公开(公告)号：EP1292552A2

公开(公告)日：2003-03-19

申请号：EP01944625.1

申请日：2001-06-18

Applicant: Symyx Technologies, Inc.

Inventor： DIAMOND, Gary M. ,  GOH, Christopher ,  LECLERC, Margarete, K. ,  MURPHY, Vince ,  TURNER, Howard, W.

IPC: C07B61/00 ,  C08F4/60 ,  C08F10/00

CPC classification number: C08F110/14 ,  B01J2219/00274 ,  B01J2219/00738 ,  C08F4/659 ,  C08F4/65908 ,  C08F210/16 ,  C40B40/00 ,  Y02P20/582 ,  C08F4/6592 ,  C08F210/14

Abstract: A method is disclosed for screening potential catalysts for polymerization performance. The method includes the steps of reacting a potential catalyst with at least a first monomer under polymerization conditions, determining the polymerization performance of the catalyst with the at least first monomer, and using the determination as a predictor for the polymerization performance of the catalyst for at least a second monomer, wherein the first and second monomers are different from each other and the first monomer is an olefin other than ethylene. The method provides a useful, concrete and tangible result that has particular value for identifying appropriate catalysts for olefin polymerization and copolymerization.

公开(公告)号：EP1174185A3

公开(公告)日：2002-04-10

申请号：EP01117143.6

申请日：2001-07-13

Applicant: Symyx Technologies, Inc.

Inventor： Van Erden, Lynn ,  Turner, Howard ,  Lowe, David

IPC: B01J19/00 ,  G01N35/02

CPC classification number: B01L3/5025 ,  B01J3/04 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/00477 ,  B01J2219/00585 ,  B01J2219/00601 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00736 ,  G01N35/028

Abstract: An apparatus for use in parallel reaction of materials. The apparatus includes a base (32) having a plurality of reaction wells, each of the reaction wells (30) having a closed lower end (84) and open upper end for receiving reactant materials. A cover (34) is configured for sealing engagement with the base to form a housing enclosing the plurality of reaction wells and defining a common pressure chamber (26) in communication with the reaction wells. The apparatus further includes a flow restriction device (92) positioned adjacent to the open ends of the reaction wells to provide communication between the reaction wells and the pressure chamber while reducing cross-talk between the reactants and an inlet port (70) in communication with the pressure chamber for supplying pressurized fluid to the chamber to pressurize the reaction wells. The housing is configured to sustain a pressure substantially above atmospheric pressure.

公开(公告)号：EP1178309A1

公开(公告)日：2002-02-06

申请号：EP01117934.8

申请日：2001-07-24

Applicant: Symyx Technologies, Inc.

Inventor： Srinivasan, Ravi ,  Pinkas, Daniel Meron ,  Guan, Shenhen ,  Myslovaty, Michael ,  Spitkovsky, Michael ,  Engstrom, James R. ,  Bergh, H. Sam

IPC: G01N30/62 ,  B01J19/00

CPC classification number: G01N30/18 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00704 ,  G01N30/466 ,  G01N30/6004 ,  G01N30/6095 ,  G01N30/66 ,  G01N30/8631 ,  G01N2030/185 ,  G01N2030/208 ,  G01N2030/3084 ,  G01N2030/8881

Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.

Abstract translation: 本发明的气相色谱通常包括四个或更多个分析通道。 具体地说，配置四个或更多个气相色谱柱用于平行分析四种或更多种气态样品，其中使用包含四个或更多微量检测器的微量检测器阵列进行检测。 在一个实施例中，四个或更多个微检测器510是微制造的检测器，并且与基板或与安装在基板上的一个或多个微芯片体整体形成。 在优选实施例中，微检测器阵列包括具有一个或多个薄膜检测丝的四个或更多个热导检测器。 还公开了用于高度平行的气相色谱仪的优选的加热环境。

公开(公告)号：EP1164514A1

公开(公告)日：2001-12-19

申请号：EP01119550.0

申请日：1999-10-19

Applicant: Symyx Technologies, Inc.

Inventor： Lacy, Steven D. ,  McFarland, Eric W. ,  Safir, Adam L. ,  Turner, Stephen J. ,  Van Erden, Lynn ,  Wang, Pei

IPC: G06F17/50

CPC classification number: C40B50/02 ,  B01J19/0046 ,  B01J2219/00477 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/007 ,  C40B60/14

Abstract: A computer-implemented method for generating a library design for a combinatorial library of materials, a combinatorial library being a collection of two or more members that contain some variance in chemical composition, chemical amount, reaction conditions, and/or processing conditions, a member being a single position in a library, the method comprising: defining a set of one or more sources and one or more destinations, each source being electronic data representing a component to be used in preparing the combinatorial library and each destination being electronic data representing a conceptual arrangement of cells representing a combinatorial library, the cells corresponding to members of the combinatorial library and/or locations on a physical substrate; defining one or more mappings, the mappings in the aggregate defining a composition for each of a plurality of materials assigned to a plurality of cells in the arrangement; defining one or more parameters, each parameter being electronic data being electronic data corresponding to a process condition to be applied to one or more cells of the arrangement representing the combinatorial library; defining one or more parameter values for each of the parameters, the parameter values representing an amount of the corresponding process condition to be applied to one or more of the cells of the arrangement; and generating a data file defining the library design, the data file comprising electronic data describing the source elements, the destination elements, the mappings, the parameters and the parameter values.

