公开(公告)号：JP2504490B2

公开(公告)日：1996-06-05

申请号：JP28228787

申请日：1987-11-10

申请人： HOFFMANN LA ROCHE

发明人： KUIRIKO BURANKA ,  ROORANTO YAUNIN ,  HANSU PEETAA MERUKI ,  FURENTSUI MARUTEI ,  HENRI RAMUTSU

IPC分类号： A61K31/415 ,  A61K31/4184 ,  A61K31/425 ,  A61K31/428 ,  A61K31/44 ,  A61K31/55 ,  A61K31/551 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D233/54 ,  C07D233/64 ,  C07D235/14 ,  C07D235/26 ,  C07D243/14 ,  C07D277/62 ,  C07D277/64 ,  C07D401/06 ,  C07D471/04 ,  C07D487/04 ,  C07D521/00

公开(公告)号：JPH0859715A

公开(公告)日：1996-03-05

申请号：JP22395494

申请日：1994-08-26

申请人： KONISHIROKU PHOTO IND

发明人： KIKUCHI TOMOE ,  KAMIYAMA MIKIO ,  HAYASHI KENJI

IPC分类号： G01N33/545 ,  C07D235/26 ,  C08F2/22 ,  C08F2/44 ,  C09B69/10 ,  G03G9/087 ,  G03G9/09

摘要： PURPOSE: To obtain particles used as an electrophotographic yellow toner or a carrier for an immunological diagnostic reagent by copolymerizing a monomer component containing a hydrophobic monomer in an aqueous system containing yellow organic pigment particles dispersed in the presence of a surfactant. CONSTITUTION: The polymeric particles containing a pigment are flocculated particles having a particle diameter of

公开(公告)号：JPH08500082A

公开(公告)日：1996-01-09

申请号：JP51155092

申请日：1992-12-21

IPC分类号： C07D333/38 ,  A61K31/235 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/47 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  C07C59/90 ,  C07C67/31 ,  C07C69/738 ,  C07C205/45 ,  C07C205/56 ,  C07C225/22 ,  C07C229/44 ,  C07D215/22 ,  C07D215/233 ,  C07D215/56 ,  C07D231/56 ,  C07D235/26 ,  C07D333/24 ,  C07D471/04

公开(公告)号：JPH07258221A

公开(公告)日：1995-10-09

申请号：JP5220695

申请日：1995-03-13

申请人： THOMAE GMBH DR K

发明人： GERUHARUTO MIIMU ,  NORUBERUTO HAUERU ,  UUBUE RIISU ,  YAKOBUSU KONSUTANTEINUSU ANTON ,  BUORUFUGANKU BUIINEN ,  MIHAERU ENTSUEROOTO

IPC分类号： C07D235/20 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/425 ,  A61K31/435 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D235/18 ,  C07D235/26 ,  C07D235/28 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

公开(公告)号：JPH07224059A

公开(公告)日：1995-08-22

申请号：JP29938994

申请日：1994-12-02

申请人： EISAI CO LTD

发明人： MIYAKE KAZUTOSHI ,  MATSUKURA MASAYUKI ,  HIROSHIMA OSAMU ,  MORI NOBUYUKI ,  ISHIHARA HIROKI ,  MUSHA TAKASHI ,  HAMANO SUKEYUKI

IPC分类号： C07D235/08 ,  A61K31/00 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/44 ,  A61K31/496 ,  A61K31/505 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07D221/02 ,  C07D235/02 ,  C07D235/06 ,  C07D235/10 ,  C07D235/12 ,  C07D235/26 ,  C07D235/28 ,  C07D403/10 ,  C07D471/04 ,  C07D487/04

摘要： PURPOSE:To obtain a new biphenylmethane derivative useful as an agent for the treatment of hypertension and/or cardiac insufficiency and its pharmacologically permissible salt. CONSTITUTION:This biphenylmethane derivative is a compound expressed by formula I [R is H, an alkyl, a cycloalkyl, a halogenated alkyl, S-R (R is H, an alkyl, a cycloalkyl, etc.), etc.; R and R each is H, a halogen, a lower alkyl, etc.; R is H or a lower alkyl; R is group of formula II, carboxyl, etc.; R is H, a halogen, hydroxy or a lower alkoxy; A =A --A =A is CH=CH-CH =CH, etc.] or its pharmacologically permissible salt, e.g. 7-methyl-2-eta- propyl-3-[(2'-(1H-tetrazol-5-yl)-biphenyl-4-yl)methyl]-3H-imidazo[4,5- b]pyridine. The compound of formula I wherein R is group of formula II can be produced by using a compound of formula III as a starting substance, reacting with a nitrile compound and reacting the reaction product with an azide of formula IV.

公开(公告)号：JPH0753373A

公开(公告)日：1995-02-28

申请号：JP12483894

申请日：1994-06-07

申请人： TAKEDA CHEMICAL INDUSTRIES LTD

发明人： INADA YOSHIYUKI ,  KUBO KEIJI

IPC分类号： A61K31/135 ,  A61K31/18 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/275 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/38 ,  A61K31/40 ,  A61K31/402 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/433 ,  A61K31/4422 ,  A61K31/465 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/54 ,  A61K31/541 ,  A61K31/549 ,  A61K31/55 ,  A61K31/554 ,  A61K31/575 ,  A61K31/585 ,  A61K45/00 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P25/20 ,  A61P25/24 ,  A61P25/28 ,  A61P27/06 ,  A61P43/00 ,  C07D235/26 ,  C07D235/28 ,  C07D235/30

摘要： PURPOSE:To provide an agent for the prevention or treatment of angiotensin II-mediated diseases, having suppressed side actions of drug and composed of a combination of a compound (salt) having angiotensin II antagonistic action consisting of a specific benzimidazole with a compound having diuretic action or Ca antagonistic action. CONSTITUTION:This agent for the prevention or treatment of various angiotensin II-mediated diseases can be prepared by combining (A) a compound (salt) expressed by the formula [R is a (substituted)hydrocarbon group; R is an (esterified)carboxyl; R is a group capable of forming anion or group convertible to the anion-forming group; X is a group to bond a phenylene group to a phenyl group directly or through a spacer containing (R is H or an alkyl) ; (n) is 1 or 2; ring A is benzene ring which may have substituent in addition to R ] with (B) a compound having diuretic action or a compound having calcium antagonistic action.

