recombinant DNA molecules and polypeptides used to produce the microorganism, said microorganism comprising an intracellular lysine decarboxylase activity and an enhanced lysine import activity or comprising an intracellular and an extracellular lysine decarboxylase activity or comprising an intracellular and extracellular lysine decarboxylase activity and an enhanced lysine import activity. The present invention also relates to a processes for the production of cadaverine using recombinant microorganisms.

    摘要翻译： 本发明涉及包含DNA分子的重组微生物在脱氨酸形式中的用途，其改善了尸胺的产生，以及用于产生微生物的重组DNA分子和多肽，所述微生物包含细胞内赖氨酸脱羧酶活性和增强的 赖氨酸进入活性或包含细胞内和细胞外赖氨酸脱羧酶活性或包含细胞内和细胞外赖氨酸脱羧酶活性和增强的赖氨酸进口活性。 本发明还涉及使用重组微生物生产尸胺的方法。

    GENETICALLY MODIFIED MICROORGANISM FOR IMPROVED PRODUCTION OF FINE CHEMICALS ON SUCROSE
    17.
    发明公开
    GENETICALLY MODIFIED MICROORGANISM FOR IMPROVED PRODUCTION OF FINE CHEMICALS ON SUCROSE 审中-公开
    自由之家MIKROORGANISMUS ZUR VERBESSERTEN HERSTELLUNG VON FEINCHEMIKALIEN AUF SUCROSE

    公开(公告)号：EP3140412A1

    公开(公告)日：2017-03-15

    申请号：EP15735633.8

    申请日：2015-05-07

    申请人： BASF SE

    发明人： KRAWCZYK, Joanna Martyna ,  HAEFNER, Stefan ,  SCHROEDER, Hartwig ,  ZELDER, Oskar

    IPC分类号： C12P7/46 ,  C12R1/01 ,  C12N9/12

    CPC分类号： C12N15/102 ,  C07K14/195 ,  C12N15/74 ,  C12N2510/02 ,  C12P7/46 ,  C12Y207/11

    摘要： The present invention relates to a modified microorganism having, compared to its wildtype,—a reduced activity of an enzyme encoded by the ptsA-gene,—a reduced activity of an enzyme encoded by the ptsH-gene or—a reduced activity of an enzyme encoded by the ptsA-gene and a reduced activity of an enzyme encoded by the ptsH-gene, wherein the wildtype from which the modified microorganism has been derived belongs to the family of Pasteurellaceae. The present invention also relates to a method for producing succinic acid and to the use of modified microorganisms.

    摘要翻译： 本发明涉及一种经修饰的微生物，其与野生型相比具有降低的由ptsA基因编码的酶的活性， - 由ptsH基因编码的酶的活性降低或酶活性降低 由ptsA基因编码并且由ptsH基因编码的酶的活性降低，其中已经衍生了经修饰的微生物的野生型属于巴氏杆菌科。 本发明还涉及生产琥珀酸的方法和使用改性微生物。