公开(公告)号：EP1161988A2

公开(公告)日：2001-12-12

申请号：EP01116443.1

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES

Inventor： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A. M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

Abstract: A method for parallel processing of a plurality of reaction mixtures and for monitoring the consumption or production of a gas-phase component of the reaction mixtures, the method comprising reacting the reaction mixtures in a plurality of vessels such that the pressure in the vessels changes as the gas-phase component of the reaction mixtures is consumed or produced, sensing the pressure within the vessels, passing the gas-phase component of the reaction mixture into or out of the vessels in response to the pressure sensed within the vessels, and recording the pressure changes within each of the vessels.

Abstract translation: 一种用于反应混合物中的多个并行处理和用于监测反应混合物的气相组分的消耗或生产的方法，包括在容器的多元反应的反应混合物的方法检测所做的压力在血管中的变化如 反应混合物的气相组分被消耗或产生，感测所述容器内的压力，使所述反应混合物的气相组分流入或流出所述容器的响应于血管内感测到的压力，并记录该 在每个容器的压力的变化。

公开(公告)号：EP1158290A2

公开(公告)日：2001-11-28

申请号：EP01112606.7

申请日：2001-05-23

Applicant: Symyx Technologies, Inc.

Inventor： Hajduk, Damian ,  Carlson, Eric ,  Freitag, Christopher J. ,  Kosolov, Oleg

IPC: G01N19/00 ,  G01N35/02

CPC classification number: B01L3/5085 ,  B01J2219/00707 ,  B01J2219/00718 ,  G01N5/00 ,  G01N11/00 ,  G01N19/00 ,  G01N29/02 ,  G01N29/222 ,  G01N2203/0286 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/02818 ,  G01N2291/106 ,  Y10T436/12

Abstract: An apparatus and method for screening combinatorial libraries of materials by measuring the response of individual library members to mechanical perturbations is described. The apparatus generally includes a sample holder for containing the library members, an array of probes for mechanically perturbing individual library members, and an array of sensors for measuring the response of each of the library members to the mechanical perturbations. Library members undergoing screening make up a sample array, and individual library members constitute elements of the sample array that are confined to specific locations on the sample holder. During screening, the apparatus mechanically perturbs individual library members by displacing the sample array (sample holder) and the array of probes. Typically, all of the elements of the sample array are perturbed simultaneously, but the apparatus also can also perturb individual or groups of sample array elements sequentially. The flexible apparatus and method can screen libraries of materials based on many different bulk physical properties, including Young's modulus (flexure, uniaxial extension, biaxial compression, and shear); hardness (indentation), failure (stress and strain at failure, toughness), adhesion (tack, loop tack), and flow (viscosity, melt flow indexing, and rheology), among others.

Abstract translation: 用于通过测量个体的文库成员，以机械扰动的响应筛选的材料组合文库的装置和方法进行说明。 该装置包括用于容纳所述文库成员的探针阵列，用于机械扰动个别文库成员的基因的反弹样本保持器，以及传感器阵列，用于测量每个文库成员的机械扰动的响应。 接受筛查库成员组成一个样本阵列，和单个文库成员构成的样本阵列的元件没有被限制于在样品架的特定位置。 在筛选中，该装置机械通过移动样品阵列（样品保持器）和探针的阵列扰乱个别文库成员。 典型地，所有的样本阵列的元件是扰动同时，但该装置，以便因此可以顺序扰乱样品阵列元件的个体或组。 柔性装置和方法可以筛选的基于许多不同的整体物理性能，包括杨氏模量（挠曲，单轴拉伸，双轴压缩和剪切的）材料的库; 硬度（压痕），心力衰竭（应力和应变在失败，韧性），粘合性（粘性，环形粘性），和流（粘度，熔体流动索引，和流变），等等。

公开(公告)号：EP1144107A2

公开(公告)日：2001-10-17

申请号：EP99964099.8

申请日：1999-12-03

Applicant: Symyx Technologies, Inc.

