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    NEAR REAL TIME OPTICAL PHASE CONJUGATION
    15.
    发明公开
    NEAR REAL TIME OPTICAL PHASE CONJUGATION 有权
    快速实时光相位共轭

    公开(公告)号：EP2478466A1

    公开(公告)日：2012-07-25

    申请号：EP10816257.9

    申请日：2010-09-14

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： HENG, Xin

    IPC: G06K9/00

    CPC classification number: A61B18/203 ,  A61B2018/00452 ,  A61B2018/00642 ,  A61B2018/00779 ,  G01N21/4795 ,  G01N2201/0675 ,  G02B26/06 ,  G03H1/0443 ,  G03H1/2294 ,  G03H2001/0072

    Abstract: An optical system and associated method enable near real time optical phase conjugation. In the method, a translucent medium is illuminated by a sample illumination beam. Light scattered by the medium is directed to an electronic image sensor while a reference beam is also directed to the electronic image sensor. The scattered light and the reference beam form an interference pattern at the electronic image sensor. A digital representation of the interference pattern is recorded using the electronic image sensor, and the characteristics of a conjugate of the sample beam are computed from the numerical representation. A conjugate beam having the computed characteristics is generated using a configurable optical element and directed back to the translucent medium. The generation of the conjugate beam may be accomplished using a spatial light modulator.

    DEVICE AND METHOD FOR OPTICALLY EXAMINING THE INTERIOR OF A TURBID MEDIUM
    16.
    发明公开
    DEVICE AND METHOD FOR OPTICALLY EXAMINING THE INTERIOR OF A TURBID MEDIUM 有权
    DEVICE AND METHOD FOR光学调查成果具有关节的混浊介质

    公开(公告)号：EP2384431A2

    公开(公告)日：2011-11-09

    申请号：EP09787366.5

    申请日：2009-10-06

    Applicant: Koninklijke Philips Electronics N.V.

    Inventor： VAN BEEK, Michael, C. ,  RENSEN, Wouter, H., J. ,  HARBERS, Rik

    IPC: G01N21/47 ,  G01N21/49 ,  G01N21/59 ,  A61B5/00

    CPC classification number: A61B5/0059 ,  A61B5/4528 ,  G01N21/4795 ,  G01N2201/0626 ,  G01N2201/0635 ,  G01N2201/0675 ,  G01N2201/124

    Abstract: A device (1; 10; 20; 30; 40) for optically examining the interior of a turbid medium (5) is provided. The device comprises an illumination system (2; 12; 22; 32; 42) adapted for illuminating a turbid medium (5) to be examined and an imaging device (106) adapted for generating images from detected light. The illumination system (2; 12; 22; 32; 42) is adapted to be operable in at least a first mode in which a wide area image is acquired by illuminating the turbid medium (5) and a surrounding area. From this wide area image, the region or regions of interest (110) at which the turbid medium (5) is actually situated can be determined. Then, these regions of interest (110) can be illuminated in a second mode. Thus, no light which has not been coupled to the turbid medium (5) and which might cause overexposure of the detector unit of the imaging device (106) will reach the imaging device (106).

    Abstract translation: 的装置（1; 10; 20; 30; 40），用于光学检查混浊介质的内部设置。 照明系统的装置包括：（2; 42 12; 22 32 ;;）方便照射混浊介质待检查并于成像适于从检测到的光产生图像设备（106）。 的照明系统（2; 12; 22; 32; 42）是angepasst成可操作在大面积中哪一个大面积被照亮的至少第一模式和其中一个第二模式的至少一个选定区域（110） 被照亮。

    Method and apparatus for combination of localization microscopy and structured illumination microscopy
    18.
    发明授权
    Method and apparatus for combination of localization microscopy and structured illumination microscopy 有权
    定位显微镜和结构化照明显微镜组合的方法和设备

    公开(公告)号：EP2801854B1

    公开(公告)日：2017-07-19

    申请号：EP13002490.4

    申请日：2013-05-10

    Applicant: Ruprecht-Karls-Universität Heidelberg

    Inventor： Rossberger, Sabrina ,  Dithmar, Stefan Prof. Dr. ,  Best, Gerrit ,  Cremer, Christoph Prof. Dr.

