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    APPARATUS FOR PULSED ELECTRIC FIELD NEUROMODULATION VIA AN INTRA-TO-EXTRAVASCULAR APPROACH
    22.
    发明公开
    APPARATUS FOR PULSED ELECTRIC FIELD NEUROMODULATION VIA AN INTRA-TO-EXTRAVASCULAR APPROACH 审中-公开
    用于脉冲电场神经调节的装置，通过一种内部外部方法

    公开(公告)号：EP3173123A1

    公开(公告)日：2017-05-31

    申请号：EP16204100.8

    申请日：2006-12-21

    Applicant: Medtronic Ardian Luxembourg S.à.r.l.

    Inventor： DEMARAIS, Denise ,  CLARK, Benjamin J. ,  ZADNO, Nicolas ,  THAI, Erik ,  GIFFORD, Hanson, III

    IPC: A61N1/32 ,  A61N1/36 ,  A61N1/05 ,  A61M5/14 ,  A61B18/14 ,  A61M37/00 ,  A61B18/00 ,  A61B18/12

    CPC classification number: A61B18/1477 ,  A61B18/1206 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00613 ,  A61B2018/126 ,  A61M5/14 ,  A61M37/00 ,  A61N1/05 ,  A61N1/0514 ,  A61N1/0551 ,  A61N1/321 ,  A61N1/327 ,  A61N1/36007

    Abstract: Methods and apparatus are provided for pulsed electric field neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other conditions in target neural fibers. In some embodiments, the ITEV PEF system comprises an intravascular catheter having one or more electrodes configured for intra-to-extravascular placement across a wall of patient's vessel into proximity with target neural fibers.; With the electrode(s) passing from an intravascular position to an extravascular position prior to delivery of the PEF, a magnitude of applied voltage or energy delivered via the electrode(s) and necessary to achieve desired neuromodulation may be reduced relative to an intravascular PEF system having one or more electrodes positioned solely intravascularly. The methods and apparatus of the present invention may, for example, be used to modulate one or more target neural fibers that contribute to renal function.

    Abstract translation: 提供了用于脉冲电场神经调节的方法和装置，所述脉冲电场神经调节通过血管内 - 血管外途径进行，例如以实现不可逆电穿孔或电融合，细胞凋亡的坏死和/或诱导，基因表达的改变，细胞因子上调中的变化和目标中的其他条件 神经纤维。 在一些实施例中，ITEV PEF系统包括具有一个或多个电极的血管内导管，所述电极被配置用于穿过患者血管的壁到达血管外的位置以接近目标神经纤维。 由于在递送PEF之前电极从血管内位置通过血管外位置到达血管外位置，因此相对于血管内PEF可以降低经由电极递送并且实现期望的神经调节所必需的施加电压或能量的量值 系统具有单个血管内定位的一个或多个电极。 例如，本发明的方法和设备可用于调节对肾功能有贡献的一种或多种目标神经纤维。

    FLEXIBLE MICROWAVE CATHETERS FOR NATURAL OR ARTIFICIAL LUMENS
    24.
    发明公开
    FLEXIBLE MICROWAVE CATHETERS FOR NATURAL OR ARTIFICIAL LUMENS 审中-公开
    灵活的MIKROWELLENKATHETERFÜRNATÜRLICHEODERKÜNSTLICHELUMEN

    公开(公告)号：EP3095407A3

    公开(公告)日：2017-03-08

    申请号：EP16171295.5

    申请日：2012-04-09

    Applicant: Covidien LP

    Inventor： Brannan, Joseph D. ,  Ladtkow, Casey M.

    IPC: A61B18/18 ,  A61N5/02 ,  A61B18/00 ,  A61B18/14 ,  A61B17/00

    CPC classification number: A61B18/1815 ,  A61B17/00234 ,  A61B18/1492 ,  A61B18/18 ,  A61B90/10 ,  A61B2017/00323 ,  A61B2018/00023 ,  A61B2018/00077 ,  A61B2018/00172 ,  A61B2018/0022 ,  A61B2018/00226 ,  A61B2018/00232 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00345 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1846 ,  A61B2018/1861 ,  A61B2018/1884 ,  A61B2018/1892 ,  A61N5/022