Inventor： FREITAG, Christopher, J. ,  HAJDUK, Damian ,  NIELSEN, Ralph, B. ,  SAFIR, Adam ,  TIEDE, Richard

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/0029 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00691 ,  B01J2219/0072 ,  B01J2219/00722 ,  C40B40/14 ,  C40B60/14 ,  Y10S526/92 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: A method and apparatus (10) for reacting a plurality of different mixtures in parallel in a semi-batch or continuous mode is provided. Each reaction is contained within a reactor vessel (102), the reactor vessels (102) combined into a reactor block (100). Reactant(s) to be added during the reaction are kept in a header barrel (202), which has a plunger (402) to feed reactant(s) from the header barrel (202) through a transfer line (302) into the reactor vessel (102). The plunger (402) is moved using a drive system (500). The header barrels (202) are optionally combined in a header block (200). The header block (200) is sealed to a plate (300) containing the transfer lines (302), which in turn is sealed to the reactor block (100). A latch mechanism (600) is provided for easy sealing of the reactor (100) and header blocks (200) to the plate (300). The entire apparatus (10) may be placed on a rocker or rotating plate for mixture as the reaction is proceeding.

公开(公告)号：EP1129773A2

公开(公告)日：2001-09-05

申请号：EP01105047.3

申请日：2001-03-01

Applicant: Symyx Technologies, Inc.

Inventor： Lugmair, Claus G. ,  Poojary, Damodara M. ,  Hagemeyer, Alfred

IPC: B01J19/00

CPC classification number: B01J37/0201 ,  B01J19/0046 ,  B01J23/892 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14

Abstract: A method and system for the in situ synthesis of a combinatorial library including impregnating a first component with a second component. The method and system advantageously may be employed in the synthesis of materials for screening for usefulness as a catalyst.

Abstract translation: 用于原位合成组合文库的方法和系统，包括用第二组分浸渍第一组分。 该方法和系统有利地用于合成用于筛选作为催化剂的有用性的材料。

公开(公告)号：EP1113991A2

公开(公告)日：2001-07-11

申请号：EP99949737.3

申请日：1999-09-17

Applicant: SYMYX TECHNOLOGIES

Inventor： GIAQUINTA, Daniel ,  DEVENNEY, Martin ,  HALL, Keith, Anthony ,  GOLDWASSER, Isy

IPC: C01F11/02 ,  C01F17/00 ,  C07B61/00 ,  C04B35/01 ,  C04B35/622 ,  C23C14/04 ,  C23C16/04

CPC classification number: B82Y25/00 ,  B01J19/0046 ,  B01J2219/00351 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00599 ,  B01J2219/0065 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00745 ,  B01J2219/00754 ,  C01B13/185 ,  C40B40/18 ,  C40B50/08 ,  C40B60/14

Abstract: A combinatorial method for discovering or optimizing materials is disclosed. The method uses solution-based components that are mixed and dispensed into regions on a substrate for drying and/or heat-treating. The drying and/or heat-treating produces materials that can be tested for a desired property.

公开(公告)号：EP1113869A2

公开(公告)日：2001-07-11

申请号：EP00916026.8

申请日：2000-03-03

Applicant: Symyx Technologies, Inc.

Inventor： BERGH, S., Howard ,  GUAN, Shenheng

IPC: B01J19/00

CPC classification number: B01L3/5027 ,  B01F5/0601 ,  B01F15/0264 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00308 ,  B01J2219/00337 ,  B01J2219/00353 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00452 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00641 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00783 ,  B01J2219/00835 ,  B01J2219/00871 ,  B01L3/0293 ,  B01L3/5025 ,  B01L3/502707 ,  B01L7/54 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/14 ,  B01L2300/18 ,  B01L2400/0487 ,  C01B3/40 ,  C07C17/23 ,  C07C45/34 ,  C07C45/35 ,  C07C45/38 ,  C07C45/46 ,  C07C45/54 ,  C07C45/72 ,  C40B30/08 ,  C40B40/18 ,  G01N30/90 ,  G01N31/10 ,  G01N35/028 ,  G01N2035/00158 ,  C07C47/06 ,  C07C47/22 ,  C07C47/04 ,  C07C49/403 ,  C07C47/127 ,  G01N30/466

Abstract: A chemical processing microsystem useful for identifying and optimizing materials (e.g., catalysts) that enhance chemical processes or for characterizing and/or optimizing chemical processes is disclosed. The chemical processing microsystem comprises a plurality of microreactors (600) and, in a preferred embodiment, a plurality of microseparators (900) integral with the chemical processing microsystem (10). The microreactors (600) are preferably diffusion-mixed microreactors formed in a plurality of laminae that include a modular, interchangeable candidate-material array (100). The material array (100) comprises a plurality of different candidate materials (e.g., catalysts), preferably arranged at separate, individually addressable portions of a substrate (e.g., wafer). The microseparators (900) are similarly formed in a plurality of laminae that include a modular, interchangeable adsorbent array (700). The adsorbent array (700) comprises one or more adsorbents, preferably arranged at separate, individually addressable portions of a substrate to spatially correspond to the plurality of different candidate materials. Modular microfluidic distribution systems are also disclosed. The chemical processing microsystem can be integrated into a material evaluation system that enables a comprehensive combinatorial material science research program.