    IPC: G02B21/00 ,  G01N21/64 ,  G02B21/16 ,  G02B21/36 ,  G02B27/58

    CPC classification number: G02B21/367 ,  G01N21/6445 ,  G01N21/6458 ,  G01N2201/0675 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/361 ,  G02B27/58

    Abstract: The invention relates to a fluorescent microscope and a respective method for obtaining super-resolution images of a sample labelled with at least one type fluorescent label by combining localization microscopy and structured illumination microscopy. In an aspect, the fluorescent microscope comprises one or more light sources and an illumination system having a structured illumination path, in which a pattern generation system is positioned, for illuminating the sample with structured illumination light and a localization illumination path for illuminating the sample with localization illumination light. A switching mechanism is configured to switch between a first, a second and/or a third mode, wherein in the first mode at least a portion of the light emitted from the one or more light sources propagates through one of the illumination paths; in the second mode at least a portion of the light emitted from the one or more light sources propagates through the other one of the illumination paths; and in the third mode at least a portion of the light emitted from one or more of the light sources propagates through one illumination path while simultaneously at least another portion of the light emitted from one or more of the light sources propagates through the other illumination path. At least one image detector positioned in an optical detection path, configured to detect at least a portion of fluorescent light emitted from fluorescent molecules of the illuminated sample. Another aspect concerns a method for obtaining super-resolution image data of a sample labeled with at least one type of fluorescent label comprising illuminating the sample with localization illumination light and with structured illumination light; detecting at least a portion of the fluorescent light emitted from the excited fluorescent molecules of the at least one fluorescent label, thereby obtaining at least one image of the illuminated sample; and processing the obtained at least one image of the sample image to obtain super-resolution image data.

    Abstract translation: 本发明涉及荧光显微镜和相应的方法，用于通过组合定位显微镜和结构化照明显微镜来获得用至少一种类型的荧光标签标记的样品的超分辨率图像。 在一个方面，荧光显微镜包括一个或多个光源以及具有结构化照明路径的照明系统，图案生成系统位于该结构化照明路径中，用于利用结构化照明光照亮样本以及用于照亮样本的定位照明路径 定位照明灯。 切换机构被配置为在第一模式，第二模式和/或第三模式之间切换，其中在第一模式中，从一个或多个光源发射的光的至少一部分传播通过照明路径之一; 在第二模式中，从一个或多个光源发射的光的至少一部分传播通过照明路径中的另一个; 并且在第三模式中，从一个或多个光源发射的光的至少一部分传播通过一个照明路径，同时从一个或多个光源发射的光的至少另一部分传播通过另一个照明路径 。 位于光学检测路径中的至少一个图像检测器，被配置为检测从照射样本的荧光分子发射的荧光的至少一部分。 另一方面涉及用于获得用至少一种类型的荧光标签标记的样本的超分辨率图像数据的方法，包括用定位照明光和结构化照明光照亮样本; 检测从至少一个荧光标记的激发的荧光分子发射的荧光的至少一部分，由此获得照射的样本的至少一个图像; 并处理所获得的样本图像的至少一个图像以获得超分辨率图像数据。

    Plasmonic microscopy
    19.
    发明公开
    Plasmonic microscopy 审中-公开
    Plasmonmikroskopie

    公开(公告)号：EP2653903A1

    公开(公告)日：2013-10-23

    申请号：EP12165040.2

    申请日：2012-04-20

    Applicant: FOM Institute for Atomic and Molecular Physics

    Inventor： Johnson, Patrick Michael ,  Gjonaj, Bergin

    IPC: G02B21/34 ,  G02B21/00 ,  G01N21/64

    CPC classification number: G02B21/004 ,  G01N21/554 ,  G01N2201/0675 ,  G02B21/0072 ,  G02B21/34

