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公开(公告)号：US20240307316A1
公开(公告)日：2024-09-19
申请号：US18605959
申请日：2024-03-15
申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College , Inha University , Baylor College of Medicine
CPC分类号： A61K9/4866 , A61K9/4825 , A61K33/08 , A61P17/02
摘要： In one aspect, the disclosure relates to compounds comprising one or more lignin derivatives, at least one organic peroxide, and a pharmaceutically-acceptable carrier. In an aspect, the one or more lignin derivatives can be or include thiolated lignosulfonate (TLS), sodium lignosulfonate (SLS), or a combination thereof. In one aspect, the SLS can be grafted to a polymer or copolymer such as poly(lactic-co-glycolic) acid (PLGA) in order to form a shell of a core-shell nanoparticle, wherein the shell surrounds a core of the inorganic peroxide and protects the core from premature activation in an aqueous wound environment. In another aspect, the pharmaceutically-acceptable carrier can be a hydrogel forming polymer such as a methacrylated gelatin, which can assist in modulating the properties of the lignin derivatives to be suitable for injection. Also disclosed herein are methods of using the disclosed compositions for the treatment of wounds in subjects, including in diabetic subjects.
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公开(公告)号：US20240280295A1
公开(公告)日：2024-08-22
申请号：US18431730
申请日：2024-02-02
CPC分类号： F24T10/20 , E21B7/00 , E21B11/06 , F24T2010/53
摘要： Disclosed are various approaches for using controlled fractures in geothermal systems. In some examples, a method includes drilling at least one injection well bore. The method can also include cutting at least a first slot at an angle to the injection well bore, where the first slot has a first end connected to the injection well bore and a distal end. The method can include cutting at least a second slot at an angle to the injection well bore, where the second slot has a first end connected to the distal end of the first slot and a distal end. The method can also include drilling at least one production well bore, where the production well bore is connected to the distal end of the second slot.
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公开(公告)号：US12049233B2
公开(公告)日：2024-07-30
申请号：US16901634
申请日：2020-06-15
CPC分类号： B60W50/14 , B60W30/08 , B60W40/12 , B60W2050/0052 , B60W2050/0059 , B60W2050/0075 , B60W2300/12 , B60W2420/403 , B60W2420/408 , B60W2420/54 , B60W2530/201 , B60W2554/20 , B60W2556/50 , B60W2556/55
摘要： A system and method are disclosed for overheight vehicle impact avoidance and incident detection. A detection subsystem of the system determines whether an incoming vehicle is clear to pass, depending at least on its height. The detection subsystem relies on distance sensors located along the freeway to detect the highest point of the vehicle and outputs an indication of whether the vehicle can pass. A warning subsystem receives the indication that a vehicle is overheight and provides a warning indication to the driver about the vehicle's inability to pass an upcoming structure. The warning subsystem may also perform a variety of other tasks, such as, for example, logging a variety of information about the vehicle and the incident, sending data about the incident locally to a central command, and generating reports.
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公开(公告)号：US20240238268A1
公开(公告)日：2024-07-18
申请号：US18690468
申请日：2022-09-09
发明人： Hung Wen (Kevin) Lin
IPC分类号： A61K31/4545 , A61K38/45 , A61P25/28
CPC分类号： A61K31/4545 , A61K38/45 , A61P25/28
摘要： Therapeutics and methods treating Alzheimer's disease or a pre-Alzheimer's disease condition in a patient comprising administering a pharmaceutical composition containing a therapeutically effective dose therapeutic, wherein the therapeutic contains a PRMT4 inhibitor, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof. According to a further embodiment, the PRMT4 inhibitor is one of TP-064 and SCFFBXO9.