    Abstract: A coupler for coupling a flexible coaxial cable (32), a fluid cooling system (40) and the outer sheath (35) of a catheter (30), the coupler comprising:
    a fluid coupler body (845a) including:
    a fluid inlet (842a) configured to operably couple to a source of cooling fluid and receive fluid therefrom;
    a fluid outlet (843a) configured to operably couple to a fluid discharge; and
    an outer sheath coupler (845b) forming an aperture for coupling with an outer sheath (35) of a catheter while forming a fluid-tight seal therewith; and

    a fluid sealing system (819) housed in the fluid coupler body including:
    a distal sealing diaphragm (819a) configured to form a fluid-tight seal about an outer surface of an inflow lumen (842) and a fluid-tight seal with an interior surface of the fluid coupler body (845a) defining an outflow plenum (843b) in fluid communication with the fluid outlet (843a); and
    a proximal sealing diaphragm (819b) configured to form a fluid-tight seal about an outer surface of the coaxial cable (32) and a fluid-tight seal with an interior surface of the fluid coupler body(845a) thereby forming an inflow plenum (842b) in fluid communication with the fluid inlet (842a).

    Abstract translation: 一种微波输送装置，包括具有内部导体的同轴馈线，同轴地设置在内部导体周围的内部电介质绝缘体以及同轴地设置在内部电介质周围的外部导体，以及可操作地连接到远端的辐射部分。 辐射部分包括辐射部分内部导体，其可操作地耦合到同轴馈线内部导体的远端并且从同轴馈线内部导体的远端延伸;屏蔽外部导体，螺旋形缠绕在辐射部分内部导体上并且可操作地耦合到同轴馈线外部导体; 以及位于所述辐射部分内部导体和所述屏蔽外部导体之间的屏蔽电介质，其中所述屏蔽外部导体的宽度根据其沿所述同轴馈线内部导体的纵向位置而变化，以及帽，其可操作地耦合到所述辐射部分的远端 部分内导体和屏蔽外导体，以在它们之间提供电连接。

    ENERGY DELIVERY DEVICE
    25.
    发明公开
    ENERGY DELIVERY DEVICE 审中-公开
    ENERGIEVERSORGUNGSVORRICHTUNG

    公开(公告)号：EP3135237A1

    公开(公告)日：2017-03-01

    申请号：EP16192867.6

    申请日：2013-03-15

    Applicant: Covidien LP

    Inventor： SALAHIEH, Amr ,  SAUL, Tom

    IPC: A61B18/14 ,  A61M25/10

    CPC classification number: A61B18/1492 ,  A61B18/1815 ,  A61B18/20 ,  A61B2018/00154 ,  A61B2018/00238 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/00744 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00863 ,  A61B2018/1435 ,  A61B2090/064 ,  A61B2090/3966 ,  A61L29/085 ,  A61L29/14 ,  A61M2025/105 ,  F04C2270/041

    Abstract: An energy delivery system for delivering electrical energy to tissue, includes an elongate catheter member defining a longitudinal axis and dimensioned for passage within a body vessel and an expandable treatment member mounted to the catheter member. The treatment member includes an inflatable element adapted to transition between an initial condition and an at least partially expanded condition upon introduction of an anesthetic solution within the inflatable element, an electrode for delivering electrical energy to at least the nerve tissue associated with the body vessel to cause at least partial denervation thereof and at least one aperture dimensioned to permit passage of the anesthetic solution from the inflatable element to contact the body vessel whereby the solution at least enters the body vessel to at least partially anesthetize the nerve tissue therewithin. The electrode may be mounted to at least the inflatable element of the treatment member and may be generally helical.

    Abstract translation: 用于将电能递送到组织的能量递送系统包括限定纵向轴线并且被设计成用于在体内容器内通过的细长导管构件和安装到导管构件的可扩张治疗构件。 处理构件包括适于在引入可充气元件内的麻醉溶液之间的初始状态和至少部分膨胀状态之间转变的可充气元件，用于将电能传递到至少与身体血管相关联的神经组织的电极， 引起其至少部分去神经支配和至少一个孔口，其尺寸允许麻醉剂溶液从可膨胀元件通过以接触身体血管，由此溶液至少进入体内血管以至少部分麻醉其中的神经组织。 电极可以安装到处理构件的至少可膨胀元件，并且可以是大致螺旋形的。

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