    Abstract: A scanning plasmonic microscope apparatus is described comprising a sample holder comprising a dielectric substrate, preferably a transparent dielectric substrate, covered with at least one metallic thin-film comprising plasmon-generating nanostructures adjacently arranged to at least one scanning area, said scanning area comprising a continuous, flat metallic surface for supporting one or more samples, preferably a biological sample; a spatial light modulator in optical alignment with said sample holder, said spatial light modulator comprising pixels for illuminating at least part of said nanostructures with light of a predetermined phase; a storage medium comprising target coordinates associated with target points in said at least one scanning area; and, phase information for controlling said pixels so that surface plasmon waves emitted by pixel-illuminated nanostructures are substantially in phase (focussed) in at least one of said target points in said at least one scanning area; and, an image sensor configured to image photons, which are scattered away from said scanning area when surface plasmons in said target point interact with at least part of said one or more samples; and, a scanner controller for controlling pixels in said spatial light modulator, said pixels illuminating at least part of said nanostructures on the basis of said phase information.

    Abstract translation: 描述了一种扫描等离子体显微镜装置，其包括样品保持器，该样品保持器包括电介质基底，优选为透明电介质基底，被至少一个金属薄膜覆盖，所述金属薄膜包括相邻地布置在至少一个扫描区域上的等离子体发生纳米结构，所述扫描区域包括 连续的，平坦的金属表面，用于支撑一个或多个样品，优选生物样品; 与所述样品保持器光学对准的空间光调制器，所述空间光调制器包括用于用预定相的光照亮所述纳米结构的至少一部分的像素; 存储介质，包括与所述至少一个扫描区域中的目标点相关联的目标坐标; 以及用于控制所述像素的相位信息，使得由像素照明的纳米结构发射的表面等离子体波在所述至少一个扫描区域中的至少一个所述目标点中基本上同相（聚焦） 以及图像传感器，被配置为对在所述目标点中的表面等离子体激元与所述一个或多个样本的至少一部分相互作用时，从所述扫描区域散射的光子成像; 以及用于控制所述空间光调制器中的像素的扫描器控制器，所述像素基于所述相位信息照亮所述纳米结构的至少一部分。

    Vibrational Microscopy Imaging System
    20.
    发明公开
    Vibrational Microscopy Imaging System 有权
    振动显微成像系统

    公开(公告)号：EP2211219A3

    公开(公告)日：2013-03-20

    申请号：EP10151529.4

    申请日：2010-01-25

    Applicant: President and Fellows of Harvard College

    Inventor： Xie, Xiaoliang Sunney ,  Freudinger, Christian ,  Min, Wei

    IPC: G02B21/00 ,  G02B21/08 ,  G01H9/00 ,  G01J3/10 ,  G01J3/44 ,  G01N21/65

    CPC classification number: G02B21/002 ,  G01J3/10 ,  G01J3/44 ,  G01J2003/1282 ,  G01N21/65 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2201/0675 ,  G02B21/082

    Abstract: A microscopy imaging system is disclosed that includes a light source system, a spectral shaper, a modulator system, an optics system, an optical detector and a processor. The light source system is for providing a first train of pulses and a second train of pulses. The spectral shaper is for spectrally modifying an optical property of at least some frequency components of the broadband range of frequency components such that the broadband range of frequency components is shaped producing a shaped first train of pulses to specifically probe a spectral feature of interest from a sample, and to reduce information from features that are not of interest from the sample. The modulator system is for modulating a property of at least one of the shaped first train of pulses and the second train of pulses at a modulation frequency. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of a train of pulses of interest transmitted or reflected through the common focal volume. The processor is for detecting a modulation at the modulation frequency of the integrated intensity of substantially all of the optical frequency components of the train of pulses of interest due to the non-lincar interaction of the shaped first train of pulses with the second train of pulses as modulated in the common focal volume, and for providing an output signal for a pixel of an image for the microscopy imaging system.

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