SUBSTRATE FOR ANALYZING COVERAGE OF SELF-ASSEMBLED MOLECULES AND ANALYZING METHOD USING THE SAME
    6.
    发明申请
    SUBSTRATE FOR ANALYZING COVERAGE OF SELF-ASSEMBLED MOLECULES AND ANALYZING METHOD USING THE SAME 审中-公开
    用于分析自组装分子的覆盖的基板和使用其的分析方法

    公开(公告)号:US20100015718A1

    公开(公告)日:2010-01-21

    申请号:US12517769

    申请日:2007-11-26

    IPC分类号: G01N33/00

    摘要: Provided are a substrate for analyzing the coverage of self-assembled molecules and a method for analyzing the coverage of the self-assembled molecules in nanowire and nanochannel patterned on solid surface, solid surface, or bulk solid surface by using the nanoparticles. According to the method, the presence of specific functional groups of self-assembled molecules and the degree of reaction can be analyzed by introducing nanoparticles to a biomaterial immobilization substrate including self-assembled molecules and measuring the number of gold nanoparticles existing on the surface. The substrate for analyzing the coverage of self-assembled molecules includes: a biomaterial immobilization substrate; a self-assembled molecular layer formed on the substrate and having a functional group capable of reacting with an amine group; a capture DNA molecule having an amine group bounded to the self-assembled molecular layer; and a probe DNA molecule bound to the capture DNA molecule and having nanoparticles attached to on the surface.

    摘要翻译: 本发明提供了一种用于分析自组装分子的覆盖物的底物以及通过使用纳米颗粒分析在固体表面,固体表面或体固体表面上图案化的纳米线和纳米通道中的自组装分子的覆盖率的方法。 根据该方法,可以通过将纳米颗粒引入包括自组装分子的生物材料固定化基质并测量表面上存在的金纳米颗粒的数量来分析自组装分子的特定官能团的存在和反应程度。 用于分析自组装分子的覆盖的底物包括:生物材料固定基质; 形成在基板上并具有能够与胺基反应的官能团的自组装分子层; 具有与自组装分子层结合的胺基的捕获DNA分子; 和与捕获DNA分子结合并且具有附着在表面上的纳米颗粒的探针DNA分子。