-
1.发明公开
公开(公告)号：EP2362731A4
公开(公告)日：2012-07-25
申请号：EP09824027
申请日：2009-10-22
发明人： DANG QUN , CHUNG DE MICHAEL , GIBSON TONY S , JIANG HONGJIAN , CASHION DANIEL K , BAO JIANMING , LAN PING , LU HUAGANG , MAKARA GERGELY M , ROMERO F ANTHONY , SEBHAT IYASSU , WODKA DARIUSZ
IPC分类号： C07F9/6558 , A01N43/50 , A61K31/415 , C07F9/6506 , C07F9/6574
CPC分类号： C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
-
公开(公告)号：EP2348857A4
公开(公告)日：2012-07-18
申请号：EP09822430
申请日：2009-10-12
发明人： BOOKSER BRETT C , DANG QUN , GIBSON TONY S , JIANG HONGJIAN , CHUNG DE MICHAEL , BAO JIANMING , JIANG JINLONG , KASSICK ANDY , KEKEC AHMET , LAN PING , LU HUAGANG , MAKARA GERGELY M , ROMERO F ANTHONY , SEBHAT IYASSU , WILSON DAVID , WODKA DARIUSZ
IPC分类号： C07F9/6506 , A61K31/415 , C07F9/6558 , C07F9/6571
CPC分类号： C07F9/65068 , C07F9/65583 , C07F9/657181
-
公开(公告)号：EP2352374A4
公开(公告)日：2012-03-28
申请号：EP09824011
申请日：2009-10-19
发明人： DANG QUN , CHUNG DE MICHAEL , GIBSON TONY S , JIANG HONGJIAN , CASHION DANIEL K , BAO JIANMING , LAN PING , LU HUAGANG , MAKARA GERGELY M , ROMERO F ANTHONY , SEBHAT IYASSU , WODKA DARIUSZ
IPC分类号： C07D235/26 , A61K31/4184 , C07D235/28 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
CPC分类号： C07D235/28 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
-
公开(公告)号：EP3204385A4
公开(公告)日：2018-03-28
申请号：EP15848373
申请日：2015-10-08
申请人： MERCK SHARP & DOHME
发明人： UJJAINWALLA FEZ , TAN JOHN QIANG , DANG QUN , SINZ CHRISTOPHER J , WANG MING , CHEN YILI , CAI JIAQIANG
IPC分类号： C07D239/36 , A61P7/06 , C07D413/06
CPC分类号： C07D239/36 , A61P7/06 , C07D413/06
摘要： The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
-
5.发明公开2'-DISUBSTITUTED SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES 审中-公开2'-核苷二取代AND METHOD FOR其用于病毒病的治疗
公开(公告)号：EP2909210A4
公开(公告)日：2016-04-06
申请号：EP13847502
申请日：2013-10-11
申请人： MERCK SHARP & DOHME
发明人： GIRIJAVALLABHAN VINAY , BOGEN STEPHANE , PAN WEIDONG , DANG QUN , DAVIES IAN
IPC分类号： C07D487/04 , A61K31/5025 , A61P31/12
CPC分类号： A61K31/706 , A61K31/7056 , A61K38/21 , A61K45/06 , C07D487/04 , C07H7/06 , A61K2300/00
-
6.发明公开2'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开2'-取代的核苷及使用方法进行病毒疾病治疗
公开(公告)号：EP2696681A4
公开(公告)日：2014-10-01
申请号：EP12771566
申请日：2012-04-11
申请人： MERCK SHARP & DOHME
发明人： GIRJAVALLABHAN VINAY , NJOROGE F GEORGE , BOGEN STEPHANE , VERMA VISHAL , BENNETT FRANK , KEREKES ANGELA , ARASAPPAN ASHOK , PISSARNITSKI DIMITRI , DANG QUN , DAVIES IAN , OLSEN DAVID B , STAMFORD ANDREW , VACCA JOSEPH P
IPC分类号： C07H21/02 , A61K31/7042 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07H19/06 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213
CPC分类号： A61K31/7072 , A01N47/36 , A61K31/7042 , A61K31/7068 , A61K45/06 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/207 , C07H19/213 , A01N2300/00 , A01N43/54 , A01N43/56 , A01N43/653 , A01N43/76 , A01N43/82 , A01N43/84 , A01N43/90
