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    Multipotent neural stem cell cDNA libraries
    2.
    发明授权
    Multipotent neural stem cell cDNA libraries 失效
    多能神经干细胞cDNA文库

    公开(公告)号：US07105342B2

    公开(公告)日：2006-09-12

    申请号：US09925911

    申请日：2001-08-09

    申请人： Samuel Weiss ,  Brent Reynolds

    发明人： Samuel Weiss ,  Brent Reynolds

    IPC分类号： C12N15/63 ,  C12N15/12

    CPC分类号： G01N33/5058 ,  A01K2217/05 ,  A61K48/00 ,  C07K14/47 ,  C07K14/475 ,  C07K14/82 ,  C12N5/0623 ,  C12N9/0065 ,  C12N9/2471 ,  C12N2500/25 ,  C12N2500/46 ,  C12N2500/90 ,  C12N2501/11 ,  C12N2501/148 ,  C12N2501/15 ,  C12N2501/392 ,  C12N2501/91 ,  C12N2503/02 ,  C12N2510/00 ,  C12Y302/01023 ,  G01N33/5008 ,  G01N33/5017 ,  G01N33/5023 ,  G01N33/5073 ,  G01N2500/00 ,  G01N2510/00

    摘要： cDNA libraries may be obtained from neural cell cultures produced by using growth factors to induce the proliferation of multipotent neural stem cells. The libraries may be obtained from both cultured normal and dysfunctional neural cells and from neural cell cultures at various stages of development. This information allows for the identification of the sequence of gene expression during neural development and can be used to reveal the effects of biological agents on gene expression in neural cells. Additionally, nucleic acids derived from dysfunctional tissue can be compared with that of normal tissue to identify genetic material which may be the cause of the dysfunction. This information could then be used in the design of therapies to treat the neurological disorder. A further use of the technology would be in the diagnosis of genetic disorders or for use in identifying neural cells at a particular stage in development.

    摘要翻译： cDNA文库可以从使用生长因子产生的神经细胞培养物获得以诱导多能神经干细胞的增殖。 文库可以从培养的正常和功能障碍的神经细胞和来自神经细胞培养物的不同发展阶段获得。 该信息允许在神经发育期间鉴定基因表达序列，并且可以用于揭示生物剂对神经细胞中的基因表达的影响。 另外，来自功能障碍组织的核酸可以与正常组织的核酸进行比较，以鉴定可能是功能障碍的原因的遗传物质。 然后可以将该信息用于设计治疗神经障碍的治疗。 该技术的进一步使用将在于遗传疾病的诊断或用于在发育的特定阶段鉴定神经细胞。