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公开(公告)号：US12011508B2
公开(公告)日：2024-06-18
申请号：US16965078
申请日：2019-02-01
IPC分类号： A61K9/51 , A61K31/05 , A61K31/366 , A61L29/08 , A61L29/16 , A61M25/10 , C08F220/34
CPC分类号： A61K9/5153 , A61K9/5138 , A61K31/05 , A61K31/366 , A61L29/085 , A61L29/16 , A61M25/10 , C08F220/34 , A61L2300/216 , A61L2400/12 , A61M2025/105
摘要： In one aspect, the disclosure relates to compositions, methods, and devices pertaining to polymeric nanoparticle compositions (pNP), pNP compositions comprising a therapeutic agent, devices comprising a drug-coated balloon comprising a disclosed pNP comprising a therapeutic agent, and methods for treating peripheral artery disease using the disclosed compositions and devices. In further aspects, the pNP comprises a poly (lactic-co-glycolic) acid possessing a positive charge for firm attachment to the balloon matrix, followed by adhesion to the negatively charged bilayer of the vascular wall. In still further aspects, the therapeutic agent comprises a resveratrol or derivative thereof, a quercetin or derivative thereof, or combinations thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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6.发明公开公开(公告)号：US20240018610A1
公开(公告)日：2024-01-18
申请号：US18350071
申请日：2023-07-11
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , C12Q2600/16 , C12Q2600/156
摘要： Embodiments of the present disclosure provide for embodiments of a panel of oligonucleotides for use in a multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) assay for the identification of rotavirus A and B and genotypes thereof. Another aspect of the disclosure encompasses embodiments of an RT-PCR multiplex method for determining whether an equine is infected with an equine rotavirus.
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公开(公告)号：US20230400860A1
公开(公告)日：2023-12-14
申请号：US18331466
申请日：2023-06-08
发明人： Jonathan Shi
CPC分类号： G05D1/0214 , G05D1/0291 , G01C21/383
摘要： System and methods for enabling a mobile robot for autonomous missions are described. Despite some mobile robots having the capability of safely traversing complex terrains, mobile robots still behave like a typical machine which can only respond to a human's commands via an interactive controller. For example, a human will drive the mobile robot to desired locations, position it, and activate actions as desired in order to complete a mission. As such, it is desirable to enable a mobile robot with the capability of executing and completing a mission without a human's involvement. The present disclosures includes innovative technology which enables an ordinary user to quickly define a complex mission in the form that a mobile robot can understand and automatically execute it accordingly.
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公开(公告)号：US11790244B2
公开(公告)日：2023-10-17
申请号：US16230691
申请日：2018-12-21
发明人： David Sathiaraj
CPC分类号： G06N5/02 , G06F16/285 , G07C13/00
摘要： A system and method for generating a predictive model include accessing data from a dynamic dataset and a static dataset, generating a unique individual profile for each of a plurality of subjects within a population, assigning a class attribute to each subject, and based on the unique individual profile and the class attribute for each subject, developing a classification model based on the unique individual profile and the class attribute for each of the plurality of subject, and generating an individual score for each of the plurality of subjects using the classification model. The unique individual profile is generated from the data in the dynamic and the static datasets.
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公开(公告)号：US11767263B2
公开(公告)日：2023-09-26
申请号：US17740779
申请日：2022-05-10
发明人： Guoqiang Li , Harper Meng
IPC分类号： C04B26/16 , C04B26/04 , C08G18/32 , B29C73/18 , C04B26/26 , C04B28/02 , C04B20/10 , C08G18/66 , C08G18/76 , C08G18/42 , C08L75/04 , C08G18/10 , D01F6/70 , C04B111/00 , C04B111/72 , C04B103/00 , D01D5/12
CPC分类号： C04B26/16 , B29C73/18 , C04B20/1037 , C04B26/04 , C04B26/26 , C04B28/02 , C08G18/10 , C08G18/3206 , C08G18/4238 , C08G18/664 , C08G18/7671 , C08L75/04 , C04B2103/0065 , C04B2111/00612 , C04B2111/72 , C08G2110/0025 , C08G2280/00 , C08G2350/00 , D01D5/12 , D01F6/70 , C08G18/10 , C08G18/3206
摘要： Provided is a method for altering properties of tension programmed fibrous shape memory polymer. The method can include applying a protective coating to the tension programmed shape memory polymer, then applying a supportive coating to the tension programmed shape memory polymer to form a coated fiber. The protective coating avoids contact between the shape memory polymer and chemicals used in the supportive coating that can decompensate the shape memory polymer.
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公开(公告)号：US11759438B2
公开(公告)日：2023-09-19
申请号：US16610382
申请日：2018-05-01
IPC分类号： A61K31/137 , A61K9/00 , A61K9/06 , A61K31/404 , A61K31/48 , A61K45/06
CPC分类号： A61K31/137 , A61K31/404 , A61K31/48 , A61K9/0048 , A61K9/06 , A61K45/06
摘要： This invention features compositions, methods, and kits for treating conditions associated with pathological ocular neovascularization, reducing scarring in the eye, treating dry eye, treating macular degeneration, and treating keratitis by administering a serotonin receptor agonist.
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