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公开(公告)号:US12116402B2
公开(公告)日:2024-10-15
申请号:US17538731
申请日:2021-11-30
申请人: SANOFI PASTEUR INC.
发明人: Stephen F. Anderson , Natalie Anosova , Nicola Beltraminelli , Pierre Garrone , Harold Kleanthous , Majid Mehtali , Jianxin Zhang
CPC分类号: C07K16/1282 , A61K39/40 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/30 , C07K2317/31 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要: Monoclonal antibodies, or antigen-binding fragments thereof, that bind to Clostridium difficile (C. difficile) toxin A or toxin B and methods of using the same to detect or treat C. difficile infections and/or C. difficile-associated disease.
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公开(公告)号:US20240277828A1
公开(公告)日:2024-08-22
申请号:US18653422
申请日:2024-05-02
申请人: SANOFI PASTEUR INC
发明人: Timothy ALEFANTIS , Mario BARRO , Anthony BYERS , Guadalupe CORTES-GARCIA , Philippe-Alexandre GILBERT , Harold KLEANTHOUS , Armaghan NAIK , Konstantin PUGACHEV , Saranya SRIDHAR , Thorsten VOGEL , William WARREN
IPC分类号: A61K39/145 , A61K39/00 , A61P37/04
CPC分类号: A61K39/145 , A61P37/04 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/70
摘要: Disclosed herein are multivalent vaccine or immunogenic compositions comprising one or more recombinant influenza virus hemagglutinin (HA), one or more recombinant influenza virus neuraminidase (NA), and an optional adjuvant. Also disclosed are methods of using the vaccine or immunogenic composition.
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公开(公告)号:US11904012B2
公开(公告)日:2024-02-20
申请号:US17400390
申请日:2021-08-12
申请人: SANOFI PASTEUR INC.
发明人: Tod Strugnell , Eliud Oloo , Raymond Oomen
IPC分类号: C07K14/005 , C07K14/11 , C07K16/10 , C07K16/18 , A61K39/145 , A61P31/16 , C12N7/00 , A61K39/00
CPC分类号: A61K39/145 , A61P31/16 , C07K14/005 , C12N7/00 , A61K2039/5258 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要: The present invention provides, among other things, modified recombinant HA polypeptides with broadened immunogenic profile that extends coverage to antigenically distinct influenza strains and methods of making and using the same.
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公开(公告)号:US11827668B2
公开(公告)日:2023-11-28
申请号:US17813445
申请日:2022-07-19
申请人: SANOFI PASTEUR INC.
IPC分类号: C07K14/11 , G01N33/569 , C07K14/005 , C07K16/10
CPC分类号: C07K14/11 , C07K14/005 , C07K16/10 , G01N33/569 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2800/22
摘要: The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
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公开(公告)号:US20210401963A1
公开(公告)日:2021-12-30
申请号:US17471825
申请日:2021-09-10
发明人: Kyungjun AN , Dongsoo HAM , Hun KIM , Sunghyun KIM , Jinhwan SHIN , Robert HOPFER , Richard D. KENSINGER , Moe KYAW , Philippe TALAGA
IPC分类号: A61K39/09
摘要: Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 21 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to either tetanus toxoid (TT) or CRM197, wherein the Streptococcus pneumoniae serotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11 A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F, where the capsular polysaccharides of two of serotypes 1, 3, and 5 and one or both of serotypes 15B and 22F are conjugated to TT and the remaining capsular polysaccharides are conjugated to CRM197. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject.
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公开(公告)号:US20210128715A1
公开(公告)日:2021-05-06
申请号:US17041784
申请日:2019-03-27
申请人: SANOFI PASTEUR INC.
发明人: Tod STRUGNELL , Eliud OLOO , Raymond OOMEN , Thorsten VOGEL , Harold KLEANTHOUS
IPC分类号: A61K39/145 , C07K14/11 , A61P31/16
摘要: The present disclosure relates to a cluster-based consensus approach for generating recombinant hemagglutinin (HA) polypeptides. The disclosure further relates to influenza vaccine compositions comprising the recombinant HA polypeptides.
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公开(公告)号:US10927151B2
公开(公告)日:2021-02-23
申请号:US15580192
申请日:2016-06-09
申请人: SANOFI PASTEUR, INC.
IPC分类号: C07K14/11 , G01N33/569 , C07K14/005 , C07K16/10
摘要: The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
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公开(公告)号:US10925957B2
公开(公告)日:2021-02-23
申请号:US16258094
申请日:2019-01-25
发明人: Ted Milburn Ross , Tim Alefantis , Donald Martin Carter, Jr. , Christopher Austin Darby , Harold Kleanthous
IPC分类号: A61K39/145 , A61K39/12 , A61K39/00
摘要: Co-administration (for example, immunogenic cocktail compositions and/or prime boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides is provided. Coadministration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (for example, a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.
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公开(公告)号:US08741314B2
公开(公告)日:2014-06-03
申请号:US13738698
申请日:2013-01-10
申请人: Sanofi Pasteur Inc.
发明人: Robert P. Ryall
IPC分类号: A61K39/095 , A61K39/385 , A61K39/02 , A61K39/00 , A01N43/04 , C07H1/00 , A61K39/116
CPC分类号: A61K47/64 , A61K39/095 , A61K39/116 , A61K39/39 , A61K47/02 , A61K47/08 , A61K47/24 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/55505 , A61K2039/6037 , A61K2039/70
摘要: The present invention describes a combined vaccine that offers broad protection against meningococcal disease caused by the pathogenic bacteria Neisseria meningitidis. The vaccine is comprised of four distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. Purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y are chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long-lasting immunity to a variety of N. meningitidis strains in children as well as adults.
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公开(公告)号:US20240335525A1
公开(公告)日:2024-10-10
申请号:US18682372
申请日:2022-08-10
申请人: SANOFI PASTEUR INC.
发明人: Mario BARRO , Yvonne CHAN , Guadalupe CORTES-GARCIA , Raul GOMILA , Liqun HAN , Justin KLEKOTA , Fuqin MA , Satyajit RAY , Svetlana STEGALKINA , Tod STRUGNELL , Irina USTYUGOVA , Thorsten VOGEL , Jianxin ZHANG
IPC分类号: A61K39/145 , A61K39/00 , A61P37/04 , C07K14/005 , C07K14/705 , C12N9/24
CPC分类号: A61K39/145 , A61P37/04 , C07K14/005 , C07K14/70596 , C12N9/2402 , C12Y302/01018 , A61K2039/645 , C07K2319/02 , C12N2760/16134
摘要: Provided are modified influenza virus subtype 2 neuraminidase molecules lacking all or substantially all of the stalk region that form active, soluble tetrameric neuraminidase when expressed in host cells and vaccine compositions comprising the tetrameric neuraminidase or a nucleic acid encoding the modified monomeric influenza virus subtype 2 neuraminidase molecules that forms tetrameric NA when expressed in a cell. Also provided are methods of using the vaccine compositions to vaccinate or immunize a subject against influenza virus.
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