摘要： The present invention relates to 2′-Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Substituted Nucleoside Derivative, and methods of using the 2′-Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的2'-取代的核苷衍生物：及其药学上可接受的盐，worin A，B，X，R 1，R 2和R 3如所定义。 因此，本发明涉及组合物，其包含至少一个2'-取代的核苷衍生物，以及使用该2'-取代的核苷衍生物用于治疗或在患者中预防HCV感染症的方法。
-
公开(公告)号：EP3204363A4
公开(公告)日：2018-04-04
申请号：EP15849713
申请日：2015-10-08
申请人： MERCK SHARP & DOHME
发明人： UJJAINWALLA FEZ , TAN JOHN QIANG , DANG QUN , SINZ CHRISTOPHER J , CRESPO ALEJANDRO , WANG MING , CHEN YILI , CAI JIAQIANG , WU FAN , DU XIAOXING
IPC分类号： C07D239/26 , A61K31/505 , A61P7/06
CPC分类号： C07D239/36 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
-
8.发明公开2'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开2'-叠氮取代的核苷及使用方法进行病毒疾病治疗
公开(公告)号：EP2697242A4
公开(公告)日：2014-10-01
申请号：EP12771707
申请日：2012-04-11
申请人： MERCK SHARP & DOHME
发明人： GIRIJAVALLABHAN VINAY , NJOROGE F GEORGE , BOGEN STEPHANE , BENNETT FRANK , VERMA VISHAL , ARASAPPAN ASHOK , CHEN KEVIN , HUANG YING , KEREKES ANGELA , NAIR LATHA , PISSARNITSKI DMITRI , DANG QUN , DAVIES IAN , OLSEN DAVID B , STAMFORD ANDREW , VACCA JOSEPH P
IPC分类号： C07H21/02 , C07H19/06 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213
摘要： The present invention relates to 2′-Azido Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Azido Substituted Nucleoside Derivative, and methods of using the 2′-Azido Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的2'-叠氮取代的核苷衍生物：它们，worin B，X，R1，R2和R3如在定义和药学上可接受的盐。 因此，本发明涉及组合物，其包括至少一个2'-叠氮取代的核苷衍生物，以及使用该2'-叠氮取代的核苷衍生物用于治疗或在患者中预防HCV感染症的方法。
-
公开(公告)号：EP3204384A4
公开(公告)日：2018-04-18
申请号：EP15848319
申请日：2015-10-08
申请人： MERCK SHARP & DOHME
发明人： UJJAINWALLA FEZ , TAN JOHN QIANG , DANG QUN , SINZ CHRISTOPHER J , WANG MING , CAI JIAQIANG , DU XIAOXING , CHEN YILI
IPC分类号： C07D471/20 , A61K31/4412 , A61K31/4439 , A61P7/08 , C07D401/14 , C07D471/04
CPC分类号： C07D213/82 , A61P7/08 , C07D401/04
摘要： The present invention concerns compounds of formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
-
10.发明公开SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开取代的苯并呋喃化合物及其用于治疗病毒疾病的方法
公开(公告)号：EP3013334A4
公开(公告)日：2016-11-16
申请号：EP14816866
申请日：2014-06-19
申请人： MERCK SHARP & DOHME
发明人： LIU HONG , DAI XING , PALANI ANANDAN , HE SHUWEN , NARGUND RAVI , XIAO DONG , DANG QUN , PENG XUANJIA , LI PENG
IPC分类号： A61K31/343 , A61K31/4439 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61P31/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/14
CPC分类号： C07D405/14 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K45/06 , C07D405/04 , C07D413/14 , C07D471/04 , C07D471/14 , C07D487/14 , C07D491/048 , C07D498/04
-
-
-
-
-
-
-
-
-
搜索结果
29 条记录 (耗时 0.011 秒)
