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    Production method of optically active diphenylalanine compounds
    13.
    发明公开
    Production method of optically active diphenylalanine compounds 审中-公开
    光学活性的Diphenylalaninverbindungen制造方法

    公开(公告)号：EP1724253A3

    公开(公告)日：2009-11-04

    申请号：EP06252438.4

    申请日：2006-05-09

    Applicant: Ajinomoto Co., Inc.

    Inventor： Hamada, Takayuki, Ajinomoto Co., Inc. ,  Yatagai, Masanobu, Ajinomoto Co., Inc.

    IPC: C07C227/16 ,  C07C227/32 ,  C07C229/36 ,  C07C233/51

    CPC classification number: C07C227/20 ,  C07C231/12 ,  C07C229/36 ,  C07C233/47 ,  C07C233/51

    Abstract: The present invention provides a production method including reacting a diphenylmethylene halide compound represented by the following formula (1) with a malonic acid diester compound represented by the following formula (2) in an organic solvent selected from N-methyl-2-pyrrolidone, N-ethyl-2-pyrrolidone and N,N-dimethylformamide, in the presence of a base selected from an alkali metal hydride and an alkali metal t-butoxide to give a diester compound represented by the following formula (3), and then subjecting the diester compound to hydrolysis and decarboxylation to give a diphenylalanine compound represented by the following formula (4).
    According to the present invention, diphenylalanine compound (4) can be obtained industrially advantageously in a high yield.

    wherein each symbol is as defined in the specification.

    PROCESS FOR THE PREPARATION OF AMIDES
    20.
    发明公开
    PROCESS FOR THE PREPARATION OF AMIDES 审中-公开
    制备酰胺的过程

    公开(公告)号：EP1092705A1

    公开(公告)日：2001-04-18

    申请号：EP00921060.0

    申请日：2000-04-27

    Applicant: IHARA CHEMICAL INDUSTRY CO., LTD.

    Inventor： HIYOSHI, Hidetaka Ihara Chem. Ind. Co., Ltd. ,  TANIGUCHI, Shuji Ihara Chemical Ind. Co., Ltd. ,  SUZUKI, Junko

    IPC: C07C231/10 ,  C07C221/00 ,  C07C225/06 ,  C07C231/12 ,  C07C233/31 ,  C07C233/47 ,  C07C233/51 ,  C07C233/61 ,  C07C233/63 ,  C07C235/34 ,  C07D263/42

    CPC classification number: C07C233/63 ,  C07C221/00 ,  C07C231/10 ,  C07C231/12 ,  C07C231/14 ,  C07C233/47 ,  C07C233/51 ,  C07C233/83 ,  C07D263/42 ,  C07C225/06 ,  C07C233/30

    Abstract: The present invention aims at providing important intermediates used in production of a phenylalkanoic acid amide compound showing an excellent fungicidal effect; and novel and simple processes for producing such an intermediate or a raw material compound used in production of the intermediate.
    The present invention relates to a process for producing an amide compound represented by the following general formula
    [wherein R is an alkyl group, a cycloalkyl group, a haloalkyl group, an aryl group, a substituted aryl group, an arylalkyl group, a substituted arylalkyl group, an (aryl)(alkoxy)alkyl group or a (substituted aryl)(alkoxy)alkyl group; R 1 and R 2 are each independently an alkyl group, a cycloalkyl group, a haloalkyl group, an arylalkyl group, a substituted arylalkyl group, an aryl group, a substituted aryl group or a hydrogen atom, and may bond with each other to form a ring together with the carbon atom with which they bond; and R 3 is an alkyl group, a cycloalkyl group, a haloalkyl group, an arylalkyl group, a substituted arylalkyl group, an aryl group, a substituted aryl group or a hydrogen atom], which process comprises reacting a nitrile compound represented by the following general formula
    (wherein R, R 1 and R 2 each have the same definition as given above) with an acid to give rise to intramolecular ring closure to obtain an oxazolinone compound represented by the following general formula
    (wherein R, R 1 and R 2 each have the same definition as given above), and reacting the oxazolinone compound with a carboxy compound represented by the following general formula
    (wherein Y is a hydrogen atom, a carboxyl group or a salt of the carboxyl group; and R 3 has the same definition as given above) in the presence of a base.

    Abstract translation: 本发明的目的在于提供用于生产显示优异杀真菌效果的苯基链烷酸酰胺化合物的重要中间体; 以及制备用于生产中间体的这种中间体或原料化合物的新颖和简单的方法。 本发明涉及通式[其中R是烷基，环烷基，卤代烷基，芳基，取代的芳基，芳基烷基，取代的芳基烷基，芳基烷基，芳基烷基， （芳基）（烷氧基）烷基或（取代芳基）（烷氧基）烷基; R 1和R 2各自独立地为烷基，环烷基，卤代烷基，芳基烷基，取代的芳基烷基，芳基，取代的芳基或氢原子，并且可以彼此键合以形成环 与它们所键合的碳原子一起; 和R3是烷基，环烷基，卤代烷基，芳基烷基，取代的芳基烷基，芳基，取代的芳基或氢原子〕的方法，该方法包括使由以下通式 式（其中R，R 1和R 2各自具有与上面给出的定义相同的含义）与分子内的环闭合以得到由以下通式表示的恶唑啉酮化合物（其中R，R 1和R 2各自具有相同的定义 如上所述），并使恶唑啉酮化合物与由下列通式（其中Y为氢原子，羧基或羧基的盐;以及R3具有与上面给出的定义相同的定义）代表的羧基化合物在 基地的存在。

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