公开(公告)号：JPH072839A

公开(公告)日：1995-01-06

申请号：JP1756894

申请日：1994-02-14

申请人： THOMAE GMBH DR K

发明人： FUORUKUHARUTO AUSHIYUTERU ,  HERUMUUTO PIIPERU ,  FURANKU HINMERUSUBATSUHA ,  GIYUNTAA RINTSU ,  TOOMASU MIYUURAA ,  YOHANESU BUAIZENBERUGAA ,  BURAIAN GUUTO

IPC分类号： A61K31/415 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61K31/535 ,  A61K31/5355 ,  A61P3/08 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D235/14 ,  C07D235/26 ,  C07D235/28 ,  C07D235/30 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D413/06 ,  C07D471/04 ,  C07D473/00 ,  C07D473/04 ,  C07D473/06 ,  C07D473/30 ,  C07D487/16

公开(公告)号：JPH0631225B2

公开(公告)日：1994-04-27

申请号：JP23617988

申请日：1988-09-20

申请人： BEERINGAA INGERUHAIMU ITARIA SPA

发明人： MARUKO TORUKOONI ,  ARUTEYURO DONETSUTEI ,  ROSAMARIA MIKERETSUCHI ,  ANNAMARIA UBERUTSUCHI ,  MATSUSHIMO NIKORA ,  ANTONIO JIAKETSUCHI ,  ERUNESUTO MONTAANYA

IPC分类号： C07D487/18 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/46 ,  A61K31/55 ,  A61P1/00 ,  A61P1/08 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/18 ,  A61P25/20 ,  A61P43/00 ,  C07D235/26 ,  C07D401/12 ,  C07D403/12 ,  C07D451/04 ,  C07D451/06 ,  C07D451/12 ,  C07D451/14 ,  C07D453/02 ,  C07D453/06 ,  C07D471/08 ,  C07D487/08

摘要： New pharmacologically active benzimidazoline-2-oxo-1-carboxylic acid derivatives which are 5-HT receptor antagonists useful as antiemetic agents and as gastric prokinetic agents of the following formula: wherein R represents a hydrogen atom, C1-6 alkyl, C1-6 alkenyl or C1-6 alkynil; R1 and R2 may be at the same time or not a hydrogen atom, halogen, trifluoromethyl, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 acyl, carboxyl, C1-6 alkoxycarbonyl, hydroxy, nitro, amino optionally C1-4 alkyl N-mono or di-substituted, C1-6 acylamino, C1-6 alkoxycarbonylamino, carbamoyl optionally C1-4 alkyl N-mono or di-substituted, cyano, C1-6alkylsulphinyl, C1-6 alkylsulphonyl, amino sulphonyl optionally C1-4 alkyl N-mono or di-substituted, C1-4 alkyl N-mono or di-substituted aminosulphonylamino, aminosulphonylamino; Y is oxygen or is N - R3 in which R3 is a hydrogen, a C1-6 alkyl or optionally substituted by one or more C1-6 alkoxy benzyl; A is a group selected from: wherein p is 0, 1; r is 0, 1, 2, 3; R4 is hydrogen atom or a C1-4 alkyl; R5 is a hydrogen atom, C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-4 alkyl,substituted phenyl C1-4 alkyl or R5 is a group of formula wherein R6 is hydrogen atom, C1-4 alkyl or an amino group and R7 is hydrogen atom or C1-6 alkyl, tautomers thereof and acid addition salts of the aforesaid compounds. The processes for the preparation of the compounds of formula (I) as well as pharmaceutical compositions containing them are also described.

公开(公告)号：JPH06503073A

公开(公告)日：1994-04-07

申请号：JP50028192

申请日：1991-11-28

IPC分类号： A61K31/495 ,  A61K31/496 ,  A61K31/505 ,  A61P25/04 ,  A61P25/06 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P43/00 ,  C07D207/24 ,  C07D207/26 ,  C07D207/263 ,  C07D207/27 ,  C07D233/30 ,  C07D233/32 ,  C07D233/36 ,  C07D233/42 ,  C07D235/26 ,  C07D239/10 ,  C07D239/34 ,  C07D239/38 ,  C07D263/20 ,  C07D263/22 ,  C07D265/10 ,  C07D295/06 ,  C07D295/073 ,  C07D295/088 ,  C07D295/12 ,  C07D307/52 ,  C07D333/20

公开(公告)号：JPH0625153B2

公开(公告)日：1994-04-06

申请号：JP2420690

申请日：1990-02-02

申请人： YAMANOUCHI PHARMA CO LTD

发明人： OOTA MITSUAKI ,  KOIDE TOKUO ,  SUZUKI TAKESHI ,  MATSUHISA AKIRA ,  OOMORI JUNYA ,  MYATA KEIJI ,  YANAGISAWA ISAO

IPC分类号： A61K31/415 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/47 ,  A61K31/475 ,  A61K31/535 ,  A61K31/5355 ,  A61K31/54 ,  A61K31/541 ,  A61P1/00 ,  A61P1/08 ,  A61P23/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/18 ,  A61P25/20 ,  A61P43/00 ,  C07D235/20 ,  C07D235/26 ,  C07D235/30 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04